Published Feb. 28 & March 6 (EPO); Feb. 22 & 29 (WO)
Akzo Nobel Contraceptive WO 96/06113
Arnhem, Netherlands antibodies
Zona pellucida protein fragments, antibodies against these peptides;for contraception.
American Cyanamid Pig somatotropin WO 96/05311
Wayne, N.J. peptide
Biologically active pig somatotropin polypeptide; for enhancinganimal growth.
American Cyanamid Streptococcal WO 96/05859
Wayne, N.J. vaccines
Immunogenic streptococcal polysaccharide-protein conjugates; forpreparing vaccines for immunization.
Arch Develop. Corp. Dopamine WO 96/05319
Chicago producing cells
Vectors with genes for dopamine biosynthetic enzymes; fortransfection of cells and increased dopamine production.
Ariad Gene Therapeutics Expression WO 96/06111
Cambridge, Mass. obstruction
Regulated obstruction or elimination of expression of a target gene incells and organisms.
Ariad Pharma DNA-binding WO 96/06110
Cambridge, Mass. chimeras
Chimeric proteins that have at least two different DNA bindingdomains, encoding genes.
Athena Neurosciences Integrin-blocking WO 96/05304
S. San Francisco molecules
Gene for integrin-blocking molecules, encoded protein; for inhibitingleukocyte adhesion and endothelial migration.
Beckman Instruments Streptococcus WO 96/06174
Fullerton, Calif. detection kits
Gene for Streptococcus pyrogenes DNase B; for production and usein infection detection kits.
Bio Merieux Trypanosome WO 96/05312
Marcy-l'Etoile, France antigen
Trypanosoma cruzi antigen, encoding gene; for detection andtreatment of Chagas' disease.
Bio Merieux Rickettsia ribosomal WO 96/06186
Marcy-l'Etoile, France RNA
Ribosomal RNA fragments of Rickettsia bacteria; for identifyingspecies.
Boehringer Mannheim Gene therapy WO 96/05297
Mannheim, Germany minus selection
Vectors in which the gene of interest can be separated from themarker gene; for gene therapy.
Bristol-Myers Squibb Mutant cancer EPO 699 756
New York antibodies
Mutant BR96 antibodies and functional equivalents that are reactivewith human carcinomas, encoding genes.
Bristol-Myers Squibb Therapeutic EPO 699 766
New York antibody fusions
Fusion proteins of antibodies and a non-lymphokine cellular factor;for generating therapeutics.
Ciba-Geigy Antitumor WO 96/05298
Basel, Switzerland antisense oligos
Antisense oligos to S-adenosylmethionine decarboxylase; for use asan antitumor agent.
Ciba-Geigy Glutamate receptor WO 96/06167
Basel, Switzerland
Gene for human glutamate receptor, encoded protein, antibodies to it,preparation methods.
Collagen Corporation Mutated EPO 699 752
Palo Alto, Calif. procollagens
Mutated procollagen chains having an inserted proteolyticrecognition site, encoding genes; for tissue engineering.
Columbia Univ. Kaposi's-associated WO 96/06159
New York herpes
DNA sequence that is specific to Kaposi's sarcoma-associated herpesvirus, encoded protein, antibodies; for therapy.
Connaught Labs Retroviral-like WO 96/05292
Willowdale, Ont. particles
Non-infectious retroviral-like particles that have a foreign antigeninserted; for diagnosis and making antibodies.
Connaught Labs Multiply mutated WO 96/06177
Willowdale, Ont. retroviruses
Retroviruses with multiple mutations; for creating non-infectious,retrovirus-like particles.
Cytogen Synthetic genes WO 96/06188
Princeton, N.J.
Binding of ligands to random peptide libraries; for identifyingsynthetic genes for use in therapy.
Duke Univ. Male contraceptive WO 96/05305
Durham, N.C.
Amino terminal peptide domain of sperm-specific tyrosine kinase; forcontraception.
