Published Nov. 11 (EPO); Nov. 5 (WO); Nov. 11 (GB)
American Home ProductsWO 98/49271
Differentiating neuronal cells
Human NT2 neuronal precursor cells transfected with ß2 adrenergic receptors; for enhancing differentiation.
American Home ProductsWO 98/49297
MORT1 apoptosis gene
Wild-type and deleted versions of the MORT1 gene; for studying interactions in apoptosis pathways.
Thousand Oaks, Calif.
Chimeric fusions of osteoprotegrin dimerization domains, encoding gene sequences; for therapeutics.
Cancer metastasis models
Cancer metastasis models using the expression of green fluorescent protein in tumors as a marker.
Applied Res. SystemsWO 98/49291
Inducible leucine zippers
Curacao, Netherlands Antilles
Gene sequences for glucocorticoid-induced leucine zippers, encoded proteins, fragments; for inhibiting apoptosis.
Appligene-OncorWO 98/49274 & 49275
Thermostable DNA polymerase
Thermostable DNA polymerase from Thermococcus fumicolans bacteria, coding sequences, thermostable inteins.
Aquila BiopharmaWO 98/49312 & 49313
Proteins encoding granulocytic erhlichia, a tick-borne intracellular bacteria, encoding genes; for vaccines.
Bio MerieuxWO 98/49285
Multiple sclerosis antibody ligands
Marcy l'Etoile, France
Polypeptides that react with antibodies from multiple sclerosis patients; for diagnostics and therapeutics.
Bruker-Franzen AnalytikGB 2 325 002
Charged primers for improved detection of PCR amplified samples analyzed by MALDI-TOF mass spectrometry.
Canadian Agriculture MinistryWO 98/49320
alpha-amylase reporter genes
Use of alpha-amylase genes encoding enzymes of different electrophoretic mobilities for reporter genes.
Collateral TherapeuticsWO 98/49300
Truncated vascular endothelial growth factor (VEGF) genes, encoded VEGFs; for gene therapy to stimulate angiogenesis.
De Novo EnzymeWO 98/49311
Cleavable ricin-like toxins
Ricin-like toxin having the A and B chains attached by a linker susceptible to a disease-specific protease.
Eastman ChemicalWO 98/49337
Bioluminescent reporter gene inserted into bacterial cells used to monitor toxins in wastewater.
Florida, Univ. ofWO 98/49347
Tissue transfection detection
Co-transfection of reporter and therapeutic genes; for optical detection of transfection in target tissues.
Fundacao Oswaldo CruzEPO 877 086
YF virus vaccines
Rio de Janeiro, Brazil
Recombinant infectious YF virus cDNA, plasmids, production methods; for making YF virus vaccines.
Genelabs Technol.WO 98/49314
Redwood City, Calif.
Highly immunogenic polypeptide antigens of Helicobacter pylori, encoding genes; for vaccines and therapeutics.
S. San Francisco
Nerve growth factor (NGF) variants that have trkC binding activity, encoding gene sequences; for neuronal disorders.
Genetic Engin. & Biotech. Ctr.WO 98/49327
Bacterial infection detection
Fusions and conjugates of bacterial adhesins; for detection of infections by red cell hemagglutination.
Genetics Inst.WO 98/49302
Secreted protein genes
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Human phosphomannomutase, encoding gene sequences; for carbohydrate-deficient glycoprotein syndrome type 1.
Helix Res. Inst.WO 98/49276
Neurite inhibiting kinase
Serine-threonine protein kinase, encoding gene sequences; for inhibiting neurite extension.
Helix Res. Inst.WO 98/49282
Gene expression change detection
Detecting gene expression changes caused by transfected genes by comparing control and transfected cells.
Helix Res. Inst.WO 98/49284
Nuclear transport of proteins
Detection of proteins transported to the nucleus by using a promoter region linked to a reporter gene.
HoechstEPO 877 088
Translation initiation regulation
Regulation of protein translation initiation in eukaryotes using complementary mRNA leader sequences [in German].
Hoffmann-La RocheWO 98/49309
Chemokines and encoding gene sequences involved in brain pathogenesis; for treating neuroinflammation.
Thymidylate synthase antisense
Thymidylate synthase antisense oligos; for treating cancer cell resistance to inhibitors of this enzyme.
Oligonucleotides having specific structural motifs that specifically induce specific cytokines; for therapy.
Inactive PSA precursors
Inactive precursor forms of prostate-specific antigen (PSA) in serum, antibodies; for diagnosis of prostate cancer.
EF-1-alpha regulatory sequences
Regulatory sequences from the hamster EF-1-alpha gene, for linkage to structural genes and subsequent transfection.
Imperial Coll. InnovationsWO 98/48842
Liver gene therapy
Modified baculoviruses having genes encoding therapeutics; for delivery to liver cells.
Incyte PharmaWO 98/49298
Heat shock-like protein
Palo Alto, Calif.
Heat shock-like protein, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Incyte PharmaWO 98/49301
Retinoid binding protein
Palo Alto, Calif.
Human retinoid binding protein, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Incyte PharmaWO 98/49304
Neuronal extracellular matrix protein
Palo Alto, Calif.
Neuronal extracellular matrix protein, encoding gene sequences, vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/49306
Human C-type lectin
Palo Alto, Calif.
Human C-type lectin, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Incyte PharmaWO 98/49319
Palo Alto, Calif.
Human lysophopholipase, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.
Indian Biotechnology SecretaryEPO 877 087
Amycolatopsis cloning vectors
New Delhi, India
Cloning vectors for Amycolatopsis species prepared in and isolated from E. coli.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49292
Proteins associated with killer cell activating receptors (KAR); for affecting KAR function.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49334
Ribosome entry site vector
Internal ribosome entry site nucleotide sequence; for enhanced retroviral vector packaging and gene therapy.
INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49335
Chimeric retrovirus envelopes
Construction and expression of chimeric retrovirus envelope proteins; for therapeutics and gene therapy.
Klingemann, H.WO 98/49268
NK cells expressing cytokines
Natural killer (NK) cell line that expresses cytokines; for treating cancer and purging cancer cells.
Kosan BiosciencesWO 98/49315
Combinatorial polyketide libraries
Combinatorial polyketide libraries from manipulated host synthase genes; for making erythromycin-like therapeutics.
Ludwig Inst.WO 98/49299
Leukemia-associated genes, fragments, functional variants, antibodies; for diagnostics and therapeutics.
McGill Univ.WO 98/49294
Fusion proteins having nuclear localization and reporter sequences; for visualization in cell nuclei.
McGill Univ.WO 98/49325
Macrocyclic lactone resistance
Nematode P-glycoprotein homologs, encoding gene sequences; for treating resistance to macrocyclic lactone drugs.
Merck, Sharp & DohmeWO 98/49293
GABAA receptor theta subunit
Gene sequence for the theta subunit of the GABAA receptor, encoded protein; for designing modulators
Minnesota, Univ. ofWO 98/49350
Liver mutation correction
In vivo use of recombinagenic oligonucleotides to correct genetic lesions in liver cells.
Mishra, L.WO 98/48827
Early liver development genes
Genes for proteins expressed in early liver development, encoded proteins; for studying liver disease.
Mt. Sinai Med. Ctr.WO 98/48834
Flu tumor antigens
Recombinant influenza viruses that express tumor-associated antigens; for vaccination of cancer patients.
Mt. Sinai Med. Ctr.WO 98/49269
Knockout mice having disrupted endogenous neurofilament genes; for studying neurodegenerative diseases.
Netherlands Cancer Inst.EPO 877 082
Gene targeting by homologous recombination and sibling-selection; for generating mutants.
Newcastle, Univ. ofWO 98/49328
Bacillus production system
Regulated expression or alteration of Bacillus subtilis wprA gene; for enhanced secretion of recombinant proteins.
Oxford BioMedicaGB 2 325 003
Retroviral vector production
Retroviral vector production systems using lentivirus-based vector particles that can infect non-dividing cells.
Pasteur MerieuxWO 98/49318
Helicobacter pylori urease A and B subunits, encoding gene sequences; for making antiulcer vaccines.
Pennsylvania, Univ. ofWO 98/49338
Bacterial insertion of test DNA for detecting enzymes that post-translationally modify proteins.
Regeneron PharmaWO 98/49296
Human Cerberus proteins
Human Cerberus proteins, encoding gene sequences, primers, ligands; for antagonizing bone morphogenic protein activity.
Rhone-Poulenc RorerWO 98/49321
Anti-angiogenic tumor agents
Adenovirus-mediated delivery of anti-angiogenic factors into tumor cells.
Royal Free Hosp. Med. Sch.WO 98/49333
Eukaryotic expression cassette
Eukaryotic gene expression cassette having a myosin light chain enhancer and promoter linked to a structural gene.
Sembiosys GeneticsWO 98/49326
Fusion production method
Expression of recombinantly produced proteins using fusions with pro-peptides; for cleavage and subsequent purification.
SmithKline BeechamEPO 877 030
EPO primary response gene
Erythropoietin (EPO) primary response gene 1, encoded protein, production methods; for diagnostics/therapeutics.
SmithKline BeechamEPO 877 083
G protein-coupled receptor
Human G protein-coupled receptor (HCEPT09), encoding gene sequences, production methods; for therapeutics.
SmithKline BeechamEPO 877 085
Lyme disease vaccines
Borrelia burgdorferi OspA antigens, encoding genes; for Lyme disease vaccines.
Sonderegger, P.WO 98/49322
Neurotrypsins, encoding gene sequences; for use in developing therapeutics.
Highly transformable bacteria
La Jolla, Calif.
Gram negative bacteria having the Hte mutation; for making highly transformable E. coli cells.
Phosphatases and kinases
Redwood City, Calif.
Phosphatases and kinases, encoding genes, antibodies; for screening modulators, diagnostics, therapeutics.
Takeda ChemicalWO 98/48616
Vitamin D transgenics
Transgenics having a transfected 25-hydroxylated vitamin D3 24-hydroxylase gene; for calcium regulation disease study.
Takeda ChemicalWO 98/49295
G protein-coupled receptor ligand
Ligand for G protein-coupled receptor from pituitaries, encoding gene sequences; for diagnostics and therapeutics.
Texas, Univ. ofWO 98/49286
Selection of displayed antibodies
Directed evolution and selection of enzymes and antibodies displayed on host cell surfaces.
UCP2 gene expression regulators
S. San Francisco
UCP2 gene transcription regulators, UCP2 transcriptional promoters; for use in high-throughput therapeutic screens.
UnitikaEPO 877 084
Thermostable diaphorase gene
Thermostable Bacillus diaphorase gene, encoded protein, production methods.
Vlamms Inst. Biotechnol.WO 98/49290
Syndecan binding proteins
Proteins that bind to the cytoplasmic domain of syndecan; for affecting cytoskeletal-mediated signalling.
Wistar Inst.WO 98/49270
Colorectal cancer T cells
Stable cytolytic T cell lines against colorectal carcinoma, methods for generating these cell lines.
Yale Univ.WO 98/49303
New Haven, Conn.
Tick polypeptides, fragments, multimers, fusions, encoding gene sequences, antibodies; for vaccines.
Mammalian cytokine-like receptor, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Cytokine-like factor 7
Mammalian cytokine-like factor 7, encoding gene sequences, antibodies; for therapeutics.