Published April 10 & 17 (EPO); April 4 & 11 (WO)

Alabama, Univ. of RNA virus WO 96/10400

Birmingham, Ala. genome recovery

Recombinant methods for recovering RNA virus genomes using viralparticle proteins; for vaccines and gene therapy.

Amoco RNA sequence EPO 707 076

Chicago amplification

RNA templates replicated by Qa replicase having target-specificprobes attached to both ends; for amplification.

Aviron Influenza/ WO 96/10632 & 10633

Burlingame, Calif. RSV mutants

Recombinant influenza and respiratory syncytial viruses (RSV);mutants, expression, electroporation, and vaccines.

Bayer Attenuated influenza WO 96/10641

Leverkusen, Germany strains

Attenuated influenza virus strains, methods of production; forvaccination.

Becton Dickinson Species-specific EPO 707 075

Franklin Lakes, N.J. mycobacterium detection

Species-specific oligonucleotide probes for Mycobacterium kansasii;for detection without cross-reactivity.

Boehringer Mannheim Matrix nucleic EPO 705 905

Mannheim, Germany acid polymerization

Polymerization and amplification of specific nucleic acid sequencesusing a solid support matrix (in German).

Emory Univ. IGF-1 receptor WO 96/10401

Atlanta regulation

Regulation of insulin-like growth factor (IGF)-1 receptor expressionusing antisense and sense oligonucleotides.

Fuso Pharma Pneumonia probe WO 96/10647

Osaka, Japan

DNA probe derived from Streptococcus pneumoniae; for detectionand diagnosis of pneumonia.

Harvard Univ. Endothelial WO 96/10628

Cambridge, Mass. cell enhancer

Endothelial cell-specific enhancer DNA sequence; for treatingarteriosclerosis.

Hybridon Finderons WO 96/10080

Worcester, Mass.

RNases called finderons that contain a target sequence andendonucleolytically cleave an RNA sequence.

Immuno Factor IX EPO 705 901

Vienna, Austria separation

Methods for separating pro-Factor IX from Factor IX using a pHgradient (in German).

Indiana Univ. Polyol-induced WO 96/10335

Bloomington, Ind. transfection

Cell transfection methods using polyols; for greater transductionefficiencies.

INSERM (Natl. Inst. Antiviral RNase WO 96/10636

Hlth. Med. Res.) L inhibition


Genes for proteins with RNase L inhibitory activity, encodedproteins; for developing antiviral agents.

Introgene Adenoviral gene EPO 707 071

Rijswijk, the Netherlands therapy vector

Adenoviral-based vector lacking sequences that hastenimmunological response to transfected cells; for gene therapy.

Johns Hopkins Univ. Lymphoid/epithelioid WO 96/10092

Baltimore tumor proteins

Genes for proteins associated with lymphoid and epithelioid tumors,encoded proteins, antibodies; for diagnosis.

Joslin Diabetes Ctr. IRS-2 WO 96/10629

Boston polypeptide

Gene for the IRS-2 polypeptide, encoded polypeptide, preparationmethods.

La Jolla Cancer Res. Fdn. Trophinin/ WO 96/10414

La Jolla, Calif. trophinin-assisting proteins

Trophinin and trophinin-assisting proteins, encoding genes; formodifying cell adhesion.

Life Technologies Thermostable WO 96/10640

Gaithersburg, Md. DNA polymerase

Gene for a thermostable DNA polymerase from Thermotoganeapolitana, encoded protein; for sequencing/amplification.

Ludwig Inst. Cancer Res. Tumor WO 96/10577

New York rejection antigen precursors

Genes for tumor rejection antigen precursors, encoded proteins; fordiagnosis and therapy.

Manitoba, Univ. of Parietaria EPO 707 065

Winnipeg, Manitoba pollen allergens

Parietaria pollen allergens identified by phage library screening; fordiagnosis and therapy.

Merck Sharp & Dohme GABAA WO 96/10637

Hoddesdon, U.K. receptor subunits

Genes for subunits of the GABAA receptor, encoded proteins; forscreening for antagonists.

