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Home » Newsletters » BioWorld Science

BioWorld Science

May 20, 2025

View Archived Issues
Woman receiving radiotherapy treatments for cancer

Amphiregulin drives metastasis through a paradoxical ‘badscopal’ effect of radiotherapy

Researchers at the University of Chicago have shed light on the role of tumor-promoting factors induced by radiotherapy and their potential impact on future therapeutic strategies. The article, published in Nature on May 14, 2025, points to radiation-induced amphiregulin as a key driver of tumor metastasis. Read More

Rationalizing the design of styrylquinolinium derivatives to bind c-Myc G-quadruplexes in breast cancer

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions of the c-Myc promoter can form G-quadruplex structures, which can be targeted using small molecules containing a styrylquinolinium core, which then downregulate oncogenic c-Myc. The challenge, however, is specificity. Read More
High-density lipoprotein particles and red blood cells

Repair Biotechnologies’ REP-0003 designated orphan drug for homozygous familial hypercholesterolemia

Repair Biotechnologies Inc.’s REP-0003 has been awarded orphan drug designation by the FDA for the treatment of homozygous familial hypercholesterolemia (HoFH). Read More
Illustration of kidneys floating over gloved hand

Sanegene Bio’s SGB-3383 cleared to enter clinic in China for complement-mediated kidney diseases

Suzhou Sanegene Bio Inc. has gained clinical trial approval in China for SGB-3383 for the treatment of complement-mediated kidney diseases, including IgA nephropathy, C3 glomerulopathy, immune complex-mediated membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome. Read More

Bristol Myers Squibb patents new BCL-6 degradation inducers

Bristol Myers Squibb Co. has disclosed proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase-binding moiety covalently bonded to a B-cell lymphoma 6 protein (BCL-6)-targeting moiety through a linker. They are reported to be useful for the treatment of cancer and autoimmune diseases. Read More
CAR T cell

PRGN-3008 exerts potent antitumoral activity and surpasses conventional CAR T

CAR T-cell therapy for B-cell malignancies has still to be improved regarding durability, manufacturing complexity or toxicity, among others. Precigen Inc. has presented data regarding the preclinical development and efficacy of PRGN-3008, a PD-1-expression inhibitor cell therapy targeting CD19 that was built in a next-generation ultra CAR T platform. Read More
Photomicrograph of diffuse large B-cell lymphoma

MALT1 inhibitor SY-12696 proves efficient for treating BTKi-resistant DLBCL

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an important factor from a complex downstream of Bruton tyrosine kinase (BTK) in the B-cell receptor (BCR) signaling pathway. Read More

Neurobiogen divulges new MAO-B inhibitors for Parkinson’s disease

Neurobiogen Co Ltd. has synthesized monoamine oxidase-B (MAO-B) inhibitors reported to be useful for the treatment of Parkinson’s disease. Read More

BMP4 inhibition offers dual benefit in AMD: antifibrotic and antineovascularization effects

Age-related macular degeneration (AMD) is the primary cause of blindness in people aged 65 and older in developed nations. Recent estimates suggest that, globally, the number of individuals affected by AMD could rise to approximately 288 million by 2040. Read More
3D Rendering of tumor microenvironment

New oncolytic virus expressing FLT3L enhances antitumor immunity by activating dendritic cells

Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA-approved T-VEC, have shown safety and some clinical benefit, their limited effectiveness as standalone treatments underscores the need for combination therapies. Read More

Roche describes new GTPase KRAS mutant inhibitors

Scientists at F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have identified macrocyclic compounds acting as GTPase KRAS (G12D mutant) and/or (G13D mutant) inhibitors reported to be useful for the treatment of cancer. Read More

New FABP inhibitors disclosed in patent

Scientists at Jubilant Biosys Ltd. and the University of Texas System have divulged fatty acid binding protein (FABP) inhibitors reported to be useful for the treatment of cancer. Read More
Illustration of brain in head highlighting the blood-brain barier.

An adeno-associated virus to deliver therapeutic genes efficiently to the brain

It is far easier and safer to inject drugs into veins than directly into the brain, yet it is extremely difficult for systemically delivered drugs to cross the blood-brain barrier and achieve therapeutic concentrations there.

Read More

Chengdu Zeling Biomedical Technology discovers new PARP-1 inhibitors

Chengdu Zeling Biomedical Technology Co. Ltd. has described poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1) inhibitors reported to be useful for the treatment cancer. Read More

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