Published Nov. 11 (EPO); Nov. 5 (WO); Nov. 11 (GB)

American Home ProductsWO 98/49271

Differentiating neuronal cells

Madison, N.J.

Human NT2 neuronal precursor cells transfected with ß2 adrenergic receptors; for enhancing differentiation.

American Home ProductsWO 98/49297

MORT1 apoptosis gene

Madison, N.J.

Wild-type and deleted versions of the MORT1 gene; for studying interactions in apoptosis pathways.

AmgenWO 98/49305

Osteoprotegrin fusions

Thousand Oaks, Calif.

Chimeric fusions of osteoprotegrin dimerization domains, encoding gene sequences; for therapeutics.

AnticancerWO 98/49336

Cancer metastasis models

San Diego

Cancer metastasis models using the expression of green fluorescent protein in tumors as a marker.

Applied Res. SystemsWO 98/49291

Inducible leucine zippers

Curacao, Netherlands Antilles

Gene sequences for glucocorticoid-induced leucine zippers, encoded proteins, fragments; for inhibiting apoptosis.

Appligene-OncorWO 98/49274 & 49275

Thermostable DNA polymerase

Illkirch, France

Thermostable DNA polymerase from Thermococcus fumicolans bacteria, coding sequences, thermostable inteins.

Aquila BiopharmaWO 98/49312 & 49313

Granulocytic erhlichia

Worcester, Mass.

Proteins encoding granulocytic erhlichia, a tick-borne intracellular bacteria, encoding genes; for vaccines.

Bio MerieuxWO 98/49285

Multiple sclerosis antibody ligands

Marcy l'Etoile, France

Polypeptides that react with antibodies from multiple sclerosis patients; for diagnostics and therapeutics.

Bruker-Franzen AnalytikGB 2 325 002

MALDI-TOF spectrometry

Bremen, Germany

Charged primers for improved detection of PCR amplified samples analyzed by MALDI-TOF mass spectrometry.

Canadian Agriculture MinistryWO 98/49320

alpha-amylase reporter genes

Ottawa, Ont.

Use of alpha-amylase genes encoding enzymes of different electrophoretic mobilities for reporter genes.

Collateral TherapeuticsWO 98/49300

Truncated VEGFs

San Diego.

Truncated vascular endothelial growth factor (VEGF) genes, encoded VEGFs; for gene therapy to stimulate angiogenesis.

De Novo EnzymeWO 98/49311

Cleavable ricin-like toxins

Burnaby, B.C.

Ricin-like toxin having the A and B chains attached by a linker susceptible to a disease-specific protease.

Eastman ChemicalWO 98/49337

Wastewater monitoring

Kingsport, N.Y.

Bioluminescent reporter gene inserted into bacterial cells used to monitor toxins in wastewater.

Florida, Univ. ofWO 98/49347

Tissue transfection detection

Gainesville, Fla.

Co-transfection of reporter and therapeutic genes; for optical detection of transfection in target tissues.

Fundacao Oswaldo CruzEPO 877 086

YF virus vaccines

Rio de Janeiro, Brazil

Recombinant infectious YF virus cDNA, plasmids, production methods; for making YF virus vaccines.

Genelabs Technol.WO 98/49314

Antiulcer therapeutics

Redwood City, Calif.

Highly immunogenic polypeptide antigens of Helicobacter pylori, encoding genes; for vaccines and therapeutics.

GenentechWO 98/49308

NGF variants

S. San Francisco

Nerve growth factor (NGF) variants that have trkC binding activity, encoding gene sequences; for neuronal disorders.

Genetic Engin. & Biotech. Ctr.WO 98/49327

Bacterial infection detection

Havana, Cuba

Fusions and conjugates of bacterial adhesins; for detection of infections by red cell hemagglutination.

Genetics Inst.WO 98/49302

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

GenzymeWO 98/49324

Human phosphomannomutase

Haverhill, U.K.

Human phosphomannomutase, encoding gene sequences; for carbohydrate-deficient glycoprotein syndrome type 1.

Helix Res. Inst.WO 98/49276

Neurite inhibiting kinase

Chiba, Japan

Serine-threonine protein kinase, encoding gene sequences; for inhibiting neurite extension.

Helix Res. Inst.WO 98/49282

Gene expression change detection

Chiba, Japan

Detecting gene expression changes caused by transfected genes by comparing control and transfected cells.

Helix Res. Inst.WO 98/49284

Nuclear transport of proteins

Chiba, Japan

Detection of proteins transported to the nucleus by using a promoter region linked to a reporter gene.

