Published March 29 (EPO); March 23 (WO); March 29 (GB)

Actinova WO 00/15803

Immunoglobulin binding protein

Cambridge, UK

Immunoglobulin light chain binding protein, encoding gene sequences, mutations; for therapeutics.

Alabama, Univ. of WO 00/15648

Apoptosis therapeutic

Birmingham, Ala.

Adenoviral vector encoding the pro-apoptotic Bax gene; for therapeutics that cause cell death.

Aston Univ. WO 00/15777

Specific binding partners

Birmingham, UK

Protein libraries, encoding gene sequences; for identifying proteins interacting with specific binding partners.

BASF-Lynx Bioscience WO 00/15786

GABA receptor modulators

Heidelberg, Germany

Proteins that are part of the metabotropic GABA receptor complex from the CNS; for finding modulators.

Biogen WO 00/15247

Multiple myeloma treatment

Cambridge, Mass.

Methods for treating multiple myeloma and myeloma-induced bone resorption using integrin ligand adhesion antagonists.

Bressagen WO 00/15664

Modified hGH

Thebarton, Australia

Modified human growth hormone (hGH), production using ubiquitin fusion proteins; for therapeutics.

California, Univ. of WO 00/15660

Staphylococcus antibacterial

Oakland, Calif.

Target of RNAIII activating protein from Staphylococcus aureus, humanized antibodies; for inhibiting infection.

California, Univ. of WO 00/15771

Vanadium haloperoxidases

Oakland, Calif.

Recombinant vanadium haloperoxidases, encoding gene sequences, production methods.

California, Univ. of WO 00/15821

Heart-specific gene expression

La Jolla, Calif.

Recombinant adenoviral vector with the cardiac ankyrin repeat protein promoter; for gene expression in heart.

Calif. Inst. Technol. WO 00/15242 & 15773

HER2/neu expression regulation

Pasadena, Calif.

Regulation of HER2/neu oncogene expression by synthetic polyamides; for cancer therapeutics.

Calydon WO 00/15820

Adenoviral vector regulation

Sunnyvale, Calif.

Adenovirus vectors containing reversible physiological state-specific transcriptional regulatory elements.

Cancer Res. Camp. Technol. WO 00/15663

HIV entry suppression


LD78_ isoform of MIP-1a chemokine; for suppressing activity of the CCR5 co-receptor involved in HIV cellular entry.

Centeon Pharma EPO 989 184

Defective coagulation transgenics

Marburg, Germany

Transgenics with defective Factor XIII coagulation; for wound healing and bleeding analysis.

Children's Hosp. WO 00/15819

HIV vector packaging cells


Packaging cell lines for generating accessory protein independent HIV-derived retroviral vector particles.

Copenhagen Univ. WO 00/15804

Peroxidase production

Copenhagen, Denmark

Production of peroxidases in cells having a less reducing environment than normal.

Cornell Univ. GB 2 341 926

Rod-cone degeneration

Ithaca, N.Y.

Genetic markers for progressive rod-cone degeneration located on chromosome 9; for diagnostics.

Curagen WO 00/15851

Gene relatedness patterns

New Haven, Conn.

Geometrical and hierarchical gene relatedness classification based on gene expression patterns.

Dana-Farber Cancer Inst. WO 00/15651



Attractin, encoding gene sequences; for regulating the immune response.

Dynal WO 00/15842

Isolating primer extensions

Oslo, Norway

Methods for isolating primer extension products using modular oligonucleotides having attached magnetic beads.

Edinburgh, Univ. of WO 00/15764

Embryonic stem cell isolation

Edinburgh, UK

Derivation and propagation of embryonic stem cells using compounds that inhibit signalling in differentiated cells.

Eli Lilly WO 00/15781

FGF inhibitors


SPROUTY-1 related proteins; for inhibiting fibroblast growth factor (FGF) and treating cancer and developmental defects.

Erasmus Univ. WO 00/15839

Bone damage risk

Rotterdam, the Netherlands

Screening for polymorphisms in the vitamin D receptor gene; for determining susceptibility to bone damage.

Erasmus Univ. WO 00/15840

Heart disease risk

Rotterdam, the Netherlands

Screening for polymorphisms in the vitamin D receptor gene; for determining susceptibility to heart disease.

European Molec. Biol. Lab WO 00/15843

Genetic suppression therapy

Heidelberg, Germany

Identification of dominant suppression agents useful in genetic suppression therapy.

Flinders Technol. WO 00/15776

Separating genetic material

Bedford Park, Australia

Separation of genetic material from samples having genetic material from multiple sources using a solid medium.

Florida, Univ. of WO 00/15783

_1-adrenoreceptor antisense

Gainesville, Fla.

Antisense oligonucleotides targeted to _1-adrenoreceptor-specific mRNA; for treating hypertension and heart disease.

