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BioWorld - Tuesday, December 9, 2025
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Australian coins and bills

Kazia raises AU$50M to advance PI3K/mTOR inhibitor paxalisib

Dec. 5, 2025
By Tamra Sami
No Comments
Kazia Therapeutics Ltd. raised AU$50 million (US$33.15 million) in a private placement of equity securities to advance lead candidate paxalisib, a brain-penetrant dual PI3K/mTOR inhibitor in clinical trials for brain cancer and advanced breast cancer.
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Green and red bispecific antibodies

Crescent, Kelun in two-way deal, including PD-1/VEGF bispecific

Dec. 5, 2025
By Marian (YoonJee) Chu
No Comments
Crescent Biopharma Inc. teamed with Sichuan Kelun-Biotech Biopharmaceutical Co. Ltd. to generate “parallel” data of its PD-1/VEGF bispecific antibody, CR-001. The goal is to get 2027 readouts of the bispecific as a monotherapy and as a combination therapy with antibody-drug conjugates in both the U.S. and China.
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Blue test tubes and dropper

Natera envisions cancer-testing future with $450M Foresight buy

Dec. 5, 2025
By Annette Boyle
Natera Inc. completed the acquisition of Foresight Diagnostics Inc. in a deal structured as $275 million up front plus contingent payments of up to $175 million based on achieving certain milestones for revenue and reimbursement coverage. The companies expect to close the transaction in the second quarter of 2026.
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Invest compass

Cancer blood test maker Freenome going public with $330M SPAC

Dec. 5, 2025
By Holland Johnson
Freenome Holdings Inc. reported it is going public via a special purpose acquisition company. The company said it expects to raise $330 million, which it plans to use for the 2026 launch of its blood-based screening tests for multiple cancers. Backed by an affiliate of Perceptive Advisors - Perceptive Capital Solutions Corp. (PCSP) – and joined by RA Capital, the arrangement includes a commitment of $240 million in equity investments plus about $90 million more held by the SPAC’s trust fund. Other notable investors, including ADAR1 Capital, Bain Capital Life Sciences, and Farallon Capital Management have signed on to participate in the deal.

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3D Euro symbol
Immuno-oncology

Laigo raises €11.5M seed money for targeted protein degradation

Dec. 5, 2025
By Nuala Moran
No Comments
Laigo Bio BV has raised €11.5 million (US$13.7 million) in a seed round for the further development of a new approach to inducing targeted protein degradation by E3 ubiquitin ligases.
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Cancer

Synnovation Therapeutics discovers new NRF2 inhibitors

Dec. 5, 2025
Synnovation Therapeutics Inc. has described heterocyclic compounds acting as nuclear factor erythroid 2-related factor 2 (NFE2-related factor 2; NFE2L2; NRF2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

New FGFR3 inhibitors disclosed in Onco3r Therapeutics patent

Dec. 5, 2025
Onco3r Therapeutics BV has divulged fibroblast growth factor receptor 3 (FGFR3) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Shandong Luye Pharmaceutical describes new salts of CDK2/cyclin E1 inhibitors

Dec. 5, 2025
Shandong Luye Pharmaceutical Co. Ltd. has identified salts of CDK2/cyclin E1 inhibitors reported to be useful for the treatment of cancer.
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Immuno-oncology

Lanova Medicines divulges new STn-targeting ADCs

Dec. 5, 2025
Lanova Medicines Ltd. has synthesized antibody-drug conjugates (ADCs) comprising antibodies targeting sialyl-Tn antigen (STn) linked to an exatecan derivative through a linker reported to be useful for the treatment of cancer.
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Cancer

Wigen Biomedicine patents new PI3Kα inhibitors

Dec. 5, 2025
Wigen Biomedicine Technology (Shanghai) Co. Ltd. has disclosed phosphatidylinositol 3-kinase α (PI3Kα) inhibitors reported to be useful for the treatment of solid cancers and hematological cancers.
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