Published March 29 (EPO); March 23 (WO); March 29 (GB)
Actinova WO 00/15803
Immunoglobulin binding protein
Cambridge, UK
Immunoglobulin light chain binding protein, encoding gene sequences, mutations; for therapeutics.
Alabama, Univ. of WO 00/15648
Apoptosis therapeutic
Birmingham, Ala.
Adenoviral vector encoding the pro-apoptotic Bax gene; for therapeutics that cause cell death.
Aston Univ. WO 00/15777
Specific binding partners
Birmingham, UK
Protein libraries, encoding gene sequences; for identifying proteins interacting with specific binding partners.
BASF-Lynx Bioscience WO 00/15786
GABA receptor modulators
Heidelberg, Germany
Proteins that are part of the metabotropic GABA receptor complex from the CNS; for finding modulators.
Biogen WO 00/15247
Multiple myeloma treatment
Cambridge, Mass.
Methods for treating multiple myeloma and myeloma-induced bone resorption using integrin ligand adhesion antagonists.
Bressagen WO 00/15664
Modified hGH
Thebarton, Australia
Modified human growth hormone (hGH), production using ubiquitin fusion proteins; for therapeutics.
California, Univ. of WO 00/15660
Staphylococcus antibacterial
Oakland, Calif.
Target of RNAIII activating protein from Staphylococcus aureus, humanized antibodies; for inhibiting infection.
California, Univ. of WO 00/15771
Vanadium haloperoxidases
Oakland, Calif.
Recombinant vanadium haloperoxidases, encoding gene sequences, production methods.
California, Univ. of WO 00/15821
Heart-specific gene expression
La Jolla, Calif.
Recombinant adenoviral vector with the cardiac ankyrin repeat protein promoter; for gene expression in heart.
Calif. Inst. Technol. WO 00/15242 & 15773
HER2/neu expression regulation
Pasadena, Calif.
Regulation of HER2/neu oncogene expression by synthetic polyamides; for cancer therapeutics.
Calydon WO 00/15820
Adenoviral vector regulation
Sunnyvale, Calif.
Adenovirus vectors containing reversible physiological state-specific transcriptional regulatory elements.
Cancer Res. Camp. Technol. WO 00/15663
HIV entry suppression
London
LD78_ isoform of MIP-1a chemokine; for suppressing activity of the CCR5 co-receptor involved in HIV cellular entry.
Centeon Pharma EPO 989 184
Defective coagulation transgenics
Marburg, Germany
Transgenics with defective Factor XIII coagulation; for wound healing and bleeding analysis.
Children's Hosp. WO 00/15819
HIV vector packaging cells
Boston
Packaging cell lines for generating accessory protein independent HIV-derived retroviral vector particles.
Copenhagen Univ. WO 00/15804
Peroxidase production
Copenhagen, Denmark
Production of peroxidases in cells having a less reducing environment than normal.
Cornell Univ. GB 2 341 926
Rod-cone degeneration
Ithaca, N.Y.
Genetic markers for progressive rod-cone degeneration located on chromosome 9; for diagnostics.
Curagen WO 00/15851
Gene relatedness patterns
New Haven, Conn.
Geometrical and hierarchical gene relatedness classification based on gene expression patterns.
Dana-Farber Cancer Inst. WO 00/15651
Attractin
Boston
Attractin, encoding gene sequences; for regulating the immune response.
Dynal WO 00/15842
Isolating primer extensions
Oslo, Norway
Methods for isolating primer extension products using modular oligonucleotides having attached magnetic beads.
Edinburgh, Univ. of WO 00/15764
Embryonic stem cell isolation
Edinburgh, UK
Derivation and propagation of embryonic stem cells using compounds that inhibit signalling in differentiated cells.
Eli Lilly WO 00/15781
FGF inhibitors
Indianapolis
SPROUTY-1 related proteins; for inhibiting fibroblast growth factor (FGF) and treating cancer and developmental defects.
