Published Dec. 9 (EPO); Dec. 3 (WO)
Acacia BiosciencesWO 98/54333
CAAX processing enzymes
Mammalian CAAX processing enzymes, encoding gene sequences, antibodies; for modulator assays.
Thousand Oaks, Calif.
Glia cell line-derived neurotrophic factor (GDNF), encoding gene sequences; for treating neuronal disorders.
DNA methylation alteration
Use of methioninase to alter methylation of DNA; for altering tissue development and designing therapeutics.
Axys PharmaWO 98/54300
S. San Francisco
Nematode worms having deletions in genes associated with Alzheimer's, deletion construction; for therapeutics.
Babraham Inst.WO 98/54312
Ribosome complex display
Ribosome complexes used for in vitro display and selection of proteins; for efficient isolation of encoding genes.
Babraham Inst.WO 98/54348
Synthetic telomeric DNA constructs; for chromosomal region targeting and deletion in embryonic stem cells.
Baxter Intl.WO 98/54345
Mini-adenoviral vectors having a minimal cis-element and genome; for expressing Factor VIII.
Biotica Technol.WO 98/54308
Mutants with disrupted rapamycin synthesis genes; for producing polyketide variants.
Bystryn, J.-C.WO 98/54343
Recovering shed antigens from cancer cells grown in serum-free medium; for preparing cancer vaccines.
Canadian Natl. Res. Counc.WO 98/54331
Mutant glycosyltransferases lacking proteolytic enzyme sites, enzyme-deficient cells; for increased expression.
Cell TherapeuticsWO 98/54303
Lysophosphatidic acid acyltransferase
Lysophosphatidic acid acyltransferase, encoding gene sequences.
Creative BiomoleculesWO 98/54344
Bone morphogen modulators
Modulators of bone morphogen OP-1, encoding gene sequences, modulator assays.
Dana-Farber Cancer Inst.WO 98/54220
Adipocyte thermogenesis activator
Adipocyte thermogenesis activator PGC-1, encoded proteins, fusions, antigenic peptides, antisense, transgenics.
Dana-Farber Cancer Inst.WO 98/54323
CD27-mediated apoptosis genes
Siva genes which are involved in CD27-mediated apoptosis, encoded proteins, antisense, antibodies, transgenics.
UDP-galactose epimerase, encoding gene sequences, cloning methods.
Modification of galactomannans in guar by using UDP-galactose epimerase antisense.
Adenoviral fiber mutants
Reduced affinity adenoviral fiber trimer; for expression and virus inactivation by competitive binding.
Hanil Synthetic FiberWO 98/54339
Recombinant protein production
Masan, S. Korea
High level production of human G-CSF and growth hormone using yeast-derived promoters.
Harvard Univ.WO 98/53830
TGF-beta signalling modulators
Interacting domains of FAST-1 and Smad2 complexes; for modulating TGF-beta signalling pathways.
Human Genome SciencesWO 98/54199
Tissue plasminogen activator (tPA)-like protease, encoding gene sequences; for modulator screens and therapeutics.
Human Genome SciencesWO 98/54201
TNF receptor-like protein 8
Human tumor necrosis factor (TNF) receptor-like protein 8, encoded protein; for modulator screen and therapeutics.
Human Genome SciencesWO 98/54202
TNF receptor 8
Human tumor necrosis factor (TNF) receptor 8, encoded protein; for modulator screen and therapeutics.
Human Genome SciencesWO 98/54206
32 human secreted proteins
32 human secreted proteins, encoding gene sequences, antibodies, production methods; for diagnostics.
Hunig, T.WO 98/54225
Human CD28 antibodies
Monoclonal antibodies against human CD28; for non-specific activation of T cells.
Lysophosphatidic acid acyltransferase
Lysophosphatidic acid acyltransferase, encoding gene sequences, fragments, antibodies, analogs, modulators.
Incyte PharmaWO 98/54319
Metal response element binding protein
Palo Alto, Calif.
Metal response element binding protein, encoding gene sequences, antibodies, modulators; for therapy.
Incyte PharmaWO 98/54320
Human metaxin protein
Palo Alto, Calif.
Human metaxin protein, encoding gene sequences, antibodies, modulators; for therapy.
Incyte PharmaWO 98/54321
Human DP1 homolog
Palo Alto, Calif.
Human DP1 homolog, encoding gene sequences, antibodies, modulators; for therapy.
Incyte PharmaWO 98/54324
Multiple endocrine neoplasia protein
Palo Alto, Calif.
Human multiple endocrine neoplasia type 1 protein, encoding gene sequences, antibodies, modulators; for therapy.
Inst. Child Hlth.WO 98/54347
Integrin-targeting vectors having binding, polycation, and lipid moieties and gene sequences to be transfected.
Kyowa Hakko KogyoEPO 882 794
Humanized ganglioside antibody
Human complementary determining region (CDR)-grafted antibody to ganglioside GM2.
