Published June 5 & 12 (EPO); May 30 & June 6 (WO)
Ajinomoto Antithrombotic WO 96/17078
Antibody to human Von Willebrand factor; for use in antithrombotictherapy.
Akzo Nobel Terminal repeat WO 96/17079
Arnhem, the Netherlands amplification
Amplification method using terminal repeats, relatively constanttemperature, and no serial reagent additions.
Astra PBP ligand WO 96/16082
Sodertlje, Sweden assay
Gene for variants of penicillin binding proteins (PBP), encodedproteins; for assaying PBP ligands.
Biotech. Biol. Sci. Res. Coun. Nisin variants WO 96/16180
Genes for nisin variants, encoded proteins, transformed cells, nisinproduction methods.
Byk Gulden Helicobacter WO 96/17066
Konstanz, Germany inhibitor screen
Cells expressing Helicobacter P-type ATPase; for screening ulcertherapeutics.
California, Univ. of Cryptidin WO 96/16075
Genes for cryptidin, encoded proteins; for use in detecting andtreating inflammation.
Cayla Hybrid suicide WO 96/16183
Toulouse, France genes
Hybrid suicide genes coding for activators of nucleotide baseanalogues; for cell destruction.
Chiron Viagene Alphavirus EPO 716 148 &
Emeryville, Calif. vectors WO 96/17072
Recombinant alphavirus vectors, methods of use; for gene therapy.
Cohen-Haguenauer, O. Retroviral WO 96/17071
Paris integration vector
Expression vector allowing genomic integration of retroviral vectors,cells, DNA sequences causing integration.
Columbia Univ. KS-specific WO 96/15779
New York herpesvirus
DNA from a Kaposi's sarcoma (KS)-specific herpesvirus, encodedproteins, antibodies; for vaccination.
CRC Biopharmaceutical Res. Cytotoxic WO 96/16176
Darlinghurst, Australia erbB3 binding protein
Fusion protein with erbB3 binding and toxin regions; for cytotoxicaction against cells overexpressing erbB3.
Du Pont Compound WO 96/17082
Wilmington, Del. microsatellites
Compound microsatellites used to screen genomes forpolymorphisms.
Duke Univ. Hemorrhagic WO 96/16975
Durham, N.C. telangiectasia diagnosis
Probes for gene mutations in the TGF receptor family; for diagnosinghereditary hemorrhagic telangiectasia.
Eisai Cell adhesion WO 96/16170
Proteins involved in the regulation of cell-cell adhesion; formodifying cell adhesion.
French Assoc. Myopathy Calcium- WO 96/16175
Paris dependent protease
Gene for calcium-dependent protease, mutations by deletion orsubstitution, encoded proteins.
Genetic Therapy Tissue-specific WO 96/16676 &
Gaithersburg, Md. adenoviral vectors 17053
Adenoviral vector systems that are replication-deficient butspecifically replicate in tumor cells.
Glaxo Cepaholsporin WO 96/16174
Greenford, U.K. conversion
Bacterial amidohydrolases; for one-step conversion of cephalosporinC and derivatives to 7-aminocephalosporin.
Grunenthal Fibrinolytic EPO 714 982
Aachen, Germany hybrid proteins
Hybrid proteins with fibrinolytic and thrombin inhibiting activity (inGerman).
Human Genome Sciences Choline WO 96/15806
Rockville, Md. acetyltransferase
Gene for human choline acetyltransferase polypeptide, encodedpolypeptide; for treating neurodegeneration.
Human Genome Sciences G-coupled WO 96/16087
Rockville, Md. receptor
Gene for a human G-coupled receptor polypeptide, encodedpolypeptide; for identifying agonists/antagonists.
Icos Calneurin WO 96/16172
Isolation of calneurin and calneurin inhibitors; for modulatinganchoring protein function.
Imperial Coll. Polycationic gene WO 96/15811
Polycationic peptides linked to integrin receptor ligands; for use as agene therapy delivery vehicle.
Incyte Pharma Liver expressed WO 96/16979
Palo Alto, Calif. chemokines
Genes for chemokines expressed in livers and pituitaries, encodedproteins, antibodies; for treating inflammation.
Indiana Univ. Phenylalanine-free WO 96/17064
Bloomington, Ind. proteins
Natural proteins modified to remove phenylalanine residues,encoding genes; for treating phenylketonuria.
Inst. Plant Genetics Embryonal cardiac WO 96/16163
Gaitersieben, Germany muscle cells
Embryonal cardiac muscle cells transfected with marker genes; forcell-mediated gene transplants.
Inst. Psychiatry Assessing clozapine WO 96/17081
Gene for serotonin 5-HT2A receptor with a specific polymorphism;for assessing responsiveness to neuroleptic agents.
Japanese Cancer Inst. Chromosome EPO 714 981
Tokyo 8 cancer gene
Chromosome 8 gene in deletion region common to lung, liver, andcolorectal cancers, encoded protein.
Johns Hopkins Univ. Hedgehog WO 96/16668
Baltimore cleavage polypeptides
Polypeptides derived from hedgehog gene from specific cleavage bythe autoproteolytic domain of the protein.
Krebs Res. Inst. Yeast secretion WO 96/16181
Heidelberg, Germany vector
Yeast expression plasmid coding for fusion peptides with signalpeptide; for secretion.
