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Home » Topics » Disease categories and therapies » Ocular

Ocular
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Eye wireframe illustration
Ocular

Chinese IND clearance for anti-IGF-1R antibody NTB-003 for thyroid eye disease

June 5, 2025
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Biocytogen Pharmaceuticals (Beijing) Co. Ltd. and Nanjing Chia Tai Tianqing Pharmaceutical Co. Ltd. have announced IND clearance by China’s National Medical Products Administration (NMPA) for NTB-003 (formerly BCG-009) for thyroid eye disease.
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Ocular

New CB1 and CB2 receptor modulators disclosed in Inmed patent

May 30, 2025
Inmed Pharmaceuticals Inc. has divulged cannabinoid CB1 and/or CB2 receptor modulators reported to be useful for the treatment of neurodegeneration and age-related macular degeneration.
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Ocular

AAV8-RK-hBBS10 gene therapy restores vision in Bardet-Biedl syndrome type 10 model

May 29, 2025
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Bardet-Biedl syndrome (BBS) is a group of rare autosomal recessive ciliopathies characterized by dysfunction of primary cilia, which affects multiple organ systems and leads to early-onset obesity, progressive retinal degeneration resulting in vision loss or blindness, and renal abnormalities that may progress to renal failure. Mutations in the BBS10 gene are the second most prevalent cause of BBS, accounting for over 20% of cases.
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Ocular

BMP4 inhibition offers dual benefit in AMD: antifibrotic and antineovascularization effects

May 20, 2025
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Age-related macular degeneration (AMD) is the primary cause of blindness in people aged 65 and older in developed nations. Recent estimates suggest that, globally, the number of individuals affected by AMD could rise to approximately 288 million by 2040.
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Ocular

Neuroplastin 65 knockout disrupts visual function by altering the retina

May 14, 2025
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Researchers from Tongji University School of Medicine and collaborating institutions have discovered that NP65 plays a crucial role in maintaining normal visual function in mice. The study, published in Frontiers in Cellular Neuroscience, found that mice lacking NP65 exhibit impaired visual responses.
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Ocular

CTX-114 enhances surface binding and function of complement factor H

May 13, 2025
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Among the most significant genetic risk factors for age-related macular degeneration is the Y402H variant of complement factor H, which, along with its splice isoform FHL-1, impairs binding to the retinal surface.
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Close up of woman's bulging eyes
Ocular

Identifying NNMT as a therapeutic target in an autoimmune eye disorder

May 9, 2025
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Individuals with autoimmune diseases affecting the thyroid can suffer eye complications in the form of Graves’ orbitopathy, in which inflammation in and around the orbit leads to eyelid retraction, eye bulging and other symptoms.
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Illustration of human eye
Ocular

SBT-272 confers neuroprotection in experimental glaucoma

May 9, 2025
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The progression of neurodegeneration during experimental glaucoma is tied to the early degradation of anterograde transport along retinal ganglion cells to central brain targets, which is followed by frank optic nerve degeneration.
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Ocular

ABI-201 confers protection against age-related macular degeneration

May 8, 2025
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ABI-201 is an engineered AAV.N54 vector that expresses a soluble CD59 variant and a complement 3 (C3) inhibitor fusion protein. ABI-201 was developed by Avirmax Biopharma Inc. to confer photoreceptor protection against retinal damage. The effects of ABI-201 were tested in a sodium iodate-induced retinal damage model in nonhuman primates, a widely used model for testing therapies for age-related macular degeneration (AMD).
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Drug R&D concept image.
Ocular

Surrozen’s SZN-8141 ameliorates retinopathy in murine models

May 7, 2025
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Recent evidence has suggested that the use of norrin mimetics targeting both frizzled-4 (FZD4) and low-density lipoprotein receptor-related protein 5 (LRP5) may be highly effective at modulating retinal vascular leakage. When combined with an anti-VEGF therapy, it was hypothesized to have an additive benefit potential for treating retinal vascular disorders.
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