Erasmus Univ. WO 00/15839
Bone damage risk
Rotterdam, the Netherlands
Screening for polymorphisms in the vitamin D receptor gene; for determining susceptibility to bone damage.
Erasmus Univ. WO 00/15840
Heart disease risk
Rotterdam, the Netherlands
Screening for polymorphisms in the vitamin D receptor gene; for determining susceptibility to heart disease.
European Molec. Biol. Lab WO 00/15843
Genetic suppression therapy
Heidelberg, Germany
Identification of dominant suppression agents useful in genetic suppression therapy.
Flinders Technol. WO 00/15776
Separating genetic material
Bedford Park, Australia
Separation of genetic material from samples having genetic material from multiple sources using a solid medium.
Florida, Univ. of WO 00/15783
_1-adrenoreceptor antisense
Gainesville, Fla.
Antisense oligonucleotides targeted to _1-adrenoreceptor-specific mRNA; for treating hypertension and heart disease.
Florida, Univ. of WO 00/15822
Retinal disease therapy
Gainesville, Fla.
In vivo expression of heterologous genes controlled by retinal pigment epithelial cell-specific promoters.
French Atomic Energy Comm. WO 00/15841
Cancer cell detection
Paris
Fluorescence-based probe assay for detecting intrachromosome imbalance in interphase nuclei; for finding cancer cells.
Gardino Investment WO 00/15788
Transplantation facilitation
Curacao, Netherlands Antilles
Gene sequences encoding oncofetal ferritin protein, encoding gene sequences; for facilitating transplantation.
Gene Logic WO 00/15847
Genomic knowledge discovery
Gaithersburg, Md.
Genomic knowledge discovery using automated iterative methods to search databases and infer characteristics.
Genelabs Technol. WO 00/15848
Nucleic acid ligand binding
Redwood City, Calif.
Competitive binding assays for measuring the binding affinities of ligands for nucleic acids.
Genentech WO 00/15666
Cancer therapeutics
S. San Francisco
Genes amplified in tumor cells, overexpressed encoded proteins; for developing cancer therapeutics.
Genentech WO 00/15792
Angiogenesis modulators
S. San Francisco
Polypeptides and antagonists for the modulation of angiogenesis and vascularization in the heart.
Genentech WO 00/15796
Secreted transmembrane proteins
S. San Francisco
Secreted transmembrane polypeptides, chimeras, fusions, encoding gene sequences, antibodies; for therapeutics.
Genentech WO 00/15797
Immune disease proteins
S. San Francisco
Proteins and encoding gene sequences for the treatment of immune-related diseases.
Genetics Inst. WO 00/15249
Kaposi's treatment
Cambridge, Mass.
Methods for using interleukin (IL)-12 to treat AIDS-associated Kaposi's sarcoma.
Genvec WO 00/15823
Alternatively targeted adenoviruses
Gaithersburg, Md.
Adenoviral fiber protein fusion with a heterologous peptide; for alternative targeting of adenoviral vectors.
Glaxo WO 00/15833
EST sequencing
Greenford, UK
Run-off sequencing of relatively short portions of nucleic acids; for identifying expressed sequence tags (ESTs).
Hanmi Pharma WO 00/15661
Bacterial protein production
Kyunggi-do, S. Korea
Modified E. coli enterotoxin II signal peptide; for expressing a fusion with a heterologous protein.
Hanmi Pharma WO 00/15808
Protein production in milk
Kyunggi-do, S. Korea
Mammary gland-specific expression system using the _-casein promoter of the native Korean goat; for protein production.
Harvard Univ. WO 00/15246
Regulating lung growth
Cambridge, Mass.
Methods for regulating lung tissue growth using hedgehog-like proteins; for therapeutics.
Henkel WO 00/15828
Polycarboxylic acid production
Gulph Mills, Penn.
Bacterial strains and methods for making polycarboxylic acids.
