Published Oct. 28 (EPO); Oct. 22 (WO)
Allelix NeuroscienceWO 98/46619
Glycine transporter
S. Plainfield, N.J.
Glycine transporter, encoding gene sequences, vectors, production methods; for identifying bioactive agents.
American Home ProductsWO 98/46636
Beta-amyloid binding proteins
Madison, N.J.
Binding proteins for beta-amyloid, encoding gene sequences, production methods; for diagnostics and therapeutics.
AmgenWO 98/46751
Osteoprotegerin binding protein
Thousand Oaks, Calif.
Osteoprotegerin binding protein, encoding gene, production method; for influencing bone growth.
AntiviralsWO 98/46740
Restenosis antisense
Portland, Ore.
Antisense against cytomegalovirus (CMV); for inhibiting restenosis in CMV-infected angioplasty patients.
Arch Develop.WO 98/46637
Herpes apoptosis inhibitor
Chicago
Herpes simplex virus gene encoding an inhibitor of apoptosis, encoding gene sequences, temperature-sensitive mutant.
Babraham Inst.WO 98/46768
Phenolic acid esterase
Babraham, U.K.
Phenolic acid esterase, encoding gene sequences, production methods; for therapeutics.
Barnes-Jewish Hosp.WO 98/46738
Fungi antigen assay
St. Louis
Consecutive screens of cDNA expression libraries with target and non-target fungi antigens; for finding antigens.
BayerEPO 874 057
Intron amplified expression
Pittsburgh
Vector containing a donor intron sequence; for increased expression of Factor VIII.
Biomolecular Engin. Inst.EPO 874 046
Signal transduction factor
Osaka, Japan
Signal transduction factor, encoding gene sequences; for therapeutics.
BiopharmEPO 874 052
Protein phosphatase
Heidelberg, Germany
Human protein phosphatase, encoding gene sequences; for treating phosphorylation-dependent disease states.
British Defense MinistryWO 98/46729
Sensitive reporter gene assays
Farnborough, U.K.
Mutated luciferases having increased affinity for ATP; for more sensitive reporter gene assays.
CalgeneWO 98/46763 & 46765
Fatty acid desaturases
Davis, Calif.
Fatty acid desaturases, encoding gene sequences; for making unsaturated fats.
California, Univ. ofWO 98/46083
Lentivirus-induced immunity
Oakland, Calif.
Using dendritic cells transfected with lentivirus vectors encoding antigen epitopes; for immunity to HIV.
Cell GenesysWO 98/46728
Adeno-associated viral vectors
Foster City, Calif.
Recombinant adeno-associated viral vectors expressing REP/CAP proteins; for producing high titers in stable cell lines.
Cell TherapeuticsWO 98/46730
Phosphatidic phosphatase
Seattle
Human phosphatidic phosphatase, encoding gene sequences, variants; for therapeutics and diagnostics.
CNRS (Natl. Ctr. Sci. Res.)WO 98/46777
Baculovirus production system
Paris
Preparation of recombinant membrane receptors in a baculovirus-infected insect cell production system.
Chemoserotherapeutic Res. Inst.WO 98/46739
T cell immunomodulators
Kumamoto, Japan
Immunomodulatory molecules identified by screening random phage peptide libraries with CTLA-4 antibodies.
DendreonWO 98/46769
Prostate cancer immunoresponse
Mountain View, Calif.
Prostate-specific acid phosphatase, encoding gene sequences; for producing an immunoresponse against prostate cancer.
European Oncology Inst.WO 98/46744
Signal transducer therapeutics
Milan, Italy
Proteins that bind signal transducers containing an EH domain, encoding gene sequences; for therapeutics.
Ferring Farmaceutisk LabWO 98/46642
Modified TNF-alpha
Vanlose, Denmark
Modified tumor necrosis factor (TNF)-alpha polypeptides, encoding gene sequences; for preventing chronic inflammation.
Genetics Inst.WO 98/46757
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
Genetics inst.WO 98/46771
Cobra venom protease
Cambridge, Mass.
Cobra venom protease mocarhagin, encoding gene sequences, purification methods; for therapeutics.
GenzymeWO 98/46779-46781
Expression persistence vector
Framingham, Mass.
Adenoviral vectors with a cytomegalovirus promoter regulating transgene transcription; for expression persistence.
