All Clarivate websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.

More information on our cookie policy.

BioWorld. Link to homepage.

Clarivate
  • BioWorld
  • BioWorld MedTech
  • BioWorld Asia
  • BioWorld Science
  • Data Snapshots
    • BioWorld
    • BioWorld MedTech
  • Special reports
    • Aging
    • Biosimilars
    • Artificial intelligence
    • Coronavirus
    • IVDs on the rise
    • Science '22 in Review
    • Top Biopharma Trends of 2022
    • Top Med-tech Trends of 2022
    • Premium reports
      • BioWorld Financings Reports
      • Disease Incidence & Prevalence Summaries

BioWorld. Link to homepage.

  • sign in
  • Sign Out
  • My Account
Subscribe
BioWorld - Monday, March 27, 2023
Home » Topics » Ear, Nose and Throat, BioWorld Science

Ear, Nose and Throat, BioWorld Science
Ear, Nose and Throat, BioWorld Science RSS Feed RSS

Man holding hand up to ear
Ear, Nose & Throat

Researchers create humanized mouse model for DFNA9 carrying the p.P51S variant of COCH gene

Feb. 22, 2023
No Comments
Researchers from the University of Antwerp reported the characterization of a novel clinically relevant mouse model of DFNA9 (deafness, autosomal dominant 9), an autosomal dominant inherited disorder characterized by vestibular dysfunction and adult-onset progressive hearing loss caused by different heterozygous mutations in the COCH gene.
Read More
Lab mouse
Ear, Nose and Throat

WFS1 gene plays crucial roles in cochlear maintenance and hair cell survival, murine model shows

Feb. 20, 2023
No Comments
Wolfram syndrome is a neurodegenerative disease characterized by neurological symptoms, as well as diabetes, optic atrophy and hearing loss, among others. The WFS1 gene encodes a protein named Wolframin and it accounts for about 99% of cases, 60% of which present with hearing loss. To date, of all animal models of Wolfram syndrome developed carrying a variant or deletion of one exon of Wfs1, none mimics the early-onset hearing loss.
Read More
Illustration demonstrating parts of the ear
Biomarkers

CEP250 gene variant found behind non-syndromic hearing loss

Feb. 20, 2023
No Comments
The CEP250 gene encodes centrosome-associated protein CEP250, involved in the formation of active centrosome components and cell cycle progression. CEP250 has been previously implicated in atypical Usher syndrome, which is characterized by early-onset hearing loss and mild retinitis pigmentosa.
Read More
Induced pluripotent stem cells
Ear, Nose & Throat

New patient-derived iPSC line and humanized mouse model of TMEM43-associated hearing loss

Feb. 17, 2023
No Comments
The TMEM43 gene encodes a transmembrane protein that is associated with connexin-linked function in cochlear glia-like supporting cells (GLSs), and mutations in this gene have been recently associated with hearing loss (HL).
Read More
Ear illustration
Ear, Nose & Throat

Improved hearing loss in gerbils upon AC-102 cochlear implantation

Feb. 16, 2023
No Comments
To restore hearing function in patients with hearing loss or deafness, cochlear implantation is seen as the only method that works, but insertion of the electrode array may cause direct mechanical injury to the cochlea, with the subsequent loss attributed to an inflammatory response driven by proinflammatory cytokines, reactive oxygen species and apoptotic signals.
Read More
Man holding hand up to ear
Ear, Nose & Throat

SENS-501 demonstrates preliminary safety and efficacy in preclinical models

Feb. 16, 2023
No Comments
Otoferlin is a calcium sensor protein critical for the transmission of the signal from inner hair cells (IHCs) to the spiral ganglion neurons (SGNs), and it is encoded by the OTOF gene. Pathogenic biallelic loss of function variations in OTOF result in failure of synaptic transmission, causing autosomal recessive deafness 9 (DFNB9), which is a congenital severe-to-profound auditory neuropathy.
Read More
Ear and sound waves illustration
Ear, Nose and Throat

