Published March 4 & 11 (EPO); February 26 & March 5 (WO); March 4 (GB)

Abbott Labs WO 98/07753 Mammaglobin Abbott Park, Ill. Mammary gland-derived mammaglobin, partial gene sequences; for detecting and treating breast cancer.

Abbott Labs WO 98/07857 Breast cancer-related uteroglobin Abbott Park, Ill. Gene for a member of the uteroglobin family, encoded pro-tein, antibodies; for treating breast cancer.

Allelix Neuroscience WO 98/07854 Human glycine transporter Mississauga, Ont.

Gene for the human GlyT-2 glycine transporter, encoded protein; for therapeutics.

Arch Develop. WO 98/07878 Muscle-specific gene expression Chicago, Ill. Tissue-specific expression vectors for muscles; for long-term gene expression in muscle cells.

Arch Develop. WO 98/08953 Herpes latency control Chicago, Ill. Use of herpes simplex ORF P gene and protein to screen for agents affecting viral latency.

Austin Res. Inst. WO 98/07837 Modulating cells for transplant Heidelberg, Australia Genes for glcosyltransferases that reduce carbohydrate epitopes; for cell and organ transplantation.

Behring Diagnostics EPO 826 772 Human mucin Marburg, Germany Gene for human mucin, encoded protein; for diagnostics and therapeutics that stimulate immune response [in German].

Bergmann, J.E., et al. WO 98/07850 Pre-symptomatic Alzheimer's detection Hamburg, Germany Detection of Alzheimer's and Down syndrome with linked genes near the amyloid precursor protein gene on chromosome 21.

Bergmann, J.E., et al. WO 98/07851 Breast cancer gene antisense Hamburg, Germany Antisense for L-oncogenes in the genetic locus for breast cancer predisposition; for diagnosis and therapy.

Beth Israel Deaconess Hosp. WO 98/07870 RAFTK genes Boston RAFTK genes, encoded polypeptides; for developing screening assays, diagnostics, and therapeutics.

Biomerieux WO 98/08946 Rheumatoid arthritis diagnostic Marcy l'Etoile, France Artificial antigen derived from filaggrin and identified by antibodies to filaggrin; for rheumatoid arthri-tis diagnosis.

Boehringer Mannheim WO 98/07885 Mass assay for nucleic acids Mannheim, Germany Nucleic acid assay using mass determination; for parallel detection of different nucleic acid sequences.

British Defense Ministry WO 98/08952 Anthrax vaccines Farnborough, U.K. Expression and production of recombinant Bacillus anthra-cis protective antigens; for vaccine production.

Brussells Free Univ. EPO 828 006 Parvovirus integration Brussells, Belgium Increasing the efficiency of integration of a parvoviral vector by adding foreign DNA sequences.

California, Univ. of WO 98/07738 Ig mRNAs for allergies Oakland, Calif. Sense/antisense sequences of trans-spliced immunoglobu-lin (Ig) mRNAs; for controlling Ig synthesis and allergies.

California, Univ. of WO 98/07887 Bipolar disease diagnosis Oakland, Calif. Genes and DNA sequences on chromosome 18p associated with bipolar mood disor-der; for diagnosis and therapy.

California, Univ. of WO 98/08933 Neuronal development metalloproteases Oakland, Calif. Genes for the KUZ family of metalloproteases involved in neuronal development, encoding genes, antibodies.

Cancer Res. Camp. Technol. WO 98/08973 Uniform global PCR amplification London Randomly primed, anchored single-stranded DNA; for uniform global PCR amplification for differen-tial gene ex-pres-sion.

Ctr. Applied Microbiol. WO 98/07864 Exocytosis fusion toxin Salisbury, U.K. Fusion protein with a clostridial toxin, target moiety, and exocytosis protein cleavage activity; for vaccines.

Chiron WO 98/07858 & 07860 Polyhomeotic tumor suppressor oncogene Emeryville, Calif. Human tumor suppressor oncogene polyhomeotic I; for use identi-fying chromosome 12 p13 region and diagnosing cancer.

Chiron WO 98/08874 Meningitis vaccines Emeryville, Calif. Antibodies against Neisseria meningitidis antigens, epitope mimetics; for making vaccines eliciting little autoimmunity.

