Published September 25 & October 2 (EPO & GB); September 19 &26 (WO)
Astra GB 2 299 085
Yeast production system
Transfection vector with a yeast signal peptide sequence; forproduction and secretion in yeast.
Bavarian Nordic Res. Inst. WO 96/28563
Therapeutic antimicrobial vectors
Vectors expressing antimicrobial peptides with tumor or viralspecific regulatory elements; for therapy.
Bavarian Nordic Res. Inst. WO 96/28564
Viral infection gene therapy
Recombinant vectors useful for gene therapy of viral infections anddiseases associated with B and T cells.
Baylor Coll. Med. WO 96/28189
HIV expression inhibition
Double transdominant fusion gene that simultaneously inhibits twofunctions essential for HIV expression.
Baylor Coll. Med. WO 96/29423
Retrovirus host expansion
Methods for increasing the host range of retroviral vectors bycoadministration of adenoviruses.
Becton Dickinson WO 96/28550
Franklin Lakes, N.J.
Gene for human restrictin, encoded protein, antibodies; for detectionin human brain.
Bio Merieux WO 96/28552
Rheumatoid arthritis-associated retrovirus
Rheumatoid arthritis-associated retrovirus, antibodies to encodedproteins; for diagnosis and treatment.
Boehringer Ingelheim WO 96/29093
Tumor cell vaccine
Tumor cells transfected with a gene encoding an antigen alreadyrecognized by antibodies from the patient.
British Columbia, Univ. of WO 96/28559
Antimicrobial peptide production
Method for microbial production of antimicrobial cationic peptidesthat bind lipopolysaccharides.
California, Univ. of WO 96/29338
Adrenal hyperplasia genes
Genomic DNA and cDNA sequences and variants that are associatedwith congenital lipoid adrenal hyperplasia.
Chugai WO 96/28554
Gene for a protein kinase, encoded protein, variants, plasmid forproducing the protein kinase.
Genentech WO 96/28548
Receptor kinase activator
S. San Francisco
Activator of Rse and Mer receptor protein tyrosine kinases, encodinggene; for enhancing cell growth and survival.
Genzyme EPO 735 139
High expression of hormones
Transfection with genomic DNA sequences coding for dimericglycoprotein hormones; for higher levels of expression.
Greenstein, R.J. WO 96/29398
Tissue-specific gene expression.
DNA vectors with effective upstream enhancer regions for tissue- andorgan-specific expression of genes.
Hirano, T. EPO 733 643
Pre-B lymphocyte growth
Gene for a membrane protein that supports pre-B lymphocyte growth,encoded protein, production methods.
Hisamitsu Pharma WO 96/28560
Adeno-associated virus helper
Production of adeno-associated virus using cells infected with a virushelper plasmid.
Hisamitsu Pharma WO 96/28565
HIV gene therapy vector
Recombinant HIV vector having genes encoding cytotoxins; for genetherapy.
Hisamitsu Pharma WO 96/29096
Gene transfer preparation
Gene transfer preparation using freeze drying and various additives;for increased transfection efficiency.
Hisamitsu Pharma WO 96/29349
Adeno-associated virus antibodies
Monoclonal antibodies that recognize adeno-associated virus CAPprotein; for detection and purification.
Hisamitsu Pharma WO 96/29393
Cells for HIV vectors
Recombinant HIV-producing cells; for efficient and stablepreparation of HIV vectors.
Hoechst Schering Agrevo WO 96/28562
Virus replication inhibition
Inhibition of virus replication by expression of chromosomallyencoded dominantly negative mutations.
Human Genome Sciences WO 96/28546
Tumor necrosis factor receptor
Gene for human tumor necrosis factor receptor, encoded protein,production method; for therapy.
Human Genome Sciences WO 96/29401
B lymphocyte translocation genes
Human B lymphocyte translocation genes 2 and 3, encoded proteins;for treating abnormal cell growth.
IAF Bio Vac WO 96/29412
Gene for a proteinase K resistant surface protein of Neisseriameningitidis, encoded protein, antibodies; for therapy.
Illinois, Univ. of WO 96/29403
BCL2-derived suppressor elements
Genetic suppressor elements derived from the apoptosis-related geneBCL2; for sensitization to chemotherapy.
Immunol. & Molec. Genetics Inst. WO 96/28547
Dermatomyositis-specific auto-antigen, gene encoding it, productionmethods.
Incyte Pharma WO 96/28549
Palo Alto, Calif.
Gene for hyaluronan receptor expressed in human umbilical veinendothelial cells, encoded protein, antisense.
Indiana Univ. WO 96/29348
T cell receptor antibodies
Monoclonal antibodies against a T cell receptor; for affecting T cellactivation and growth during transplantation.
INRA (Natl. Inst. Agron. Res.) WO 96/29400
Regulatable baculovirus vector
Recombinant baculovirus-based vector that includes a retinoic acidreceptor binding site; for regulating expression.
Koike, C. WO 96/28966 & 28967
Gene transfection for modifying surface antigens on the organs oftransgenic animals; for transplantation.
Ligand Pharma WO 96/29405
Human ob gene control regions
San Diego, Calif.
Isolation and cloning of the promoter and other control regions of thehuman ob gene; for treating obesity.