German Hlth. Welfare Res. Inst.EPO 874 054
Ig-cytokine fusion
Oberschleissheim, Germany
Vector expressing an immunoglobulin (Ig)-cytokine fusion protein; for insertion into B cells [in German].
Gist-BrocadesWO 98/46772
Fungi production system
Delft, Netherlands
Recombinant gene sequences that can be amplified and are inserted into filamentous fungi; for protein production.
Gist-BrocadesWO 98/46774
Yeast production method
Delft, Netherlands
Yeast cells with at least two gene copies chromosomally integrated; for recombinant protein production.
Hayashibara SeibutsuEPO 874 048
Desert hedgehog protein
Okayama, Japan
Human Desert hedgehog protein, encoding gene sequences; for studying hereditary morphological abnormalities.
HoechstWO 98/46742
Lungworm antigen
Frankfurt, Germany
Lungworm immunogenic protein, encoding gene sequences, production methods; for diagnostics and vaccines.
Human Genome SciencesWO 98/46746
Extracellular/EGF-like protein
Rockville, Md.
Extracellular/epidermal growth factor (EGF)-like protein, encoding gene sequences, antagonists; for therapeutics.
Imperial Coll. Sci. Technol.WO 98/46733
Chromosome transfer into ES cells
London
Microcells that contain chromosomes or their fragments; for introducing genetic material into embryonic stem (ES) cells.
Incyte PharmaWO 98/46752
Integral transmembrane protein
Palo Alto, Calif.
Human integral transmembrane protein, encoding gene sequences, antisense, antibodies, modulators.
Incyte PharmaWO 98/46753
Gene transcription regulator
Palo Alto, Calif.
Human regulator of gene transcription, encoding gene sequences, antisense, antibodies, modulators.
Incyte PharmaWO 98/46754
Human Rho protein
Palo Alto, Calif.
Human Rho protein, encoding gene sequences, antibodies, modulators, production methods.
Incyte PharmaWO 98/46758
Tumor-associated Kazal inhibitor
Palo Alto, Calif.
Human tumor-associated Kazal inhibitor, encoding gene sequences, antibodies, antagonists; for therapeutics.
Japan Sci. Technol.WO 98/46734
HIV infection model
Kawaguchi, Japan
Transgenics expressing CD4 and fusin (CXCR4); for studying HIV infection and AIDS progression.
LeaddWO 98/46760
Apoptosis-inducing protein
Leiden, Netherlands
Apoptosis-inducing protein from the chicken anemia virus, encoding gene sequences; for cancer gene therapy.
LillyWO 98/46639
Fungal gene inhibitors
Indianapolis
Fungal IPC synthase, encoding gene, vectors, expression system; for identifying fungal inhibitors.
Max Planck Inst.WO 98/46789
Reporter gene system
Munich, Germany
Reporter-vector systems using a photoprotein, transfected cells; for studying molecular interactions.
Millennium BiotherapeuticsWO 98/46641 & 46643
Connective tissue growth factor family
Cambridge, Mass.
Tango proteins that are related to TNF and connective tissue growth factors, encoding gene sequences.
Millennium BiotherapeuticsWO 98/46755
Cysteine-rich secreted proteins
Cambridge, Mass.
Cysteine-rich secreted proteins, encoding gene sequences, fusions, antibodies, transgenics.
Millennium BiotherapeuticsWO 98/46756
Small secreted protein-1
Cambridge, Mass.
Small secreted protein-1, encoding gene sequences, for diagnostics, screens, and therapeutics.
Millennium PharmaWO 98/46620
G protein-coupled receptor
Cambridge, Mass.
G protein-coupled receptor, encoding gene sequences, antibodies, fusion proteins, transgenics.
Millennium PharmaWO 98/46638
TH2 cell-specific gene
Cambridge, Mass.
Protein differentially expressed in TH2 cell subpopulations, encoding gene sequences; for diseases involving T cells.
Millennium PharmaWO 98/46736
Multidrug resistance-associated protein
Cambridge, Mass.
Multidrug resistance-associated protein, encoding gene, antisense, antibodies, transgenics; for finding modulators.
Millennium PharmaWO 98/46748
Thyroid genes
Cambridge, Mass.
TRBP polypeptides, encoding gene sequences, fragments, homologs; for thyroid-related disorders.
NIH (Natl. Inst. Hlth.)WO 98/46761
Hepatitis E antigens
Bethesda, Md.
