Published May 26 (EPO); May 20 (WO); May 26 (GB)
Actinova WO 99/24559
Nuclear targeting
Cambridge, U.K.
Bacterial protein H; for the delivery of agents to eukaryotic nuclei.
Biogen WO 99/23867
Immunomodulatory protein
Cambridge, Mass.
A myelin-oligodendrocyte glycoprotein family member expressed in germinal B cells; for immunomodulation.
Brigham & Women's Hosp. WO 99/24595
APP gene expression modulators
Boston, Mass.
Translation enhancer element of the human amyloid precursor protein (APP) gene; for identifying expression modulators.
British Agriculture Ministry GB 2 331 521
Salmonella vaccine
London
Attenuated Salmonella strains that have difficulty colonizing the alimentary tract; for vaccines.
British Defense Ministry GB 2 331 523
Anthrax vaccines
Farnborough, U.K.
Methods of preparing Bacillus anthracis protective antigens or fragments; for vaccines.
British Natl. Environ. Res. Counc. WO 99/24567
Tissue cement proteins
Swindon, U.K.
Tissue cement proteins from blood-sucking ectoparasites; for bonding animal tissues and making vaccines.
British Columbia, Univ. of WO 99/24576
Pathogenic bacteria immunoresponse
Vancouver, B.C.
Pathogenic E. coli translocated intimin receptor, encoding gene sequences; for inducing immunoresponse.
California, Univ. of WO 99/24454
ß2-adrenergic receptor polymorphisms
Oakland, Calif.
Specific amplification of large segments of the human ß2-adrenergic receptor gene; for polymorphism identification.
California, Univ. of WO 99/24620
Cervical dysplasia screen
Oakland, Calif.
Measuring biochemical markers of angiogenesis and/or apoptosis; for screening cervical dysplasia.
Canadian Agriculture Ministry WO 99/24592
Plant production system
Saint-Foy, Que.
Production of heterologous human proteins in transgenic alfalfa plants; for diagnostics and therapeutics.
Chiron WO 99/24578
Neisseria vaccines
Siena, Italy
Neisseria meningitidis proteins, encoding gene sequences; for diagnostics and vaccines.
Chugai Res. Inst. Molec. Med. WO 99/24568
Steroid binding protein
Ibaraki, Japan
Membrane-bound steroid binding protein, encoding gene sequences.
Columbia Univ. WO 99/24457
Forebrain neuron transgene expression
New York
Calcium-calmodulin dependent kinase IIa promoter linked to transgenes; for specific expression in forebrain neurons.
Columbia Univ. WO 99/24553
HIV gp120 crystals
New York
HIV envelope glycoprotein gp120 crystals; for identifying mimics, variants, and modulators of binding molecules.
CSIRO (Comm. Sci. Ind. Res. Org.) WO 99/24590
Bioremediation suicide vector
Campbell, Australia
Suicide vector for expressing esterases that hydrolyze organophosphates and insecticidal toxins.
Curagen WO 99/24571
Cardiac hypertrophy genes
New Haven, Conn.
Identification of genes differentially expressed in cardiac hypertrophy, encoded proteins; for diagnosis and treatment.
Cygene WO 99/24621
Specific sequence detection
Alachua, Fla.
Methods for detecting of specific nucleotide sequences using triplex formation and signal amplification.
Cytimmune WO 99/24066
Enhancing vaccine response
College Park, Md.
Methods for enhancing immune responses by targeting multiple immune system components; for vaccines.
Daiichi WO 99/24609
Gene analysis method
Kyoto, Japan
Gene analysis method using single-stranded polynucleotides immobilized on a solid support.
Dalhousie Univ. WO 99/24582
Reovirus syncytial-forming proteins
Halifax, N.S.
Reovirus proteins involved in membrane fusion and syncytial formation, encoding gene sequences.
Dana-Farber Cancer Inst. WO 99/24464 & 24465
Modified HIV antigens
Boston, Mass.
Stabilized, glycosylated primate HIV envelope polypeptides modified proximal to the CD4 and chemokine receptor sites.
Du Pont WO 99/24573
Soybean vectors
Wilmington, Del.
Soybean gene homolog of the Phaseolus vulgaris transcription factor, chimeras for vectors; for higher gene expression.
Du Pont WO 99/24574
Plant transcription activators
Wilmington, Del.
