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BioWorld - Sunday, October 1, 2023
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

Flare Therapeutics divulges new PPARγ inverse agonists for treatment of bladder cancer

Sep. 29, 2023
No Comments
Flare Therapeutics Inc. has patented peroxisome proliferator-activated receptor γ (PPARγ, PPARG) inverse agonists reported to be useful for the treatment of bladder cancer.
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Immuno-oncology

Firefly Bio patents new antibody-drug conjugates

Sep. 29, 2023
No Comments
Researchers at Firefly Bio Inc. have prepared antibody-drug conjugates (ADCs) comprising monoclonal antibodies targeting HER2 covalently linked to stimulator of interferon genes protein (STING; TMEM173) agonists through a linker. They are reported to be useful for the treatment of cancer, autoimmune disease, inflammation and infections.
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Test tube, dropper
Cancer

FHND-5071, a novel RET kinase inhibitor with promising preclinical metabolism and PK characteristics

Sep. 29, 2023
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Researchers from Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd. and affiliated organizations have published preclinical data for the novel rearranged during transfection (RET) kinase inhibitor, FHND-5071.
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Cancer

NOTCH1 rearrangements as targetable feature of reninoma tumors

Sep. 29, 2023
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Reninomas are rare renin-secreting kidney tumors, resulting from a neoplastic expansion of juxtaglomerular cells of the kidney, which are cells that regulate blood pressure via the secretion of renin. Based on previous research that has proposed a central role for NOTCH1 signaling in the regulation of renin secretion by juxtaglomerular cells, researchers from Wellcome Sanger Institute, University of Cambridge, and affiliated organizations aimed to investigate the role of NOTCH1 in reninoma.
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Cancer

Insilico Medicine prepares and tests new DGK-α inhibitors

Sep. 28, 2023
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Several Insilico Medicine Inc. patents describe diacylglycerol kinase α (DGK-α, DGKA) inhibitors reported to be useful for the treatment of cancer and viral infection.
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Cancer

Sichuan Huiyu Pharmaceuticals reports PI3K and/or KRAS inhibitors

Sep. 28, 2023
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Sichuan Huiyu Pharmaceuticals Co. Ltd. and Sichuan Huiyu Seacross Pharma Technology Ltd. have jointly described new phosphatidylinositol 3-kinase (PI3K) and/or GTPase KRAS (G12C mutant) inhibitors reported to be useful for the treatment of cancer and autoimmune diseases.
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Cancer

Novel benzofuran derivative with relevant anticancer properties reported

Sep. 28, 2023
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Researchers from the University of Minnesota and collaborators have synthesized and evaluated a novel series of antiproliferative benzofuran derivatives that led to the identification of [I] as the most potent candidate.
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Conceptual image for brain cancer treatment
Immuno-oncology

Grant supports Pathios Therapeutics’ development of small-molecule GPR65 inhibitors for malignant brain tumors

Sep. 28, 2023
No Comments
Pathios Therapeutics Ltd. has been awarded a £567,000 (~US$727,000) grant from the U.K. Government’s innovation agency, Innovate UK, that will enable the company to expand its development of novel small-molecule GPR65 inhibitors into the area of malignant brain tumors.
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Breast cancer cells.
Cancer

Selective HDAC3 inhibitor with potent antitumor activity in TNBC models

Sep. 28, 2023
No Comments
Researchers from Birla Institute of Technology & Science, Pilani and Jadavpur University have reported novel HDAC3 inhibitors as potential candidates for the treatment of breast cancer. Synthesis and optimization of a series of pyrazino-hydrazide-based HDAC3 inhibitors led to the characterization of compound [I] as the lead candidate with potent HDAC3 inhibitory activity (IC50=14 nM) and at least 121-fold selectivity.
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Cervical cancer cell
Immuno-oncology

Lenti-HPV-07 vaccine achieves complete HPV-induced tumor eradication in the preclinical setting

Sep. 28, 2023
No Comments
Among all human papillomavirus (HPV) types described so far, the two most abundant – HPV16 and HPV18 – are responsible for 71% of all cervical cancers. The vaccines currently used are effective in preventing viral infection, but have no effect on already infected or maligned cells.
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