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BioWorld - Monday, December 11, 2023
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Clinical trial virtual display

Three phase IIIs: BMS, Merck and Sanofi release new cancer data

Dec. 7, 2023
By Lee Landenberger
No Comments
Three giants have produced new phase III study data for their already approved, big name therapies. Two were positive and the third was stopped for futility.
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Bladder cancer illustration
Cancer

Ractigen files to begin phase I study in Australia with saRNA drug candidate for bladder cancer

Dec. 7, 2023
No Comments
Ractigen Therapeutics Co. Ltd. has submitted a clinical trial application in Australia seeking to conduct a phase I study of RAG-01, a small activating RNA (saRNA) drug candidate, in patients with non-muscle-invasive bladder cancer who have not responded to Bacillus Calmette-Guérin (BCG) therapy.
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Cancer

Janssen Pharmaceutica describes new MAP3K14 inhibitors for cancer

Dec. 7, 2023
No Comments
Janssen Pharmaceutica NV had disclosed new pyrrolidinone derivatives acting as NF-κB-inducing kinase (NIK; MAP3K14) inhibitors and reported to be useful for the treatment of cancer.
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Cancer

GT Apeiron Therapeutics identifies new kinesin-like protein KIF18A inhibitors

Dec. 7, 2023
No Comments
Kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer have been detailed in a recent GT Apeiron Therapeutics patent.
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Cancer

MC2 receptor ligands reported in Radionetics Oncology patent

Dec. 7, 2023
No Comments
Radionetics Oncology Inc. has patented new melanocortin MC2 receptor ligands reported to be useful for the diagnosis and treatment of cancer.
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Cancer

Biotheryx discloses new CDK protein degraders

Dec. 7, 2023
No Comments
Biotheryx Inc. has developed new proteolysis targeting chimeras (PROTACs) comprising a E3 ubiquitin ligase binding moiety covalently bonded to a CDK protein-targeting moiety through a linker.
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Arvinas, Pfizer broaden scope of ER-targeting therapy after impressive phase Ib breast cancer readout

Dec. 6, 2023
By Jennifer Boggs
No Comments
While early stage and involving a relatively small patient population, the interim phase Ib readout from the combination cohort testing estrogen receptor (ER)-targeting candidate vepdegestrant in combination with CDK4/6 inhibitor Ibrance (palbociclib) in heavily pretreated patients with ER-positive/HER2-negative breast cancer was impressive enough to prompt partners Arvinas Inc. and Pfizer Inc. to expand development work on the program. The results also struck a chord on the Street, with shares of Arvinas (NASDAQ:ARVN) gaining 31% on the day.
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Antibodies

Celltrion, Cyron ink $882M deal for polyspecific antibodies

Dec. 6, 2023
By Marian (YoonJee) Chu
No Comments
South Korean pharmaceuticals Celltrion Inc. and Cyron Therapeutics Co. Ltd. are teaming up to discover and develop bispecific and trispecific antibodies, collectively called polyspecific antibodies, under the ₩1.158 trillion (US$882.38 million) joint research agreement inked on Dec. 6. Under the terms, privately held Daegu-based Cyron will discover and develop at least three polyspecific antibodies for blood and solid cancers pre-selected by Incheon-based Celltrion via Cryon’s CD-3 targeting T-cell engager platform that helps engage T cells to attack cancer cells.
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Genentech’s inavolisib improves survival for PIK3CA-mutated breast cancer

Dec. 5, 2023
By Karen Carey
No Comments
The oral drug inavolisib, when added to two other therapies, significantly improved progression-free survival in the first-line phase III treatment of advanced hormone receptor-positive, HER2-negative breast cancer in which patients have a PIK3CA mutation.
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Replimune’s lead candidate misses two phase II endpoints

Dec. 5, 2023
By Lee Landenberger
No Comments
Replimune Group Inc.’s lead candidate, RP-1 (vusolimogene oderparepvec), took a solid hit as it missed both primary endpoints in the Cerpass phase II study of skin cancer. Despite some better results from the study and good news from other studies along with a plan to drop some programs, the company’s stock still suffered.
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