Cornell Univ. WO 98/08394 Breast cancer diagnosis Ithaca, N.Y.Antibodies to BRCA1 and BRCA2 gene encoded proteins from milk fat globule membranes; for breast cancer diagnosis.

Dong Wha Pharma WO 98/07869 Hepatitis B antiviral screens Seoul, S. Korea Histidine tagged hepatitis B virus polymerase, encoding gene; for purification and antiviral agent screening.

Fred Hutchinson Cancer Res. Ctr. WO 98/08860 Myogenesis control protein Seattle, Wash. Gene for a protein that interacts with MyoD family tran-scriptional activators; for controlling myogenesis.

Genesis Res. & Develop. WO 98/08542 Mycobacterial vaccines Auckland, New Zealand Immunogenic mycobacterial proteins, encoding genes; for diagnosing and treating mycobacterial infections.

Genesis Res. & Develop. WO 98/08965 Apoptosis modulation Auckland, New Zealand CD95 gene regulatory sequences and transcription factors that bind them; for controlling apoptosis.

Genetics Inst. WO 98/07853, 07855, 07856, 07859 Secreted protein genes Cambridge, Mass. Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Genetics Inst. WO 98/08949 P-selectin ligand Cambridge, Mass. Gene for a P-selectin ligand glycoprotein, encoded protein, expression system; for treating inflammation.

Genvec WO 98/07865 & 07877 Targeted adenoviruses Rockville, Md. Chimeric adenovirus fiber protein that includes a conforma-tionally constrained cell targeting moiety.

Genzyme WO 98/08541 Reduced immune response to adenovirus Framingham, Mass. Diminished immune response to adenoviral vectors by coadmin-istra-tion of CD40 ligand antibodies to reduce CD4+ T cells.

German Hlth. & Welfare Inst. EPO 826 775 Conditional expression vectors Oberscleissheim, Germany Episomally replicating eukaryotic vector system; for condi-tional gene expression [in German].

Harvard Univ. WO 98/07845 Transcription factor assay Cambridge, Mass. Interaction trap assay using prokaryotic cells; for studying transcription factor binding.

Harvard Univ. WO 98/08956 Treating graft rejection Cambridge, Mass. Modified cyclosporin and cyclophilin; for transfecting stem cells and treating graft versus host disease.

HSC Res. & Develop. WO 98/07849 TGFß-related tumor suppressor Toronto, Ont. Tumor suppressor MAD2 gene, encoded protein that partici-pates in the TGFß signalling pathway.

Human Genome Sciences WO 98/07735 Plasminogen activator inhibitor Rockville, Md. Gene for a pancreas-derived plasminogen activator inhibitor, encoded protein, expression vector; for therapeutics.

Human Genome Sciences WO 98/07749 Colon cancer growth factors Rockville, Md.

Human growth factors related to Xenopus laevis XAG protein and found in colon cancers, encoding gene; for therapeutics.

Human Genome Sciences WO 98/07754 TI receptor-like ligand II Rockville, Md. TI receptor-like ligand II protein, encoding gene, vectors, expression system.

Human Genome Sciences WO 98/07862 Human chemokine ß-16 Rockville, Md. Gene for human chemokine ß-16, encoded protein; for diagno-sis and therapy of immune system disorders.

Human Genome Sciences WO 98/07880 Endokine-* Rockville, Md. Endokine-* gene, a TNF gene family member, encoded protein, expression methods; for diagnostics and therapeu-tics.

Human Genome Sciences WO 98/07881 TI receptor-like ligand I Rockville, Md. TI receptor-like ligand I protein, encoding gene, vectors, expression system.

Human Genome Sciences WO 98/08870 Interleukin-19 Rockville, Md. Gene for interleukin-19, encoded protein, expression system; for modulating cytokine production.

Human Genome Sciences WO 98/08969 IL-1 receptor accessory molecule Rockville, Md. Soluble immunoglobulin superfamily-related interleukin (IL)-1 receptor accessory molecule, encoding gene.

Hybridon WO 98/07734 Targeted oligos Cambridge, Mass. Oligos derivatized with lipophilic groups cleavable by tissue enzymes; for delivering oligos to cells.