Recombinant proteins from a Pakistani strain of hepatitis E; for diagnostics and vaccines.
NIH (Natl. Inst. Hlth.)WO 98/46778
Transgenomic virus production
Bethesda, Md.
Chimeric primary viruses that are designed to produce secondary viruses in producer host cells.
New Jersey, Med. Dent. Univ.WO 98/46737
GDNF gene
Newark, N.J
Human glial cell-derived neurotrophic factor (GDNF) gene and promoter; for studying GDNF action.
Ohio Univ.WO 98/46735
Diabetes transgenics
Athens, Ohio
Transgenics that cannot express functional growth hormone (GH) receptors or GH binding protein; for studying diabetes.
St. Jude Children's Hosp.WO 98/46749
Nucleoside transport protein
Memphis, Tenn.
Nucleoside transport protein that is insensitive to nitrobenzylmercaptopuriniboside, encoding gene.
SearleWO 98/46750
Hematopoietic receptor agonists
Chicago
Chimeric and multifunctional hematopoietic receptor agonists, encoding gene sequences, production methods.
SmithKline BeechamEPO 874 047
Human 7-transmembrane receptor
Philadelphia
Human 7-transmembrane receptor HMTMF81, encoding gene sequences; for therapeutics.
SmithKline BeechamEPO 874 050
Integrin ligand
Philadelphia
Integrin ligand, encoding gene sequences, production methods; for inflammatory disorder therapeutics.
SmithKline BeechamEPO 874 051
Lyme disease vaccine
Rixensart, Belgium
Borrelia burgdorferi surface protein antigens showing little homology with other antigens; for Lyme disease vaccines.
SmithKline BeechamEPO 874 053
Antibacterial screens
Philadelphia
3-Dehydroquinate synthase, encoding gene sequences, production methods; for antibacterial screens.
Snow Brand Milk ProductsEPO 874 045 & WO 98/46644
Osteoclast formation inhibitor
Sapporo, Japan
Osteoclast formation inhibition protein, encoding gene sequences; for treating osteoporosis and arthritis.
StratageneWO 98/46271
Bacterial virus gene delivery
La Jolla, Calif.
Eucaryotic cells transfected with bacterial virus receptor genes; for delivery of genes using bacterial viruses.
Sumitomo ElectricWO 98/46745
dlg family protein
Osaka, Japan
Gene encoding a protein of the dlg family, encoded protein, antibodies; for detection and anticancer agent development.
TakedaEPO 873 998
Dendritic cell receptor
Osaka, Japan
Human dendritic cell receptor protein, fragments, antibodies, modulators; for determining receptor levels.
TakedaWO 98/46767
Lecithin-cholesterol acyltransferase
Osaka, Japan
Lecithin-cholesterol acyltransferase-like protein, encoding gene sequences, antibodies; for treating atherosclerosis.
Temple Univ.WO 98/46726
A-myb oncogene transgenics
Philadelphia
Transgenics and isolated cells having disrupted A-myb oncogene; for gene locus inactivation.
Texas, Univ.
Mycobacterial immunity vectors
Austin, Texas
Mycobacterial shuttle vector encoding heterologous protein antigens; for administration and induction of immunity.
Texas, Univ. ofWO 98/46741
DNA fragmentation factor
Austin, Texas
DNA fragmentation factor, encoding gene sequences, primers, antibodies, production methods; for therapeutics.
ThermogenWO 98/46770
Esterase enzymes
Chicago
Thermostable enzymes for ester hydrolysis, encoding gene sequences, expression vectors; for therapeutics.
TransgeneEPO 874 049
MHC gene expression
Strasbourg, France
CIITA gene sequences, encoded protein; for cell-specific expression of MHC genes [in French].
Unigene LabsWO 98/46722
High level protein expression
Fairfield, N.J.
Multiple transcription cassettes and operably linked promoters; for high level expression of secreted proteins.
Washington Univ.WO 98/46622
Neurotrophic factor receptors
St. Louis
Receptors for TGF-beta related neurotrophic factors, encoding gene sequences; for identifying other related genes.
Wellcome TrustWO 98/46743
LDL receptor-related protein
London
LDL receptor-related protein, encoding gene sequences; for diagnosis and treatment of insulin-dependent diabetes.
Whitehead Inst.WO 98/46747
Y chromosome genes
Cambridge, Mass.
Genes from the non-recombining region of the Y chromosome that are X chromosome homologs.