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Home » Newsletters » BioWorld

BioWorld

Aug. 25, 2023

View Archived Issues
Heart with blocked arteries

Merck’s phase III Coralreef program brings oral bid to PCSK9 ecosystem

Merck & Co. Inc. is pledging major resources on its prospect in the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor space with a phase III program that together will enroll about 17,000 subjects and test oral peptide MK-0616’s effect on tackling low-density lipoprotein cholesterol. Read More
Vaxxas HD-MAP

SK Bioscience, Vaxxas partner to develop needle-free typhoid vaccine

SK Bioscience Co. Ltd.  and Vaxxas Pty. Ltd. have entered into a joint development agreement that could revolutionize vaccines by developing a vaccine-delivery device combination product using Vaxxas’ high-density microarray patch (HD-MAP) coupled with SK Bioscience’s typhoid vaccine, Skytyphoid. Read More
Closeup of wheelchair

With Sandoz’s MS approval, a biosimilar goes after big game

Biosimilars continue to pose cheaper alternatives to their established, blockbuster counterparts. The U.S. FDA has approved Tyruko (natalizumab-sztn) from Sandoz Inc., the generics business of Novartis AG. It is the first approved biosimilar to Biogen Inc.’s blockbuster Tysabri (natalizumab), an injectable monoclonal antibody for treating adults with relapsing forms of multiple sclerosis (MS). Read More

Big pharma piles on; Astrazeneca latest to file lawsuit over IRA

With the U.S. Centers for Medicare & Medicaid Services soon expected to publish the list of 10 drugs selected for the first round of the Inflation Reduction Act’s (IRA) price negotiations, Astrazeneca plc is the latest to file a challenge. It’s the first non-U.S.-headquartered company to do so and, unlike the other challenges, Astrazeneca’s complaint focuses on the impact to the Orphan Drug Act (ODA). In a statement, the Cambridge, U.K.-based firm said the “drug price negotiation provisions of the IRA run headlong into the goals” of the ODA. Read More
Cancer research illustration

Multiple KRAS targeting strategies paving way for combination therapies

KRAS-mutated tumors were once untreatable. In fact, KRAS was something of a poster child for so-called undruggability. Several laboratories are investigating strategies to address other mutations and uses beyond non-small cell lung cancer (NSCLC) and colorectal cancer. If you can't bind KRAS to block it, use a glue or combine multiple weapons. This is the idea behind two new approaches that target cancers caused by this proto-oncogene. Read More
Clinical-trial-syringe-and-pills1.png

Clinical trial data down from 2021 but up 18% from 2019

The first seven months of 2023 saw clinical trial data up 1.43% compared to the same time period last year. From January through July this year, BioWorld reported on 2,064 drugs in phase I-III, compared to 2,035 in the same time period in 2022. The number of trial updates is down 14.07% from the 2,402 in 2021 and down from 2020’s 2,096, but up 18.15% from 2019’s 1,747. Read More

BioWorld Insider Podcast – The struggle is real: The first half of 2023 was an uphill climb

Guests Karen Carey, BioWorld’s managing editor, and Mike Ward, Clarivate’s global head of Life Sciences and Healthcare Thought Leadership, discuss the deals, financing and M&A landscape for the first half of 2023 and how U.K. biopharmas are faring post Brexit. Read More

Appointments and advancements for Aug. 25, 2023

New hires and promotions in the biopharma industry, including: Aprea, Elucida Oncology. Read More

Financings for Aug. 25, 2023

Biopharmas raising money in public or private financings, including: Celyad, Excepgen, Eyenovia, Peak Bio, Rayzebio. Read More

In the clinic for Aug. 25, 2023

Clinical updates, including trial initiations, enrollment status and data readouts and publications: . Read More

Other news to note for Aug. 25, 2023

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Cordavis, CVS, Novartis, Sandoz. Read More

Regulatory actions for Aug. 25, 2023

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Akebia, Alentis, Astrazeneca, Bioxytran, Collegium, Comanche, Gilead, Merck, Novaliq, Taysha Gene Therapies. Read More

Money raised by biopharma

Total raised in public, private and other financings of biopharma companies, comparing 2023 vs. 2022 vs. 2021 vs. 2020 vs. 2019. Read More

Biopharma money raised: Jan. 1-Aug. 24, 2023

Year-to-date money raised in public, private and other financings of biopharma companies. Read More

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