Plant homologs of yeast and human regulators of AP-1 type transcription factor activity.
Feiss, M., et al. WO 99/24456
Modified lambda terminase
Iowa City, Iowa
Histidine-tagged lambda terminase enzymes, encoding gene sequences; for purification of the modified terminase.
Fred Hutchinson Cancer Res. Ctr. WO 99/24603
Yeast chemotherapeutic screen
Seattle, Wash.
Yeast-based synthetic lethal screens; for identifying drug targets for cancer chemotherapeutics.
GeneMedicine WO 99/24596
Nucleic acid vaccines
The Woodlands, Texas
Nucleic acid-based vaccines that encode multiple epitopes that induce immunoresponses.
Genencor Intl. WO 99/24562
Directed evolution enhancement
Rochester, N.Y.
Increasing the directed evolution of genes using helper phage to package DNA sequences into phagemids.
Genetics Inst. WO 99/24057 & 24508
BMP-11
Cambridge, Mass.
Bone morphogenic protein (BMP)-11, encoding gene, production methods; for tissue maintenance and contraception.
Genetics Inst. WO 99/24469
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Gorczynski, R.M. WO 99/24565
Immunosuppression for graft rejection
Willowdale, Ont.
OX-2 protein, encoding gene sequences; for immunosuppression in autoimmune disease and graft rejection.
Gropep WO 99/24470
Mammalian milk growth factor
Adelaide, Australia
Mammalian milk growth factor, mutants, derivatives, analogs, functionally active fragments, encoding gene sequences.
Guelph, Univ. of WO 99/24588
Delaying fruit ripening
Guelph, Ont.
Endo-ß-mannanase cDNA from plant tissues, antisense, encoded protein; for delaying fruit ripening and softening.
Harvard Univ. WO 99/24570
Transcriptional activator protein
Cambridge, Mass.
Proteins that interact with CIITA, an MHC class II transcriptional activator, encoding gene sequences.
Hoechst Marion Roussel WO 99/24473
Phosphorylated VASP antibodies
Frankfurt, Germany
Antibodies against phosphorylated vasodilator-stimulated phosphoprotein (VASP); for diagnostics and therapeutics.
Human Genome Sciences WO 99/24836
125 secreted proteins
Rockville, Md.
125 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Iconix Pharma WO 99/24563
Identifying gene function
Mountain View, Calif.
Two-step, scalable method for identifying gene function and modulators by using transfected microbial strains.
Immunomedics WO 99/24472
Immunoconjugates
Morris Plains, N.J.
Glycosylated antibodies and antibody fragments having reactive ketone groups; for making immunoconjugates.
Incyte Pharma WO 99/24463
Signal peptide-containing proteins
Palo Alto, Calif.
Signal peptide-containing proteins, encoding gene sequences, modulators; for diagnosis and therapeutics.
Incyte Pharma WO 99/24587
Phospholipase A2
Palo Alto, Calif.
Human phospholipase A2 polypeptides, encoding gene sequences, antibodies, modulators; for therapeutics.
Innogenetics WO 99/24054
Hepatitis C vaccines
Ghent, Belgium
Multimer peptides derived from hepatitis C virus envelope proteins that react with patient antibodies; for vaccines.
Innogenetics WO 99/24466
Hepatitis C infection diagnosis
Ghent, Belgium
Using annexin V, tubulin, and apolipoprotein B binding to hepatitis C virus envelope proteins for infection diagnosis.
Innogenetics WO 99/24607
Helicobacter diagnostics
Ghent, Belgium
PCR-based method to detect and type iceA gene alleles from Helicobacter pylori, antibodies; for diagnostics.
INSERM (Natl. Inst. Hlth. Med. Res.) EPO 918 091
Doublecortin
Paris
XLIS gene, encoded protein called doublecortin; for diagnostics and therapeutics.
Iowa St. Univ. WO 99/24575
Maize starch synthase
Ames, Iowa
Maize gene encoding starch synthase, encoded enzyme, mutations; for affecting strach synthesis.
Ixion Biotech. WO 99/24619
Quantitative PCR
Alachua, Fla.
Materials and methods for quantitative PCR; for measuring target polynucleotide templates.
Johns Hopkins Univ. WO 99/23880
Drug candidate mimics
Baltimore, Md.
