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BioWorld Science

July 16, 2018

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CARD-carrying AML killer

Cytokine gene therapy improves spinal cord regeneration

Metabolic differences of ApoE variants

APTO-253 is able to induce DNA damage in AML cells and can exploit BRCA1/2 recombination deficiency

Kelch-like family member 7: role in breast cancer progression and utility as prognostic marker

Rare, common genetic variants contribute to preterm birth

Landos Biopharma initiates phase I study of BT-11

CytoDyn to evaluate PRO-140 in cancer and immunological indications

ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine qualifies for phase II/III testing

Novel zebrafish models of Cantu syndrome using CrispR/Cas9-based nucleotide editing

Discovery of [18F]SWR-4-127, a novel PARP-1 selective 18F-PET tracer for neuroimaging

FDA lifts clinical hold on phase I/II combination study of axalimogene filolisbac plus durvalumab

Janssen patents OGA inhibitors

Idenix and Merck & Co. disclose anti-HIV-1 compounds

OBI Pharma initiates phase I study of OBI-888 in patients with solid tumors

University of Nebraska identifies NF-kappaB activation inhibitors

GlaxoSmithKline presents NRF2 activators

Atossa Genetics initiates phase II study of endoxifen in neoadjuvant breast cancer

FDA approves first drug to treat smallpox

Researchers find a relationship between prediabetes and overactive bladder

FDA approves Xtandi for nonmetastatic castration-resistant prostate cancer

RegenxBio begins first-in-human study with RGX-121 gene therapy for Hunter's syndrome

BGI-Shenzhen synthesizes new cancer vaccines

First-in-human study explores use of BAY-2287411 in mesothelin-expressing tumors

Brain-targeted gene editing using CRISPR-Gold in mice models of fragile X syndrome

MaxCyte's cleared to begin clinical study of CAR therapy MCY-M11

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