Ludwig Inst. Cancer Res. WO 96/28461
X chromosome MAGE family
Nucleic acids that are members of the MAGE family found on the Xchromosome.
Ludwig Inst. Cancer Res. WO 96/29409
Tumor rejection antigens
RAGE tumor rejection antigens, encoding genes; for detection andtreatment of cancer.
Medenica, R.D. WO 96/28473
Lung carcinoma antibodies
Hilton Head Isl., S.C.
Human monoclonal antibody against lung tumor antigens; forimmunotherapy.
Merck GB 2 299 336
Recombination after transfection
Selection of a favorable site in the mouse genome for insertion andexpression of a recombinant gene.
Merck WO 96/29413
Human papillomavirus type 18
DNA sequences encoding human papillomavirus type 18 and itsderivatives
Michigan, Univ. of WO 96/28568
CD40 binding protein
Ann Arbor, Mich.
CD40 cytoplasmic domain binding protein, encoding gene,antibodies to the protein.
Mitsui Toatsu EPO 735 140
Increased E. coli production
Coexpression of glutathione reductase in E. coli; for increasedproduction of recombinant proteins.
NIH (Natl. Inst. Hlth.) WO 96/29417
IL-13 receptor specific chimeras
Chimeric molecules with an effector attached to a domain that targetsthe IL-13 receptor; for treating cancer.
New York, St. Univ. WO 96/29433
Neural expression inhibition
Stony Brook, N.Y.
Gene for protein that inhibits the expression of neural proteins innon-neural tissues, encoded protein.
Novo Nordisk WO 96/29391
Cell production strains
Host cells expressing reduced levels of metalloprotease; forrecombinant protein production.
Novo Nordisk WO 96/29418
Recombinant Bacillus by conjugation
Bacillus strains encoding recombinant proteins by introducing genesvia conjugation with a donor cell.
Procter & Gamble WO 96/28556
Proteinase K variants
Proteinase K variants, encoding genes; for decreased adsorption onand increased hydrolysis in cleaning surfaces.
Procter & Gamble WO 96/28557
Subtilisin DY variants
Subtilisin DY variants, encoding genes; for decreased adsorption onand increased hydrolysis in cleaning surfaces.
Procter & Gamble WO 96/28558
Thermitase variants, encoding genes; for decreased adsorption on andincreased hydrolysis in cleaning surfaces.
Rhone-Poulenc Rorer WO 96/28553
Recombinant viruses with gene encoding lecithin-cholesterolacyltransferase and variants; for dyslipoproteinemia.
St. Louis Univ. EPO 733 706
Apoptosis regulating proteins
St. Louis, Mo.
Genes for proteins that interact with an adenovirus protein thatprotects against cell death; for apoptosis regulation.
Salk Inst. EPO 733 705
Thyroid hormone analogs
La Jolla, Calif.
Gene for proteins having hormone binding and/or transcriptionactivating characteristics of thyroid hormone.
Sibia Neurosciences WO 96/29404
La Jolla, Calif.
Genes encoding a human metabotropic glutamate receptor subtype,encoded protein; for identifying antagonists.
Sloan-Kettering Inst. WO 96/28190
Gene transfer imaging
Marker gene that can be transfected and then detected by a non-invasive, clinically applicable method of imaging.
Stichting EPO 733 369
Gene for the metalloprotease, gelatinase B, encoded protein; fortreating tissue destructive diseases.
Sumitomo Electric WO 96/29350
Fas ligand antibodies
Monoclonal antibodies against Fas ligands and active fragments; fordetection.
Terumo WO 96/28569
Pulmonary adenocarcinoma antibodies
Monoclonal antibodies against human pulmonary adenocarcinomacell antigens; for cancer diagnosis.
Texas, Univ. of WO 96/29402
Tumor marker protein
Tumor marker protein, its encoding gene, hybridization probes,antibodies; for cancer diagnosis.
Thomas Jefferson Univ. WO 96/28555
Cyclin-dependent kinase-like proteins
Human cyclin-dependent kinase-like proteins, encoding genes,expression vectors, antibodies.
Toyota EPO 733 709
Mutated farnesyldiphosphate synthetase
Mutated farnesyldiphosphate synthetase, gene encoding this mutein;for modified synthesis.
Transkaryotic Therapies WO 96/29411
Targeting DNA constructs used for homologous recombination incells and during gene therapy.
Tularik WO 96/29341
Transcription activator protein
S. San Francisco
Gene for human signal transducer and activator of transcription,encoded protein; for drug screens.
Utah, Univ. of WO 96/28573
Cardiac arrhthymia channel
Salt Lake City, Utah
Gene for a major subunit of a potassium channel involved in acquiredlong QT syndrome, a cardiac arrhthymia.
Wisconsin, Univ. of WO 96/29429
Protein-RNA interaction detection
Method and system to detect protein-RNA interactions usingchimeric genes and a reporter gene.
Zeneca GB 2 299 084 & WO 96/29410
Antibodies from MEL cells
Transfection of murine erythroleukemia (MEL) cells, introductioninto host, antibodies against transfected antigens.
(c) 1997 American Health Consultants. All rights reserved.