Published Nov. 11 (EPO); Nov. 5 (WO); Nov. 11 (GB)
American Home ProductsWO 98/49271
Differentiating neuronal cells
Madison, N.J.
Human NT2 neuronal precursor cells transfected with ß2 adrenergic receptors; for enhancing differentiation.
American Home ProductsWO 98/49297
MORT1 apoptosis gene
Madison, N.J.
Wild-type and deleted versions of the MORT1 gene; for studying interactions in apoptosis pathways.
AmgenWO 98/49305
Osteoprotegrin fusions
Thousand Oaks, Calif.
Chimeric fusions of osteoprotegrin dimerization domains, encoding gene sequences; for therapeutics.
AnticancerWO 98/49336
Cancer metastasis models
San Diego
Cancer metastasis models using the expression of green fluorescent protein in tumors as a marker.
Applied Res. SystemsWO 98/49291
Inducible leucine zippers
Curacao, Netherlands Antilles
Gene sequences for glucocorticoid-induced leucine zippers, encoded proteins, fragments; for inhibiting apoptosis.
Appligene-OncorWO 98/49274 & 49275
Thermostable DNA polymerase
Illkirch, France
Thermostable DNA polymerase from Thermococcus fumicolans bacteria, coding sequences, thermostable inteins.
Aquila BiopharmaWO 98/49312 & 49313
Granulocytic erhlichia
Worcester, Mass.
Proteins encoding granulocytic erhlichia, a tick-borne intracellular bacteria, encoding genes; for vaccines.
Bio MerieuxWO 98/49285
Multiple sclerosis antibody ligands
Marcy l'Etoile, France
Polypeptides that react with antibodies from multiple sclerosis patients; for diagnostics and therapeutics.
Bruker-Franzen AnalytikGB 2 325 002
MALDI-TOF spectrometry
Bremen, Germany
Charged primers for improved detection of PCR amplified samples analyzed by MALDI-TOF mass spectrometry.
Canadian Agriculture MinistryWO 98/49320
alpha-amylase reporter genes
Ottawa, Ont.
Use of alpha-amylase genes encoding enzymes of different electrophoretic mobilities for reporter genes.
Collateral TherapeuticsWO 98/49300
Truncated VEGFs
San Diego.
Truncated vascular endothelial growth factor (VEGF) genes, encoded VEGFs; for gene therapy to stimulate angiogenesis.
De Novo EnzymeWO 98/49311
Cleavable ricin-like toxins
Burnaby, B.C.
Ricin-like toxin having the A and B chains attached by a linker susceptible to a disease-specific protease.
Eastman ChemicalWO 98/49337
Wastewater monitoring
Kingsport, N.Y.
Bioluminescent reporter gene inserted into bacterial cells used to monitor toxins in wastewater.
Florida, Univ. ofWO 98/49347
Tissue transfection detection
Gainesville, Fla.
Co-transfection of reporter and therapeutic genes; for optical detection of transfection in target tissues.
Fundacao Oswaldo CruzEPO 877 086
YF virus vaccines
Rio de Janeiro, Brazil
Recombinant infectious YF virus cDNA, plasmids, production methods; for making YF virus vaccines.
Genelabs Technol.WO 98/49314
Antiulcer therapeutics
Redwood City, Calif.
Highly immunogenic polypeptide antigens of Helicobacter pylori, encoding genes; for vaccines and therapeutics.
GenentechWO 98/49308
NGF variants
S. San Francisco
Nerve growth factor (NGF) variants that have trkC binding activity, encoding gene sequences; for neuronal disorders.
Genetic Engin. & Biotech. Ctr.WO 98/49327
Bacterial infection detection
Havana, Cuba
Fusions and conjugates of bacterial adhesins; for detection of infections by red cell hemagglutination.
Genetics Inst.WO 98/49302
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
GenzymeWO 98/49324
Human phosphomannomutase
Haverhill, U.K.
Human phosphomannomutase, encoding gene sequences; for carbohydrate-deficient glycoprotein syndrome type 1.
Helix Res. Inst.WO 98/49276
Neurite inhibiting kinase
Chiba, Japan
Serine-threonine protein kinase, encoding gene sequences; for inhibiting neurite extension.
Helix Res. Inst.WO 98/49282
Gene expression change detection
Chiba, Japan
Detecting gene expression changes caused by transfected genes by comparing control and transfected cells.
Helix Res. Inst.WO 98/49284
Nuclear transport of proteins
Chiba, Japan
Detection of proteins transported to the nucleus by using a promoter region linked to a reporter gene.
