Published April 10 & 17 (EPO); April 4 & 11 (WO)
Alabama, Univ. of RNA virus WO 96/10400
Birmingham, Ala. genome recovery
Recombinant methods for recovering RNA virus genomes using viralparticle proteins; for vaccines and gene therapy.
Amoco RNA sequence EPO 707 076
RNA templates replicated by Qa replicase having target-specificprobes attached to both ends; for amplification.
Aviron Influenza/ WO 96/10632 & 10633
Burlingame, Calif. RSV mutants
Recombinant influenza and respiratory syncytial viruses (RSV);mutants, expression, electroporation, and vaccines.
Bayer Attenuated influenza WO 96/10641
Leverkusen, Germany strains
Attenuated influenza virus strains, methods of production; forvaccination.
Becton Dickinson Species-specific EPO 707 075
Franklin Lakes, N.J. mycobacterium detection
Species-specific oligonucleotide probes for Mycobacterium kansasii;for detection without cross-reactivity.
Boehringer Mannheim Matrix nucleic EPO 705 905
Mannheim, Germany acid polymerization
Polymerization and amplification of specific nucleic acid sequencesusing a solid support matrix (in German).
Emory Univ. IGF-1 receptor WO 96/10401
Regulation of insulin-like growth factor (IGF)-1 receptor expressionusing antisense and sense oligonucleotides.
Fuso Pharma Pneumonia probe WO 96/10647
DNA probe derived from Streptococcus pneumoniae; for detectionand diagnosis of pneumonia.
Harvard Univ. Endothelial WO 96/10628
Cambridge, Mass. cell enhancer
Endothelial cell-specific enhancer DNA sequence; for treatingarteriosclerosis.
Hybridon Finderons WO 96/10080
RNases called finderons that contain a target sequence andendonucleolytically cleave an RNA sequence.
Immuno Factor IX EPO 705 901
Vienna, Austria separation
Methods for separating pro-Factor IX from Factor IX using a pHgradient (in German).
Indiana Univ. Polyol-induced WO 96/10335
Bloomington, Ind. transfection
Cell transfection methods using polyols; for greater transductionefficiencies.
INSERM (Natl. Inst. Antiviral RNase WO 96/10636
Hlth. Med. Res.) L inhibition
Genes for proteins with RNase L inhibitory activity, encodedproteins; for developing antiviral agents.
Introgene Adenoviral gene EPO 707 071
Rijswijk, the Netherlands therapy vector
Adenoviral-based vector lacking sequences that hastenimmunological response to transfected cells; for gene therapy.
Johns Hopkins Univ. Lymphoid/epithelioid WO 96/10092
Baltimore tumor proteins
Genes for proteins associated with lymphoid and epithelioid tumors,encoded proteins, antibodies; for diagnosis.
Joslin Diabetes Ctr. IRS-2 WO 96/10629
Gene for the IRS-2 polypeptide, encoded polypeptide, preparationmethods.
La Jolla Cancer Res. Fdn. Trophinin/ WO 96/10414
La Jolla, Calif. trophinin-assisting proteins
Trophinin and trophinin-assisting proteins, encoding genes; formodifying cell adhesion.
Life Technologies Thermostable WO 96/10640
Gaithersburg, Md. DNA polymerase
Gene for a thermostable DNA polymerase from Thermotoganeapolitana, encoded protein; for sequencing/amplification.
Ludwig Inst. Cancer Res. Tumor WO 96/10577
New York rejection antigen precursors
Genes for tumor rejection antigen precursors, encoded proteins; fordiagnosis and therapy.
Manitoba, Univ. of Parietaria EPO 707 065
Winnipeg, Manitoba pollen allergens
Parietaria pollen allergens identified by phage library screening; fordiagnosis and therapy.
Merck Sharp & Dohme GABAA WO 96/10637
Hoddesdon, U.K. receptor subunits
Genes for subunits of the GABAA receptor, encoded proteins; forscreening for antagonists.
