Published Oct. 28 (EPO); Oct. 22 (WO)

Allelix NeuroscienceWO 98/46619

Glycine transporter

S. Plainfield, N.J.

Glycine transporter, encoding gene sequences, vectors, production methods; for identifying bioactive agents.

American Home ProductsWO 98/46636

Beta-amyloid binding proteins

Madison, N.J.

Binding proteins for beta-amyloid, encoding gene sequences, production methods; for diagnostics and therapeutics.

AmgenWO 98/46751

Osteoprotegerin binding protein

Thousand Oaks, Calif.

Osteoprotegerin binding protein, encoding gene, production method; for influencing bone growth.

AntiviralsWO 98/46740

Restenosis antisense

Portland, Ore.

Antisense against cytomegalovirus (CMV); for inhibiting restenosis in CMV-infected angioplasty patients.

Arch Develop.WO 98/46637

Herpes apoptosis inhibitor


Herpes simplex virus gene encoding an inhibitor of apoptosis, encoding gene sequences, temperature-sensitive mutant.

Babraham Inst.WO 98/46768

Phenolic acid esterase

Babraham, U.K.

Phenolic acid esterase, encoding gene sequences, production methods; for therapeutics.

Barnes-Jewish Hosp.WO 98/46738

Fungi antigen assay

St. Louis

Consecutive screens of cDNA expression libraries with target and non-target fungi antigens; for finding antigens.

BayerEPO 874 057

Intron amplified expression


Vector containing a donor intron sequence; for increased expression of Factor VIII.

Biomolecular Engin. Inst.EPO 874 046

Signal transduction factor

Osaka, Japan

Signal transduction factor, encoding gene sequences; for therapeutics.

BiopharmEPO 874 052

Protein phosphatase

Heidelberg, Germany

Human protein phosphatase, encoding gene sequences; for treating phosphorylation-dependent disease states.

British Defense MinistryWO 98/46729

Sensitive reporter gene assays

Farnborough, U.K.

Mutated luciferases having increased affinity for ATP; for more sensitive reporter gene assays.

CalgeneWO 98/46763 & 46765

Fatty acid desaturases

Davis, Calif.

Fatty acid desaturases, encoding gene sequences; for making unsaturated fats.

California, Univ. ofWO 98/46083

Lentivirus-induced immunity

Oakland, Calif.

Using dendritic cells transfected with lentivirus vectors encoding antigen epitopes; for immunity to HIV.

Cell GenesysWO 98/46728

Adeno-associated viral vectors

Foster City, Calif.

Recombinant adeno-associated viral vectors expressing REP/CAP proteins; for producing high titers in stable cell lines.

Cell TherapeuticsWO 98/46730

Phosphatidic phosphatase


Human phosphatidic phosphatase, encoding gene sequences, variants; for therapeutics and diagnostics.

CNRS (Natl. Ctr. Sci. Res.)WO 98/46777

Baculovirus production system


Preparation of recombinant membrane receptors in a baculovirus-infected insect cell production system.

Chemoserotherapeutic Res. Inst.WO 98/46739

T cell immunomodulators

Kumamoto, Japan

Immunomodulatory molecules identified by screening random phage peptide libraries with CTLA-4 antibodies.

DendreonWO 98/46769

Prostate cancer immunoresponse

Mountain View, Calif.

Prostate-specific acid phosphatase, encoding gene sequences; for producing an immunoresponse against prostate cancer.

European Oncology Inst.WO 98/46744

Signal transducer therapeutics

Milan, Italy

Proteins that bind signal transducers containing an EH domain, encoding gene sequences; for therapeutics.

Ferring Farmaceutisk LabWO 98/46642

Modified TNF-alpha

Vanlose, Denmark

Modified tumor necrosis factor (TNF)-alpha polypeptides, encoding gene sequences; for preventing chronic inflammation.

Genetics Inst.WO 98/46757

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.

Genetics inst.WO 98/46771

Cobra venom protease

Cambridge, Mass.

Cobra venom protease mocarhagin, encoding gene sequences, purification methods; for therapeutics.

GenzymeWO 98/46779-46781

Expression persistence vector

Framingham, Mass.

Adenoviral vectors with a cytomegalovirus promoter regulating transgene transcription; for expression persistence.

