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BioWorld Science

Dec. 21, 2009

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Direct antagonism of NOTCH transcriptional activity shows potent antiproliferative effects in vivo

Interim data from phase I trial of Cortiject in diabetic macular edema disclosed at ISOPT

ABT-263 shows favorable safety and PK profiles in phase I/IIa trial in CLL

Recent data suggest Ontak may enhance endogenous immunity to breast cancer antigens

Treatment with entinostat plus aromatase inhibitor is well tolerated in breast cancer

Novartis discovers novel compounds for the treatment of parasitic infections

Takeda claims glucokinase activators for the treatment of diabetes

Vitae Pharmaceuticals presents 11beta-HSD1 inhibitors for obesity therapy

The University of Utah discloses PKC activators for cancer therapy

Novel muscarinic receptor agonists in early development at Lundbeck

Pfizer's Toviaz superior to Detrol LA in treating urge urinary incontinence

FDA's ODAC recommends not approving Tarceva as first-line NSCLC therapy

InSite Vision to advance new ocular anti-inflammatory candidate ISV-303

FDA's ODAC to review ChemGenex's Omapro for chronic myeloid leukemia

Advanced Life Sciences' Restanza effective against tularemia in nonhuman primates

FDA grants orphan drug designation to Clinuvel's afamelanotide for solar urticaria

Hybrigenics to begin phase IIb efficacy trial of inecalcitol in hormone-refractory prostate cancer

BioAlliance gains French Drug Agency's approval to initiate phase II clonidine trial

Advaxis and GOG begin phase II trial of ADXS11-001 in advanced cervix cancer

ALS TDI and Applied Proteomics complete first stage of collaboration on ALS biomarkers

Syntiron grants Sanofi Pasteur exclusive worldwide license to MRSA vaccine

Nanotherapeutics acquires Oscient's ramoplanin and Epix's PRX-3140

Almac Discovery begins phase I trial of intranasal granisetron spray for CINV

Intercell reports interim data from ongoing phase II trial of P. aeruginosa vaccine

Mayo Clinic licenses molecular breast imaging technology to Gamma Medica-Ideas

Merck & Co. to acquire Avecia's biologics business

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