Published Feb. 28 & March 6 (EPO); Feb. 22 & 29 (WO)

Akzo Nobel Contraceptive WO 96/06113

Arnhem, Netherlands antibodies

Zona pellucida protein fragments, antibodies against these peptides;for contraception.

American Cyanamid Pig somatotropin WO 96/05311

Wayne, N.J. peptide

Biologically active pig somatotropin polypeptide; for enhancinganimal growth.

American Cyanamid Streptococcal WO 96/05859

Wayne, N.J. vaccines

Immunogenic streptococcal polysaccharide-protein conjugates; forpreparing vaccines for immunization.

Arch Develop. Corp. Dopamine WO 96/05319

Chicago producing cells

Vectors with genes for dopamine biosynthetic enzymes; fortransfection of cells and increased dopamine production.

Ariad Gene Therapeutics Expression WO 96/06111

Cambridge, Mass. obstruction

Regulated obstruction or elimination of expression of a target gene incells and organisms.

Ariad Pharma DNA-binding WO 96/06110

Cambridge, Mass. chimeras

Chimeric proteins that have at least two different DNA bindingdomains, encoding genes.

Athena Neurosciences Integrin-blocking WO 96/05304

S. San Francisco molecules

Gene for integrin-blocking molecules, encoded protein; for inhibitingleukocyte adhesion and endothelial migration.

Beckman Instruments Streptococcus WO 96/06174

Fullerton, Calif. detection kits

Gene for Streptococcus pyrogenes DNase B; for production and usein infection detection kits.

Bio Merieux Trypanosome WO 96/05312

Marcy-l'Etoile, France antigen

Trypanosoma cruzi antigen, encoding gene; for detection andtreatment of Chagas' disease.

Bio Merieux Rickettsia ribosomal WO 96/06186

Marcy-l'Etoile, France RNA

Ribosomal RNA fragments of Rickettsia bacteria; for identifyingspecies.

Boehringer Mannheim Gene therapy WO 96/05297

Mannheim, Germany minus selection

Vectors in which the gene of interest can be separated from themarker gene; for gene therapy.

Bristol-Myers Squibb Mutant cancer EPO 699 756

New York antibodies

Mutant BR96 antibodies and functional equivalents that are reactivewith human carcinomas, encoding genes.

Bristol-Myers Squibb Therapeutic EPO 699 766

New York antibody fusions

Fusion proteins of antibodies and a non-lymphokine cellular factor;for generating therapeutics.

Ciba-Geigy Antitumor WO 96/05298

Basel, Switzerland antisense oligos

Antisense oligos to S-adenosylmethionine decarboxylase; for use asan antitumor agent.

Ciba-Geigy Glutamate receptor WO 96/06167

Basel, Switzerland

Gene for human glutamate receptor, encoded protein, antibodies to it,preparation methods.

Collagen Corporation Mutated EPO 699 752

Palo Alto, Calif. procollagens

Mutated procollagen chains having an inserted proteolyticrecognition site, encoding genes; for tissue engineering.

Columbia Univ. Kaposi's-associated WO 96/06159

New York herpes

DNA sequence that is specific to Kaposi's sarcoma-associated herpesvirus, encoded protein, antibodies; for therapy.

Connaught Labs Retroviral-like WO 96/05292

Willowdale, Ont. particles

Non-infectious retroviral-like particles that have a foreign antigeninserted; for diagnosis and making antibodies.

Connaught Labs Multiply mutated WO 96/06177

Willowdale, Ont. retroviruses

Retroviruses with multiple mutations; for creating non-infectious,retrovirus-like particles.

Cytogen Synthetic genes WO 96/06188

Princeton, N.J.

Binding of ligands to random peptide libraries; for identifyingsynthetic genes for use in therapy.

Duke Univ. Male contraceptive WO 96/05305

Durham, N.C.

Amino terminal peptide domain of sperm-specific tyrosine kinase; forcontraception.

Environmental Res. Inst. Hybridoma IL-5 WO 96/06162

Tokyo mRNA

Hybridoma that expresses interleukin (IL)-5 mRNA but does notmake IL-5; for drug screening.

