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BioWorld Science

July 9, 2002

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Potential use of nemifitide in the treatment of severe depression

Taiwan investigators report biological activity of new antiplatelet agent

Potent, reversible, fast/tight-binding inhibitor of COMT identified at BIAL/Portela

Korean researchers report antithrombotic activity, mechanism of action of J-78 at IUPHAR 2002

Promising antimetastatic activity determined for PKC-412 in melanoma-bearing mice

Coadministration of OC144-093 enhances oral bioavailability of paclitaxel in cancer patients

Preclinical profile of PA-457, a betulinic acid derivative, discussed this week at AIDS conference

Immunotherapeutic potential of tucaresol in HIV suggested by pilot study results

HE-2000 effects on immune parameters, inflammatory gene expression and viremia in HIV

In vitro and in vivo findings for KUL-7211 support potential in ureteral colic and urolithiasis

KMD-3213 effective in rat model of BPH

Biovitrum describes 5-HT2C ligands for obesity and other disorders

Banyu claims novel ORL1 antagonists with analgesic activity

Additive cardioprotective effects demonstrated for JTV-519 + cariporide in rat hearts

Novel PDE7 inhibitors designed at Byk Gulden (Altana Pharma)

New antibacterial piperidines in early development at Aventis

Researchers at Chugai describe antitumor styryl derivatives

Isoxazole compounds and their use in diabetes reported by Takeda

NO-aspirin possesses cardioprotective effects unrelated to COX inhibition in SHR hearts

Oxigene's antitumor compound Oxi-6197 approved for preclinical studies by the NCI

Natalizumab is effective and well tolerated in patients with ulcerative colitis

Anastrozole alone better than tamoxifen or anastrozole + tamoxifen in early breast cancer

A new surgically implantable haloperidol formulation for long-term treatment of schizophrenia

Extended-release divalproex sodium tested for the prophylaxis of migraine

Synergistic clinical benefits of combination therapy with statins and fibrates

Atazanavir shows a better lipid profile than nelfinavir in HIV-infected patients

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