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Home » Newsletters » BioWorld Science

BioWorld Science

April 21, 2023

View Archived Issues
Tissue-resident memory T cells in the lung of smoker patients

Tissue-resident memory cells in lung may drive lung cancer in smokers

Differences in the immune reactions between smokers and nonsmokers may explain why only 20% of patients with lung cancer respond to immunotherapy treatment. Understanding these differences in the evolution of lung cancer between smokers and nonsmokers could be the key to unlocking new treatments. Read More

Altered gut microbiome contributes to symptoms of anorexia

Research led by the University of Copenhagen and Herlev-Gentofte University Hospital shows that individuals with the eating disorder anorexia nervosa have an abnormal gut microbiome that likely contributes to symptoms associated with the condition. Published in the April 17, 2023, issue of Nature Microbiology, the study showed multiple differences in the species and amounts of bacteria and viruses present in the gut of people with the condition compared with healthy controls. Read More
Cancer cell and target

POLQ inhibitor ZM-0088 inhibits tumor growth, preclinical data reveal

Dysfunction of the homologous recombination (HR) pathways leads to genomic instability and tumorigenesis. In this scenario, DNA polymerase... Read More
Multiple myeloma cells in the bone marrow.

Preclinical data on selective IKZF1/3 degrader ICP-490 reported

Several immunomodulatory drugs (IMiDs) such as lenalidomide have greatly improved the management of multiple myeloma (MM)... Read More

Anti-LILRB2 KA-1769 suppresses tumor growth in vivo

It is known that M2 macrophages play a key role at maintaining an immunosuppressive microenvironment inside the tumor. Kyinno... Read More
Brain scan illustration

Grant supports Ventus in development of NLRP3 PET tracer

Ventus Therapeutics Inc. has been awarded a $150,000 grant by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to support... Read More

Palacky University patents new platinum complexes for multiple myeloma

Palacky University has disclosed platinum complexes reported to be useful for the treatment of multiple myeloma. Read More

CSPC Pharmaceutical’s antibody-drug conjugate SYS-6010 cleared to enter clinic in China for advanced solid tumors

CSPC Pharmaceutical Group Ltd.’s antibody-drug conjugate SYS-6010 has obtained clinical trial approval from China’s National Medical Products... Read More
CDK2 with cyclin E

Incyclix Bio’s CDK2 inhibitor INX-315 shows antitumor activity in CCNE1-amplified cancers

Cyclin-dependent kinases (CDK) are serine/threonine kinases that act as regulatory enzymes involved in cell proliferation. The dysregulation of CDK activity occurs through overexpression of cyclin E1, a binding partner of CDK2, which is observed in several cancers such as high-grade serous ovarian cancer (HGSOC), bladder cancer, gastric cancer and estrogen receptor-positive breast cancer, among others. Selective inhibition of CDK2 may thus be considered a therapeutic approach to regaining cell cycle control. Read More

Chiesi Farmaceutici divulges new TGFBR1 inhibitors for IPF

Chiesi Farmaceutici SpA has synthesized pyridazinyl amino derivatives acting as TGF-β receptor type-1 (TGFBR1; ALK5; SKR4; TβR-I) inhibitors reported for be useful for the treatment of idiopathic pulmonary fibrosis (IPF). Read More

ACT-903, an α‑fetoprotein‑maytansinoid conjugate with efficacy in colorectal cancer models

Researchers from Alpha Cancer Technologies Inc. and affiliated organizations presented data from a study that aimed to assess the effects of ACT-101-maytansinoid conjugates in models of colorectal cancer. Read More
Metastatic melanoma cells.

The potent pan-RAF inhibitor PHI-501 shows efficacy in BRAF- and NRAS-mutated metastatic melanoma

PHI-501 is a novel pan-RAF inhibitor being developed for acute myeloid leukemia. Big data, an artificial intelligence (AI)-based drug discovery platform and cell-based investigation identified PHI-501 as potentially useful against melanoma, and researchers from Pharos Ibio Co. Ltd. presented preclinical evaluation of the drug for this new indication. Read More

Michigan State University describes new MAPT aggregation inhibitors for Alzheimer’s disease

Michigan State University has identified microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be useful for the treatment of Alzheimer’s disease. Read More

Caraway Therapeutics presents new mucolipin activators

Caraway Therapeutics Inc. has divulged mucolipin (MCOLN; TRPML) activators reported to be useful for the treatment of metabolic diseases, aging, cancer, ciliopathy, neurodegeneration and muscle disorders. Read More
Lung cancer illustration

Smad3 promotes polarization of tumor-associated neutrophils to a protumor state in NSCLC

Researchers from The Chinese University of Hong Kong and collaborators have discovered a promising target for immunotherapy in non-small-cell lung carcinoma (NSCLC). Their study investigated the regulation of tumor-associated neutrophils (TANs), in particular TGF-β1/Smad3 signaling, and their response to the microenvironment in NSCLC patients. Read More

Other news to note for April 21, 2023

Additional early-stage research and drug discovery news in brief, from: Locanabio. Read More

Preclinical conference data for April 21, 2023: AACR

New and updated preclinical data presented at the American Association for Cancer Research annual meeting in Orlando, Fla., by: Fusion Pharmaceuticals, Ose Immunotherapeutics, Salarius Pharmaceuticals. Read More

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