Kyowa Hakko KogyoEPO 882 799
Monoclonal antibodies against vascular endothelial growth factor (VEGF) receptor flt-1; for treating metastases.
Leiden, State Univ. ofWO 98/54314
Peptide fragments and modified variants of ubiquicidine; for use as antimicrobials.
Marie Curie Res. Inst.WO 98/54318
Bladder cancer-associated gene
Tumor suppressor gene on chromosome 9 that is deleted in bladder cancer; for diagnostics and therapeutics.
Mass. Inst. Technol.WO 98/54299
Tumor suppressor genes
Tumor suppressor genes that control cell fate and proliferation in C. elegans and other species.
Mass. Inst. Technol.WO 98/54363
Detection of DNA mutations, mismatches, and polymorphisms using helix-random chain thermodynamics.
McGill Univ.WO 98/54313
DNA methyltransferase genomic nucleic acid sequences, antisense oligos; for developing gene therapy methods.
Medical Analysis SystemsWO 98/54218
Cardiac troponin I fragments
Human cardiac troponin I fragments having greater immunologic reactivity than the intact protein.
MRC (Med. Res. Counc.)WO 98/54338
Promoter identification by determining the effect of sequence motifs on RNA polymerase transcription.
Mondiale Res. Fdn.WO 98/54317
CCR5 HIV-1 co-receptor variants
Variants of CCR5 HIV-1 co-receptor associated with infection resistance, probes; for diagnostics.
NIH (Natl. Inst. Hlth.)WO 98/54325
Human frizzled-related proteins
Human frizzled-related proteins, fragments; for antagonizing wnt family cytokine signalling.
New York, State Univ. ofWO 98/53854
Immune response stimulation
Chimeric proteins having Salmonella antigen domains; for stimulating class I-restricted immune response.
Ohio Sate Univ.WO 98/54353
Nucleotide integrase particles
Methods for making a ribonucleoprotein particle having nucleotide integrase activity.
Peptide TherapeuticsWO 98/54209
Human MAFA, encoding gene sequences, antibodies, fragments, ligands; for affecting cell activation in vivo.
Pharmacia & UpjohnWO 98/54216
FREAC transcription factor
Transcription factor FREAC 11 of the forkhead family, encoding gene sequences; for regulating lipid metabolism.
Res. Corp. Technol.WO 98/54315
Cell growth-control oligos
Partial cDNA that encodes PKR, antisense, oligo fragments; for controlling cell growth.
Samyang GenexWO 98/54336
Antimicrobial fusion production
Seoul, S. Korea
Fusions having acidic peptides linked to antimicrobial peptides; for production without toxicity to the host.
Hepsin serine protease knockouts
Knockout mice, and their progeny, with disrupted hepsin serine protease gene.
Scripps Inst.WO 98/54311
La Jolla, Calif.
Derivatives and fusions of three zinc finger domain proteins; for controlling genome transcription processes.
TNF-alpha gene mutations
Changes in the 5'-flanking region of the TNF-alpha gene are measured for diagnosing juvenile rheumatoid arthritis.
Sloan-Kettering Inst.WO 98/54200
Bcl-8 gene sequences, probe oligos, agents blocking expression; for treating diffuse large cell lymphoma.
SmithKline BeechamEPO 882 791
Wnt-11 polypeptides, encoding gene sequences, production method; for diagnostics and therapeutics.
SmithKline BeechamEPO 882 792
GEF family peptides
Guanine nucleotide exchange factor (GEF) family peptides, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamEPO 882 793
Frizzled gene homolog
Human 7-transmembrane receptor gene similar to mouse frizzled-6 gene; encoded peptides; for therapeutics.
SmithKline BeechamEPO 882 795
Recombinant secA1 polypeptides from Staphylococcus aureus, encoding gene sequences; for antibacterial screen.
SmithKline BeechamEPO 882 796
Streptococcus pneumoniae rnc polypeptides, encoding gene sequences, production method; for antibacterial screen.
Subsidiary No. 3WO 98/54366
HIV infection replication
Identification of cellular genes necessary for HIV replication and their inhibitors; for down-regulation.
Sumitomo ElectricEPO 882 790
TRAF family protein
TRAF family member protein, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Sodium channel receptor
Le Plessie Robinson, France
Sodium channel receptor, encoding gene sequences, production methods; for therapeutics.
Texas, Univ. ofWO 98/54322
Osteoblast specific factor-2
Osteoblast specific factor-2, encoding gene sequences, splice variants, transgenics; for therapeutics.
Zurich Inst. Biotechnol.WO 98/54329
Mutant E. coli alkanoates
Production of medium chain length poly-3-hydroxy alkanoates in mutant E. coli strains.
Beta subfamily chemokine
Human chemokine that is a member of the beta subfamily, encoding gene sequences; for regulating inflammation.