A new public offering of 4.5 million shares of common stock at $9.50 per share will help to float Regulus Therapeutics Inc.'s pipeline of drugs targeting microRNAs, including its lead compound RG-101 for hepatitis C virus. The offering is expected to raise gross proceeds of $42.8 million, and will close on or about July 22.
When Adelene Perkins looks back on her career, starting with a B.S. in chemical engineering from Villanova University, through her current position as president and CEO of Infinity Pharmaceuticals Inc., one theme that emerges is "optionality," a philosophy of continuously developing multiple viable options and paths at the same time.
Osaka, Japan-based Mitsubishi Tanabe Pharma Corp. moved to acquire Canadian vaccine developer Medicago Inc. for $357 million, or $1.16 in cash per share, a premium of about 22.1 percent to the closing price of Medicago's stock on July 11. The acquisition follows a successful strategic alliance in 2012, under which the companies agreed to develop and commercialize at least three vaccines using Medicago's virus-like particle (VLP) technology.
Celgene International Sarl's successful multiple myeloma drug, Revlimid (lenolidomide), met an important benchmark in newly diagnosed patients in a Phase III study.
The FDA slapped a clinical hold on Achillion Pharmaceuticals Inc.'s hepatitis C virus (HCV) drug sovaprevir after elevations in liver enzymes turned up in a Phase I trial, though the agency will allow continued enrollment and treatment of patients in the ongoing Phase II trial of sovaprevir with ACH-3102 and ribavirin for treatment-naive genotype 1 HCV.
Prosensa Holding B.V., of Leiden, the Netherlands, became the first European biotech company in 10 years to file for its initial public offering (IPO) on the Nasdaq to support development of its products for Duchenne's muscular dystrophy and other programs. It plans to raise about $78 million.
Vical Inc. and Astellas Pharma Inc. began a Phase III trial of Transvax, a vaccine for cytomeglovirus (CMV), in 500 hematopoietic cell transplant recipients, with Astellas taking the lead and Vical providing development, regulatory and manufacturing support.
When Trevor Baglin, a hematologist at Addenbrooke's Hospital at Cambridge University had a head injury patient with a much-better-than-expected outcome, he did something unusual. He got very curious.