Incyte WO 98/08950 Monocyte activating cytokine Palo Alto, Calif. Gene for monocyte activating cytokine, encoded protein, primers, antibodies; for cancer and immune diseas-es.

Insearch WO 98/08970 Protozoan parasite detection Haymarket, Australia Detection of protozoan parasites by PCR-based assays for ITS1 sequences.

JCR Pharma EPO 828 005 Neuronal tumor apoptosis Ashiya, Japan Vectors with herpes simplex genes; for delivering apoptotic agents to nervous system tumor cells.

Jensen, P.R. WO 98/07846 Artificial promoter libraries Sogardsvej, Denmark Construction of artificial promoter libraries from double-stranded DNA fragments; for expression optimization.

Johns Hopkins Univ. WO 98/08864 FGF homologous factors Baltimore, Md. Fibroblast growth factor (FGF) homologous factors, encoding genes; for therapeutics.

Johns Hopkins Univ. WO 98/08945 Neuronal NO synthase inhibitor Baltimore, Md. Protein inhibitor of neuronal nitric oxide (NO) synthase; for regulating NO-dependent processes.

Kirin Beer WO 98/07873 Yeast production system Tokyo Marker gene-containing expression vectors allowing multicopy integration into yeast chromosomes; for protein production.

Kyowa Hakko Kogyo WO 98/08869 Hematopoietic stem cell growth factor Tokyo Hematopoietic stem cell growth factor, encoding gene, anti-bodies; for inducing stem cell growth.

Leuven Res. & Develop. WO 98/07748 Genes implicated in cancer Leuven, Belgium Genes from the PLAG and CTNNB1 gene family; for cancer diagnosis and therapy.

Life Technologies WO 98/08865 Capped mRNA isolation Rockville, Md. CAP binding domain peptide of the protein synthesis initia-tion factor, encoding gene; for isolating capped mRNAs.

Lubitz, W. WO 98/07874 Phage vaccines Vienna, Austria Operator sequences from lambdoid phages with different thermostability in repressor binding; for vaccines.

Ludwig Inst. Cancer Res. WO 98/07737 Colorectal cancer diagnosis New York T cell activation-associated proteins; for determining aberrant APC protein presence and colorectal cancer risk.

Ludwig Inst. Cancer Res. WO 98/07832 VEGF-D New York Vascular endothelial cell growth factor (VEGF)-D, encoding genes, antibodies, expression system; for angiogenesis.

Mass. Inst. Technol. WO 98/08959 Protein overproduction Cambridge, Mass. Overproduction of proteins with an initial amino acid resi-due other than methionine.

Massachusetts, Univ. of WO 98/07841 Human embryonic stem cells Amherst, Mass. Nuclear transplantation methods for producing human embryon-ic stem cells; for making transgenics having specific genes.

Mayo Clinic WO 98/08943 Transgenic arthritis model Rochester, Minn. Transgenic mice with a human HLA-DQ transgene and deficient in mouse H-2 class II molecules; for arthritis model.

MRC (Med. Res. Coun.) WO 98/07876 Tissue-specific vector expression London Self-replicating, episomal vectors for long-term, persistent tissue-specific expression of genes.

Millennium Biotherapeutics WO 98/07736 EGF-related don-1 gene Cambridge, Mass. Epidermal growth factor (EGF)-related gene called don-1, encoded protein, expression methods, splice forms.

Millennium Pharma WO 98/08861 Retinitis pigmentosa genes Cambridge, Mass. Retinitis pigmentosa-associated genes, encoded proteins, fusions, antibodies, expression systems; for diagnosis.

Mitsubishi Chemical WO 98/07838 Telomerase gene Tokyo Telomerase gene, encoded enzyme; for identifying modulators for treating cancer and aging.

NIH (Natl. Inst. Hlth.) WO 98/08947 DNA immunization enhancement Bethesda, Md. Enhancement of DNA immunization by coadministration of cytokines during transfection.

Netherlands Cancer Inst. WO 98/07852 Ubiquination inhibitors Amsterdam, Nether-lands Assays for inhibitors of the E2F transcription factor ubiqu-ination domain function.

Nippon Zeon WO 98/07866 Laryngotracheitis virus antigen Tokyo Antigenic protein from infectious laryngotracheitis virus, encoding gene; for therapeutics.