Kv7.4 activator ACOU-082 prevents age-related hearing loss, study shows

Feb. 15, 2023
No Comments
Hearing loss related to aging is mostly predicted by the degree of loss of outer hair cells. Investigators from Acousia Therapeutics GmbH have tested the novel Kv7.4 channel activator ACOU-082 in mice.
Read More
Illustration demonstrating parts of the ear
Biomarkers

Study reveals new risk loci for otosclerosis

Jan. 26, 2023
No Comments
Otosclerosis affects about 0.3% of population and it is among the most common cause of conductive hearing loss. Otosclerosis is highly familial, with positive family history reported in about 50% to 60% of cases. The disease is characterized by pathologic remodeling of the bone encasing the inner ear (otic capsule).
Read More
Doctor looking in child's ear
Ear, Nose and Throat

Decibel receives CTA clearance in UK for DB-OTO for otoferlin-related hearing loss

Jan. 25, 2023
No Comments
Decibel Therapeutics Inc. has received clearance of its clinical trial application (CTA) by the U.K.'s Medicines and Healthcare products Regulatory Agency (MHRA) to initiate a phase I/II trial of gene therapy DB-OTO in pediatric patients with congenital hearing loss due to an otoferlin deficiency.
Read More
Ear, Nose and Throat

FDA awards orphan drug designation to Sensorion's OTOF-GT for otoferlin gene-mediated hearing loss

Nov. 30, 2022
No Comments
The FDA has awarded orphan drug designation to Sensorion SA's OTOF-GT, a dual vector AAV gene therapy, for the treatment of otoferlin gene-mediated hearing loss.
Read More
Previous 1 2 3 4 5 6 7 8 9 … 16 17 Next

Popular Stories

  • Today's news in brief

    BioWorld
    BioWorld briefs for March 27, 2023.
  • Today's news in brief

    BioWorld MedTech
    BioWorld MedTech briefs for March 27, 2022.
  • Kirill Pevzner and Eran Seger - Protai

    AI drug discovery startup Protai raises $12M in seed funding

    BioWorld
    Artificial intelligence (AI)-powered drug discovery startup Protai Bio Ltd. raised $12 million in additional seed funding, bringing the total amount to $20...
  • Elderly woman holding illustration of brain with missing puzzle piece

    ‘Not a slowdown, a reversal’: Truebinding tackling Alzheimer’s via galectin-3

    BioWorld
    In Alzheimer’s, the amyloid beta hypothesis has proved most persistent in terms of drug development efforts to date, but aggregation of other pathogenic factors –...
  • Livzon licenses GERD drug from Onconic in $127.5M deal

    BioWorld
    Livzon Pharmaceutical Group Inc. licensed rights to zastaprazan, a gastroesophageal reflux disease (GERD) treatment candidate, from Onconic Therapeutics Inc. in a...
black cortellis ad

BioWorld Premium

Enjoy extended coverage for the most complete market view with BioWorld, BioWorld MedTech, and BioWorld Asia in a single, easy to access subscription.

Subscribe
  • BioWorld
    • Today's news
    • Analysis and data insight
    • Clinical
    • Data Snapshots
    • Deals and M&A
    • Financings
    • Newco news
    • Opinion
    • Regulatory
    • Science
  • BioWorld MedTech
    • Today's news
    • Clinical
    • Data Snapshots
    • Deals and M&A
    • Financings
    • Newco news
    • Opinion
    • Regulatory
    • Science
  • BioWorld Asia
    • Today's news
    • Analysis and data insight
    • Australia
    • China
    • Clinical
    • Deals and M&A
    • Financings
    • Newco news
    • Regulatory
    • Science
  • BioWorld Science
    • Today's news
    • Biomarkers
    • Cancer
    • Conferences
    • Endocrine/Metabolic
    • Immune
    • Infection
    • Neurology/Psychiatric
    • Patents
  • More
    • About
    • Archives
    • Article reprints and permissions
    • Contact us
    • Cookie policy
    • Copyright notice
    • Data methodology
    • Podcasts
    • Privacy policy
    • Share your news with BioWorld
    • Staff
    • Terms of use
Follow Us

Copyright ©2023. All Rights Reserved. Design, CMS, Hosting & Web Development :: ePublishing