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BioWorld - Wednesday, December 31, 2025
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Home » Topics » BioWorld Science, Patents

BioWorld Science, Patents
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Endocrine/metabolic

Fortvita Biologics discovers new GLP-1R agonists

Dec. 29, 2025
Fortvita Biologics Inc. has described glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of autoimmune diseases, cardiovascular disorders, inflammatory disorders, diabetes, lung diseases, neurological disorders, obesity and renal disorders, among others.
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Infection

New DHODH inhibitors for malaria disclosed in patent

Dec. 29, 2025
Medicines for Malaria Venture and The University of Texas System have divulged dihydroorotate dehydrogenase (DHODH) (Plasmodium falciparum and Plasmodium vivax) inhibitors reported to be useful for the treatment of malaria.
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Immuno-oncology

Hanx Biopharmaceuticals describes new TRBV12-targeting ADCs

Dec. 29, 2025
Hanx Biopharmaceuticals Inc. has identified antibody-drug conjugates (ADCs) consisting of an antibody targeting TRBV12 covalently linked to cytotoxic drugs through linkers reported to be useful for the treatment of T-cell leukemia and T-cell lymphoma.
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Cancer

Shenzhen Chipscreen Biosciences divulges new MNK1 and MNK2 inhibitors

Dec. 29, 2025
Shenzhen Chipscreen Biosciences Ltd. has synthesized MAPK-interacting kinase 1 (MNK1) and/or MAPK-interacting kinase 2 (MNK2) inhibitors reported to be useful for the treatment of cancer.
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Neurology/psychiatric

Neushen Therapeutics patents new OGA inhibitors

Dec. 29, 2025
Neushen Therapeutics Inc. has disclosed N-acetyl-β-D-glucosaminidase (O-GlcNAcase; OGA) inhibitors reported to be useful for the treatment of Alzheimer’s disease.
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Gastrointestinal

Haisco Pharmaceutical discovers new TNF-α/TNFR1 interaction inhibitors

Dec. 24, 2025
Haisco Pharmaceutical Group Co. Ltd. has described compounds acting as TNF-α/tumor necrosis factor receptor superfamily member 1A (TNFR1) interaction inhibitors reported to be useful for the treatment of psoriasis, Crohn’s disease, ulcerative colitis and rheumatoid arthritis.
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Cancer

New Raf kinase B degradation inducers disclosed in Shenzhen Targetrx patent

Dec. 24, 2025
Shenzhen Targetrx Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN)-binding moiety covalently linked to Raf kinase B (V600E mutant)-targeting moiety through linker reported to be useful for the treatment of cancer.
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Cancer

Chinese scientists describe new CD73 inhibitors

Dec. 24, 2025
Researchers at Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College have identified 5’-nucleotidase (CD73) inhibitors reported to be useful for the treatment of cancer, fibrosis, cerebral ischemia, depression, sleep disorders, Parkinson’s disease, immunological disorders and inflammatory disorders, among others.
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Cancer

China Pharmaceutical University divulges new TEAD inhibitors

Dec. 24, 2025
China Pharmaceutical University has synthesized transcriptional enhancer factor (TEAD) inhibitors reported to be useful for the treatment of cancer, fibrosis, metabolic diseases and inflammatory disorders.
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Immuno-oncology

Jiangsu Simcere Biologics patents new antibody-drug conjugates

Dec. 24, 2025
Jiangsu Simcere Biologics Co. Ltd. has disclosed antibody-drug conjugates (ADC) comprising an antibody huAb-H3aL3-IgG1 targeting cadherin-17 (CDH17) covalently linked to a camptothecin derivative through a linker reported to be useful for the treatment of cancer.
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