Florida, Univ. of WO 00/15822

Retinal disease therapy

Gainesville, Fla.

In vivo expression of heterologous genes controlled by retinal pigment epithelial cell-specific promoters.

French Atomic Energy Comm. WO 00/15841

Cancer cell detection


Fluorescence-based probe assay for detecting intrachromosome imbalance in interphase nuclei; for finding cancer cells.

Gardino Investment WO 00/15788

Transplantation facilitation

Curacao, Netherlands Antilles

Gene sequences encoding oncofetal ferritin protein, encoding gene sequences; for facilitating transplantation.

Gene Logic WO 00/15847

Genomic knowledge discovery

Gaithersburg, Md.

Genomic knowledge discovery using automated iterative methods to search databases and infer characteristics.

Genelabs Technol. WO 00/15848

Nucleic acid ligand binding

Redwood City, Calif.

Competitive binding assays for measuring the binding affinities of ligands for nucleic acids.

Genentech WO 00/15666

Cancer therapeutics

S. San Francisco

Genes amplified in tumor cells, overexpressed encoded proteins; for developing cancer therapeutics.

Genentech WO 00/15792

Angiogenesis modulators

S. San Francisco

Polypeptides and antagonists for the modulation of angiogenesis and vascularization in the heart.

Genentech WO 00/15796

Secreted transmembrane proteins

S. San Francisco

Secreted transmembrane polypeptides, chimeras, fusions, encoding gene sequences, antibodies; for therapeutics.

Genentech WO 00/15797

Immune disease proteins

S. San Francisco

Proteins and encoding gene sequences for the treatment of immune-related diseases.

Genetics Inst. WO 00/15249

Kaposi's treatment

Cambridge, Mass.

Methods for using interleukin (IL)-12 to treat AIDS-associated Kaposi's sarcoma.

Genvec WO 00/15823

Alternatively targeted adenoviruses

Gaithersburg, Md.

Adenoviral fiber protein fusion with a heterologous peptide; for alternative targeting of adenoviral vectors.

Glaxo WO 00/15833

EST sequencing

Greenford, UK

Run-off sequencing of relatively short portions of nucleic acids; for identifying expressed sequence tags (ESTs).

Hanmi Pharma WO 00/15661

Bacterial protein production

Kyunggi-do, S. Korea

Modified E. coli enterotoxin II signal peptide; for expressing a fusion with a heterologous protein.

Hanmi Pharma WO 00/15808

Protein production in milk

Kyunggi-do, S. Korea

Mammary gland-specific expression system using the _-casein promoter of the native Korean goat; for protein production.

Harvard Univ. WO 00/15246

Regulating lung growth

Cambridge, Mass.

Methods for regulating lung tissue growth using hedgehog-like proteins; for therapeutics.

Henkel WO 00/15828

Polycarboxylic acid production

Gulph Mills, Penn.

Bacterial strains and methods for making polycarboxylic acids.

Hitachi EPO 989 193

Analyzing long DNAs


Methods for analyzing long DNAs or fragments using probe hybridization and fractionation.

Hoechst Marion Roussel WO 00/15838

Antifungal screens

Puteaux, France

Essential genes from Candida yeast strains; for screening antifungal therapeutics.

Human Genome Sciences WO 00/15759

IL 17-like receptor

Rockville, Md.

Interleukin (IL) 17-like receptor protein, encoding gene, production methods; for finding modulators and therapeutics.

Hyman, E.D. WO 00/15846

Cloning method

Metarie, La.

Zero background cloning method using biotin-labelled DNA separated by streptavidin paramagnetic beads.

Igen Intl. WO 00/15850

Nucleic acid cleaving enzymes

Gaithersburg, Md.

Assays for enzymes that cleave or join nucleic acids using electrochemiluminescent labels.

Incyte Genomics WO 00/15770

Serine-threonine kinases

Palo Alto, Calif.

Serine-threonine kinases, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/15793

Human GPCR proteins

Palo Alto, Calif.

Human GPCR proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/15794

Cell junction protein

Palo Alto, Calif.

Human cell junction PDZ protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/15799

RNA-associated proteins

Palo Alto, Calif.

RNA-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/15806

ATP synthase subunit homolog

Palo Alto, Calif.

ATP synthase subunit homolog, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/15844

Nucleic acid sequencing

Palo Alto, Calif.

Nucleic acid sequencing methods using solid phase capturable chain terminators.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/16102

Tyrosine kinase receptor control


Compounds that co-aggregate with a tyrosine kinase receptor; for controlling cell process activation by this receptor.

Johns Hopkins Univ. WO 00/15795

Chromosome 11 cancer genes


Genes from the tumor-suppressing fragment of human chromosome 11, cancer-associated polymorphisms.