HoechstEPO 877 088
Translation initiation regulation
Frankfurt, Germany
Regulation of protein translation initiation in eukaryotes using complementary mRNA leader sequences [in German].
Hoffmann-La RocheWO 98/49309
Neuroinflammation therapeutics
Basel, Switzerland
Chemokines and encoding gene sequences involved in brain pathogenesis; for treating neuroinflammation.
HybridonWO 98/49287
Thymidylate synthase antisense
Cambridge, Mass.
Thymidylate synthase antisense oligos; for treating cancer cell resistance to inhibitors of this enzyme.
HybridonWO 98/49288
CMI-inducing cytokines
Cambridge, Mass.
Oligonucleotides having specific structural motifs that specifically induce specific cytokines; for therapy.
HybritechWO 98/49323
Inactive PSA precursors
San Diego
Inactive precursor forms of prostate-specific antigen (PSA) in serum, antibodies; for diagnosis of prostate cancer.
IcosWO 98/49289
EF-1-alpha regulatory sequences
Bothell, Wash.
Regulatory sequences from the hamster EF-1-alpha gene, for linkage to structural genes and subsequent transfection.
Imperial Coll. InnovationsWO 98/48842
Liver gene therapy
London
Modified baculoviruses having genes encoding therapeutics; for delivery to liver cells.
Incyte PharmaWO 98/49298
Heat shock-like protein
Palo Alto, Calif.
Heat shock-like protein, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Incyte PharmaWO 98/49301
Retinoid binding protein
Palo Alto, Calif.
Human retinoid binding protein, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Incyte PharmaWO 98/49304
Neuronal extracellular matrix protein
Palo Alto, Calif.
Neuronal extracellular matrix protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/49306
Human C-type lectin
Palo Alto, Calif.
Human C-type lectin, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Incyte PharmaWO 98/49319
Human lysophopholipase
Palo Alto, Calif.
Human lysophopholipase, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Indian Biotechnology SecretaryEPO 877 087
Amycolatopsis cloning vectors
New Delhi, India
Cloning vectors for Amycolatopsis species prepared in and isolated from E. coli.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49292
KAR-associated proteins
Paris
Proteins associated with killer cell activating receptors (KAR); for affecting KAR function.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49334
Ribosome entry site vector
Paris
Internal ribosome entry site nucleotide sequence; for enhanced retroviral vector packaging and gene therapy.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49335
Chimeric retrovirus envelopes
Paris
Construction and expression of chimeric retrovirus envelope proteins; for therapeutics and gene therapy.
Klingemann, H.WO 98/49268
NK cells expressing cytokines
Winnetka, Ill.
Natural killer (NK) cell line that expresses cytokines; for treating cancer and purging cancer cells.
Kosan BiosciencesWO 98/49315
Combinatorial polyketide libraries
Burlingame, Calif.
Combinatorial polyketide libraries from manipulated host synthase genes; for making erythromycin-like therapeutics.
Ludwig Inst.WO 98/49299
Leukemia-associated genes
New York
Leukemia-associated genes, fragments, functional variants, antibodies; for diagnostics and therapeutics.
McGill Univ.WO 98/49294
Nuclear localization
Montreal
Fusion proteins having nuclear localization and reporter sequences; for visualization in cell nuclei.
McGill Univ.WO 98/49325
Macrocyclic lactone resistance
Montreal
Nematode P-glycoprotein homologs, encoding gene sequences; for treating resistance to macrocyclic lactone drugs.
Merck, Sharp & DohmeWO 98/49293
GABAA receptor theta subunit
Hoddeson, U.K.
Gene sequence for the theta subunit of the GABAA receptor, encoded protein; for designing modulators
Minnesota, Univ. ofWO 98/49350
Liver mutation correction
Minneapolis
In vivo use of recombinagenic oligonucleotides to correct genetic lesions in liver cells.
Mishra, L.WO 98/48827
Early liver development genes
Bethesda, Md.
Genes for proteins expressed in early liver development, encoded proteins; for studying liver disease.
Mt. Sinai Med. Ctr.WO 98/48834
Flu tumor antigens
New York
Recombinant influenza viruses that express tumor-associated antigens; for vaccination of cancer patients.
Mt. Sinai Med. Ctr.WO 98/49269
Neurofilament knockouts
New York
Knockout mice having disrupted endogenous neurofilament genes; for studying neurodegenerative diseases.
Netherlands Cancer Inst.EPO 877 082
Mutant generation
Amsterdam, Netherlands
Gene targeting by homologous recombination and sibling-selection; for generating mutants.