Hitachi EPO 989 193
Analyzing long DNAs
Tokyo
Methods for analyzing long DNAs or fragments using probe hybridization and fractionation.
Hoechst Marion Roussel WO 00/15838
Antifungal screens
Puteaux, France
Essential genes from Candida yeast strains; for screening antifungal therapeutics.
Human Genome Sciences WO 00/15759
IL 17-like receptor
Rockville, Md.
Interleukin (IL) 17-like receptor protein, encoding gene, production methods; for finding modulators and therapeutics.
Hyman, E.D. WO 00/15846
Cloning method
Metarie, La.
Zero background cloning method using biotin-labelled DNA separated by streptavidin paramagnetic beads.
Igen Intl. WO 00/15850
Nucleic acid cleaving enzymes
Gaithersburg, Md.
Assays for enzymes that cleave or join nucleic acids using electrochemiluminescent labels.
Incyte Genomics WO 00/15770
Serine-threonine kinases
Palo Alto, Calif.
Serine-threonine kinases, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/15793
Human GPCR proteins
Palo Alto, Calif.
Human GPCR proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/15794
Cell junction protein
Palo Alto, Calif.
Human cell junction PDZ protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/15799
RNA-associated proteins
Palo Alto, Calif.
RNA-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/15806
ATP synthase subunit homolog
Palo Alto, Calif.
ATP synthase subunit homolog, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/15844
Nucleic acid sequencing
Palo Alto, Calif.
Nucleic acid sequencing methods using solid phase capturable chain terminators.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/16102
Tyrosine kinase receptor control
Paris
Compounds that co-aggregate with a tyrosine kinase receptor; for controlling cell process activation by this receptor.
Johns Hopkins Univ. WO 00/15795
Chromosome 11 cancer genes
Baltimore
Genes from the tumor-suppressing fragment of human chromosome 11, cancer-associated polymorphisms.
Karolinska Innovations WO 00/15824
Nuclear targeting
Stockholm
Nucleic acid sequences linked to a nuclear localization signal from an antennapedia peptide; for targeting.
Kishimoto, T. EPO 989 186
Cytokine function regulation
Osaka, Japan
STAT function-regulatory protein, encoding gene sequences, antisense; for regulating cytokine function.
Kohn, L.D., et al. WO 00/15768
Immune activation by DNA
Bethesda, Md.
Immune activation of antigen-presenting cells using immunogenic double-stranded polynucleotides.
Krebs Res. Ctr. WO 00/15837
Oligomer grid production
Heidelberg, Germany
Methods of quality control in the production of oligomer grids having phosphates linked to signal generators.
Kyowa Hakko Kogyo EPO 989 136
p53 activity restoration
Tokyo
Peptides having cyclic structure that restore activity to p53 protein mutants.
M&E Biotech WO 00/15807
Osteoporosis therapeutic
Hersholm, Denmark
Inducing an immune response to osteoprotegerin ligand; for preventing osteoporosis and other bone loss.
Maryland, Univ. of WO 00/15252
Immunotherapy
Baltimore
Methods for using Zot or zonulin to inhibit antigen-presenting cell activity; for immunotherapy.
Max Delbruck Ctr. Molec. Biol. WO 00/15784
EDG6 receptor
Berlin
Human and mouse G-protein coupled EDG6 receptor, fragments, variants, mutations, encoding gene; for therapeutics.
Millennium Pharma WO 00/15790 & 15826
Body weight modulators
Cambridge, Mass.
Leptin-induced gene, encoded proteins; for finding modulators and agents that affect body weight.
Mt. Sinai Sch. Med. WO 00/15853
HIV protein production
New York
Genetically engineered Newcastle disease virus vectors; for producing heterologous proteins from the HIV genome.
New Jersey, Med. & Dent. Univ. WO 00/15782
Ribosomal frameshift sequences
New Brunswick, N.J.
Methods for identifying ribosomal frameshift sequences; for regulating gene expression using these sequences.