HoechstEPO 877 088

Translation initiation regulation

Frankfurt, Germany

Regulation of protein translation initiation in eukaryotes using complementary mRNA leader sequences [in German].

Hoffmann-La RocheWO 98/49309

Neuroinflammation therapeutics

Basel, Switzerland

Chemokines and encoding gene sequences involved in brain pathogenesis; for treating neuroinflammation.

HybridonWO 98/49287

Thymidylate synthase antisense

Cambridge, Mass.

Thymidylate synthase antisense oligos; for treating cancer cell resistance to inhibitors of this enzyme.

HybridonWO 98/49288

CMI-inducing cytokines

Cambridge, Mass.

Oligonucleotides having specific structural motifs that specifically induce specific cytokines; for therapy.

HybritechWO 98/49323

Inactive PSA precursors

San Diego

Inactive precursor forms of prostate-specific antigen (PSA) in serum, antibodies; for diagnosis of prostate cancer.

IcosWO 98/49289

EF-1-alpha regulatory sequences

Bothell, Wash.

Regulatory sequences from the hamster EF-1-alpha gene, for linkage to structural genes and subsequent transfection.

Imperial Coll. InnovationsWO 98/48842

Liver gene therapy


Modified baculoviruses having genes encoding therapeutics; for delivery to liver cells.

Incyte PharmaWO 98/49298

Heat shock-like protein

Palo Alto, Calif.

Heat shock-like protein, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.

Incyte PharmaWO 98/49301

Retinoid binding protein

Palo Alto, Calif.

Human retinoid binding protein, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.

Incyte PharmaWO 98/49304

Neuronal extracellular matrix protein

Palo Alto, Calif.

Neuronal extracellular matrix protein, encoding gene sequences, vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/49306

Human C-type lectin

Palo Alto, Calif.

Human C-type lectin, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.

Incyte PharmaWO 98/49319

Human lysophopholipase

Palo Alto, Calif.

Human lysophopholipase, encoding gene sequences, vectors, host cells, antisense, antibodies, modulators.

Indian Biotechnology SecretaryEPO 877 087

Amycolatopsis cloning vectors

New Delhi, India

Cloning vectors for Amycolatopsis species prepared in and isolated from E. coli.

INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49292

KAR-associated proteins


Proteins associated with killer cell activating receptors (KAR); for affecting KAR function.

INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49334

Ribosome entry site vector


Internal ribosome entry site nucleotide sequence; for enhanced retroviral vector packaging and gene therapy.

INSERM (Natl. Inst. Hlth. Med. Res.)WO 98/49335

Chimeric retrovirus envelopes


Construction and expression of chimeric retrovirus envelope proteins; for therapeutics and gene therapy.

Klingemann, H.WO 98/49268

NK cells expressing cytokines

Winnetka, Ill.

Natural killer (NK) cell line that expresses cytokines; for treating cancer and purging cancer cells.

Kosan BiosciencesWO 98/49315

Combinatorial polyketide libraries

Burlingame, Calif.

Combinatorial polyketide libraries from manipulated host synthase genes; for making erythromycin-like therapeutics.

Ludwig Inst.WO 98/49299

Leukemia-associated genes

New York

Leukemia-associated genes, fragments, functional variants, antibodies; for diagnostics and therapeutics.

McGill Univ.WO 98/49294

Nuclear localization


Fusion proteins having nuclear localization and reporter sequences; for visualization in cell nuclei.

McGill Univ.WO 98/49325

Macrocyclic lactone resistance


Nematode P-glycoprotein homologs, encoding gene sequences; for treating resistance to macrocyclic lactone drugs.

Merck, Sharp & DohmeWO 98/49293

GABAA receptor theta subunit

Hoddeson, U.K.

Gene sequence for the theta subunit of the GABAA receptor, encoded protein; for designing modulators

Minnesota, Univ. ofWO 98/49350

Liver mutation correction


In vivo use of recombinagenic oligonucleotides to correct genetic lesions in liver cells.

Mishra, L.WO 98/48827

Early liver development genes

Bethesda, Md.

Genes for proteins expressed in early liver development, encoded proteins; for studying liver disease.

Mt. Sinai Med. Ctr.WO 98/48834

Flu tumor antigens

New York

Recombinant influenza viruses that express tumor-associated antigens; for vaccination of cancer patients.

Mt. Sinai Med. Ctr.WO 98/49269

Neurofilament knockouts

New York

Knockout mice having disrupted endogenous neurofilament genes; for studying neurodegenerative diseases.

Netherlands Cancer Inst.EPO 877 082

Mutant generation

Amsterdam, Netherlands

Gene targeting by homologous recombination and sibling-selection; for generating mutants.