Garvan Inst. Med. Res. Bone-specific WO 96/05299

Darlinghurst, Australia expression

Vector with sequences causing bone-specific expression; forscreening bone therapeutics in cells and transgenics.

Genetic Therapy Resistant retroviral WO 96/04934

Gaithersburg, Md. vectors

Retroviral vectors made by producer cell lines that are resistant tolysis by serum; for gene delivery.

Gist-Brocades Mutant penicillin WO 96/05318

Delft, Netherlands G acylases

Mutated a-lactam penicillin G acylase genes, encoded proteins,expression vectors.

Green Cross Human serum EPO 699 687

Osaka, Japan albumin

Recombinant human serum albumin produced by cells and purifiedby heating and chromatographic recovery.

Harvard Univ. FELV variants EPO 699 758

Cambridge, Mass.

Feline leukemia virus (FELV) variants; for generating cell lines toproduce defective/attenuated viruses for vaccines.

Hitachi Chemical Chlamydia EPO 699 688

Tokyo antibody

Monoclonal antibody to the major outer membrane protein ofChlamydia pneumoniae; for diagnosis.

Hoechst Cationic drug EPO 699 753

Frankfurt, Germany transport protein

Protein for the transport of xenobiotic and pharmaceuticalcompounds, encoding gene (in German).

Human Genome Sciences Human CGRP WO 96/04928

Rockville, Md. receptor

Gene for human calcitonin gene related peptide (CGRP) receptor,encoded protein; for antagonist screening and therapy.

Human Genome Sciences Human WO 96/05221

Rockville, Md. calcitonin receptor

Gene for human calcitonin receptor, encoded protein; for antagonistscreening and therapeutic development.

Human Genome Sciences Human WO 96/05225

Rockville, Md. adrenergic receptor

Gene for human adrenergic receptor, encoded protein; for identifyingagonists and antagonists.

Human Genome Sciences Human C5a WO 96/05226

Rockville, Md. receptor

Gene for human C5a receptor, encoded protein; for identifyingagonists and antagonists.

Human Genome Sciences Human WO 96/05856 &

Rockville, Md. chemokines 06169

Genes for human chemokines, encoded proteins; for identifyingantagonists and treating inflammation.

Immuno Encephalitis EPO 698 665

Vienna, Austria virus clone

Cloned tick-borne infectious encephalitis virus, its preparation; forvaccine production (in German).

Immunogen Bcl-Y apoptosis WO 96/05232

Cambridge, Mass. gene

Gene for Bcl-Y protein, encoded protein, antibodies, expressionvectors; for preventing apoptosis.

Immunomedics Lymphoma/ WO 96/04925

Morris Plains, N.J. leukemia immunoconjugates

Immunoconjugates of cytotoxic agents and humanized antibodies toB cell lymphomas and leukemias; for cancer therapy.

INSERM (Natl. Inst. Heart attack WO 96/05324

Hlth. Med. Res.) assay


In vitro detection of a predisposition for heart attacks usingcorrelated polymorphisms in angiotensin genes.

Karo Bio Orphan receptor WO 96/05300

Huddinge, Sweden

Gene for OR-1, an orphan receptor belonging to the nuclear receptorfamily; encoded protein.

Kyowa Hakko Kogyo MxA WO 96/05230

Tokyo antibodies

Monoclonal antibody against the human protein MxA, hybridomacell line; for viral infection diagnosis.

La Jolla Cancer Res. Fdn. Retinoblastoma WO 96/06168

La Jolla, Calif. zinc fingers

Retinoblastoma protein-interacting zinc finger proteins, encodinggenes; for modulating cell growth.

Eli Lilly BK enhancer EPO 699 764

Indianapolis vectors

Eukaryotic expression vectors with the BK virus enhancer; for humanprotein C production.

Mass. Gen. Hosp. Chemotherapy WO 96/04789

Boston sensitization

Viral vectors with cytochrome P450 gene; for transfection into braincancer cells and sensitization to chemotherapy.

