Published May 26 (EPO); May 20 (WO); May 26 (GB)

Actinova WO 99/24559

Nuclear targeting

Cambridge, U.K.

Bacterial protein H; for the delivery of agents to eukaryotic nuclei.

Biogen WO 99/23867

Immunomodulatory protein

Cambridge, Mass.

A myelin-oligodendrocyte glycoprotein family member expressed in germinal B cells; for immunomodulation.

Brigham & Women's Hosp. WO 99/24595

APP gene expression modulators

Boston, Mass.

Translation enhancer element of the human amyloid precursor protein (APP) gene; for identifying expression modulators.

British Agriculture Ministry GB 2 331 521

Salmonella vaccine


Attenuated Salmonella strains that have difficulty colonizing the alimentary tract; for vaccines.

British Defense Ministry GB 2 331 523

Anthrax vaccines

Farnborough, U.K.

Methods of preparing Bacillus anthracis protective antigens or fragments; for vaccines.

British Natl. Environ. Res. Counc. WO 99/24567

Tissue cement proteins

Swindon, U.K.

Tissue cement proteins from blood-sucking ectoparasites; for bonding animal tissues and making vaccines.

British Columbia, Univ. of WO 99/24576

Pathogenic bacteria immunoresponse

Vancouver, B.C.

Pathogenic E. coli translocated intimin receptor, encoding gene sequences; for inducing immunoresponse.

California, Univ. of WO 99/24454

ß2-adrenergic receptor polymorphisms

Oakland, Calif.

Specific amplification of large segments of the human ß2-adrenergic receptor gene; for polymorphism identification.

California, Univ. of WO 99/24620

Cervical dysplasia screen

Oakland, Calif.

Measuring biochemical markers of angiogenesis and/or apoptosis; for screening cervical dysplasia.

Canadian Agriculture Ministry WO 99/24592

Plant production system

Saint-Foy, Que.

Production of heterologous human proteins in transgenic alfalfa plants; for diagnostics and therapeutics.

Chiron WO 99/24578

Neisseria vaccines

Siena, Italy

Neisseria meningitidis proteins, encoding gene sequences; for diagnostics and vaccines.

Chugai Res. Inst. Molec. Med. WO 99/24568

Steroid binding protein

Ibaraki, Japan

Membrane-bound steroid binding protein, encoding gene sequences.

Columbia Univ. WO 99/24457

Forebrain neuron transgene expression

New York

Calcium-calmodulin dependent kinase IIa promoter linked to transgenes; for specific expression in forebrain neurons.

Columbia Univ. WO 99/24553

HIV gp120 crystals

New York

HIV envelope glycoprotein gp120 crystals; for identifying mimics, variants, and modulators of binding molecules.

CSIRO (Comm. Sci. Ind. Res. Org.) WO 99/24590

Bioremediation suicide vector

Campbell, Australia

Suicide vector for expressing esterases that hydrolyze organophosphates and insecticidal toxins.

Curagen WO 99/24571

Cardiac hypertrophy genes

New Haven, Conn.

Identification of genes differentially expressed in cardiac hypertrophy, encoded proteins; for diagnosis and treatment.

Cygene WO 99/24621

Specific sequence detection

Alachua, Fla.

Methods for detecting of specific nucleotide sequences using triplex formation and signal amplification.

Cytimmune WO 99/24066

Enhancing vaccine response

College Park, Md.

Methods for enhancing immune responses by targeting multiple immune system components; for vaccines.

Daiichi WO 99/24609

Gene analysis method

Kyoto, Japan

Gene analysis method using single-stranded polynucleotides immobilized on a solid support.

Dalhousie Univ. WO 99/24582

Reovirus syncytial-forming proteins

Halifax, N.S.

Reovirus proteins involved in membrane fusion and syncytial formation, encoding gene sequences.

Dana-Farber Cancer Inst. WO 99/24464 & 24465

Modified HIV antigens

Boston, Mass.

Stabilized, glycosylated primate HIV envelope polypeptides modified proximal to the CD4 and chemokine receptor sites.

Du Pont WO 99/24573

Soybean vectors

Wilmington, Del.

Soybean gene homolog of the Phaseolus vulgaris transcription factor, chimeras for vectors; for higher gene expression.