Nexia Biotech WO 00/15772
Therapeutics produced in urine
Ste. Anne de Bellevue, Que.
Recombinant protein production in urine using the uromodulin gene promoter linked to a heterologous protein gene.
Nizo Food Res. WO 00/15655
Peptide purification
Ede, the Netherlands
Purification of peptides from biological fluids using chromatographic membranes and enzymatic hydrolysis.
North American Vaccine WO 00/15760
Streptococcal vaccines
Columbia, Md.
Streptococcal C _ protein; for vaccines that are bacteriocidal with complement alone.
Pan Pacific Pharma WO 00/15774
Bee venom protein
Menlo Park, Calif.
Honey bee venom protein, encoding gene sequences, antibodies; for treating inflammatory diseases.
Pedersen, L.O., et al. WO 00/15665
Immunoglobulin superfamily protein
Copenhagen, Denmark
Production of a functional MHC class I immunoglobulin superfamily protein in bacteria; for therapeutics.
Pfizer EPO 989 187
Pharmaceutical intermediates
Groton, Conn.
Transformation of organics by Monosporium and Thamosylum bacteria; for making pharmaceutical intermediates.
Pioneer Hi-Bred WO 00/15800
Blood vessel damage inhibitor
Des Moines, Iowa
Plant Rac polypeptides, encoding genes; for transfection to prevent reperfusion injuries and blood vessel damage.
Pittsburgh, Univ. of WO 00/15264
Cellular cancer therapy
Pittsburgh
In situ injection of antigen-presenting cells having enhanced cytokine expression; for infections and cancer.
Queensland, Univ. of WO 00/15654
Cyclized conotoxins
St. Lucia, Australia
Cyclized conotoxin peptides, production methods; for therapeutics.
Rothman, J.E. WO 00/15263
Hydrogel DNA delivery
New York
Gene delivery system that uses microparticles fabricated from pH-sensitive hydrogels in collapsed states.
Sci. Invest. Council WO 00/15787
Death inducer obliterator
Madrid, Spain
Genes encoding human and mouse death inducer obliterator-1, encoded protein, expression methods.
Scripps Res. Inst. WO 00/15209
HER2/neu expression regulation
La Jolla, Calif.
Regulation of HER2/neu oncogene expression by synthetic polyamides; for cancer therapeutics.
Sensor Technol. WO 00/16099
Carbohydrate assays
Shrewsbury, Mass.
Reduced valency carbohydrate binding ligands; for measuring carbohydrates using fluorescence resonance energy transfer.
Sequus Pharma WO 00/15825
Condensed plasmid-liposomes
Menlo Park, Calif.
Condensed plasmid-liposomes having cationic liposomes and polycationic condensing agents; for gene transfection.
Shimadzu EPO 989 192
Stopping PCR inhibition
Kyoto, Japan
Efficient amplification of nucleic acids using sulfated polysaccharides and dithiothreitol to stop PCR inhibitors.
Siffert, W. WO 00/15785
G-protein dysregulation
Essen, Germany
Modifications in the gene for the G_3-subunit of human G-proteins; for determining G-protein dysregulation risk.
Signalgene WO 00/15834 & 15835
Breast cancer risk
Montreal
Determination of androgen and vitamin D receptor genotype; for diagnosing breast cancer susceptibility.
Signalgene WO 00/15836
Breast cancer risk
Montreal
Determination of estrogen and vitamin D receptor genotype; for diagnosing breast cancer susceptibility.
SmithKline Beecham WO 00/15255
Herpes infection treatment
Rixensart, Belgium
Methods for using the antigenic herpes glycoprotein D to induce immunity to herpes infection.
SmithKline Beecham WO 00/15650
Multidrug resistance inhibitors
Philadelphia
Rat MDR1A protein, encoding gene sequences, production methods; for finding multidrug resistance inhibitors.