Newcastle, Univ. ofWO 98/49328

Bacillus production system

Newcastle, U.K.

Regulated expression or alteration of Bacillus subtilis wprA gene; for enhanced secretion of recombinant proteins.

Oxford BioMedicaGB 2 325 003

Retroviral vector production

Oxford, U.K.

Retroviral vector production systems using lentivirus-based vector particles that can infect non-dividing cells.

Pasteur MerieuxWO 98/49318

Antiulcer vaccines

Lyon, France

Helicobacter pylori urease A and B subunits, encoding gene sequences; for making antiulcer vaccines.

Pennsylvania, Univ. ofWO 98/49338

Post-translational modification


Bacterial insertion of test DNA for detecting enzymes that post-translationally modify proteins.

Regeneron PharmaWO 98/49296

Human Cerberus proteins

Tarrytown, N.Y.

Human Cerberus proteins, encoding gene sequences, primers, ligands; for antagonizing bone morphogenic protein activity.

Rhone-Poulenc RorerWO 98/49321

Anti-angiogenic tumor agents

Antony, France

Adenovirus-mediated delivery of anti-angiogenic factors into tumor cells.

Royal Free Hosp. Med. Sch.WO 98/49333

Eukaryotic expression cassette


Eukaryotic gene expression cassette having a myosin light chain enhancer and promoter linked to a structural gene.

Sembiosys GeneticsWO 98/49326

Fusion production method

Calgary, Alberta

Expression of recombinantly produced proteins using fusions with pro-peptides; for cleavage and subsequent purification.

SmithKline BeechamEPO 877 030

EPO primary response gene


Erythropoietin (EPO) primary response gene 1, encoded protein, production methods; for diagnostics/therapeutics.

SmithKline BeechamEPO 877 083

G protein-coupled receptor


Human G protein-coupled receptor (HCEPT09), encoding gene sequences, production methods; for therapeutics.

SmithKline BeechamEPO 877 085

Lyme disease vaccines

Rixensart, Belgium

Borrelia burgdorferi OspA antigens, encoding genes; for Lyme disease vaccines.

Sonderegger, P.WO 98/49322


Zurich, Switzerland

Neurotrypsins, encoding gene sequences; for use in developing therapeutics.

StratageneWO 98/49266

Highly transformable bacteria

La Jolla, Calif.

Gram negative bacteria having the Hte mutation; for making highly transformable E. coli cells.

SugenWO 98/49317

Phosphatases and kinases

Redwood City, Calif.

Phosphatases and kinases, encoding genes, antibodies; for screening modulators, diagnostics, therapeutics.

Takeda ChemicalWO 98/48616

Vitamin D transgenics

Osaka, Japan

Transgenics having a transfected 25-hydroxylated vitamin D3 24-hydroxylase gene; for calcium regulation disease study.

Takeda ChemicalWO 98/49295

G protein-coupled receptor ligand

Osaka, Japan

Ligand for G protein-coupled receptor from pituitaries, encoding gene sequences; for diagnostics and therapeutics.

Texas, Univ. ofWO 98/49286

Selection of displayed antibodies

Austin, Texas

Directed evolution and selection of enzymes and antibodies displayed on host cell surfaces.

TularikWO 98/49265

UCP2 gene expression regulators

S. San Francisco

UCP2 gene transcription regulators, UCP2 transcriptional promoters; for use in high-throughput therapeutic screens.

UnitikaEPO 877 084

Thermostable diaphorase gene

Amagasaki, Japan

Thermostable Bacillus diaphorase gene, encoded protein, production methods.

Vlamms Inst. Biotechnol.WO 98/49290

Syndecan binding proteins

Zwijnaarde, Belgium

Proteins that bind to the cytoplasmic domain of syndecan; for affecting cytoskeletal-mediated signalling.

Wistar Inst.WO 98/49270

Colorectal cancer T cells

Philadelphia, Penn.

Stable cytolytic T cell lines against colorectal carcinoma, methods for generating these cell lines.

Yale Univ.WO 98/49303

Tick vaccines

New Haven, Conn.

Tick polypeptides, fragments, multimers, fusions, encoding gene sequences, antibodies; for vaccines.

ZymogeneticsWO 98/49307

Cytokine-like receptor


Mammalian cytokine-like receptor, encoding gene sequences, antibodies; for diagnostics and therapeutics.

ZymogeneticsWO 98/49310

Cytokine-like factor 7


Mammalian cytokine-like factor 7, encoding gene sequences, antibodies; for therapeutics.