North Carolina, Univ. of WO 98/08935 Immortalized liver cell line Chapel Hill, N.C. Immortalized human liver cells made by transfecting with c-myc exon se-quences controlled by an SV40 promoter.

Nyfotek WO 98/08958 Bacterial expression system Trondheim, Norway Expression vector derived from prokaryotic regulatory se-quences; for protein expression in bacterial hosts.

Okazaki, T., et al. WO 98/08964 Artificial mammalian chromosomes Aichi, Japan Production of artificial mammalian chromosomes by introduc-ing a telomere and centromere into cells.

Ophidian Pharma WO 98/08540 Botulism vaccine Madison, Wis. Soluble recombinant proteins derived from Clostridium botu-linum toxins; for use as immunogens in vaccines.

Osteoscreen WO 98/07844 Bone formation modulator assay San Antonio, Texas Reporter gene linked to the parathyroid hormone-releasing peptide promoter; for finding modulators of bone forma-tion.

Pasteur Inst. WO 98/07847 Mycobacterial differential diagnosis Lille, France Mycoplasma tuberculosis complex-specific genes and their products; for differential diagnosis.

Pasteur Inst. WO 98/08937 Antifungal agent assay Paris Proteins having ß(1-3)glucanosyltransferase activities; for identifying antifungal agents.

Penn State Univ. WO 98/08957 Tumor targeting chimera University Park, Penn. Chimeric protein with effector and interleukin-13 recep-tor target-ing domains; for tumor targeting.

Phairson Medical WO 98/08863 Therapeutic protein London Gene for a protein useful in therapeutics and cosmetics, encoded protein.

Pharmacyclics WO 98/07733 Texaphyrin-mediated RNA degradation Sunnyvale, Calif. Oligos internally derivatized with a texaphyrin metal com-plex; for breaking down RNA.

Sankyo WO 98/07863 High activity interferons Tokyo Highly active human gamma-interferon variants; for treating viral infections, cancer, and autoimmune diseases.

Signal Pharma WO 98/08955 NF-kappaB activation control San Diego, Calif. Stimulus-inducible I(kappa) B kinase signalsome; for treat-ing diseases associated with NF-kappaB activation.

SmithKline Beecham EPO 826 774 Bacterial infection therapeutics Philadelphia, Penn. Genes for staphylococcal FAB1 polypeptides, encoded pro-teins; for use in treating bacterial infections.

SmithKline Beecham EPO 828 003 Human serine protease Brentford, U.K. Gene for a human serine protease, encoded protein, oligos, primers; for detecting polymorphisms.

Snow Brand Milk Products WO 98/07840 Osteoclast formation inhibition Sapporo, Japan Genes for osteoclast formation inhibiting proteins, encoded proteins; for treating osteoporosis and rheumatism.

Somatogen WO 98/08954 Increased hemoproteins Boulder, Colo. Enhancing heme production in cells by increasing available delta-aminolevulinic acid; for increasing hemoproteins.

Sugen WO 98/07835 Protein tyrosine kinase structure Redwood City, Calif. Crystal structures of a protein tyrosine kinase complexed with various ligands; for identifying modulators.

Teikoku Hormone WO 98/07848 Autoantibody assay Tokyo MPO fragment reacting with myeloperoxidase-specific antineu-trophil cytoplasmic antibody; for autoanti-body detection.

Texas, Univ. of WO 98/07861 Anti-cell growth factor Austin, Texas Anti-cell growth factor from cells exposed to viral vectors; for treating cancer.

Ventana Genetics WO 98/07886 Cell growth-promoting proteins Salt Lake City, Utah Methods for identifying genes encoding pro-teins that have cell growth-promoting activity, interfering antibodies.

Warner-Lambert WO 98/08948 Glycogen storage enhancer Morris Plains, N.J. Gene for a protein that is targeted to glycogen, encoded protein; for increasing cellular glycogen.

Wistar Inst. WO 98/08866 Cancer-related gene Philadelphia, Penn. Mouse cDNA encoding BIN1-associated U1-specific protein, encoded protein, antibodies; for cancer treatment.

Yoshida, S. WO 98/08938 Telomerase proteins Aichi, Japan Proteins with telomerase activity; for antibody diagnostics and screening inhibitors.

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