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Home » Newsletters » BioWorld Science

BioWorld Science

Oct. 6, 2022

View Archived Issues
Telomerase illustration.

Biosynthesis of telomerase from a coding mRNA

Arizona State University scientists have discovered an unprecedented pathway in a fungus to produce telomerase RNA (TER) from a protein-encoding messenger RNA (mRNA). Unlike in animals and other fungi, this fungal TER is transcribed by RNA polymerase III, lacks a protective 5′ cap and it is processed from the 3′-untranslated region of an mRNA transcript. This telomerase has two essential structural domains that keep it active. For now, scientists have only observed this process in the fungus Ustilago maydis, or Mexican truffle. “In animals, and even in Ascomycota, which is another fungal phylum, the telomerase RNA is transcribed by RNA polymerase II as an independent gene. This is the only case among all different kingdoms in eukaryotes that the telomerase RNA is processed from the mRNA molecule. It is a very unusual biogenesis pathway.” Julian Chen told BioWorld. Read More
Human aging illustration

Genetic influences on longevity depend on sex and age

Researchers have gained new insights into both genetic and nongenetic factors affecting life span, and how they differ between males and females. Several genes were correlated with longevity, according to a study by the École Polytechnique Fédérale de Lausanne (EPFL). However, some did not affect life span until males reached a certain age. Early access to nutrients during growth also affected longevity, as they saw in their study of more than 3,000 mice and verified with human data. “This study is one of the biggest studies on mass longevity. We were looking for genetic determinants of longevity but there are non-genetic determinants affecting longevity,” the first author Maroun Bou Sleiman, researcher at EPFL, told Bioworld. Read More
Amyloid plaques forming between neurons

Bispecific antibody targeting TREM2 and TfR reduces amyloid burden in murine AD model

It is known that triggering receptor expressed on myeloid cells 2 (TREM2) plays a key role, such as regulating microglial migration or phagocytosis... Read More
Cancer cells

Model Medicines launches oncology programs targeting AXL and BRD4

Model Medicines Inc. has launched oncology programs focused on the discovery and development of therapeutics against two... Read More

NIA award supports Oligomerix's development of tau self-association small-molecule inhibitor

Oligomerix Inc. has been awarded US$2.49 million from the National Institute on Aging (NIA) to support clinical development of its lead... Read More
Cancer research illustration

Novel platinum (II) complexes show better antitumor efficacy than oxaliplatin

Researchers from Zhejiang University of Technology presented the discovery of platinum (II) complexes with promising physicochemical... Read More

TMAO promotes immune activation and enhances immune checkpoint blockade therapy in PDAC

Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with poor prognosis and immunotherapy has failed at improving patient... Read More

Clarametyx receives IND clearance for novel immune-enabling antibody therapy CMTX-101

Clarametyx Biosciences Inc. has received FDA clearance of its IND application for first-in-human phase I evaluation of CMTX-101, a novel... Read More
brain-stroke-ischemia.png

FSAP-SPD as a new therapeutic strategy in ischemic stroke

Previous studies have revealed that factor VII-activating protease (FSAP) levels are raised in patients as well as mice after stroke. Read More
Colorized scanning electron micrograph of N. gonorrhoeae bacteria.

Intravacc awarded NIAID contract to develop prophylactic intranasal gonorrhea vaccine

Intravacc BV has been awarded a contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), for the development of a prophylactic intranasal vaccine against Neisseria gonorrhoeae (NG), the cause of the sexually transmitted disease gonorrhea. Read More

Dice Molecules describes integrin αv/β1 and/or αv/β6 antagonists

Dice Molecules SV LLC has divulged new integrin αv/β1 and/or integrin αv/β6 antagonists reported to be useful for the treatment of fibrosis, rheumatoid arthritis, diabetic nephropathy, nonalcoholic steatohepatitis, focal segmental glomerulosclerosis, primary biliary cholangitis and cancer. Read More

Latigo Biotherapeutics, Lieber Institute present new Nav1.8 channel blockers

Latigo Biotherapeutics Inc. and Lieber Institute Inc. have synthesized new methyl-substituted pyridine and pyridazine compounds acting as sodium channel protein type 10 subunit α (Nav1.8) channel blockers reported to be useful for the treatment of pain, arthritis, atherosclerosis, irritable bowel syndrome, cancer and psychiatric, respiratory and neurological disorders, among other disorders. Read More

New EGFR-mutant inhibitors discovered at Blueprint Medicines

Blueprint Medicines Corp. has divulged new EGFR mutant inhibitors, particularly EGFR L858R mutant and EGFR del746-750 mutant, reported to be useful for the treatment of non-small-cell lung cancer. Read More

New GLP-1 receptor agonists synthesized at Gilead Sciences

Gilead Sciences Inc. has patented glucagon-like peptide 1 (GLP-1) receptor agonists reported to be useful for the treatment of type 2 diabetes, obesity, prediabetes, atherosclerosis, metabolic syndrome, stroke, nonalcoholic steatohepatitis and renal disorders, among other disorders. Read More

Lifearc, Provincial Health Services Authority patent DNA-PK inhibitors

Lifearc and Provincial Health Services Authority (PHSA) have presented 7-morpholino-l,6-naphthyridin-5-yl derivatives acting as DNA-dependent protein kinase (DNA-PK) inhibitors reported to be useful for the treatment of cancer. Read More

Other news to note for Oct. 6, 2022

Additional early-stage research and drug discovery news in brief, from: CSL, Elicio Therapeutics, Enzolytics, Innovation Pharmaceuticals, Lumen Bioscience, Nanology. Read More

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