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Home » Topics » Drugs » CAR T

CAR T
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CAR T cell attacking cancer cells
Immuno-oncology

‘On’ and ‘off’ switches for CAR T-cell therapies help build safety and potency

Sep. 14, 2022
By Helen Albert
A new generation of chimeric antigen receptor (CAR) T-cell therapies with advanced functions could hold the answer to improved safety and efficacy for these effective but potentially dangerous cancer therapies, shows research led by Boston University. The scientists showed it is possible to add ‘on’ or ‘off’ switches to CAR T cells, which can be activated using oral drugs with a known safety profile.
Read More
CAR T cell attacking cancer cells
Immuno-oncology

‘On’ and ‘off’ switches for CAR T-cell therapies help build safety and potency

Sep. 13, 2022
By Helen Albert
A new generation of chimeric antigen receptor (CAR) T-cell therapies with advanced functions could hold the answer to improved safety and efficacy for these effective but potentially dangerous cancer therapies, shows research led by Boston University. The scientists showed it is possible to add ‘on’ or ‘off’ switches to CAR T cells, which can be activated using oral drugs with a known safety profile.
Read More

Galapagos shifts gears with Cellpoint, Aboundbio acquisitions

June 23, 2022
By Nuala Moran
Galapagos NV is making a decisive shift away from its small-molecule roots, sealing the simultaneous acquisition of CAR T-cell therapy specialist Cellpoint BV and fully-human antibody company Aboundbio Inc. The Cellpoint deal is by far the largest, with Galapagos paying €125 million (US$132 million) cash up front, with a further €100 million to come in milestones. The price for Aboundbio of Pittsburgh, is $14 million.
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Two arrows in opposite directions

Parting shot: Bayer decides against Atara but exit wound minor

May 20, 2022
By Randy Osborne
Atara Biotherapeutics Inc. is keeping the faith and figuring out next steps with its next-generation, mesothelin-directed CAR T-cell therapies after Bayer AG ended their exclusive worldwide licensing agreement, signed in late 2020. The setup included funding and development of ATA-3271, an armored allogeneic T-cell immunotherapy, and an autologous version, ATA-2271, for high mesothelin-expressing tumors such as malignant pleural mesothelioma and non-small-cell lung cancer.
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CAR T illustration
Newco news

Inceptor Bio raises $37M to advance triplet of CAR therapies

May 19, 2022
By Michael Fitzhugh
Inceptor Bio LLC, a company developing cell therapies for difficult-to-treat cancers, has closed a $37 million series A financing led by Kineticos Ventures, the second fund founded by Inceptor CEO Shailesh Maingi. Altogether, about 40 investors have supported the company's efforts, he told BioWorld. Proceeds from the round, which follows a $26 million seed financing in 2021, will support moving Inceptor's lead CAR T program into phase I testing, a move targeted for the second half of 2023, and continued development of rare CAR-macrophage and CAR-natural killer cell programs.
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Vial and syringe with DNA
Newco news

Keeping it simple: Kelonia raises a $50M series A

May 2, 2022
By Lee Landenberger
For Kevin Friedman, the secret to making newly emergent Kelonia Therapeutics Inc. a success is reducing complexity and keeping everything as simple as possible. The Boston-based company just raised $50 million in series A funding to further its development of genetic medicines encompassing a range of diseases.
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CAR T cell attacking cancer cells

Testing viruses, vaccines, to increase solid tumor CAR T persistence

April 20, 2022
By Anette Breindl
Solid tumors have been a tougher nut to crack for CAR T cells than B-cell cancers, for two main reasons. Solid tumors have an inhibitors microenvironment that has made it difficult to get durable responses. And identifying antigens as specific as the B-cell markers CD19 and CD22 has been challenging, leading to problems with on-target, off-tumor toxicity.
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Digital cancer cells illustration

AACR 2022: Viruses, vaccines, ventricular delivery help solid tumor CAR Ts

April 13, 2022
By Anette Breindl
“We’re still a far cry from reproducible, durable benefits” with CAR T cells targeting solid tumors, Crystal Mackall told the audience at the 2022 annual meeting of the American Association for Cancer Research (AACR). But “we’re beginning to see some signals.” Mackall is the founding director of the Stanford Center for Cancer Cell Therapy.
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CAR T cell attacking cancer cells

Cellpoint acquires US, European rights to Pregene CAR T therapy in €20M+ deal

April 12, 2022
By Doris Yu
Cellpoint B.V. has picked up U.S and European rights to a chimeric antigen receptor T-cell (CAR T) therapy from Shenzhen Pregene Biopharma Co. Ltd. Cellpoint will develop and commercialize the candidate, PRG-1801, for the treatment of hematological indications.
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Non-Hodgkin lymphoma cells in the blood flow

Immpact Bio raises $111M to advance CAR T platform

Jan. 20, 2022
By Michael Fitzhugh
Cancer therapy developer Immpact Bio USA Inc. has raised $111 million to further its "logic gate"-based CAR T-cell platform, the source of a CD19/CD20 bispecific in phase I testing for B-cell non-Hodgkin lymphoma patients whose disease has returned or who has stopped responding to treatment. New data from that study, showing complete remissions in seven of eight patients treated, accompanied the appointment of a new president and CEO for the company as well as a new board chair.
Read More
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