SmithKline Beecham WO 00/15769
Antibacterial screens
Philadelphia
topA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/15775
Streptococcus antimicrobials
Philadelphia
Streptococcus aureus RNAse P ribonucleotide complex, encoding gene sequences; for antimicrobial screens.
SmithKline Beecham WO 00/15801
Meningitis therapeutics
Rixensart, Belgium
Neisseria meningitidis proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/15802
Moraxella diagnostics
Rixensrt, Belgium
Moraxella catarrhalis proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/15805
Protein kinase
Brentford, UK
Protein kinase KIAA0551, encoding gene, production methods; for neurogenerative disease therapeutics.
South Alabama Med. Sci. Fdn. WO 00/15845
T-type calcium channels
Mobile, Ala.
Pancreatic T-type calcium channel, encoding gene sequence, antisense; for therapeutics.
Stoddard, S.F., et al. WO 00/15827
Non-toxic lipopolysaccharides
Decatur, Ill.
Transformed bacterial strains for the production of quinones and non-toxic lipopolysaccharides.
Tanox WO 00/15260
Allergy therapy
Houston
Immunoglobulin (Ig)-E antibodies, fragments, encoding gene sequences; for allergic disease therapy.
Thomas Jefferson Univ. WO 00/15649
Restenosis inhibition
Philadelphia
Viral vector expressing RB2/p130; for inhibiting smooth muscle cell proliferation and preventing restenosis.
Tosoh EPO 989 185
Cleaving nucleic acids
Yamaguchi, Japan
Cleaving specific nucleic acid sequences using probes linked to an intercalater and spermine activated by irradiation.
U.S. Surgical WO 00/15789
Hydroxyproline bioadhesives
Norwalk, Conn.
Recombinant bioadhesive protein analogs containing hydroxyproline, production in bacteria.
Univ. College WO 00/15780
Breast cancer therapeutics
London
Inhibitors of Brn-3b, methods of identifying inhibitors; for treating breast and ovarian cancer.
Upither WO 00/15767
Immunotherapy methods
Utrecht, the Netherlands
Ex vivo treatment of antigen-presenting cells resulting in reduced ability to activate T cells; for immunotherapy.
Vanderbilt Univ. WO 00/15258
Angiogenesis control
Nashville, Tenn.
Modulating endothelial cell surface receptor activity for the control of angiogenesis.
Varian WO 00/15778
HPLC separation
Palo Alto, Calif.
Biopolymer matrices for separating biomolecules by reverse-phase ion-pair high performance liquid chromatography.
Virginia, Univ. of WO 00/15259
Cancer immunotherapy
Charlottesville, Va.
Pre-immunization by IgM antibodies and complement components followed by administering antibodies to C3b(1); for cancer.
Vitagenix WO 00/15265
Infection therapeutics
La Jolla, Calif.
Antisense oligonucleotides linked to uptake sequences or peptides recognized by bacteria; for treating infections.
Walter & Eliza Hall Inst. Med. Res. WO 00/15254
Malaria immunization
Parkville, Australia
Plasmodium glycosylphosphatidylinositol inositolglycan; for inducing immunity to malaria.
Yale Univ. WO 00/15779
In vitro molecular cloning
New Haven, Conn.
Efficient in vitro molecular cloning using PCR amplification that can be easily automated and scaled-up.
Yale Univ. WO 00/15849
Nucleic acid cloning
New Haven, Conn.
Cloning and amplification of nucleic acid using artificial long terminal repeat vectors.
Zonagen WO 00/15253
Fertility inhibition
The Woodlands, Texas
Recombinant production methods for human chorionic gonadotropin _ subunit; for inhibiting fertility.
Zymogenetics WO 00/15659
Stomach polypeptide
Seattle
Stomach polypeptide of the RPV.1 protein family, encoding gene, antibodies, production methods; for therapeutics.
Zymogenetics WO 00/15798
Mammalian TGF-_9
Seattle
Mammalian transforming growth factor (TGF)-_9, encoding gene sequences, antibodies; for therapeutics.