La Jolla Cancer Res. Fdn. CD40- WO 96/16665
La Jolla, Calif. associated protein
Gene for CD40-associated protein, encoded protein; for identifyingantagonists and agonists.
Lebens M.R. Stimulating WO 96/16178
Goteborg, Sweden mucosal immunity
Immunogens having mucosal membrane binding and mucosalimmunity stimulating domains.
Leeds, Univ. of Modified WO 96/16173
Leeds, U.K. cystatins
Cystatins modified by site-directed methods or hybrid production; forinhibiting proteinases.
NIH (Natl. Inst. Hlth.) AAV vector WO 96/15777
Bethesda, Md. delivery
Adeno-associated viral (AAV) vector with coding sequences for repprotein in lipid vesicles; for gene therapy.
New England In vitro WO 96/16674
Deaconess Hosp. T-lymphopoiesis
In vitro T-lymphopoiesis system in which T cells are produced fromprecursors expressing CD34.
Nippon Chemiphar Denatured LDL WO 96/17058
Gene for the denatured low-density lipoprotein (LDL) receptors ofendothelial cells, encoded protein.
Novo Nordisk Less allergenic WO 96/16177
Bagsvaerd, Denmark proteins
Production of polypeptides with reduced allergenicity by usingZipper domains.
Oravax Immunoglobulin WO 96/16974
Cambridge, Mass. variable region antibodies
Genes for immunoglobulin variable regions, production hybridomas;for making chimeric antibodies.
Pasteur Inst. Hypermuta- EPO 714 980 &
Paris genesis WO 96/17056
Using biased concentrations of deoxynucleoside triphosphates tocause hypermutagenesis in reaction mixtures.
Queensland, Univ. of Bone disease WO 96/17057
St. Lucia, Australia marker
Chromosome 17 Sox-9 gene encoded protein; for diagnosingCampomelic Dysplasia and treatment of bone disease.
Rhone-Poulenc Rorer Calcium sensor WO 96/15801
Antony, France protein
Human calcium sensor protein, fragments, gene encoding the protein;for controlling calcium regulation.
Rhone-Poulenc Rorer GAP protein WO 96/16169
Antony, France ligands
Peptides capable of binding to the GAP protein SH3 domain, genesencoding these peptides.
Rockefeller Univ. SH3 kinase WO 96/17061
New York associated protein
SH3 kinase domain associated protein, signaling domain of thisprotein, encoding genes; for cell process control.
Salk Inst. Modified hormone EPO 716 145
La Jolla, Calif. receptor genes
Genes for hormone receptors with modified transcription activationdomain position and/or copy number.
Schering T cell surface WO 96/17060
Kenilworth, N.J. antigens
Genes for T cell surface antigens, purified proteins, specificantibodies; for diagnostic kits.
Scofield, V.L. Contraceptive WO 96/15807
Pasadena, Calif. vaccine
Vaccines, contraceptives, and gene therapy delivery vectors in whichsperm cells or components act as immunogens.
Scripps Res. Inst. Enzymatic DNA WO 96/17086
La Jolla, Calif. molecules
Catalytic or enzymatic DNA molecules capable of site-specificcleavage of nucleic acids.
Synaptic Pharma Antagonists for WO 96/16542
Paramus, N.J. eating disorders
Antagonists of neuropeptide Y/peptide YY receptor; for treatingeating disorders.
Systemix Stem cell EPO 716 146
Palo Alto, Calif. marker protein
Gene for stem cell marker protein, encoded protein, antibodies,purification methods.
Takara Shuzo Transfection WO 96/17073
Kyoto, Japan by injection
Transfection by injection of foreign genes into cells in the presenceof cell adhesion-active substances.
Takeda Tripeptide EPO 716 150
Osaka, Japan primers
DNA primers coding for specific tripeptides; for screening proteinsfor these tripeptide sequences.
Thomas Jefferson Univ. EGF receptor WO 96/16988
Overexpression of mutant Type III EGF receptor, encoding genes,antibodies to muteins; for tumor inhibition.
Transgene Vectors by WO 96/17070
Strasbourg, France recombination
Preparation of viral vectors within microorganisms by intermolecularhomologous recombination; for gene therapy.
Vical IL-2 expression WO 96/17063
San Diego vector
Expression vectors with cytomegalovirus promoters; for expressinginterleukin (IL)-2.
Washington Univ. Thrombospondin WO 96/17059
St. Louis domain receptor
Receptor for the cell-binding peptide sequences of the cell-bindingdomain of thrombospondins.
Wellcome Fdn. Extracellular WO 96/16179
Greenford, U.K. prodrug activation
Vector for expressing and secreting enzymes that activate prodrugs;for killing neighboring cells.
Wistar Inst. Mutated p53 WO 96/16989
Genes for mutated p53 proteins with altered tetramerization domainsbut unaltered activity; for modifying cell growth.
Yale Univ. Localizing WO 96/17074
New Haven, Conn. transcription sites
Peptides derived from the largest subunit of RNA polymerase II; forlocalizing sites of transcription for gene therapy.
Zymogenetics Low molecular WO 96/17062 &
Seattle weight thrombopoietin 17067
Genes for low molecular weight thrombopoietin, encoded proteins,vectors, cells, production/secretion methods.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.