Karolinska Innovations WO 00/15824

Nuclear targeting


Nucleic acid sequences linked to a nuclear localization signal from an antennapedia peptide; for targeting.

Kishimoto, T. EPO 989 186

Cytokine function regulation

Osaka, Japan

STAT function-regulatory protein, encoding gene sequences, antisense; for regulating cytokine function.

Kohn, L.D., et al. WO 00/15768

Immune activation by DNA

Bethesda, Md.

Immune activation of antigen-presenting cells using immunogenic double-stranded polynucleotides.

Krebs Res. Ctr. WO 00/15837

Oligomer grid production

Heidelberg, Germany

Methods of quality control in the production of oligomer grids having phosphates linked to signal generators.

Kyowa Hakko Kogyo EPO 989 136

p53 activity restoration


Peptides having cyclic structure that restore activity to p53 protein mutants.

M&E Biotech WO 00/15807

Osteoporosis therapeutic

Hersholm, Denmark

Inducing an immune response to osteoprotegerin ligand; for preventing osteoporosis and other bone loss.

Maryland, Univ. of WO 00/15252



Methods for using Zot or zonulin to inhibit antigen-presenting cell activity; for immunotherapy.

Max Delbruck Ctr. Molec. Biol. WO 00/15784

EDG6 receptor


Human and mouse G-protein coupled EDG6 receptor, fragments, variants, mutations, encoding gene; for therapeutics.

Millennium Pharma WO 00/15790 & 15826

Body weight modulators

Cambridge, Mass.

Leptin-induced gene, encoded proteins; for finding modulators and agents that affect body weight.

Mt. Sinai Sch. Med. WO 00/15853

HIV protein production

New York

Genetically engineered Newcastle disease virus vectors; for producing heterologous proteins from the HIV genome.

New Jersey, Med. & Dent. Univ. WO 00/15782

Ribosomal frameshift sequences

New Brunswick, N.J.

Methods for identifying ribosomal frameshift sequences; for regulating gene expression using these sequences.

Nexia Biotech WO 00/15772

Therapeutics produced in urine

Ste. Anne de Bellevue, Que.

Recombinant protein production in urine using the uromodulin gene promoter linked to a heterologous protein gene.

Nizo Food Res. WO 00/15655

Peptide purification

Ede, the Netherlands

Purification of peptides from biological fluids using chromatographic membranes and enzymatic hydrolysis.

North American Vaccine WO 00/15760

Streptococcal vaccines

Columbia, Md.

Streptococcal C _ protein; for vaccines that are bacteriocidal with complement alone.

Pan Pacific Pharma WO 00/15774

Bee venom protein

Menlo Park, Calif.

Honey bee venom protein, encoding gene sequences, antibodies; for treating inflammatory diseases.

Pedersen, L.O., et al. WO 00/15665

Immunoglobulin superfamily protein

Copenhagen, Denmark

Production of a functional MHC class I immunoglobulin superfamily protein in bacteria; for therapeutics.

Pfizer EPO 989 187

Pharmaceutical intermediates

Groton, Conn.

Transformation of organics by Monosporium and Thamosylum bacteria; for making pharmaceutical intermediates.

Pioneer Hi-Bred WO 00/15800

Blood vessel damage inhibitor

Des Moines, Iowa

Plant Rac polypeptides, encoding genes; for transfection to prevent reperfusion injuries and blood vessel damage.

Pittsburgh, Univ. of WO 00/15264

Cellular cancer therapy


In situ injection of antigen-presenting cells having enhanced cytokine expression; for infections and cancer.

Queensland, Univ. of WO 00/15654

Cyclized conotoxins

St. Lucia, Australia

Cyclized conotoxin peptides, production methods; for therapeutics.

Rothman, J.E. WO 00/15263

Hydrogel DNA delivery

New York

Gene delivery system that uses microparticles fabricated from pH-sensitive hydrogels in collapsed states.

Sci. Invest. Council WO 00/15787

Death inducer obliterator

Madrid, Spain

Genes encoding human and mouse death inducer obliterator-1, encoded protein, expression methods.

Scripps Res. Inst. WO 00/15209

HER2/neu expression regulation

La Jolla, Calif.

Regulation of HER2/neu oncogene expression by synthetic polyamides; for cancer therapeutics.

Sensor Technol. WO 00/16099

Carbohydrate assays

Shrewsbury, Mass.

Reduced valency carbohydrate binding ligands; for measuring carbohydrates using fluorescence resonance energy transfer.

Sequus Pharma WO 00/15825

Condensed plasmid-liposomes

Menlo Park, Calif.

Condensed plasmid-liposomes having cationic liposomes and polycationic condensing agents; for gene transfection.

Shimadzu EPO 989 192

Stopping PCR inhibition

Kyoto, Japan

Efficient amplification of nucleic acids using sulfated polysaccharides and dithiothreitol to stop PCR inhibitors.

