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BioWorld - Thursday, June 8, 2023
Home » Topics » Cardiovascular, BioWorld Asia

Cardiovascular, BioWorld Asia
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Heartseed raises ¥2B to continue trials of iPSC-derived cardiomyocytes for heart failure

May 30, 2023
By Tamra Sami
No Comments
Heartseed Inc. raised ¥2 billion (US$14.3 million) in a series D round to continue the phase I/II Lapis trial of its allogeneic induced pluripotent stem cell (iPSC)-derived cardiomyocytes for heart failure. The lead asset, HS-001, is an investigational cell therapy consisting of clusters of purified heart muscle cells (cardiomyocyte spheroids) derived from iPSCs that are designed to restore heart muscle and function in patients with advanced heart failure.
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Lianbio garners first Asian approval for Camzyos in Macau for hypertrophic cardiomyopathy

May 16, 2023
By Tamra Sami
No Comments
Lianbio Co. Ltd. gained its first Asian approval in Macau for Camzyos (mavacamten/Myokardia Inc.) for treating adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). The company in-licensed mavacamten rights from Myokardia, now a wholly owned subsidiary of Bristol Myers Squibb Co., in August 2020 for developing and commercializing mavacamten in mainland China, Hong Kong, Macau, Taiwan, Thailand and Singapore. Mavacamten was granted breakthrough therapy designation in China in February 2022 for patients with oHCM.
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US FDA resets review clock for Cyclopharm’s Technegas for pulmonary embolism

April 25, 2023
By Tamra Sami
No Comments
After receiving a U.S. FDA complete response letter nearly two years ago, Cyclopharm Ltd. said the agency has accepted its response and reset the clock for the NDA review of its Technegas combination product for pulmonary embolisms, with a new PDUFA date set for Sept. 29.
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Transthera raises $38M, propelling TT-0420 toward market

Feb. 28, 2023
By Doris Yu
No Comments
Transthera Sciences Inc., a Nanjing, China-based company developing small-molecule therapies in cancer, inflammation and cardiovascular disease, raised ¥260 million (US$38 million) in a series D+ funding round to advance its first drug product.
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Ji Xing obtains global rights to cardiovascular candidate from Phasebio

Feb. 14, 2023
By Doris Yu
No Comments
In its first worldwide licensing deal in the cardiovascular space, Ji Xing Pharmaceuticals Ltd. acquired rights to preclinical-stage PB-6440, in development for diseases including hypertension, from Phasebio Pharmaceuticals Inc.
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Structure Therapeutics nets $33M in financing for GPCR candidates

Aug. 9, 2022
By Doris Yu
No Comments
Structure Therapeutics Inc. raised $33 million in a financing round to speed up clinical trials of its lead assets targeting chronic diseases and to improve its technology platform. Previously known as Shouti Inc., the company also has rebranded itself as Structure to “reflect its foundation in structural biology and computational design.”
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Arrowhead and Vivo co-launch firm in China with $60M investment

May 3, 2022
By Doris Yu
No Comments
Arrowhead Pharmaceuticals Inc. and Vivo Capital LLC have launched a joint venture named Visirna Therapeutics for RNA interference therapeutics in the greater China market. Arrowhead is the majority shareholder of the new entity, while Vivo invested $60 million in the new entity.
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Salubris raises $32M to continue work on cardiovascular candidate

March 15, 2022
By Doris Yu
No Comments
Salubris Biotherapeutics Inc. has raised $32 million in financing from its parent company, Shenzhen Salubris Pharmaceuticals Co. Ltd., for the development of its cardiovascular candidate. Funds will be used to continue efforts in an ongoing phase Ib trial and to initiate two additional phase Ib studies in 2022, as well as to expand the company’s pipeline.
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Ji Xing acquires rights to heart failure treatment from Cytokinetics in $400M deal

Dec. 28, 2021
By Doris Yu
No Comments
RTW Investments LP-backed Ji Xing Pharmaceuticals Ltd. has acquired greater China rights to Cytokinetics Inc.’s omecamtiv mecarbil in a deal worth up to $400 million.
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Mesoblast’s new subgroup analysis brings needed jolt to revive heart failure study

Dec. 14, 2021
By Tamra Sami
No Comments
PERTH, Australia – Stem cell therapy company Mesoblast Ltd. provided new subgroup analyses from its phase III advanced chronic heart failure trial showing a greater treatment benefit from rexlemestrocel-L in high-risk patients with chronic heart failure and low ejection fraction (HFrEF) with diabetes or ischemia.
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