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BioWorld Science

March 15, 2005

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Novel 5-HT2C agonist shows efficacy in animal models of obesity

Conformation-specific binding plays a role in imatinib and BMS-354825 resistance

ESR-1150-CL causes death in rats but not monkeys

Zonulin inhibitor spares rats from type 1 diabetes

Enrollment begins for phase II study of SLIT cisplatin

New PK data on oncological drugs presented at the ASCPT

Reolysin phase I/II study in recurrent malignant gliomas cleared to begin

Phase II data on the effects and safety of REN-1654 in postherpetic neuralgia

Two phase II clinical trials report benefits with alvimopan in bowel dysfunction

Therapeutic benefits found with VRX-496 in HIV-infected patients

New data on the pharmacokinetics of drugs against infectious diseases presented at ASCPT

PSA-TRICOM vaccines show promise in the treatment of prostate cancer

First data on the safety profile of AZD-2171 in prostate adenocarcinoma

PCK-3145 shows efficacy in the treatment of HRPC

Improved cognitive function in elderly patients treated with Cymbalta for depression

DB-289 shows efficacy for trypanosomiasis in phase IIb trial

Dainippon and Sumitomo reveal new company name and missions

SomatoKine NDA accepted for filing

Anticancer activity of a novel dual HER1/HER2 inhibitor

PAR-1 antagonist exerts antithrombotic effects in a primate model

CB2 agonist with notable PK profile shows potential for treating inflammatory pain

Pyrimidine derivatives combined with local hyperthermia exert antitumor effects in mice

Nikem Research discloses novel tachykinin receptor antagonists

Xopenex HFA metered-dose inhaler receives FDA approval

FDA Advisory Committee recommends approval of Baraclude for hepatitis B

New topical treatment of fungal infections now available in Spain

Janssen describes new treatments for gastrointestinal disorders in recent patents

Glycogen synthase kinase-3 inhibitors described in a patent

Roche claimes new agents for the treatment of diabetes and obesity

MC4 receptor agonists useful for treating diabetes reported by Eli Lilly

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