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Home » Newsletters » BioWorld Science

BioWorld Science

Dec. 14, 2023

View Archived Issues
NIH-NCI chromosomes telomeres

Tessellate Bio draws $8.4M in seed to try alternative synthetic lethality approach

With an initial €8 million (US$8.4 million) in seed funding in the bank, Tessellate Bio has emerged from stealth to tackle cancers that rely on the less well explored synthetic lethality mechanism of alternative lengthening of telomeres. Read More

NXD02-0948, a VHL-mediated, heterobifunctional Bcl-xL degrader that mitigates platelet toxicity

A new degrader strategy has been previously proposed to mitigate platelet toxicity associated with Bcl-xL degraders. This strategy consists of selectively degrading Bcl-xL by the von Hippel-Lindau protein (VHL) E3 ligase in tumor cells, but not in platelets, which minimally express VHL. DT-2216 was developed as the first Bcl-xL degrader of this kind; however, this clinical candidate has still shown some platelet toxicity in vivo. Read More
Bone marrow illustration with doctor background

RR-1752 shows good preclinical activity in myeloproliferative neoplasm models

Myeloproliferative neoplasms (MPNs) are a group of disorders of which the main hallmarks are bone marrow fibrosis and atypical megakaryocytes (MK) accumulation. Both Rho kinase (ROCK) and Aurora kinase (ARK) pathways are involved in correct MK maturation. Read More
Brain-keyhole-landscape.png

Delix awarded NIDA grant to support development of neuroplastogen for substance use disorders

Delix Therapeutics Inc. has been awarded a $320,000 grant from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, to support the advancement of DLX-007. Read More

German researchers patent new PET and fluorescent imaging agents for prostate cancer

Researchers at Albert-Ludwigs-Universität Freiburg and Deutsches Krebsforschungszentrum (DKFZ) have disclosed drug conjugates comprising fluorescent-labeled dye covalently linked to a radionuclide and a ligand targeting glutamate carboxypeptidase II (NAALADase; NAAG peptidase, FOLH1; PSMA) acting as positron-emission tomography (PET) and fluorescent imaging agents for diagnosis and treatment of prostate cancer. Read More
Transmission electron micrograph of HIV particles

Gates Foundation grant supports Gingko Bioworks’ development of live cell therapeutics for HIV and malaria

Ginkgo Bioworks Inc. has received a grant from the Bill & Melinda Gates Foundation to develop a novel cell-based technology for improving protein therapeutics delivery for patients in low- and middle-income countries. Read More

Novel PI3K/HDAC dual inhibitor disclosed

Simultaneous inhibition of phosphoinositide 3-kinase (PI3K) and histone deacetylase (HDAC) is considered a good strategy in cancer treatment, although current PI3K/HDAC dual inhibitors have limitations, such as low selectivity and moderate toxicity levels. Read More

New 18F-labeled FAPI derivative developed by tetrazine ligation shows promise as a PET tracer

Fibroblast activation protein (FAP) is a serine protease that is highly overexpressed in the stroma of most epithelial-derived tumors – including pancreatic, breast and colorectal cancers – in the context of cancer-associated fibroblasts (CAFs). Read More

Iecure’s ECUR-506 cleared to enter clinic in Australia for OTC deficiency

Iecure Inc. has received clearance from the Australian Therapeutic Goods Administration (TGA) of the company’s clinical trial notification (CTN) for ECUR-506 (formerly GTP-506), an investigational therapy in development for the treatment of ornithine transcarbamylase (OTC) deficiency in pediatric (or neonatal) patients. Read More

Gilead Sciences divulges new viral replication inhibitors

Gilead Sciences Inc. has synthesized indoline compounds acting as viral replication inhibitors reported to be useful for the treatment of herpes simplex virus infection and herpes simplex virus encephalitis. Read More
Acute myeloid leukemia

Preclinical characterization of BMS-986357 supports clinical studies

CD33 is known to be highly expressed in myeloid cells and a good therapeutic target for treating acute myeloid leukemia (AML). In the search for more potent compounds, researchers from Dragonfly Therapeutics Inc. and Bristol Myers Squibb Inc. investigated the therapeutic potential of BMS-986357, also known as CC-96191. Read More

Vandria raises series A financing to develop small-molecule mitophagy inducer pipeline

Vandria SA has announced a series A financing round raising $20.6 million (CHF18 million) to help advance its pipeline of first-in-class small-molecule mitophagy inducers. Read More

US researchers describe new RIPK2 and NOD2 inhibitors for multiple sclerosis

Researchers at Tufts University and University of Houston System have identified receptor-interacting serine/threonine-protein kinase 2 (RIPK2; RIP-2) and/or nucleotide-binding oligomerization domain-containing protein 2 (NOD2) inhibitors reported to be useful for the treatment of multiple sclerosis. Read More
Illustration demonstrating muscle contraction in amyotrophic lateral sclerosis.

Increased serum levels of cystatin C are associated with shorter survival in patients with ALS

Researchers from West China Hospital of Sichuan University presented data from a study that aimed to investigate the associations between serum cystatin C (CysC) levels and the progression and survival of patients with amyotrophic lateral sclerosis (ALS). Read More

Hangzhou Unogen Biotech presents new PRMT5 inhibitors for lymphoma

Hangzhou Unogen Biotech Ltd. has divulged protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of lymphoma. Read More

Yichang Humanwell Pharmaceutical discovers new quaternary ammonium salts for anesthesia and pain

Yichang Humanwell Pharmaceutical Co. Ltd. has described quaternary ammonium salts reported to be useful for the treatment of anesthesia and pain. Read More
Dollar sign in light bulb on yellow background

Encellin closes financing round to support development of cell encapsulation platform

Encellin Inc. has announced the closing of a US$9.9 million financing round that will support the company’s development of its cell encapsulation platform with an initial focus on type 1 diabetes. Read More

Topic alerts now available for all BioWorld subscribers

Are you trying to stay on top of developments in CAR T therapies? Drug resistance? Emerging compounds? Updates from certain regulatory agencies? Want to be the first to learn about new biomarkers or business deals? You can still find these articles in the daily BioWorld e-newsletters or on the website, but if you’re laser-focused on a specific topic, we have a way to highlight the news you need as it happens, whether we’ve published a full-length feature story or a brief update. You asked and we listened. Now, in addition to the daily news lineup, you can create topic alerts to be delivered directly to your inbox or via an RSS reader. It’s easy to set up. Instructions can be found here: https://www.bioworld.com/featured-feeds. Happy holidays! Read More

Other news to note for Dec. 14, 2023

Additional early-stage research and drug discovery news in brief, from: Ankyra Therapeutics, Kineta, Transcenta, Transcode Therapeutics. Read More

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