Environmental Res. Inst. Hybridoma IL-5 WO 96/06162
Tokyo mRNA
Hybridoma that expresses interleukin (IL)-5 mRNA but does notmake IL-5; for drug screening.
Garvan Inst. Med. Res. Bone-specific WO 96/05299
Darlinghurst, Australia expression
Vector with sequences causing bone-specific expression; forscreening bone therapeutics in cells and transgenics.
Genetic Therapy Resistant retroviral WO 96/04934
Gaithersburg, Md. vectors
Retroviral vectors made by producer cell lines that are resistant tolysis by serum; for gene delivery.
Gist-Brocades Mutant penicillin WO 96/05318
Delft, Netherlands G acylases
Mutated a-lactam penicillin G acylase genes, encoded proteins,expression vectors.
Green Cross Human serum EPO 699 687
Osaka, Japan albumin
Recombinant human serum albumin produced by cells and purifiedby heating and chromatographic recovery.
Harvard Univ. FELV variants EPO 699 758
Cambridge, Mass.
Feline leukemia virus (FELV) variants; for generating cell lines toproduce defective/attenuated viruses for vaccines.
Hitachi Chemical Chlamydia EPO 699 688
Tokyo antibody
Monoclonal antibody to the major outer membrane protein ofChlamydia pneumoniae; for diagnosis.
Hoechst Cationic drug EPO 699 753
Frankfurt, Germany transport protein
Protein for the transport of xenobiotic and pharmaceuticalcompounds, encoding gene (in German).
Human Genome Sciences Human CGRP WO 96/04928
Rockville, Md. receptor
Gene for human calcitonin gene related peptide (CGRP) receptor,encoded protein; for antagonist screening and therapy.
Human Genome Sciences Human WO 96/05221
Rockville, Md. calcitonin receptor
Gene for human calcitonin receptor, encoded protein; for antagonistscreening and therapeutic development.
Human Genome Sciences Human WO 96/05225
Rockville, Md. adrenergic receptor
Gene for human adrenergic receptor, encoded protein; for identifyingagonists and antagonists.
Human Genome Sciences Human C5a WO 96/05226
Rockville, Md. receptor
Gene for human C5a receptor, encoded protein; for identifyingagonists and antagonists.
Human Genome Sciences Human WO 96/05856 &
Rockville, Md. chemokines 06169
Genes for human chemokines, encoded proteins; for identifyingantagonists and treating inflammation.
Immuno Encephalitis EPO 698 665
Vienna, Austria virus clone
Cloned tick-borne infectious encephalitis virus, its preparation; forvaccine production (in German).
Immunogen Bcl-Y apoptosis WO 96/05232
Cambridge, Mass. gene
Gene for Bcl-Y protein, encoded protein, antibodies, expressionvectors; for preventing apoptosis.
Immunomedics Lymphoma/ WO 96/04925
Morris Plains, N.J. leukemia immunoconjugates
Immunoconjugates of cytotoxic agents and humanized antibodies toB cell lymphomas and leukemias; for cancer therapy.
INSERM (Natl. Inst. Heart attack WO 96/05324
Hlth. Med. Res.) assay
Paris
In vitro detection of a predisposition for heart attacks usingcorrelated polymorphisms in angiotensin genes.
Karo Bio Orphan receptor WO 96/05300
Huddinge, Sweden
Gene for OR-1, an orphan receptor belonging to the nuclear receptorfamily; encoded protein.
Kyowa Hakko Kogyo MxA WO 96/05230
Tokyo antibodies
Monoclonal antibody against the human protein MxA, hybridomacell line; for viral infection diagnosis.
La Jolla Cancer Res. Fdn. Retinoblastoma WO 96/06168
La Jolla, Calif. zinc fingers
Retinoblastoma protein-interacting zinc finger proteins, encodinggenes; for modulating cell growth.
Eli Lilly BK enhancer EPO 699 764
Indianapolis vectors
Eukaryotic expression vectors with the BK virus enhancer; for humanprotein C production.
Mass. Gen. Hosp. Chemotherapy WO 96/04789
Boston sensitization
Viral vectors with cytochrome P450 gene; for transfection into braincancer cells and sensitization to chemotherapy.
