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Home » Newsletters » BioWorld Science

BioWorld Science

Sep. 1, 2023

View Archived Issues
Metastasis in mouse brain.

Artificial intelligence classifies brain metastases via neuronal activity

A Spanish study led by scientists from the Cajal Institute and the National Center of Oncological Research (CNIO) combined the power of artificial neural networks and biological neuronal circuits to identify abnormal brain activity produced by secondary metastases in the CNS and classify these tumors. The work, published online on Aug. 30, 2023, in Cancer Cell, showed how damage in the brain did not depend on the tumor size but on the effect it produced on neuronal circuits, interrupting cell communication. Read More

CS-585 prevents platelet clot formation without increasing the risk for bleeding

Researchers from University of Michigan presented preclinical data for the novel oxylipin analogue CS-585 being developed as an antithrombotic agent. CS-585 was synthesized as an orally available analogue of 12(S)-hydroxy-eicosatrienoic (12-HETrE), with potent and selective prostacyclin (IP) receptor agonist activity and ability. Read More
R&D money

NIH award supports advancement of BITT’s CD40 antagonist antibody BITT-101 for Sjögren’s syndrome

Boston Immune Technologies and Therapeutics Inc. (BITT) has been awarded funding by the National Institutes of Health (NIH) to support the preclinical development of BITT-101, its CD40 antagonist antibody for treating Sjögren’s syndrome. The award will help support steps toward an IND filing next year. Read More
Heart scientific overlay

Longaevus Technologies spins off Elastin Biosciences with focus on elastin-deficiency diseases

Longaevus Technologies Ltd. has announced the spin-off of Elastin Biosciences following breakthrough preclinical results of three of its assets. Elastin Biosciences has successfully conducted experiments and identified three novel drug combinations that inhibit elastin degradation and foster its deposition, leading to an increase in elastin expression by 5-fold, and improving aortic elasticity in aged mice in vivo. Read More

Aurigene Oncology discovers new SMARCA2 and/or SMARCA4 degradation inducers

Aurigene Oncology Ltd. has reported the discovery of proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding agent coupled to probable global transcription activator SNF2L2 (SMARCA2; BAF190B; SNF2-α) and/or transcription activator BRG1 (SMARCA4; BAF190A; SNF2-β) targeting moiety via linker. They act as SMARCA2 and/or SMARCA4 degradation inducers and are reported to be useful for the treatment of cancer. Read More
3D heart in chest

Activity of novel GalNAc-siRNA option in models supports advancement into the clinic

Apolipoprotein C3 (APOC3) is one of the main regulators of triglyceride metabolism. Hypertriglyceridemia (HTG) is a major risk factor for cardiovascular disease and there is evidence that loss-of-function mutations in APOC3 correlate with decreased plasma triglyceride levels and subsequent reduced cardiometabolic dysfunction. Read More

Gilead Sciences and Novartis identify new antiviral pyrazolopyridinone compounds

Gilead Sciences Inc. and Novartis AG have jointly reported pyrazolopyridinone compounds potentially useful for the treatment of herpes virus infections. Read More

GTPase KRAS modulators reported in Quanta Therapeutics patent

GTPase KRAS modulators have been described in a recent Quanta Therapeutics Inc. patent and are reported to be useful for the treatment of cancer. Read More
Art concept for inflamed human tissue

Novel anti-IL-17A inhibitor shows similar efficacy to biological therapies in IL-17-driven disorders

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine involved in the pathogenesis of inflammatory, immune-mediated diseases such as psoriasis, psoriatic arthritis and others. Read More

Pharos Ibio divulges SOS1 inhibitors for treatment of cancer

Research at Pharos Ibio Co. Ltd. has led to the identification of son of sevenless homolog 1 (SOS1) inhibitors reported to be useful for the treatment of cancer. Read More

Pelemed patents new FLT3/RET inhibitors for acute myeloid leukemia

A Pelemed Co. Ltd. patent details new indirubin derivatives acting as inhibitors of FLT3 (FLK2/STK1) and/or proto-oncogene tyrosine-protein kinase receptor Ret (RET; CDHF12; PTC) and its mutants. They are reported to be useful for the treatment of acute myeloid leukemia. Read More
Toll like receptor in cell membrane illustration

Discovery of new metabolically stable TLR7 agonist with potent cytokine induction properties

Synthesis and optimization of a series of 1H-pyrazolo[4,3d]pyrimidine molecules at Bristol Myers Squibb Co. led to the identification of compound [I] as the lead Toll-like receptor 7 (TLR7) agonist, with EC50 values of 21 and 94 nM for human and mouse TLR7, respectively. Read More

Other news to note for Sept. 1, 2023

Additional early-stage research and drug discovery news in brief, from: Astria Therapeutics. Read More

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