Published Oct. 28 (EPO); Oct. 22 (WO)
Allelix NeuroscienceWO 98/46619
S. Plainfield, N.J.
Glycine transporter, encoding gene sequences, vectors, production methods; for identifying bioactive agents.
American Home ProductsWO 98/46636
Beta-amyloid binding proteins
Binding proteins for beta-amyloid, encoding gene sequences, production methods; for diagnostics and therapeutics.
Osteoprotegerin binding protein
Thousand Oaks, Calif.
Osteoprotegerin binding protein, encoding gene, production method; for influencing bone growth.
Antisense against cytomegalovirus (CMV); for inhibiting restenosis in CMV-infected angioplasty patients.
Arch Develop.WO 98/46637
Herpes apoptosis inhibitor
Herpes simplex virus gene encoding an inhibitor of apoptosis, encoding gene sequences, temperature-sensitive mutant.
Babraham Inst.WO 98/46768
Phenolic acid esterase
Phenolic acid esterase, encoding gene sequences, production methods; for therapeutics.
Barnes-Jewish Hosp.WO 98/46738
Fungi antigen assay
Consecutive screens of cDNA expression libraries with target and non-target fungi antigens; for finding antigens.
BayerEPO 874 057
Intron amplified expression
Vector containing a donor intron sequence; for increased expression of Factor VIII.
Biomolecular Engin. Inst.EPO 874 046
Signal transduction factor
Signal transduction factor, encoding gene sequences; for therapeutics.
BiopharmEPO 874 052
Human protein phosphatase, encoding gene sequences; for treating phosphorylation-dependent disease states.
British Defense MinistryWO 98/46729
Sensitive reporter gene assays
Mutated luciferases having increased affinity for ATP; for more sensitive reporter gene assays.
CalgeneWO 98/46763 & 46765
Fatty acid desaturases
Fatty acid desaturases, encoding gene sequences; for making unsaturated fats.
California, Univ. ofWO 98/46083
Using dendritic cells transfected with lentivirus vectors encoding antigen epitopes; for immunity to HIV.
Cell GenesysWO 98/46728
Adeno-associated viral vectors
Foster City, Calif.
Recombinant adeno-associated viral vectors expressing REP/CAP proteins; for producing high titers in stable cell lines.
Cell TherapeuticsWO 98/46730
Human phosphatidic phosphatase, encoding gene sequences, variants; for therapeutics and diagnostics.
CNRS (Natl. Ctr. Sci. Res.)WO 98/46777
Baculovirus production system
Preparation of recombinant membrane receptors in a baculovirus-infected insect cell production system.
Chemoserotherapeutic Res. Inst.WO 98/46739
T cell immunomodulators
Immunomodulatory molecules identified by screening random phage peptide libraries with CTLA-4 antibodies.
Prostate cancer immunoresponse
Mountain View, Calif.
Prostate-specific acid phosphatase, encoding gene sequences; for producing an immunoresponse against prostate cancer.
European Oncology Inst.WO 98/46744
Signal transducer therapeutics
Proteins that bind signal transducers containing an EH domain, encoding gene sequences; for therapeutics.
Ferring Farmaceutisk LabWO 98/46642
Modified tumor necrosis factor (TNF)-alpha polypeptides, encoding gene sequences; for preventing chronic inflammation.
Genetics Inst.WO 98/46757
Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
Genetics inst.WO 98/46771
Cobra venom protease
Cobra venom protease mocarhagin, encoding gene sequences, purification methods; for therapeutics.
Expression persistence vector
Adenoviral vectors with a cytomegalovirus promoter regulating transgene transcription; for expression persistence.
German Hlth. Welfare Res. Inst.EPO 874 054
Vector expressing an immunoglobulin (Ig)-cytokine fusion protein; for insertion into B cells [in German].
Fungi production system
Recombinant gene sequences that can be amplified and are inserted into filamentous fungi; for protein production.
Yeast production method
Yeast cells with at least two gene copies chromosomally integrated; for recombinant protein production.
Hayashibara SeibutsuEPO 874 048
Desert hedgehog protein
Human Desert hedgehog protein, encoding gene sequences; for studying hereditary morphological abnormalities.
Lungworm immunogenic protein, encoding gene sequences, production methods; for diagnostics and vaccines.
Human Genome SciencesWO 98/46746
Extracellular/epidermal growth factor (EGF)-like protein, encoding gene sequences, antagonists; for therapeutics.
Imperial Coll. Sci. Technol.WO 98/46733
Chromosome transfer into ES cells
Microcells that contain chromosomes or their fragments; for introducing genetic material into embryonic stem (ES) cells.
Incyte PharmaWO 98/46752
Integral transmembrane protein
Palo Alto, Calif.
Human integral transmembrane protein, encoding gene sequences, antisense, antibodies, modulators.
Incyte PharmaWO 98/46753
Gene transcription regulator
Palo Alto, Calif.
Human regulator of gene transcription, encoding gene sequences, antisense, antibodies, modulators.
Incyte PharmaWO 98/46754
Human Rho protein
Palo Alto, Calif.
Human Rho protein, encoding gene sequences, antibodies, modulators, production methods.
Incyte PharmaWO 98/46758
Tumor-associated Kazal inhibitor
Palo Alto, Calif.
Human tumor-associated Kazal inhibitor, encoding gene sequences, antibodies, antagonists; for therapeutics.
