Published May 26 (EPO); May 20 (WO); May 26 (GB)
Actinova WO 99/24559
Bacterial protein H; for the delivery of agents to eukaryotic nuclei.
Biogen WO 99/23867
A myelin-oligodendrocyte glycoprotein family member expressed in germinal B cells; for immunomodulation.
Brigham & Women's Hosp. WO 99/24595
APP gene expression modulators
Translation enhancer element of the human amyloid precursor protein (APP) gene; for identifying expression modulators.
British Agriculture Ministry GB 2 331 521
Attenuated Salmonella strains that have difficulty colonizing the alimentary tract; for vaccines.
British Defense Ministry GB 2 331 523
Methods of preparing Bacillus anthracis protective antigens or fragments; for vaccines.
British Natl. Environ. Res. Counc. WO 99/24567
Tissue cement proteins
Tissue cement proteins from blood-sucking ectoparasites; for bonding animal tissues and making vaccines.
British Columbia, Univ. of WO 99/24576
Pathogenic bacteria immunoresponse
Pathogenic E. coli translocated intimin receptor, encoding gene sequences; for inducing immunoresponse.
California, Univ. of WO 99/24454
ß2-adrenergic receptor polymorphisms
Specific amplification of large segments of the human ß2-adrenergic receptor gene; for polymorphism identification.
California, Univ. of WO 99/24620
Cervical dysplasia screen
Measuring biochemical markers of angiogenesis and/or apoptosis; for screening cervical dysplasia.
Canadian Agriculture Ministry WO 99/24592
Plant production system
Production of heterologous human proteins in transgenic alfalfa plants; for diagnostics and therapeutics.
Chiron WO 99/24578
Neisseria meningitidis proteins, encoding gene sequences; for diagnostics and vaccines.
Chugai Res. Inst. Molec. Med. WO 99/24568
Steroid binding protein
Membrane-bound steroid binding protein, encoding gene sequences.
Columbia Univ. WO 99/24457
Forebrain neuron transgene expression
Calcium-calmodulin dependent kinase IIa promoter linked to transgenes; for specific expression in forebrain neurons.
Columbia Univ. WO 99/24553
HIV gp120 crystals
HIV envelope glycoprotein gp120 crystals; for identifying mimics, variants, and modulators of binding molecules.
CSIRO (Comm. Sci. Ind. Res. Org.) WO 99/24590
Bioremediation suicide vector
Suicide vector for expressing esterases that hydrolyze organophosphates and insecticidal toxins.
Curagen WO 99/24571
Cardiac hypertrophy genes
New Haven, Conn.
Identification of genes differentially expressed in cardiac hypertrophy, encoded proteins; for diagnosis and treatment.
Cygene WO 99/24621
Specific sequence detection
Methods for detecting of specific nucleotide sequences using triplex formation and signal amplification.
Cytimmune WO 99/24066
Enhancing vaccine response
College Park, Md.
Methods for enhancing immune responses by targeting multiple immune system components; for vaccines.
Daiichi WO 99/24609
Gene analysis method
Gene analysis method using single-stranded polynucleotides immobilized on a solid support.
Dalhousie Univ. WO 99/24582
Reovirus syncytial-forming proteins
Reovirus proteins involved in membrane fusion and syncytial formation, encoding gene sequences.
Dana-Farber Cancer Inst. WO 99/24464 & 24465
Modified HIV antigens
Stabilized, glycosylated primate HIV envelope polypeptides modified proximal to the CD4 and chemokine receptor sites.
Du Pont WO 99/24573
Soybean gene homolog of the Phaseolus vulgaris transcription factor, chimeras for vectors; for higher gene expression.
Du Pont WO 99/24574
Plant transcription activators
Plant homologs of yeast and human regulators of AP-1 type transcription factor activity.
Feiss, M., et al. WO 99/24456
Modified lambda terminase
Iowa City, Iowa
Histidine-tagged lambda terminase enzymes, encoding gene sequences; for purification of the modified terminase.
Fred Hutchinson Cancer Res. Ctr. WO 99/24603
Yeast chemotherapeutic screen
Yeast-based synthetic lethal screens; for identifying drug targets for cancer chemotherapeutics.
GeneMedicine WO 99/24596
Nucleic acid vaccines
The Woodlands, Texas
Nucleic acid-based vaccines that encode multiple epitopes that induce immunoresponses.
Genencor Intl. WO 99/24562
Directed evolution enhancement
Increasing the directed evolution of genes using helper phage to package DNA sequences into phagemids.
Genetics Inst. WO 99/24057 & 24508
Bone morphogenic protein (BMP)-11, encoding gene, production methods; for tissue maintenance and contraception.
Genetics Inst. WO 99/24469
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Gorczynski, R.M. WO 99/24565
Immunosuppression for graft rejection
OX-2 protein, encoding gene sequences; for immunosuppression in autoimmune disease and graft rejection.
