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Home » KT-621: a first-in-class STAT6 degrader for Th2-driven diseases
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Respiratory

KT-621: a first-in-class STAT6 degrader for Th2-driven diseases

May 22, 2025
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STAT6 plays a central role in regulating Th2-driven immune responses. Recent studies have identified gain-of-function mutations in the STAT6 gene that are associated with early-onset, severe allergic diseases. As a result, STAT6 has emerged as a promising therapeutic target in conditions such as asthma, eosinophilic inflammation, food allergies and atopic dermatitis, particularly in cases that are refractory to standard therapies.
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