Prelude’s JAK2 V617F inhibitor PRT-12396 gains IND clearance

Feb. 4, 2026

Prelude Therapeutics Inc. has received IND clearance from the FDA for PRT-12396, a mutant-selective JAK2 V617F inhibitor being developed for the treatment of patients with certain myeloproliferative neoplasms.

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Illustration of SCAN in Parkinson’s vs healthy subcortex

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BioWorld Science

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BioWorld Science

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