Japan Sci. Technol.WO 98/46734
HIV infection model
Transgenics expressing CD4 and fusin (CXCR4); for studying HIV infection and AIDS progression.
Apoptosis-inducing protein from the chicken anemia virus, encoding gene sequences; for cancer gene therapy.
Fungal gene inhibitors
Fungal IPC synthase, encoding gene, vectors, expression system; for identifying fungal inhibitors.
Max Planck Inst.WO 98/46789
Reporter gene system
Reporter-vector systems using a photoprotein, transfected cells; for studying molecular interactions.
Millennium BiotherapeuticsWO 98/46641 & 46643
Connective tissue growth factor family
Tango proteins that are related to TNF and connective tissue growth factors, encoding gene sequences.
Millennium BiotherapeuticsWO 98/46755
Cysteine-rich secreted proteins
Cysteine-rich secreted proteins, encoding gene sequences, fusions, antibodies, transgenics.
Millennium BiotherapeuticsWO 98/46756
Small secreted protein-1
Small secreted protein-1, encoding gene sequences, for diagnostics, screens, and therapeutics.
Millennium PharmaWO 98/46620
G protein-coupled receptor
G protein-coupled receptor, encoding gene sequences, antibodies, fusion proteins, transgenics.
Millennium PharmaWO 98/46638
TH2 cell-specific gene
Protein differentially expressed in TH2 cell subpopulations, encoding gene sequences; for diseases involving T cells.
Millennium PharmaWO 98/46736
Multidrug resistance-associated protein
Multidrug resistance-associated protein, encoding gene, antisense, antibodies, transgenics; for finding modulators.
Millennium PharmaWO 98/46748
TRBP polypeptides, encoding gene sequences, fragments, homologs; for thyroid-related disorders.
NIH (Natl. Inst. Hlth.)WO 98/46761
Hepatitis E antigens
Recombinant proteins from a Pakistani strain of hepatitis E; for diagnostics and vaccines.
NIH (Natl. Inst. Hlth.)WO 98/46778
Transgenomic virus production
Chimeric primary viruses that are designed to produce secondary viruses in producer host cells.
New Jersey, Med. Dent. Univ.WO 98/46737
Human glial cell-derived neurotrophic factor (GDNF) gene and promoter; for studying GDNF action.
Ohio Univ.WO 98/46735
Transgenics that cannot express functional growth hormone (GH) receptors or GH binding protein; for studying diabetes.
St. Jude Children's Hosp.WO 98/46749
Nucleoside transport protein
Nucleoside transport protein that is insensitive to nitrobenzylmercaptopuriniboside, encoding gene.
Hematopoietic receptor agonists
Chimeric and multifunctional hematopoietic receptor agonists, encoding gene sequences, production methods.
SmithKline BeechamEPO 874 047
Human 7-transmembrane receptor
Human 7-transmembrane receptor HMTMF81, encoding gene sequences; for therapeutics.
SmithKline BeechamEPO 874 050
Integrin ligand, encoding gene sequences, production methods; for inflammatory disorder therapeutics.
SmithKline BeechamEPO 874 051
Lyme disease vaccine
Borrelia burgdorferi surface protein antigens showing little homology with other antigens; for Lyme disease vaccines.
SmithKline BeechamEPO 874 053
3-Dehydroquinate synthase, encoding gene sequences, production methods; for antibacterial screens.
Snow Brand Milk ProductsEPO 874 045 & WO 98/46644
Osteoclast formation inhibitor
Osteoclast formation inhibition protein, encoding gene sequences; for treating osteoporosis and arthritis.
Bacterial virus gene delivery
La Jolla, Calif.
Eucaryotic cells transfected with bacterial virus receptor genes; for delivery of genes using bacterial viruses.
Sumitomo ElectricWO 98/46745
dlg family protein
Gene encoding a protein of the dlg family, encoded protein, antibodies; for detection and anticancer agent development.
TakedaEPO 873 998
Dendritic cell receptor
Human dendritic cell receptor protein, fragments, antibodies, modulators; for determining receptor levels.
Lecithin-cholesterol acyltransferase-like protein, encoding gene sequences, antibodies; for treating atherosclerosis.
Temple Univ.WO 98/46726
A-myb oncogene transgenics
Transgenics and isolated cells having disrupted A-myb oncogene; for gene locus inactivation.
Mycobacterial immunity vectors
Mycobacterial shuttle vector encoding heterologous protein antigens; for administration and induction of immunity.
Texas, Univ. ofWO 98/46741
DNA fragmentation factor
DNA fragmentation factor, encoding gene sequences, primers, antibodies, production methods; for therapeutics.
Thermostable enzymes for ester hydrolysis, encoding gene sequences, expression vectors; for therapeutics.
TransgeneEPO 874 049
MHC gene expression
CIITA gene sequences, encoded protein; for cell-specific expression of MHC genes [in French].
Unigene LabsWO 98/46722
High level protein expression
Multiple transcription cassettes and operably linked promoters; for high level expression of secreted proteins.
Washington Univ.WO 98/46622
Neurotrophic factor receptors
Receptors for TGF-beta related neurotrophic factors, encoding gene sequences; for identifying other related genes.
Wellcome TrustWO 98/46743
LDL receptor-related protein
LDL receptor-related protein, encoding gene sequences; for diagnosis and treatment of insulin-dependent diabetes.
Whitehead Inst.WO 98/46747
Y chromosome genes
Genes from the non-recombining region of the Y chromosome that are X chromosome homologs.