Du Pont WO 99/24574

Plant transcription activators

Wilmington, Del.

Plant homologs of yeast and human regulators of AP-1 type transcription factor activity.

Feiss, M., et al. WO 99/24456

Modified lambda terminase

Iowa City, Iowa

Histidine-tagged lambda terminase enzymes, encoding gene sequences; for purification of the modified terminase.

Fred Hutchinson Cancer Res. Ctr. WO 99/24603

Yeast chemotherapeutic screen

Seattle, Wash.

Yeast-based synthetic lethal screens; for identifying drug targets for cancer chemotherapeutics.

GeneMedicine WO 99/24596

Nucleic acid vaccines

The Woodlands, Texas

Nucleic acid-based vaccines that encode multiple epitopes that induce immunoresponses.

Genencor Intl. WO 99/24562

Directed evolution enhancement

Rochester, N.Y.

Increasing the directed evolution of genes using helper phage to package DNA sequences into phagemids.

Genetics Inst. WO 99/24057 & 24508


Cambridge, Mass.

Bone morphogenic protein (BMP)-11, encoding gene, production methods; for tissue maintenance and contraception.

Genetics Inst. WO 99/24469

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Gorczynski, R.M. WO 99/24565

Immunosuppression for graft rejection

Willowdale, Ont.

OX-2 protein, encoding gene sequences; for immunosuppression in autoimmune disease and graft rejection.

Gropep WO 99/24470

Mammalian milk growth factor

Adelaide, Australia

Mammalian milk growth factor, mutants, derivatives, analogs, functionally active fragments, encoding gene sequences.

Guelph, Univ. of WO 99/24588

Delaying fruit ripening

Guelph, Ont.

Endo-ß-mannanase cDNA from plant tissues, antisense, encoded protein; for delaying fruit ripening and softening.

Harvard Univ. WO 99/24570

Transcriptional activator protein

Cambridge, Mass.

Proteins that interact with CIITA, an MHC class II transcriptional activator, encoding gene sequences.

Hoechst Marion Roussel WO 99/24473

Phosphorylated VASP antibodies

Frankfurt, Germany

Antibodies against phosphorylated vasodilator-stimulated phosphoprotein (VASP); for diagnostics and therapeutics.

Human Genome Sciences WO 99/24836

125 secreted proteins

Rockville, Md.

125 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Iconix Pharma WO 99/24563

Identifying gene function

Mountain View, Calif.

Two-step, scalable method for identifying gene function and modulators by using transfected microbial strains.

Immunomedics WO 99/24472


Morris Plains, N.J.

Glycosylated antibodies and antibody fragments having reactive ketone groups; for making immunoconjugates.

Incyte Pharma WO 99/24463

Signal peptide-containing proteins

Palo Alto, Calif.

Signal peptide-containing proteins, encoding gene sequences, modulators; for diagnosis and therapeutics.

Incyte Pharma WO 99/24587

Phospholipase A2

Palo Alto, Calif.

Human phospholipase A2 polypeptides, encoding gene sequences, antibodies, modulators; for therapeutics.

Innogenetics WO 99/24054

Hepatitis C vaccines

Ghent, Belgium

Multimer peptides derived from hepatitis C virus envelope proteins that react with patient antibodies; for vaccines.

Innogenetics WO 99/24466

Hepatitis C infection diagnosis

Ghent, Belgium

Using annexin V, tubulin, and apolipoprotein B binding to hepatitis C virus envelope proteins for infection diagnosis.

Innogenetics WO 99/24607

Helicobacter diagnostics

Ghent, Belgium

PCR-based method to detect and type iceA gene alleles from Helicobacter pylori, antibodies; for diagnostics.

INSERM (Natl. Inst. Hlth. Med. Res.) EPO 918 091



XLIS gene, encoded protein called doublecortin; for diagnostics and therapeutics.

Iowa St. Univ. WO 99/24575

Maize starch synthase

Ames, Iowa

Maize gene encoding starch synthase, encoded enzyme, mutations; for affecting strach synthesis.

Ixion Biotech. WO 99/24619

Quantitative PCR

Alachua, Fla.

Materials and methods for quantitative PCR; for measuring target polynucleotide templates.

Johns Hopkins Univ. WO 99/23880

Drug candidate mimics

Baltimore, Md.