Mass. Gen. Hosp. Breast cancer WO 96/05322
Boston chloride channel
Chloride channel protein from human breast cancer cells; fordetection and diagnosis of breast cancer.
Mass. Gen. Hosp. Transplantation WO 96/06165
Boston tolerance
Pig cells genetically engineered to induce immunological tolerance;for xenograft transplantation.
Max Planck Inst. Lyme disease WO 96/05313
Heidelberg, Germany antigen
Borrelia burgdorferi antigen OspG, encoding gene; for diagnosis andprevention of Lyme disease.
MRC (Med. Res. Counc.) Zinc finger WO 96/06166
London DNA libraries
DNA libraries encoding zinc finger binding domains; for display onparticles and targeting specific sequences.
Mitsubishi Chemical Hepatitis C EPO 699 751
Tokyo antisense
Antisense compounds complementary to hepatitis C virus; forinhibiting translation and use as an antiviral agent.
Molec. Immunol. Ctr. Humanized EPO 699 755
Havana antibodies
Modified chimeric antibodies that are less immunogenic to humans,coding sequences for these antibodies.
Myriad Genetics BRCA1 EPO 699 754; WO 96/
Salt Lake City mutant alleles 05306-05308
Isolation and detection of mutant human breast and ovarian cancerpredisposing gene alleles (BRCA1).
NIH (Natl. Inst. Hlth.) Hepatitis C WO 96/05315
Bethesda, Md. vaccine
Envelope and core hepatitis C genes, encoded peptides; for diagnosisand vaccination.
Netherlands Inst. RSV antigens WO 96/06112
Hlth. Welfare
Lelystad, Netherlands
Antigenic peptides from G protein of respiratory syncytial virus(RSV); for diagnosis and treatment of RSV infection.
Oklahoma Med. Res. Fdn. Protein WO 96/05303
Oklahoma City C-binding protein
Gene for a transmembrane glycoprotein that binds protein C, encodedprotein; for regulating inflammation.
Pierre & Marie Curie, Univ. of HSV-1 WO 96/06176
Paris thymidine kinase
Thymidine kinase variant from type 1 herpes simplex virus (HSV-1);for blocking replication.
Rhone-Poulenc Rorer Acetylcholine WO 96/05301
Antony, France transport protein
Gene for acetylcholine vesicular transport protein and its associatedcontrol sequences, expression vector.
Rhone-Poulenc Rorer Adenoviral WO 96/05320
Antony, France glutathione peroxidase
Adenoviral-based vector with a gene for glutathione peroxidase; forutilization in therapy.
Rhone-Poulenc Rorer Restenosis gene WO 96/05321
Antony, France therapy
Adenoviral-based vector with a suicide gene useful in treatingrestenosis by gene therapy.
Rockefeller Univ. Obesity gene WO 96/05309
New York
Ob gene, encoded protein, antibodies to it; for modulating bodyweight.
Sumitomo Electric Epimorphin EPO 698 666
Osaka, Japan
Truncated and modified epimorphins, coding sequences for thesemuteins, expression vectors, production methods.
Synaptic Pharma Betaine/GABA WO 96/04790
Paramus, N.J. transporter
Gene for human betaine/GABA transporter, encoded protein, vectors;for drug screening.
Takeda G protein-coupled WO 96/05302
Osaka, Japan receptor protein
Gene for G protein-coupled receptor protein, gene probes, encodedprotein, production methods.
Teijin Trypsin-like enzyme EPO 699 763
Osaka, Japan
Gene for a trypsin-like enzyme from the trachea of human lungs,recombinant production.
Washington Univ. Single-chain WO 96/05224
St. Louis glycoprotein hormones
Single-chain forms of glycoprotein hormones; for making agonistsand antagonists.
Washington Univ. Haemophilus WO 96/05858
St. Louis vaccines
Haemophilus adherence and penetration proteins, encoding genes,antibodies to proteins; for vaccines.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.