Somatic transfer of modified genes; for mimicking and predicting drug candidate effects.
Johns Hopkins Univ. WO 99/24618
Myostatin variants
Baltimore, Md.
Methods for detecting myostatin mutations; for identifying animals with increased muscle mass.
Krebs Res. Inst. WO 99/24605
Cell cycle gene vector
Heidelberg, Germany
Gene promoter that can be operably attached to cell cycle genes, expression vector system.
Lilly EPO 918 090
Ketoreductase
Indianapolis, Ind.
Yeast ketoreductase gene, encoded protein; for stereospecific reduction of ketones.
Maryland, Univ. of WO 99/24564
RSV vaccines
College Park, Md.
Production of attenuated, infectious bovine respiratory syncytial virus (RSV) from synthetic cDNAs; for vaccines.
Mass. Gen. Hosp. WO 99/24455
Protein interaction detection
Boston, Mass.
Detection systems for measuring protein interactions and functional relationships.
Mass. Inst. Technol. WO 99/24059
Cardiac microvascular regulation
Cambridge, Mass.
PDGF-mediated regulation of cardiac microvascular endothelial cell gene expression.
Max Delbruck Ctr. Molec. Med. WO 99/24602
Determining transfection efficiency
Berlin, Germany
Combined reporter gene vector; for determining transfection efficiency and cell viability in parallel.
Max Planck Inst. WO 99/24593
Long-chain inulin
Berlin, Germany
Fructosyl transferase, encoding gene sequences; for producing long-chain inulin in plants.
McGill Univ. WO 99/24583
DNA methylase
Montreal, Que.
DNA demethylase gene overexpressed in cancer cells but not normal cells; for diagnostics and therapeutics.
Michigan, Univ. of WO 99/24557
Bone accessory cells
Ann Arbor, Mich.
Human bone accessory cells, preparation methods; for making osteoblasts and treating bone disorders.
Michigan Technol. Univ. WO 99/24561
Lignin biosynthesis alteration
Houghton, Mich.
Alteration of the lignin pathway 4-coumarate Co-enzyme A ligase; for affecting plant lignin biosynthesis.
Michigan St. Univ. WO 99/24068
Influenza vaccine production
E. Lansing, Mich.
Immortal bird cell lines; for replicating bird and other viruses and making influenza vaccines.
Millennium Biotherapeutics WO 99/24616
Signal peptide-containing proteins
Cambridge, Mass.
Methods for identifying nucleic acid sequences encoding signal peptide-containing proteins using yeast strains.
Millennium Pharma WO 99/24580
Essential fungal genes
Cambridge, Mass.
Essential Aspergillus fungi genes, encoded proteins, homologs; for identifying antifungal agents.
Millennium Pharma WO 99/24610
Organic molecule transporter
Cambridge, Mass.
Organic molecule transporter OCT-3 plasma membrane polypeptides, encoding gene sequences.
Mogen Intl. WO 99/24558
High-fermenting microorganisms
Leiden, Netherlands
Microorganisms having increased fermenting capability due to transfection with trehalose phosphate synthase.
Molec. Plant Prot. Biotech. WO 99/24589
Lysozyme antimicrobials
Cologne, Germany
Proteins analogous to lysozyme, encoding gene sequences; for use as antimicrobial agents.
Mosaic Technol. WO 99/24612
Signal amplification
Boston, Mass.
Multiple sequential polynucleotide displacement reactions for signal amplification and processing.
Mycogen WO 99/24581
Plant-encoded pesticidal toxins
San Diego, Calif.
Plant-optimized genes that encode pesticidal toxins, truncated genes and toxins; for protecting plants.
Neurotherapeutics WO 99/24584
Transfecting brain cancer cells
Chicago, Ill.
Transfecting a glycosyltransferase gene into glioblastoma cells; for inhibiting growth and treating brian cancer.
New York, St. Univ. of WO 99/24471
Receptor modulators
Albany, N.Y.
Methods for identifying modulators of opiate, cannabinoid, and estrogen receptors, nucleic acids encoding receptors.
Oklahoma, Univ. of WO 99/24468
Cancer susceptibility alleles
Norman, Okla.
Allelic variation in the 3' untranslated region of the prohibitin gene; for determining cancer susceptibility.
