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Home » Topics » Degradation inducer, BioWorld Science

Degradation inducer, BioWorld Science
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Cancer

Bcl-xl degradation inducers disclosed in Treeline patents

June 2, 2025
Treeline Biosciences Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1) targeting moiety via a linker acting as Bcl-xl degradation inducers reported to be useful for the treatment of cancer.
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Doctor points at molecular structure
Cancer

Chinese researchers describe first-in-class PRMT1 degrader

May 30, 2025
No Comments
PRMT1 is a key enzyme that catalyzes asymmetric dimethylation of arginine residues and overexpressed in various cancers and inflammatory diseases. While current PRMT1 inhibitors lack specificity and effectiveness, targeted degradation of PRMT1 offers a potential strategy to treat PRMT1-driven conditions and explore its nonenzymatic roles.
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Cancer

Bpgbio divulges new ESR1 degradation inducers

May 27, 2025
Bpgbio Inc. has synthesized bifunctional compounds comprising an E2 ubiquitin ligase binding ligand covalently linked to an estrogen receptor α (ER-α; ESR1) targeting moiety through a linker acting as ESR1 degradation inducers reported to be useful for the treatment of cancer.
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Pipet, test tubes, chemical structures
Cancer

A structural scaffold for protein degraders against multiple myeloma

May 26, 2025
No Comments
In their efforts to develop next-generation drugs whose structures differ from those of conventional IMiDs, researchers at Fujimoto Pharmaceutical Corp. developed FPFT-2216 through optimization of a lead compound.
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Respiratory

KT-621: a first-in-class STAT6 degrader for Th2-driven diseases

May 22, 2025
No Comments
STAT6 plays a central role in regulating Th2-driven immune responses. Recent studies have identified gain-of-function mutations in the STAT6 gene that are associated with early-onset, severe allergic diseases. As a result, STAT6 has emerged as a promising therapeutic target in conditions such as asthma, eosinophilic inflammation, food allergies and atopic dermatitis, particularly in cases that are refractory to standard therapies.
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Cancer

Chinese researchers unveil new agent for KRAS G12D-mutated tumors

May 9, 2025
No Comments
The KRAS G12D mutation is the most common oncogenic KRAS variant, identified in approximately 34% of pancreatic ductal adenocarcinoma cases, 12% of colorectal cancers and 4% of lung adenocarcinomas.
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Cancer

Novel PROTAC shows robust antitumor activity in preclinical models of prostate cancer

May 6, 2025
No Comments
Researchers from Jiangsu Hengrui Pharmaceuticals Co. Ltd. reported the discovery of SHR-3591, an orally bioavailable AR proteolysis targeting chimera (PROTAC) designed to treat prostate tumors.
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Illustration of triple-negative breast cancer cells
Cancer

A high-affinity small-molecule inhibitor of STAT3 against triple-negative breast cancer

May 2, 2025
No Comments
Triple-negative breast cancer (TNBC), which accounts for up to 20% of cases of breast cancer, is one of the most aggressive and difficult to treat subtypes of the disease.
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AI generated, 3D rendering of protein degradation
Cancer

AACR 2025: Induced proximity strategy, beyond degraders

May 2, 2025
By Anette Breindl
No Comments
Targeted protein degradation has yet to notch its first approval. But with more than two dozen agents now in clinical trials, the strategy’s ultimate clinical validation appears to be a matter of time.
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Cancer

Novel SMARCA2 PROTAC shows promise in SMARCA4-deficient tumors

April 30, 2025
SMARCA4 and SMARCA2 are essential subunits of the SWI/SNF complex, functioning as ATP-dependent chromatin remodelers that regulate gene expression and maintain cellular homeostasis. Recent research has shown that selectively targeting SMARCA2 is an effective cancer treatment strategy, with several compounds already in early clinical testing.
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