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Home » Newsletters » BioWorld

BioWorld

March 10, 2023

View Archived Issues
Woman with headache

Nasal spray Zavzpret cleared, Pfizer showing ‘growth on every measure’ in migraine

Pricing won’t be known until later for Pfizer Inc.’s Zavzpret (zavegepant), which became the first and only calcitonin gene-related peptide receptor antagonist nasal spray approved by the U.S. FDA for acute treatment of migraine with or without aura in adults. The product is slated to launch this summer. Meanwhile, Wall Street has questions about New York-based Pfizer’s performance in the migraine space. Read More
performance-hit-target.png

Flagship puts $50M toward targeted tissue-homing tech startup

In an ideal world, when a patient takes a medicine, it acts only at the specific site of disease in the human body whilst sparing healthy tissues. But it almost goes without saying that with many drug regimens, side effects or complications are part of the package. Working behind the scenes to address this limitation over the past couple of years, Cambridge, Mass.-based venture capital company Flagship Pioneering is now publicizing its platform of “programmable medicines” that directly and precisely target diseased tissue, funnelling $50 million of investment in the technology and recognising its achievements formally through the launch of Ampersand Biomedicines. Read More
White blood cells with red blood cells

AB2 Bio completes enrollment in pivotal pediatric trial for ultra-rare inflammatory disease

Swiss orphan biotech AB2 Bio Ltd. has completed enrollment in a pivotal phase III trial for its recombinant interleukin-18-binding protein drug tadekinig alfa for an inherited form of the ultra-rare condition hemophagocytic lymphohistiocytosis that results from an excess of the pro-inflammatory cytokine IL-18. Read More

Insider trading settled over profits from Audentes/Astellas merger

A California man agreed to settle insider trading charges related to Tokyo-based Astellas Pharma Inc.’s buyout offer of San Francisco-based Audentes Therapeutics Inc. in December 2019 for $3 billion. Read More
Concept art for Mitochondrial DNA.

Fumarate accumulation moderates inflammation through mitochondrial genetic material

A deficiency in fumarate metabolism could be behind a new mechanism of inflammation mediated by mitochondrial DNA and RNA. Two independent and simultaneous studies described how the accumulation of fumarate in the mitochondria released the genetic material of this organelle through vesicles, activating an inflammatory signaling pathway. Read More

Appointments and advancements for March 10, 2023

New hires and promotions in the biopharma industry, including: Alligator, Diamyd, Owkin. Read More

Financings for March 10, 2023

Biopharmas raising money in public or private financings, including: Allorion, Seelos, Tracon. Read More

Other news to note for March 10, 2023

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Abveris, Allergan, Alnylam, Endo, F-star, ICER, Icon, Invox, Leo Pharma, Les Laboratoires, Medicinova, Medison, Novelion, Olema, Orchard, Par, Qiagen, Sino, Sumitovant, Sumitoma, Twist Bioscience, Myovant. Read More

In the clinic for March 10, 2023

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Areteia, Astellas, Astrazeneca, Bergenbio, Bionomics, Clene, CNS, Eli Lilly, First Wave, Genfleet, Gensight, Lantern, Microbion, Ribon, Springworks, Vaccinex. Read More

Regulatory actions for March 10, 2023

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Avenue, Biocryst, Estrella, Janssen, Novo Nordisk, Scisparc, Soligenix, Vertex. Read More

Money raised by biopharma

Total raised in public, private and other financings of biopharma companies, comparing 2023 vs. 2022 vs. 2021 vs. 2020 vs. 2019. Read More

Biopharma money raised: Jan. 1-March 9, 2023

Year-to-date money raised in public, private and other financings of biopharma companies. Read More

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