Mogam Biotech Res. Inst. Thrombolytic EPO 707 067

Kyonggi-Do, S. Korea viper protease

Gene for a thrombin-like serine protease from the Korean viper,encoded protein; for use as a thrombolytic.

Myriad Genetics Breast EPO 705 902 & 705 903

Salt Lake City cancer gene

Chromosome 17-linked breast and ovarian cancer susceptibility gene,mutations, polymorphisms; for detection.

NIH (Natl. Inst. Hlth.) Alzheimer's WO 96/10182

Bethesda, Md. cells differentiation

Methods for differentiating between cells from normal individualsand those having Alzheimer's; for diagnosis.

NIH (Natl. Inst. Hlth.) Immunostimulatory WO 96/10419

Bethesda, Md. vector

Recombinant viral vector with genes for an immunostimulatorymolecule and an antigen to disease causing agent.

NIH (Natl. Inst. Hlth.) Pakistani WO 96/10580

Bethesda, Md. hepatitis E

Recombinant proteins from the Pakistani strain of hepatitis E, viralparticles; for diagnosis and vaccination.

New England Neural cell WO 96/10578

Deaconess Hosp. protein marker


Gene for a neural cell protein marker, encoded protein, syntheticpolypeptides.

Omnigene Selectable yeast EPO 707 068

Cambridge, Mass. vector

Yeast-based expression vector with a gene coding for resistance tothe antibiotic G418; for therapeutic production.

Pasteur Inst. Leshmania WO 96/10081

Paris vaccine

Recombinant BCG strain that contains a membrane protein antigen ofleshmania; for vaccination.

PPL Therapeutics Muteins of WO 96/10638

Roslin, U.K. a1-antitrypsin

Muteins or variants of a1-antitrypsin containing a thrombin-specifictarget region; for thrombolysis without heparin.

Pro-Neuron Stem cell WO 96/10634

Rockville, Md. inhibitors

Inhibitors of stem cell growth, methods of isolation; for acceleratingrecovery from chemotherapy.

Res. Develop. Fdn. Cationic amino EPO 705 844

Carson City, Nev. acid carrier

Gene for cationic amino acid transporter, encoded protein, antibodiesto it; for inhibiting transport.

Rhone-Poulenc Rorer Ras cancer WO 96/10087

Antony, France treatment

Methods for regulating the activity of ras proteins; for treatingcancer.

Rhone-Poulenc Rorer Adenoviral WO 96/10088 & 10642

Antony, France gene therapy vectors

Defective adenoviral-based vectors with genes that are inactivated,immunopotentiating, or cause cell death.

Rockefeller Univ. Glycosyltransferases WO 96/10086

New York

Genes for glycosyltransferases, encoded proteins; for biosynthesis ofoligosaccharides.

Rutgers Univ. Microprobe WO 96/10630

New Brunswick, N.J. cellular introduction

Introduction of materials into cells by concentrating them on a solidsupport containing coated microprobes.

St. Jude Children's Mutated WO 96/10631

Res. Hosp. influenza strains

Memphis, Tenn.

Attenuated or enhanced influenza virus strains made by mutating thematrix protein genes.

Southwest Fdn. Biomed. Res. Hepatitis WO 96/10649

San Antonio B polymerase

Gene encoding the hepatitis B virus polymerase complex, encodedprotein; for screening inhibitors.

Spectral Diagnostics Cardiac WO 96/10076, 10077 &

Toronto protein antibodies 10078

Antibodies to cardiac myoglobin/troponin/myosin; for detectingserum levels indicative of a heart attack.

Sydney, Univ. of Gene homology WO 96/10175

Sydney, Australia test

Methods for determining whether a test gene is homologous with areference gene.

Vanderbilt Univ. Hypertension- WO 96/10074

Nashville, Tenn. associated gene mutation

Cytochrome P450 arachidonic acid epoxygenase gene havingmutation associated with salt-induced hypertension.

Vanderbilt Univ. Peptic ulcer WO 96/10639

Nashville, Tenn. screen

Gene for an antigen of Helicobacter pylori that is associated with apredisposition to peptic ulceration.

_ Compiled By Chester A. Bisbee

(c) 1997 American Health Consultants. All rights reserved.