Oklahoma Med. Res. Fdn. WO 99/24614
Alzheimer's-derived toxin
Oklahoma City, Okla.
Enothelial cell-derived protein from Alzheimer's patients that is toxic to neuronal cells, antibodies; for screens.
Ono Pharma WO 99/24569
Lysophosphatidic acid receptor
Osaka, Japan
Human lysophosphatidic acid receptor, encoding gene sequences, antibodies; for screening modulators.
Oxford BioMedics GB 2 331 522
Transfecting quiescent cells
Oxford, U.K.
Retroviral vector particles capable of infecting and transducing non-dividing mammalian target cells.
Pathobiotek WO 99/24613
Human blood bacterium
Houston, Texas
Human blood bacterium associated with multiple sclerosis, chronic fatigue syndrome, and other autoimmune diseases.
Pittsburgh, Univ. of WO 99/24554
Dendritic-like cells
Pittsburgh, Penn.
Isolation, characterization, and identification of dendritic-like cells, antigens, antibodies.
Princeton Univ. WO 99/24622
Triplex in situ hybridization
Princeton, N.J.
In situ detection of target sequences in double-stranded nucleic acids using another sequence to form a triplex.
Protein Sciences WO 99/24049
Insect vaccines
Meriden, Conn.
Use of insect cells transfected with insect antigen genes as adjuvants for vaccines.
Rhone-Poulenc Agro WO 99/24585 & 24586
Herbicide-tolerant plants
Lyon, France
Mutated and chimeric hydroxy-phenyl pyruvate dioxygenases, encoded genes; for obtaining herbicide-tolerant plants.
Rhone-Poulenc Agro WO 99/24594
Disease-resistant plants
Lyon, France
Gene encoding thanatin, encoded protein, expression vector; for producing transformed disease-resistant plants.
Roche Diagnostics WO 99/24566
Tumor-specific antigens
Mannheim, Germany
Tumor-specific antigens including intron sequences, PCR mRNA products; for cancer diagnosis and therapy.
Salk Inst. WO 99/23885
Hormonally modulated cancers
La Jolla, Calif.
Use of histone deacetylase inhibitors to activate genes responsive to hormone receptors; for treating cancer.
SBL Vaccin WO 99/24467
Staphylococcus vaccines
Stockholm, Sweden
Immunoglobulin G-binding protein from Staphylococcus aureus, encoding gene sequence, antibodies; for vaccines.
Sheikhnejad, G. WO 99/24560
Methylated antisense
Ann Arbor, Mich.
Methylated antisense oligonucleotides; for inhibiting gene transcription in breast cancer cells.
SmithKline Beecham WO 99/24579
Antibacterial screens
Philadelphia, Penn.
Era polypeptides, encoding gene sequences, production methods; for screening antibacterials.
SmithKline Beecham WO 99/24601
Secreted NSL4 protein
Philadelphia, Penn.
Secreted protein NSL4 polypeptides, encoded gene sequences, production methods; for diagnostics and therapeutics.
Stanford Univ. WO 99/24453
Pro-apoptotic protein
Palo Alto, Calif.
Gene sequences encoding the Bcl-2-related ovarian killer protein, encoded protein; for manipulating apoptosis.
Statens Serum Inst. WO 99/24577
Tuberculosis vaccines
Copenhagen, Denmark
Mycoplasm tuberculosis polypeptide fragments, encoding gene sequences; for making vaccines.
Technion Res. Develop. Fdn. WO 99/24608
Screening mutated DNA
Haifa, Israel
Method for labeling single-stranded polynucleotides; for screening tissue samples for mutated DNA.
Texel WO 99/24591
Bacterial cloning vector
Dange Saint Romain, France
Non-RCR leuconostoc plasmid capable of being transferred into lactic acid bacteria; for cloning and expression.
3-Dimensional Pharma WO 99/24050
Protein unfolding curves
Exton, Penn.
High-throughput method for classifying proteins identified in a genomics screen according to thermal unfolding curves.
Utrecht Univ. WO 99/24572
Dopaminergic neuron genes
Utrecht, Netherlands
Genes having expression restricted to mesencephalic dopaminergic neurons; for psychiatric disease diagnosis.
Ventana Genetics WO 99/24617
Expression library screening
Salt Lake City, Utah
Peptide libraries displayed on light-emitting protein scaffolds; for expression library screening.