Siffert, W. WO 00/15785

G-protein dysregulation

Essen, Germany

Modifications in the gene for the G_3-subunit of human G-proteins; for determining G-protein dysregulation risk.

Signalgene WO 00/15834 & 15835

Breast cancer risk


Determination of androgen and vitamin D receptor genotype; for diagnosing breast cancer susceptibility.

Signalgene WO 00/15836

Breast cancer risk


Determination of estrogen and vitamin D receptor genotype; for diagnosing breast cancer susceptibility.

SmithKline Beecham WO 00/15255

Herpes infection treatment

Rixensart, Belgium

Methods for using the antigenic herpes glycoprotein D to induce immunity to herpes infection.

SmithKline Beecham WO 00/15650

Multidrug resistance inhibitors


Rat MDR1A protein, encoding gene sequences, production methods; for finding multidrug resistance inhibitors.

SmithKline Beecham WO 00/15769

Antibacterial screens


topA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/15775

Streptococcus antimicrobials


Streptococcus aureus RNAse P ribonucleotide complex, encoding gene sequences; for antimicrobial screens.

SmithKline Beecham WO 00/15801

Meningitis therapeutics

Rixensart, Belgium

Neisseria meningitidis proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/15802

Moraxella diagnostics

Rixensrt, Belgium

Moraxella catarrhalis proteins, encoding genes, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/15805

Protein kinase

Brentford, UK

Protein kinase KIAA0551, encoding gene, production methods; for neurogenerative disease therapeutics.

South Alabama Med. Sci. Fdn. WO 00/15845

T-type calcium channels

Mobile, Ala.

Pancreatic T-type calcium channel, encoding gene sequence, antisense; for therapeutics.

Stoddard, S.F., et al. WO 00/15827

Non-toxic lipopolysaccharides

Decatur, Ill.

Transformed bacterial strains for the production of quinones and non-toxic lipopolysaccharides.

Tanox WO 00/15260

Allergy therapy


Immunoglobulin (Ig)-E antibodies, fragments, encoding gene sequences; for allergic disease therapy.

Thomas Jefferson Univ. WO 00/15649

Restenosis inhibition


Viral vector expressing RB2/p130; for inhibiting smooth muscle cell proliferation and preventing restenosis.

Tosoh EPO 989 185

Cleaving nucleic acids

Yamaguchi, Japan

Cleaving specific nucleic acid sequences using probes linked to an intercalater and spermine activated by irradiation.

U.S. Surgical WO 00/15789

Hydroxyproline bioadhesives

Norwalk, Conn.

Recombinant bioadhesive protein analogs containing hydroxyproline, production in bacteria.

Univ. College WO 00/15780

Breast cancer therapeutics


Inhibitors of Brn-3b, methods of identifying inhibitors; for treating breast and ovarian cancer.

Upither WO 00/15767

Immunotherapy methods

Utrecht, the Netherlands

Ex vivo treatment of antigen-presenting cells resulting in reduced ability to activate T cells; for immunotherapy.

Vanderbilt Univ. WO 00/15258

Angiogenesis control

Nashville, Tenn.

Modulating endothelial cell surface receptor activity for the control of angiogenesis.

Varian WO 00/15778

HPLC separation

Palo Alto, Calif.

Biopolymer matrices for separating biomolecules by reverse-phase ion-pair high performance liquid chromatography.

Virginia, Univ. of WO 00/15259

Cancer immunotherapy

Charlottesville, Va.

Pre-immunization by IgM antibodies and complement components followed by administering antibodies to C3b(1); for cancer.

Vitagenix WO 00/15265

Infection therapeutics

La Jolla, Calif.

Antisense oligonucleotides linked to uptake sequences or peptides recognized by bacteria; for treating infections.

Walter & Eliza Hall Inst. Med. Res. WO 00/15254

Malaria immunization

Parkville, Australia

Plasmodium glycosylphosphatidylinositol inositolglycan; for inducing immunity to malaria.

Yale Univ. WO 00/15779

In vitro molecular cloning

New Haven, Conn.

Efficient in vitro molecular cloning using PCR amplification that can be easily automated and scaled-up.

Yale Univ. WO 00/15849

Nucleic acid cloning

New Haven, Conn.

Cloning and amplification of nucleic acid using artificial long terminal repeat vectors.

Zonagen WO 00/15253

Fertility inhibition

The Woodlands, Texas

Recombinant production methods for human chorionic gonadotropin _ subunit; for inhibiting fertility.

Zymogenetics WO 00/15659

Stomach polypeptide


Stomach polypeptide of the RPV.1 protein family, encoding gene, antibodies, production methods; for therapeutics.

Zymogenetics WO 00/15798

Mammalian TGF-_9


Mammalian transforming growth factor (TGF)-_9, encoding gene sequences, antibodies; for therapeutics.