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Home » Newsletters » BioWorld Science

BioWorld Science

June 2, 2023

View Archived Issues
Stained image of triple-negative breast cancer showing molecular heterogeneity

Intratumor heterogeneity mapped in large study

A study of more than a thousand tumor samples, led by the Weizmann Institute of Science in Israel, gives valuable insight into the different gene expression patterns seen in different cancers. The new findings could help address challenges associated with targeting many types of tumors, which are hard to treat in large part due to the variable nature of their cells and gene expression patterns, by helping to create better targeted therapeutics. Read More

Macrophage senescence promotes lung cancer progression

With age, senescent cells become detrimental to tissues. Mayo Clinic scientists have observed this phenomenon in the lung alveoli, where senescent macrophages accumulated in aging tissue and in early stages of non-small-cell lung cancer (NSCLC) driven by the Kras oncogene. “We found that the macrophages were present in the earliest stages of the disease. Strategies targeting these cells for elimination or preventing their accumulation would be worthwhile to test in other conditions (assuming we find they occur),” Darren Baker, a Mayo Clinic senescent cell biologist and senior author of the study, told BioWorld. Read More
3D rendering of serotonin molecular structure

New serotonin transporter inhibitors with anxiolytic and antidepressant effects

Two newly identified compounds that inhibit the... Read More
Lungs2

ROCK2 inhibitor GNS-3595 reduces IPF progression in preclinical models

Idiopathic pulmonary fibrosis (IPF) is a chronic... Read More

Vir Biotechnology patents new ENPP1 inhibitors for cancer

Vir Biotechnology Inc. has disclosed ectonucleo... Read More

Holiday notice

In accordance with the publishing schedule, BioWorld Science will not be published on Monday, June 5, 2023. Read More
Tumor necrosis factor (TNF), a cytokine involved in inflammation processes

Bioinvent's anti-TNFR2 antibody BI-1910 cleared to enter clinic

Bioinvent International AB has received IND... Read More

Impact Therapeutics and Eikon collaborate to develop and commercialize PARP1 selective inhibitors

Impact Therapeutics Inc. and Eikon Therapeutics... Read More

Baiji Youtang (Guangdong) Pharmaceutical divulges new DRAK2 inhibitors

Baiji Youtang (Guangdong) Pharmaceutical... Read More
Neon brain

Identification and development of a PET radiotracer for imaging α-synucleinopathies

α-Synucleinopathies constitute a set of neurological disorders including Parkinson’s disease (PD), dementia with Lewy bodies, multiple systems atrophy (MSA), and other rare disorders. The development of positron emission tomography (PET) tracers for imaging α-synuclein aggregates is essential for performing efficient and accurate diagnosis, tracking disease progression and monitoring efficacy of potential therapies. Read More

Insilico Medicine describes new USP1 inhibitors for cancer

Insilico Medicine IP Ltd. has identified small-molecule inhibitors of ubiquitin carboxyl-terminal hydrolase 1 (USP1) reported to be useful for the treatment of cancer. Read More

C4x Discovery's MALT1 inhibitor lead series shows reduced UGT1A1 inhibition at clinically meaningful doses

C4x Discovery Holdings plc has announced further progress in its MALT1 inhibitor program for cancer. Building on anti-cancer activity in a preclinical xenograft study, the company completed a preclinical study demonstrating its MALT1 lead compounds were free of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) liability shown by competitor chemistries. The program is continuing to identify a shortlist of preclinical candidates for further development, and a partnering program has been initiated. Read More
T cells attacking cancer cells

Medigene expands pipeline into neoantigens with programs targeting KRAS mutations and HLAs

Medigene AG has announced its pipeline expansion into neoantigens with KRAS as the first target in its MDG-10xx program, a T-cell receptor engineered T cell (TCR-T) therapy being developed in combination with the company's PD1-41BB switch receptor technology. Read More

Qilu Regor Therapeutics presents new PADI4 inhibitors

Qilu Regor Therapeutics Inc. has divulged protein-arginine deiminase type-4 (PADI4) inhibitors reported to be useful for the treatment of sepsis, cancer, bacterial, viral infections, inflammatory disorders, autoimmune diseases and metabolic diseases. Read More

Bayer signs license agreement for Cedilla's cyclinE1/CDK2 complex inhibitors

Bayer AG and Cedilla Therapeutics Inc. have entered into an exclusive license agreement to develop and commercialize Cedilla Therapeutics' cyclinE1/cyclin dependent kinase 2 (CDK2) complex inhibitors, which selectively address oncogenic drivers. Read More
Illustration of nerve cells

Vanda's ASO VCA-894A awarded US orphan drug designation for Charcot-Marie-Tooth disease type 2S

Vanda Pharmaceuticals Inc.'s antisense oligonucleotide (ASO) VCA-894A has been awarded orphan drug designation by the FDA for the treatment of Charcot-Marie-Tooth disease, axonal, type 2S (CMT2S), caused by cryptic splice site variants within IGHMBP2. Read More

Abbvie and Calico researchers discover new protein tyrosine phosphatase inhibitors

Researchers at Abbvie Inc. and Calico Life Sciences LLC have described protein tyrosine phosphatase inhibitors, particularly tyrosine-protein phosphatase non-receptor type 2 (PTPN2; TCPTP) and/or PTPN1 (PTP-1B), reported to be useful for the treatment of non-small-cell lung cancer (NSCLC). Read More

Other news to note for June 2, 2023

Additional early-stage research and drug discovery news in brief, from: Apogenix. Read More

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