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Home » Topics » Infection, BioWorld Science

Infection, BioWorld Science
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Candida albicans infection
Infection

Chinese scientists unveil new CYP51 inhibitor with broad-spectrum antifungal activity

July 21, 2025
No Comments
Azole antifungal agents are widely used to treat invasive fungal infections (IFIs), which are life-threatening in immunocompromised patients such as those undergoing chemotherapy, transplantation or intensive care.
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Infection

Hungarian team identifies new isochroman compounds for bacterial infections

July 18, 2025
Semmelweis University and University of Debrecen have jointly identified isochroman compounds reported to be useful for the treatment of bacterial infections.
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Microscope and coronavirus illustration
Infection

Results of ADME study of the small-molecule 3CLpro inhibitor SHEN-211

July 18, 2025
No Comments
SHEN-211 is a selective 3-chymotrypsin-like protease (3CLpro) inhibitor that can protect against SARS-CoV-2. In previous work, SHEN-211 demonstrated high efficacy in inhibiting 3CLpro (IC50=24 nM) and exhibited broad-spectrum antiviral properties.
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Vaccine vial and syringe
Infection

SK Bioscience submits IND for adjuvanted flu vaccine

July 18, 2025
No Comments
SK Bioscience Ltd. announced that the company has submitted an investigational new drug (IND) application to the South Korean Ministry of Food and Drug Safety.
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Transmission electron micrograph of HIV-1 virus particles
HIV/AIDS

IAS 2025: Cheat, parasitize, break the virus – fresh ideas fuel HIV research

July 18, 2025
No Comments
There is still no effective vaccine or cure for HIV. Scientists are considering options ranging from longer-term antiretroviral therapy (ART) that space out injections by several years to long-lasting pre-exposure prophylaxis (PrEP) that acts as a vaccine while immunization is achieved. What else can be done? The “Innovations in HIV virology: Translating discoveries into novel therapies” symposium in basic science at the 13th IAS Conference on HIV Science (IAS 2025), which took place from July 13 to 17, 2025, in Kigali, Rwanda, showcased some of the new ideas that the scientific community are developing.
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Transmission electron micrograph of HIV-1 virus particles
HIV/AIDS

IAS 2025: All eyes still on the HIV reservoir

July 16, 2025
By Mar de Miguel
No Comments
While people living with HIV can lead virtually normal lives thanks to antiretroviral therapy (ART), HIV persists in a latent state within cellular reservoirs that scientists do not know how to eliminate. “Transcription is a critical step in the viral life cycle. … But there are currently no drugs suppressing HIV transcription, and that may be one of the reasons why current antiretroviral therapy is not curative,” Melanie Ott told the audience at the 13th IAS Conference on HIV Science this week in Kigali, Rwanda.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

New mRNA vaccine demonstrates preclinical activity against emerging SARS-CoV-2 variants

July 14, 2025
No Comments
As of May 2023, the WHO recommends the use of a monovalent XBB.1 descendent lineage, such as omicron XBB.1.5, as the vaccine antigen for COVID-19 vaccines. However, BA.2.86 and its descendent lineages, such as JN.1, have emerged and rapidly spread worldwide.
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Coronavirus, lungs, hand holding stethoscope
Infection

New antisense oligonucleotide as broad-spectrum antiviral against SARS-CoV-2

July 10, 2025
No Comments
Researchers in France and Chile have developed antisense oligonucleotide ASO-N1 against the viral RNA encoding the nucleocapsid.
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Infection

Monoclonal antibody cross-neutralizes Nipah and Hendra viruses by targeting conserved regions

July 10, 2025
No Comments

Nipah (NiV) and Hendra (HeV) viruses, two closely related members of the Henipavirus genus, continue to raise global concern due to their high mortality rates and potential for zoonotic spillover. Despite repeated outbreaks, there are still no licensed antiviral treatments targeting these pathogens, either for control or prevention.


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Infection

Latvian Institute of Organic Synthesis describes new PfSUB1 inhibitors for malaria

July 9, 2025
Latvian Institute of Organic Synthesis has identified subtilisin-like protease 1 (PfSUB1) (Plasmodium falciparum) inhibitors reported to be useful for the treatment of malaria.
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