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Home » Topics » Drugs » CAR T

CAR T
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Immuno-oncology

Coeptis collaborates with University of Pittsburgh on SNAP-CAR T cells targeting HER2-positive cancers

Feb. 1, 2023
Coeptis Therapeutics Holdings Inc. has entered into a sponsored research agreement with the University of Pittsburgh to advance preclinical development of SNAP-CAR T cells targeting HER2, and to explore opportunities to expand the applicability of SNAP-CAR in oncology.
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Immuno-oncology

Sana receives IND clearance for CAR T-cell therapy SC-291 for B-cell malignancies

Jan. 27, 2023
Sana Biotechnology Inc. has received FDA clearance of its IND application to initiate a first-in-human study of SC-291 in patients with various B-cell malignancies. Initial clinical data from the study are expected later this year. SC-291 is a CD19-targeted allogeneic chimeric antigen receptor (CAR) T-cell therapy developed using Sana's hypoimmune platform.
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Immuno-oncology

Immpact's bispecific CAR T-cell therapy IMPT-314 cleared to enter clinic for B-cell lymphoma

Jan. 25, 2023
Immpact Bio USA Inc. has announced clearance of its IND application by the FDA for IMPT-314, a bispecific OR-Gate autologous chimeric antigen receptor (CAR) T-cell therapy targeting the B-cell antigens CD19 and CD20.
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CAR T cell attacking cancer cells
Immuno-oncology

Carina gives update on LGR5-targeted CAR T therapy for colorectal cancer

Jan. 25, 2023
Carina Biotech Pty Ltd. has received FDA...
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CAR T cell with implanted gene strand
Cancer

CD5-knockout anti-CD5 CAR T-cell product evaluated for relapsed and refractory CD5+ nodal T-cell lymphomas

Jan. 12, 2023
The relative 5-year survival for Non-Hodgkin...
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CAR T cell attacking cancer cells
Immuno-oncology

FDA clears IND for Invectys' anti-HLA-G CAR T-cell therapy IVS-3001 for solid tumors

Dec. 20, 2022
Invectys Inc. and CTMC, a joint venture between MD Anderson Cancer Center and National Resilience Inc., have announced FDA clearance of an IND application for a phase I/IIa study of IVS-3001, Invectys' lead engineered human leukocyte antigen A (HLA-G)-targeting chimeric antigen receptor (CAR) T-cell therapy for the treatment of solid tumors.
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Diagram explaining engineered CAR T cells.
Cancer

Engineering brings situational awareness to CAR T cells

Dec. 20, 2022
By Anette Breindl
Chimeric antigen receptor (CAR) T cells are astounding. In B-cell cancers, they have been transformative. Yet engineering-wise, CAR T cells are in the equivalent of the Model T era. CAR T-cell engineering has already evolved, with the addition of costimulatory domains, which affect cell expansion and signaling. But once the cells are injected into a patient, there is really no way to affect their behavior.
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Immuno-oncology

Carina submits IND application for LGR5-targeted CAR-T therapy candidate CNA-3103 for colorectal cancer

Dec. 13, 2022
Carina Biotech Pty Ltd. has submitted an IND application to the FDA to conduct a first-in-human phase I/IIa trial of CNA-3103, its LGR5-targeted chimeric antigen receptor T-cell (CAR-T) therapy candidate, in patients with advanced colorectal cancer.
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Drug Design, Drug Delivery & Technologies

Synthetic cell junctions allow tissue reconstruction

Dec. 13, 2022
By Mar de Miguel
A combination of bioengineering techniques on normal cell binding proteins could be the method of the future for selective cell binding. Scientists at the University of California, San Francisco (UCSF) have created a synthetic glue based on the expression of membrane receptors to establish the desired connection between cells. The results may be applied in different fields of cell biology or biomedicine, such as regeneration and wound repair, including the nervous system, or cancer.
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Immuno-oncology

Oncternal's autologous CAR T therapy ONCT-808 cleared to enter clinic for aggressive B-cell NHL

Oct. 4, 2022
Oncternal Therapeutics Inc. has received IND clearance from the FDA for a phase I/II study of ONCT-808.
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