Ferroptosis, an iron-dependent cell death mechanism driven by unrestricted lipid peroxidation in the plasma membrane, is an emerging therapeutic target for cancer treatment. The lipid metabolism determines ferroptotic responses, but the lipid remodeling mechanism that determines sensitivity to ferroptosis and the function of phospholipid transporters in this mechanism remain unclear. To shed light on these questions, scientists from Guangzhou Medical University and colleagues have systematically measured the expression of 49 genes encoding phospholipid transporters (phospholipid scramblases, flippases and floppases) during ferroptosis.