Newcastle, Univ. ofWO 98/49328
Bacillus production system
Newcastle, U.K.
Regulated expression or alteration of Bacillus subtilis wprA gene; for enhanced secretion of recombinant proteins.
Oxford BioMedicaGB 2 325 003
Retroviral vector production
Oxford, U.K.
Retroviral vector production systems using lentivirus-based vector particles that can infect non-dividing cells.
Pasteur MerieuxWO 98/49318
Antiulcer vaccines
Lyon, France
Helicobacter pylori urease A and B subunits, encoding gene sequences; for making antiulcer vaccines.
Pennsylvania, Univ. ofWO 98/49338
Post-translational modification
Philadelphia
Bacterial insertion of test DNA for detecting enzymes that post-translationally modify proteins.
Regeneron PharmaWO 98/49296
Human Cerberus proteins
Tarrytown, N.Y.
Human Cerberus proteins, encoding gene sequences, primers, ligands; for antagonizing bone morphogenic protein activity.
Rhone-Poulenc RorerWO 98/49321
Anti-angiogenic tumor agents
Antony, France
Adenovirus-mediated delivery of anti-angiogenic factors into tumor cells.
Royal Free Hosp. Med. Sch.WO 98/49333
Eukaryotic expression cassette
London
Eukaryotic gene expression cassette having a myosin light chain enhancer and promoter linked to a structural gene.
Sembiosys GeneticsWO 98/49326
Fusion production method
Calgary, Alberta
Expression of recombinantly produced proteins using fusions with pro-peptides; for cleavage and subsequent purification.
SmithKline BeechamEPO 877 030
EPO primary response gene
Philadelphia
Erythropoietin (EPO) primary response gene 1, encoded protein, production methods; for diagnostics/therapeutics.
SmithKline BeechamEPO 877 083
G protein-coupled receptor
Philadelphia
Human G protein-coupled receptor (HCEPT09), encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 877 085
Lyme disease vaccines
Rixensart, Belgium
Borrelia burgdorferi OspA antigens, encoding genes; for Lyme disease vaccines.
Sonderegger, P.WO 98/49322
Neurotrypsins
Zurich, Switzerland
Neurotrypsins, encoding gene sequences; for use in developing therapeutics.
StratageneWO 98/49266
Highly transformable bacteria
La Jolla, Calif.
Gram negative bacteria having the Hte mutation; for making highly transformable E. coli cells.
SugenWO 98/49317
Phosphatases and kinases
Redwood City, Calif.
Phosphatases and kinases, encoding genes, antibodies; for screening modulators, diagnostics, therapeutics.
Takeda ChemicalWO 98/48616
Vitamin D transgenics
Osaka, Japan
Transgenics having a transfected 25-hydroxylated vitamin D3 24-hydroxylase gene; for calcium regulation disease study.
Takeda ChemicalWO 98/49295
G protein-coupled receptor ligand
Osaka, Japan
Ligand for G protein-coupled receptor from pituitaries, encoding gene sequences; for diagnostics and therapeutics.
Texas, Univ. ofWO 98/49286
Selection of displayed antibodies
Austin, Texas
Directed evolution and selection of enzymes and antibodies displayed on host cell surfaces.
TularikWO 98/49265
UCP2 gene expression regulators
S. San Francisco
UCP2 gene transcription regulators, UCP2 transcriptional promoters; for use in high-throughput therapeutic screens.
UnitikaEPO 877 084
Thermostable diaphorase gene
Amagasaki, Japan
Thermostable Bacillus diaphorase gene, encoded protein, production methods.
Vlamms Inst. Biotechnol.WO 98/49290
Syndecan binding proteins
Zwijnaarde, Belgium
Proteins that bind to the cytoplasmic domain of syndecan; for affecting cytoskeletal-mediated signalling.
Wistar Inst.WO 98/49270
Colorectal cancer T cells
Philadelphia, Penn.
Stable cytolytic T cell lines against colorectal carcinoma, methods for generating these cell lines.
Yale Univ.WO 98/49303
Tick vaccines
New Haven, Conn.
Tick polypeptides, fragments, multimers, fusions, encoding gene sequences, antibodies; for vaccines.
ZymogeneticsWO 98/49307
Cytokine-like receptor
Seattle
Mammalian cytokine-like receptor, encoding gene sequences, antibodies; for diagnostics and therapeutics.
ZymogeneticsWO 98/49310
Cytokine-like factor 7
Seattle
Mammalian cytokine-like factor 7, encoding gene sequences, antibodies; for therapeutics.