German Hlth. Welfare Res. Inst.EPO 874 054

Ig-cytokine fusion

Oberschleissheim, Germany

Vector expressing an immunoglobulin (Ig)-cytokine fusion protein; for insertion into B cells [in German].

Gist-BrocadesWO 98/46772

Fungi production system

Delft, Netherlands

Recombinant gene sequences that can be amplified and are inserted into filamentous fungi; for protein production.

Gist-BrocadesWO 98/46774

Yeast production method

Delft, Netherlands

Yeast cells with at least two gene copies chromosomally integrated; for recombinant protein production.

Hayashibara SeibutsuEPO 874 048

Desert hedgehog protein

Okayama, Japan

Human Desert hedgehog protein, encoding gene sequences; for studying hereditary morphological abnormalities.

HoechstWO 98/46742

Lungworm antigen

Frankfurt, Germany

Lungworm immunogenic protein, encoding gene sequences, production methods; for diagnostics and vaccines.

Human Genome SciencesWO 98/46746

Extracellular/EGF-like protein

Rockville, Md.

Extracellular/epidermal growth factor (EGF)-like protein, encoding gene sequences, antagonists; for therapeutics.

Imperial Coll. Sci. Technol.WO 98/46733

Chromosome transfer into ES cells


Microcells that contain chromosomes or their fragments; for introducing genetic material into embryonic stem (ES) cells.

Incyte PharmaWO 98/46752

Integral transmembrane protein

Palo Alto, Calif.

Human integral transmembrane protein, encoding gene sequences, antisense, antibodies, modulators.

Incyte PharmaWO 98/46753

Gene transcription regulator

Palo Alto, Calif.

Human regulator of gene transcription, encoding gene sequences, antisense, antibodies, modulators.

Incyte PharmaWO 98/46754

Human Rho protein

Palo Alto, Calif.

Human Rho protein, encoding gene sequences, antibodies, modulators, production methods.

Incyte PharmaWO 98/46758

Tumor-associated Kazal inhibitor

Palo Alto, Calif.

Human tumor-associated Kazal inhibitor, encoding gene sequences, antibodies, antagonists; for therapeutics.

Japan Sci. Technol.WO 98/46734

HIV infection model

Kawaguchi, Japan

Transgenics expressing CD4 and fusin (CXCR4); for studying HIV infection and AIDS progression.

LeaddWO 98/46760

Apoptosis-inducing protein

Leiden, Netherlands

Apoptosis-inducing protein from the chicken anemia virus, encoding gene sequences; for cancer gene therapy.

LillyWO 98/46639

Fungal gene inhibitors


Fungal IPC synthase, encoding gene, vectors, expression system; for identifying fungal inhibitors.

Max Planck Inst.WO 98/46789

Reporter gene system

Munich, Germany

Reporter-vector systems using a photoprotein, transfected cells; for studying molecular interactions.

Millennium BiotherapeuticsWO 98/46641 & 46643

Connective tissue growth factor family

Cambridge, Mass.

Tango proteins that are related to TNF and connective tissue growth factors, encoding gene sequences.

Millennium BiotherapeuticsWO 98/46755

Cysteine-rich secreted proteins

Cambridge, Mass.

Cysteine-rich secreted proteins, encoding gene sequences, fusions, antibodies, transgenics.

Millennium BiotherapeuticsWO 98/46756

Small secreted protein-1

Cambridge, Mass.

Small secreted protein-1, encoding gene sequences, for diagnostics, screens, and therapeutics.

Millennium PharmaWO 98/46620

G protein-coupled receptor

Cambridge, Mass.

G protein-coupled receptor, encoding gene sequences, antibodies, fusion proteins, transgenics.

Millennium PharmaWO 98/46638

TH2 cell-specific gene

Cambridge, Mass.

Protein differentially expressed in TH2 cell subpopulations, encoding gene sequences; for diseases involving T cells.

Millennium PharmaWO 98/46736

Multidrug resistance-associated protein

Cambridge, Mass.

Multidrug resistance-associated protein, encoding gene, antisense, antibodies, transgenics; for finding modulators.

Millennium PharmaWO 98/46748

Thyroid genes

Cambridge, Mass.

TRBP polypeptides, encoding gene sequences, fragments, homologs; for thyroid-related disorders.

NIH (Natl. Inst. Hlth.)WO 98/46761

Hepatitis E antigens

Bethesda, Md.

