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BioWorld - Friday, September 22, 2023
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

Satyarx Pharma patents new RAD51 inhibitors for cancer

Sep. 20, 2023
No Comments
Satyarx Pharma Innovations Pvt Ltd. has disclosed novel bicyclic compounds acting as DNA repair protein RAD51 homolog 1 inhibitors reported to be useful for the treatment of cancer.
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Diagnostics

[68Ga]PF-381, a radiolabeled peptide for early detection of CD38-positive lymphomas

Sep. 20, 2023
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The discovery of new 68Ga-labeled CD38-targeted peptides for PET imaging was recently discussed by researchers from Peking University First Hospital and China National Center For Nanoscience & Technology.
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Illustration of pill being analyzed
Drug Design, Drug Delivery & Technologies

Benevolentai and Merck KGaA enter drug discovery and development collaboration

Sep. 20, 2023
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Benevolentai Ltd. has signed a strategic collaboration with Merck KGaA to identify novel drug candidates, initially for three targets in oncology, neurology and immunology.
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Lab glassware and scientist
Cancer

Rohitukine-N-oxide styryl derivatives inhibit CDK9/T1 and the growth of cancer cell lines

Sep. 20, 2023
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Rohitukine is a chromone alkaloid with antiproliferative, anti-inflammatory, and immunomodulatory activities. Although several rohitukine derivatives are being investigated as potent anticancer leads, the potential antitumor activity of the naturally occurring rohitukine-N-oxide has yet to be evaluated.
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Stem cell-derived vertebral bone with recruited breast cancer tumor cells
Musculoskeletal

The skeletal stem cell contains multitudes, with translational implications

Sep. 20, 2023
By Anette Breindl
No Comments
Long bones, vertebrae and skull bones have distinct types of stem cells, and new insights into those stem cells could lead to new ways to treat both rare developmental disorders of skull formation and the all-too-common phenomenon of bone metastases. Scientifically, the work, which was published in two papers by Matthew Greenblatt and colleagues in Nature, adds to the increasing understanding of bone’s complexities. “Bone may serve as an endocrine organ that is secreting factors throughout the body,” Greenblatt said.
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Gold dollar sign inside gold cog

Pass the (molecular) glue: Magnet school teaches new way with $50M series A

Sep. 19, 2023
By Randy Osborne
No Comments
Magnet Biomedicine Inc. emerged from stealth mode and pulled down a $50 million series A round co-led by founding investor Newpath Partners alongside Arch Venture Partners. The firm is advancing molecular glue discovery by way of rational selection and design, looking past known protein-protein interactions and what Magnet calls “tangential” degradation approaches to analyze the broader protein landscape and ultimately pair targets with rationally chosen presenters in the tissue where the disease manifests.
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Dendrimer illustration

Starpharma’s dendrimer platform delivers impressive results in bowel, ovarian cancer

Sep. 19, 2023
By Tamra Sami
No Comments
Starpharma Holdings Ltd.'s nanoscale drug delivery technology shows enhanced safety and durable responses in phase II trials compared to standard of care therapies in patients with advanced colorectal and ovarian cancer.
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Mantle cell lymphoma
Cancer

Lantern’s LP-284 cleared by FDA to enter clinic for NHL

Sep. 19, 2023
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Lantern Pharma Inc. has received FDA clearance of its IND application for LP-284, being developed for the treatment of relapsed or refractory non-Hodgkin lymphoma (NHL), including mantle cell lymphoma, double hit lymphoma and other high-grade B-cell lymphomas. Enrollment in a first-in-human phase I trial is expected to begin during the fourth quarter of this year. 
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Cancer

Chinese researchers discover new TYK2 inhibitors

Sep. 19, 2023
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Ennovabio (Zhejiang) Pharmaceuticals Co. Ltd. and Shanghai Ennova Biopharmaceutical Co. Ltd. have described 5-membered and 6-membered heterocyclic compounds acting as non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of cancer, viral infection, transplant rejection, cardiovascular and inflammatory disorders, and autoimmune, myeloproliferative and metabolic diseases.
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Cancer

Medshine Discovery presents new HIF-2α inhibitors for cancer

Sep. 19, 2023
No Comments
Medshine Discovery Inc. has divulged hypoxia inducible factor 2α (HIF-2α; EPAS1) inhibitors reported to be useful for the treatment of cancer.
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