Gropep WO 99/24470
Mammalian milk growth factor
Mammalian milk growth factor, mutants, derivatives, analogs, functionally active fragments, encoding gene sequences.
Guelph, Univ. of WO 99/24588
Delaying fruit ripening
Endo-ß-mannanase cDNA from plant tissues, antisense, encoded protein; for delaying fruit ripening and softening.
Harvard Univ. WO 99/24570
Transcriptional activator protein
Proteins that interact with CIITA, an MHC class II transcriptional activator, encoding gene sequences.
Hoechst Marion Roussel WO 99/24473
Phosphorylated VASP antibodies
Antibodies against phosphorylated vasodilator-stimulated phosphoprotein (VASP); for diagnostics and therapeutics.
Human Genome Sciences WO 99/24836
125 secreted proteins
125 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Iconix Pharma WO 99/24563
Identifying gene function
Mountain View, Calif.
Two-step, scalable method for identifying gene function and modulators by using transfected microbial strains.
Immunomedics WO 99/24472
Morris Plains, N.J.
Glycosylated antibodies and antibody fragments having reactive ketone groups; for making immunoconjugates.
Incyte Pharma WO 99/24463
Signal peptide-containing proteins
Palo Alto, Calif.
Signal peptide-containing proteins, encoding gene sequences, modulators; for diagnosis and therapeutics.
Incyte Pharma WO 99/24587
Palo Alto, Calif.
Human phospholipase A2 polypeptides, encoding gene sequences, antibodies, modulators; for therapeutics.
Innogenetics WO 99/24054
Hepatitis C vaccines
Multimer peptides derived from hepatitis C virus envelope proteins that react with patient antibodies; for vaccines.
Innogenetics WO 99/24466
Hepatitis C infection diagnosis
Using annexin V, tubulin, and apolipoprotein B binding to hepatitis C virus envelope proteins for infection diagnosis.
Innogenetics WO 99/24607
PCR-based method to detect and type iceA gene alleles from Helicobacter pylori, antibodies; for diagnostics.
INSERM (Natl. Inst. Hlth. Med. Res.) EPO 918 091
XLIS gene, encoded protein called doublecortin; for diagnostics and therapeutics.
Iowa St. Univ. WO 99/24575
Maize starch synthase
Maize gene encoding starch synthase, encoded enzyme, mutations; for affecting strach synthesis.
Ixion Biotech. WO 99/24619
Materials and methods for quantitative PCR; for measuring target polynucleotide templates.
Johns Hopkins Univ. WO 99/23880
Drug candidate mimics
Somatic transfer of modified genes; for mimicking and predicting drug candidate effects.
Johns Hopkins Univ. WO 99/24618
Methods for detecting myostatin mutations; for identifying animals with increased muscle mass.
Krebs Res. Inst. WO 99/24605
Cell cycle gene vector
Gene promoter that can be operably attached to cell cycle genes, expression vector system.
Lilly EPO 918 090
Yeast ketoreductase gene, encoded protein; for stereospecific reduction of ketones.
Maryland, Univ. of WO 99/24564
College Park, Md.
Production of attenuated, infectious bovine respiratory syncytial virus (RSV) from synthetic cDNAs; for vaccines.
Mass. Gen. Hosp. WO 99/24455
Protein interaction detection
Detection systems for measuring protein interactions and functional relationships.
Mass. Inst. Technol. WO 99/24059
Cardiac microvascular regulation
PDGF-mediated regulation of cardiac microvascular endothelial cell gene expression.
Max Delbruck Ctr. Molec. Med. WO 99/24602
Determining transfection efficiency
Combined reporter gene vector; for determining transfection efficiency and cell viability in parallel.
Max Planck Inst. WO 99/24593
Fructosyl transferase, encoding gene sequences; for producing long-chain inulin in plants.
McGill Univ. WO 99/24583
DNA demethylase gene overexpressed in cancer cells but not normal cells; for diagnostics and therapeutics.
Michigan, Univ. of WO 99/24557
Bone accessory cells
Ann Arbor, Mich.
Human bone accessory cells, preparation methods; for making osteoblasts and treating bone disorders.
Michigan Technol. Univ. WO 99/24561
Lignin biosynthesis alteration
Alteration of the lignin pathway 4-coumarate Co-enzyme A ligase; for affecting plant lignin biosynthesis.
Michigan St. Univ. WO 99/24068
Influenza vaccine production
E. Lansing, Mich.
Immortal bird cell lines; for replicating bird and other viruses and making influenza vaccines.
Millennium Biotherapeutics WO 99/24616
Signal peptide-containing proteins
Methods for identifying nucleic acid sequences encoding signal peptide-containing proteins using yeast strains.
Millennium Pharma WO 99/24580
Essential fungal genes
Essential Aspergillus fungi genes, encoded proteins, homologs; for identifying antifungal agents.
