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BioWorld Science

Nov. 14, 2002

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Novel 5-HT1B antagonists with utility in depression identified at GSK

New adenosine A1 agonists discovered by GSK researchers

Merck scientists present novel inhibitors of factor Xa and/or factor VIIa

Sankyo describes the isolation of new antifungal agents from Phoma sp.

Series of integrin antagonists for asthma and other disorders prepared at Merck & Co.

Cholesterol-lowering efficacy of SMP-500, a novel ACAT inhibitor, in hyperlipidemic hamsters

Oregovomab enhances killer T-cell responses in apoptotic ovarian cancer cells

Pretreatment of solid tumors with NHS76/PEP2 improves efficacy of chemotherapy in mice

Emodin accelerates pancreatic regeneration in acute pancreatitis in rats

Orally active 5-HT2C receptor agonist synthesized at Vernalis as potential antiobesity agent

SLV-314: neurochemical and behavioral effects detailed at Neuroscience 2002

Binding profile of atypical antipsychotic agent SM-13496

Exanta proves superior to routinely used enoxaparin for reducing risk of VTE in major surgery

Oprelvekin reported to increase platelet counts in hepatitis C patients

Potential novel use for PPARgamma agonists discussed at AASLD meeting

Improved safety profile reported for ribavirin prodrug viramidine

Potential use of the antisense oligonucleotide ISIS-14803 in chronic HCV

Commit lozenge approved by the FDA for over-the-counter sale

Drug safety announcement regarding Refludan

Seattle Genetics releases clinical and preclinical updates

Recombinant alpha 1-antitrypsin topical gel enters clinical trials

Accelerated approval plan for KRX-101

Johnson & Johnson to acquire OraPharma

Serono and Amgen sign license agreement for multiple sclerosis product

Vertex advances Aurora kinase inhibitor into preclinical development

Immtech International completes efficacy trials of DB-289

Phase II clinical trial initiated to evaluate the efficacy of 17beta-estradiol against restenosis

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