Mogam Biotech Res. Inst. Thrombolytic EPO 707 067
Kyonggi-Do, S. Korea viper protease
Gene for a thrombin-like serine protease from the Korean viper,encoded protein; for use as a thrombolytic.
Myriad Genetics Breast EPO 705 902 & 705 903
Salt Lake City cancer gene
Chromosome 17-linked breast and ovarian cancer susceptibility gene,mutations, polymorphisms; for detection.
NIH (Natl. Inst. Hlth.) Alzheimer's WO 96/10182
Bethesda, Md. cells differentiation
Methods for differentiating between cells from normal individualsand those having Alzheimer's; for diagnosis.
NIH (Natl. Inst. Hlth.) Immunostimulatory WO 96/10419
Bethesda, Md. vector
Recombinant viral vector with genes for an immunostimulatorymolecule and an antigen to disease causing agent.
NIH (Natl. Inst. Hlth.) Pakistani WO 96/10580
Bethesda, Md. hepatitis E
Recombinant proteins from the Pakistani strain of hepatitis E, viralparticles; for diagnosis and vaccination.
New England Neural cell WO 96/10578
Deaconess Hosp. protein marker
Gene for a neural cell protein marker, encoded protein, syntheticpolypeptides.
Omnigene Selectable yeast EPO 707 068
Cambridge, Mass. vector
Yeast-based expression vector with a gene coding for resistance tothe antibiotic G418; for therapeutic production.
Pasteur Inst. Leshmania WO 96/10081
Recombinant BCG strain that contains a membrane protein antigen ofleshmania; for vaccination.
PPL Therapeutics Muteins of WO 96/10638
Roslin, U.K. a1-antitrypsin
Muteins or variants of a1-antitrypsin containing a thrombin-specifictarget region; for thrombolysis without heparin.
Pro-Neuron Stem cell WO 96/10634
Rockville, Md. inhibitors
Inhibitors of stem cell growth, methods of isolation; for acceleratingrecovery from chemotherapy.
Res. Develop. Fdn. Cationic amino EPO 705 844
Carson City, Nev. acid carrier
Gene for cationic amino acid transporter, encoded protein, antibodiesto it; for inhibiting transport.
Rhone-Poulenc Rorer Ras cancer WO 96/10087
Antony, France treatment
Methods for regulating the activity of ras proteins; for treatingcancer.
Rhone-Poulenc Rorer Adenoviral WO 96/10088 & 10642
Antony, France gene therapy vectors
Defective adenoviral-based vectors with genes that are inactivated,immunopotentiating, or cause cell death.
Rockefeller Univ. Glycosyltransferases WO 96/10086
Genes for glycosyltransferases, encoded proteins; for biosynthesis ofoligosaccharides.
Rutgers Univ. Microprobe WO 96/10630
New Brunswick, N.J. cellular introduction
Introduction of materials into cells by concentrating them on a solidsupport containing coated microprobes.
St. Jude Children's Mutated WO 96/10631
Res. Hosp. influenza strains
Attenuated or enhanced influenza virus strains made by mutating thematrix protein genes.
Southwest Fdn. Biomed. Res. Hepatitis WO 96/10649
San Antonio B polymerase
Gene encoding the hepatitis B virus polymerase complex, encodedprotein; for screening inhibitors.
Spectral Diagnostics Cardiac WO 96/10076, 10077 &
Toronto protein antibodies 10078
Antibodies to cardiac myoglobin/troponin/myosin; for detectingserum levels indicative of a heart attack.
Sydney, Univ. of Gene homology WO 96/10175
Sydney, Australia test
Methods for determining whether a test gene is homologous with areference gene.
Vanderbilt Univ. Hypertension- WO 96/10074
Nashville, Tenn. associated gene mutation
Cytochrome P450 arachidonic acid epoxygenase gene havingmutation associated with salt-induced hypertension.
Vanderbilt Univ. Peptic ulcer WO 96/10639
Nashville, Tenn. screen
Gene for an antigen of Helicobacter pylori that is associated with apredisposition to peptic ulceration.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.