Millennium Pharma WO 99/24610
Organic molecule transporter
Organic molecule transporter OCT-3 plasma membrane polypeptides, encoding gene sequences.
Mogen Intl. WO 99/24558
Microorganisms having increased fermenting capability due to transfection with trehalose phosphate synthase.
Molec. Plant Prot. Biotech. WO 99/24589
Proteins analogous to lysozyme, encoding gene sequences; for use as antimicrobial agents.
Mosaic Technol. WO 99/24612
Multiple sequential polynucleotide displacement reactions for signal amplification and processing.
Mycogen WO 99/24581
Plant-encoded pesticidal toxins
San Diego, Calif.
Plant-optimized genes that encode pesticidal toxins, truncated genes and toxins; for protecting plants.
Neurotherapeutics WO 99/24584
Transfecting brain cancer cells
Transfecting a glycosyltransferase gene into glioblastoma cells; for inhibiting growth and treating brian cancer.
New York, St. Univ. of WO 99/24471
Methods for identifying modulators of opiate, cannabinoid, and estrogen receptors, nucleic acids encoding receptors.
Oklahoma, Univ. of WO 99/24468
Cancer susceptibility alleles
Allelic variation in the 3' untranslated region of the prohibitin gene; for determining cancer susceptibility.
Oklahoma Med. Res. Fdn. WO 99/24614
Oklahoma City, Okla.
Enothelial cell-derived protein from Alzheimer's patients that is toxic to neuronal cells, antibodies; for screens.
Ono Pharma WO 99/24569
Lysophosphatidic acid receptor
Human lysophosphatidic acid receptor, encoding gene sequences, antibodies; for screening modulators.
Oxford BioMedics GB 2 331 522
Transfecting quiescent cells
Retroviral vector particles capable of infecting and transducing non-dividing mammalian target cells.
Pathobiotek WO 99/24613
Human blood bacterium
Human blood bacterium associated with multiple sclerosis, chronic fatigue syndrome, and other autoimmune diseases.
Pittsburgh, Univ. of WO 99/24554
Isolation, characterization, and identification of dendritic-like cells, antigens, antibodies.
Princeton Univ. WO 99/24622
Triplex in situ hybridization
In situ detection of target sequences in double-stranded nucleic acids using another sequence to form a triplex.
Protein Sciences WO 99/24049
Use of insect cells transfected with insect antigen genes as adjuvants for vaccines.
Rhone-Poulenc Agro WO 99/24585 & 24586
Mutated and chimeric hydroxy-phenyl pyruvate dioxygenases, encoded genes; for obtaining herbicide-tolerant plants.
Rhone-Poulenc Agro WO 99/24594
Gene encoding thanatin, encoded protein, expression vector; for producing transformed disease-resistant plants.
Roche Diagnostics WO 99/24566
Tumor-specific antigens including intron sequences, PCR mRNA products; for cancer diagnosis and therapy.
Salk Inst. WO 99/23885
Hormonally modulated cancers
La Jolla, Calif.
Use of histone deacetylase inhibitors to activate genes responsive to hormone receptors; for treating cancer.
SBL Vaccin WO 99/24467
Immunoglobulin G-binding protein from Staphylococcus aureus, encoding gene sequence, antibodies; for vaccines.
Sheikhnejad, G. WO 99/24560
Ann Arbor, Mich.
Methylated antisense oligonucleotides; for inhibiting gene transcription in breast cancer cells.
SmithKline Beecham WO 99/24579
Era polypeptides, encoding gene sequences, production methods; for screening antibacterials.
SmithKline Beecham WO 99/24601
Secreted NSL4 protein
Secreted protein NSL4 polypeptides, encoded gene sequences, production methods; for diagnostics and therapeutics.
Stanford Univ. WO 99/24453
Palo Alto, Calif.
Gene sequences encoding the Bcl-2-related ovarian killer protein, encoded protein; for manipulating apoptosis.
Statens Serum Inst. WO 99/24577
Mycoplasm tuberculosis polypeptide fragments, encoding gene sequences; for making vaccines.
Technion Res. Develop. Fdn. WO 99/24608
Screening mutated DNA
Method for labeling single-stranded polynucleotides; for screening tissue samples for mutated DNA.
Texel WO 99/24591
Bacterial cloning vector
Dange Saint Romain, France
Non-RCR leuconostoc plasmid capable of being transferred into lactic acid bacteria; for cloning and expression.
3-Dimensional Pharma WO 99/24050
Protein unfolding curves
High-throughput method for classifying proteins identified in a genomics screen according to thermal unfolding curves.
Utrecht Univ. WO 99/24572
Dopaminergic neuron genes
Genes having expression restricted to mesencephalic dopaminergic neurons; for psychiatric disease diagnosis.
Ventana Genetics WO 99/24617
Expression library screening
Salt Lake City, Utah
Peptide libraries displayed on light-emitting protein scaffolds; for expression library screening.