Somatic transfer of modified genes; for mimicking and predicting drug candidate effects.

Johns Hopkins Univ. WO 99/24618

Myostatin variants

Baltimore, Md.

Methods for detecting myostatin mutations; for identifying animals with increased muscle mass.

Krebs Res. Inst. WO 99/24605

Cell cycle gene vector

Heidelberg, Germany

Gene promoter that can be operably attached to cell cycle genes, expression vector system.

Lilly EPO 918 090


Indianapolis, Ind.

Yeast ketoreductase gene, encoded protein; for stereospecific reduction of ketones.

Maryland, Univ. of WO 99/24564

RSV vaccines

College Park, Md.

Production of attenuated, infectious bovine respiratory syncytial virus (RSV) from synthetic cDNAs; for vaccines.

Mass. Gen. Hosp. WO 99/24455

Protein interaction detection

Boston, Mass.

Detection systems for measuring protein interactions and functional relationships.

Mass. Inst. Technol. WO 99/24059

Cardiac microvascular regulation

Cambridge, Mass.

PDGF-mediated regulation of cardiac microvascular endothelial cell gene expression.

Max Delbruck Ctr. Molec. Med. WO 99/24602

Determining transfection efficiency

Berlin, Germany

Combined reporter gene vector; for determining transfection efficiency and cell viability in parallel.

Max Planck Inst. WO 99/24593

Long-chain inulin

Berlin, Germany

Fructosyl transferase, encoding gene sequences; for producing long-chain inulin in plants.

McGill Univ. WO 99/24583

DNA methylase

Montreal, Que.

DNA demethylase gene overexpressed in cancer cells but not normal cells; for diagnostics and therapeutics.

Michigan, Univ. of WO 99/24557

Bone accessory cells

Ann Arbor, Mich.

Human bone accessory cells, preparation methods; for making osteoblasts and treating bone disorders.

Michigan Technol. Univ. WO 99/24561

Lignin biosynthesis alteration

Houghton, Mich.

Alteration of the lignin pathway 4-coumarate Co-enzyme A ligase; for affecting plant lignin biosynthesis.

Michigan St. Univ. WO 99/24068

Influenza vaccine production

E. Lansing, Mich.

Immortal bird cell lines; for replicating bird and other viruses and making influenza vaccines.

Millennium Biotherapeutics WO 99/24616

Signal peptide-containing proteins

Cambridge, Mass.

Methods for identifying nucleic acid sequences encoding signal peptide-containing proteins using yeast strains.

Millennium Pharma WO 99/24580

Essential fungal genes

Cambridge, Mass.

Essential Aspergillus fungi genes, encoded proteins, homologs; for identifying antifungal agents.

Millennium Pharma WO 99/24610

Organic molecule transporter

Cambridge, Mass.

Organic molecule transporter OCT-3 plasma membrane polypeptides, encoding gene sequences.

Mogen Intl. WO 99/24558

High-fermenting microorganisms

Leiden, Netherlands

Microorganisms having increased fermenting capability due to transfection with trehalose phosphate synthase.

Molec. Plant Prot. Biotech. WO 99/24589

Lysozyme antimicrobials

Cologne, Germany

Proteins analogous to lysozyme, encoding gene sequences; for use as antimicrobial agents.

Mosaic Technol. WO 99/24612

Signal amplification

Boston, Mass.

Multiple sequential polynucleotide displacement reactions for signal amplification and processing.

Mycogen WO 99/24581

Plant-encoded pesticidal toxins

San Diego, Calif.

Plant-optimized genes that encode pesticidal toxins, truncated genes and toxins; for protecting plants.

Neurotherapeutics WO 99/24584

Transfecting brain cancer cells

Chicago, Ill.

Transfecting a glycosyltransferase gene into glioblastoma cells; for inhibiting growth and treating brian cancer.

New York, St. Univ. of WO 99/24471

Receptor modulators

Albany, N.Y.

Methods for identifying modulators of opiate, cannabinoid, and estrogen receptors, nucleic acids encoding receptors.

Oklahoma, Univ. of WO 99/24468

Cancer susceptibility alleles

Norman, Okla.

Allelic variation in the 3' untranslated region of the prohibitin gene; for determining cancer susceptibility.

Oklahoma Med. Res. Fdn. WO 99/24614

Alzheimer's-derived toxin

Oklahoma City, Okla.