Mass. Gen. Hosp. Breast cancer WO 96/05322

Boston chloride channel

Chloride channel protein from human breast cancer cells; fordetection and diagnosis of breast cancer.

Mass. Gen. Hosp. Transplantation WO 96/06165

Boston tolerance

Pig cells genetically engineered to induce immunological tolerance;for xenograft transplantation.

Max Planck Inst. Lyme disease WO 96/05313

Heidelberg, Germany antigen

Borrelia burgdorferi antigen OspG, encoding gene; for diagnosis andprevention of Lyme disease.

MRC (Med. Res. Counc.) Zinc finger WO 96/06166

London DNA libraries

DNA libraries encoding zinc finger binding domains; for display onparticles and targeting specific sequences.

Mitsubishi Chemical Hepatitis C EPO 699 751

Tokyo antisense

Antisense compounds complementary to hepatitis C virus; forinhibiting translation and use as an antiviral agent.

Molec. Immunol. Ctr. Humanized EPO 699 755

Havana antibodies

Modified chimeric antibodies that are less immunogenic to humans,coding sequences for these antibodies.

Myriad Genetics BRCA1 EPO 699 754; WO 96/

Salt Lake City mutant alleles 05306-05308

Isolation and detection of mutant human breast and ovarian cancerpredisposing gene alleles (BRCA1).

NIH (Natl. Inst. Hlth.) Hepatitis C WO 96/05315

Bethesda, Md. vaccine

Envelope and core hepatitis C genes, encoded peptides; for diagnosisand vaccination.

Netherlands Inst. RSV antigens WO 96/06112

Hlth. Welfare

Lelystad, Netherlands

Antigenic peptides from G protein of respiratory syncytial virus(RSV); for diagnosis and treatment of RSV infection.

Oklahoma Med. Res. Fdn. Protein WO 96/05303

Oklahoma City C-binding protein

Gene for a transmembrane glycoprotein that binds protein C, encodedprotein; for regulating inflammation.

Pierre & Marie Curie, Univ. of HSV-1 WO 96/06176

Paris thymidine kinase

Thymidine kinase variant from type 1 herpes simplex virus (HSV-1);for blocking replication.

Rhone-Poulenc Rorer Acetylcholine WO 96/05301

Antony, France transport protein

Gene for acetylcholine vesicular transport protein and its associatedcontrol sequences, expression vector.

Rhone-Poulenc Rorer Adenoviral WO 96/05320

Antony, France glutathione peroxidase

Adenoviral-based vector with a gene for glutathione peroxidase; forutilization in therapy.

Rhone-Poulenc Rorer Restenosis gene WO 96/05321

Antony, France therapy

Adenoviral-based vector with a suicide gene useful in treatingrestenosis by gene therapy.

Rockefeller Univ. Obesity gene WO 96/05309

New York

Ob gene, encoded protein, antibodies to it; for modulating bodyweight.

Sumitomo Electric Epimorphin EPO 698 666

Osaka, Japan

Truncated and modified epimorphins, coding sequences for thesemuteins, expression vectors, production methods.

Synaptic Pharma Betaine/GABA WO 96/04790

Paramus, N.J. transporter

Gene for human betaine/GABA transporter, encoded protein, vectors;for drug screening.

Takeda G protein-coupled WO 96/05302

Osaka, Japan receptor protein

Gene for G protein-coupled receptor protein, gene probes, encodedprotein, production methods.

Teijin Trypsin-like enzyme EPO 699 763

Osaka, Japan

Gene for a trypsin-like enzyme from the trachea of human lungs,recombinant production.

Washington Univ. Single-chain WO 96/05224

St. Louis glycoprotein hormones

Single-chain forms of glycoprotein hormones; for making agonistsand antagonists.

Washington Univ. Haemophilus WO 96/05858

St. Louis vaccines

Haemophilus adherence and penetration proteins, encoding genes,antibodies to proteins; for vaccines.

_ Compiled By Chester A. Bisbee

(c) 1997 American Health Consultants. All rights reserved.