Recombinant proteins from a Pakistani strain of hepatitis E; for diagnostics and vaccines.

NIH (Natl. Inst. Hlth.)WO 98/46778

Transgenomic virus production

Bethesda, Md.

Chimeric primary viruses that are designed to produce secondary viruses in producer host cells.

New Jersey, Med. Dent. Univ.WO 98/46737

GDNF gene

Newark, N.J

Human glial cell-derived neurotrophic factor (GDNF) gene and promoter; for studying GDNF action.

Ohio Univ.WO 98/46735

Diabetes transgenics

Athens, Ohio

Transgenics that cannot express functional growth hormone (GH) receptors or GH binding protein; for studying diabetes.

St. Jude Children's Hosp.WO 98/46749

Nucleoside transport protein

Memphis, Tenn.

Nucleoside transport protein that is insensitive to nitrobenzylmercaptopuriniboside, encoding gene.

SearleWO 98/46750

Hematopoietic receptor agonists


Chimeric and multifunctional hematopoietic receptor agonists, encoding gene sequences, production methods.

SmithKline BeechamEPO 874 047

Human 7-transmembrane receptor


Human 7-transmembrane receptor HMTMF81, encoding gene sequences; for therapeutics.

SmithKline BeechamEPO 874 050

Integrin ligand


Integrin ligand, encoding gene sequences, production methods; for inflammatory disorder therapeutics.

SmithKline BeechamEPO 874 051

Lyme disease vaccine

Rixensart, Belgium

Borrelia burgdorferi surface protein antigens showing little homology with other antigens; for Lyme disease vaccines.

SmithKline BeechamEPO 874 053

Antibacterial screens


3-Dehydroquinate synthase, encoding gene sequences, production methods; for antibacterial screens.

Snow Brand Milk ProductsEPO 874 045 & WO 98/46644

Osteoclast formation inhibitor

Sapporo, Japan

Osteoclast formation inhibition protein, encoding gene sequences; for treating osteoporosis and arthritis.

StratageneWO 98/46271

Bacterial virus gene delivery

La Jolla, Calif.

Eucaryotic cells transfected with bacterial virus receptor genes; for delivery of genes using bacterial viruses.

Sumitomo ElectricWO 98/46745

dlg family protein

Osaka, Japan

Gene encoding a protein of the dlg family, encoded protein, antibodies; for detection and anticancer agent development.

TakedaEPO 873 998

Dendritic cell receptor

Osaka, Japan

Human dendritic cell receptor protein, fragments, antibodies, modulators; for determining receptor levels.

TakedaWO 98/46767

Lecithin-cholesterol acyltransferase

Osaka, Japan

Lecithin-cholesterol acyltransferase-like protein, encoding gene sequences, antibodies; for treating atherosclerosis.

Temple Univ.WO 98/46726

A-myb oncogene transgenics


Transgenics and isolated cells having disrupted A-myb oncogene; for gene locus inactivation.

Texas, Univ.

Mycobacterial immunity vectors

Austin, Texas

Mycobacterial shuttle vector encoding heterologous protein antigens; for administration and induction of immunity.

Texas, Univ. ofWO 98/46741

DNA fragmentation factor

Austin, Texas

DNA fragmentation factor, encoding gene sequences, primers, antibodies, production methods; for therapeutics.

ThermogenWO 98/46770

Esterase enzymes


Thermostable enzymes for ester hydrolysis, encoding gene sequences, expression vectors; for therapeutics.

TransgeneEPO 874 049

MHC gene expression

Strasbourg, France

CIITA gene sequences, encoded protein; for cell-specific expression of MHC genes [in French].

Unigene LabsWO 98/46722

High level protein expression

Fairfield, N.J.

Multiple transcription cassettes and operably linked promoters; for high level expression of secreted proteins.

Washington Univ.WO 98/46622

Neurotrophic factor receptors

St. Louis

Receptors for TGF-beta related neurotrophic factors, encoding gene sequences; for identifying other related genes.

Wellcome TrustWO 98/46743

LDL receptor-related protein


LDL receptor-related protein, encoding gene sequences; for diagnosis and treatment of insulin-dependent diabetes.

Whitehead Inst.WO 98/46747

Y chromosome genes

Cambridge, Mass.

Genes from the non-recombining region of the Y chromosome that are X chromosome homologs.