Enothelial cell-derived protein from Alzheimer's patients that is toxic to neuronal cells, antibodies; for screens.

Ono Pharma WO 99/24569

Lysophosphatidic acid receptor

Osaka, Japan

Human lysophosphatidic acid receptor, encoding gene sequences, antibodies; for screening modulators.

Oxford BioMedics GB 2 331 522

Transfecting quiescent cells

Oxford, U.K.

Retroviral vector particles capable of infecting and transducing non-dividing mammalian target cells.

Pathobiotek WO 99/24613

Human blood bacterium

Houston, Texas

Human blood bacterium associated with multiple sclerosis, chronic fatigue syndrome, and other autoimmune diseases.

Pittsburgh, Univ. of WO 99/24554

Dendritic-like cells

Pittsburgh, Penn.

Isolation, characterization, and identification of dendritic-like cells, antigens, antibodies.

Princeton Univ. WO 99/24622

Triplex in situ hybridization

Princeton, N.J.

In situ detection of target sequences in double-stranded nucleic acids using another sequence to form a triplex.

Protein Sciences WO 99/24049

Insect vaccines

Meriden, Conn.

Use of insect cells transfected with insect antigen genes as adjuvants for vaccines.

Rhone-Poulenc Agro WO 99/24585 & 24586

Herbicide-tolerant plants

Lyon, France

Mutated and chimeric hydroxy-phenyl pyruvate dioxygenases, encoded genes; for obtaining herbicide-tolerant plants.

Rhone-Poulenc Agro WO 99/24594

Disease-resistant plants

Lyon, France

Gene encoding thanatin, encoded protein, expression vector; for producing transformed disease-resistant plants.

Roche Diagnostics WO 99/24566

Tumor-specific antigens

Mannheim, Germany

Tumor-specific antigens including intron sequences, PCR mRNA products; for cancer diagnosis and therapy.

Salk Inst. WO 99/23885

Hormonally modulated cancers

La Jolla, Calif.

Use of histone deacetylase inhibitors to activate genes responsive to hormone receptors; for treating cancer.

SBL Vaccin WO 99/24467

Staphylococcus vaccines

Stockholm, Sweden

Immunoglobulin G-binding protein from Staphylococcus aureus, encoding gene sequence, antibodies; for vaccines.

Sheikhnejad, G. WO 99/24560

Methylated antisense

Ann Arbor, Mich.

Methylated antisense oligonucleotides; for inhibiting gene transcription in breast cancer cells.

SmithKline Beecham WO 99/24579

Antibacterial screens

Philadelphia, Penn.

Era polypeptides, encoding gene sequences, production methods; for screening antibacterials.

SmithKline Beecham WO 99/24601

Secreted NSL4 protein

Philadelphia, Penn.

Secreted protein NSL4 polypeptides, encoded gene sequences, production methods; for diagnostics and therapeutics.

Stanford Univ. WO 99/24453

Pro-apoptotic protein

Palo Alto, Calif.

Gene sequences encoding the Bcl-2-related ovarian killer protein, encoded protein; for manipulating apoptosis.

Statens Serum Inst. WO 99/24577

Tuberculosis vaccines

Copenhagen, Denmark

Mycoplasm tuberculosis polypeptide fragments, encoding gene sequences; for making vaccines.

Technion Res. Develop. Fdn. WO 99/24608

Screening mutated DNA

Haifa, Israel

Method for labeling single-stranded polynucleotides; for screening tissue samples for mutated DNA.

Texel WO 99/24591

Bacterial cloning vector

Dange Saint Romain, France

Non-RCR leuconostoc plasmid capable of being transferred into lactic acid bacteria; for cloning and expression.

3-Dimensional Pharma WO 99/24050

Protein unfolding curves

Exton, Penn.

High-throughput method for classifying proteins identified in a genomics screen according to thermal unfolding curves.

Utrecht Univ. WO 99/24572

Dopaminergic neuron genes

Utrecht, Netherlands

Genes having expression restricted to mesencephalic dopaminergic neurons; for psychiatric disease diagnosis.

Ventana Genetics WO 99/24617

Expression library screening

Salt Lake City, Utah

Peptide libraries displayed on light-emitting protein scaffolds; for expression library screening.