Published April 12 (EPO); April 6 (WO)

Adv. Res. & Technol. Inst. WO 00/19205

DNA synthesis modulators

Bloomington, Ind.

Assays for altering PAK activation of Raf-1; for identifying modulators of DNA synthesis.

Affymetrix WO 00/18962

Binding assays

Santa Clara, Calif.

Methods and compositions for amplifying detectable signals in specific binding assays using fluorescent labels.

Alabama, Univ. of WO 00/18888

Immunity modulation

Birmingham, Ala.

Gene transfer vectors for genetically modifying dendritic and B cells; for modulating immunity.

American Cyanamid WO 00/18434

Cholera holotoxin adjuvant

Madison, N.J.

Mutant cholera holotoxin; for use as an adjuvant in antigenic compositions that induce an immune response.

American Fdn. Biol. Res. WO 00/18933

Cancer immunoresponse

Rockville, Md.

Truncated forms of cancer-specific or -associated antigens; for gene therapy of dendritic cells inducing immunoresponse.

Amgen EPO 992 579

Stem cell factors

Thousand Oaks, Calif.

Stem cell factors, encoding gene sequences, production methods; for treating blood disorders.

Amgen WO 00/18914

DKR polypeptides

Thousand Oaks, Calif.

DKR polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Amgen WO 00/18917

Parkinson's transgenics

Thousand Oaks, Calif.

a-synuclein mutations that accelerate aggregation in transgenics; for Parkinson's disease models.

Antex Biologics WO 00/18910

Moraxella vaccines

Gaithersburg, Md.

Moraxella catarrhalis outer membrane proteins, encoding gene sequences; for vaccines and infection treatment.

Applied Res. Systems WO 00/18957

Sequencing method

Curacao, Netherlands Antilles

Nucleic acid amplification and sequencing using solid supports.

Aventis WO 00/18908

Smooth muscle gene expression

Antony, France

Hybrid promoters having ubiquitous promoter-enhancer elements enabling expression in smooth muscle cells.

Bayer WO 00/18912

Cholesterol activity modulation

Leverkusen, Germany

ATP binding cassette genes, encoded proteins; for modulating cholesterol-driven processes in various diseases.

Biogen WO 00/18428

Cell differentiation modulation

Cambridge, Mass.

Hedgehog and patched antagonists; for inhibiting cell and tissue growth and differentiation.

Biomedica WO 00/19207

ANP antibodies

Vienna, Austria

Polyclonal antibodies that bind to immunogenic peptides of atrial natriuretic peptide (ANP) and pro-ANP.

Biotech & Biol. Sci. Res. Counc. WO 00/18902

Large offspring syndrome

Swindon, UK

Insulin-like growth factor-2 receptor gene expression in transgenics; for diagnosing large offspring syndrome.

Boston Med. Ctr. WO 00/18964

Virulence activator screen

Boston

Finding activators of transition metal-dependent repressor of virulence gene expression in infectious pathogens.

Brigham & Women's Hosp. WO 00/18211

Cochlear gene

Boston

Cochlear gene, encoded protein, fusions, antigenic peptides, transgenics; for diagnostics and therapeutics.

Brussells Free Univ. WO 00/18883

Taxane

Brussells

Taxane and taxane derivatives from penicillin molds, production methods; for making chemotherapeutics.

California, Univ. of WO 00/18429

Bacterial vaccines

Oakland, Calif.

Modified, attenuated Haemophilus somnus strains; for expressing antigenic proteins and making vaccines.

California, Univ. of WO 00/18788

G protein subunit modulators

Oakland, Calif.

Sensory cell-specific G protein gamma subunit, encoding gene, antibodies; for screening modulators.

Chicago, Univ. of WO 00/18966

Differential gene expression

Chicago

Genome-wide identification of differentially expressed genes using improved poly-dT primers anchored at their 3' ends.

Children's Hosp. WO 00/18895

Modulating kinase activity

Boston

Peptide derivatives from the aD region of a protein kinase; for selectively modulating kinase activity.

Chiron WO 00/18916

Human genes

Emeryville, Calif.

Human genes, encoded proteins, probes, antisense, antibodies; for diagnostics and therapeutics.

Chiron WO 00/18921

FGF receptor ligands

Emeryville, Calif.

Synthetic peptides with fibroblast growth factor (FGF) receptor affinity, fusions, oligomers; for therapeutics.

Columbia Univ. WO 00/18884

Neurodegeneration treatment

New York

Motor neuron restricted protein, encoding gene sequence, antibodies, transgenics; for treating neurodegeneration.

Columbia Univ. WO 00/18959

Cancer diagnosis

New York

Tumor necrosis factor receptor-associated factor protein-interacting hereditary multiple extoses protein.

Corixa WO 00/18431

Inflammation prevention

Seattle

Immunogenic oligopeptides derived from chemokine receptor proteins; for preventing inflammatory responses.

Curagen WO 00/18918

Metabolic X syndrome genes

New Haven, Conn.

Genes whose expression is modulated in SHR rats, a metabolic X syndrome model; for diagnostics and therapeutics.

Danisco WO 00/18934

Recombinant protein production

Copenhagen, Denmark

Peptidyl prolyl cis-trans isomerases; for use in assisting secretion of recombinant proteins from production cells.

Diacrin WO 00/18413

Neural cells for transplant

Charlestown, Mass.

Neural cells having modified cell surface MHC antigens; for transplant to treat chronic pain or spasticity.

Diacrin WO 00/18414

Stroke transplant therapy

Charlestown, Mass.

Embryonic pig neural striatum cells having modified cell surface MHC antigens; for treating stroke ischemic damage.

Diversa WO 00/18909

Archeon proteins

San Diego

Genes and encoded proteins from Cenarchaem symbiosum archeons, antibodies, production methods.

Fleischmann, W.R. WO 00/18427

Diseased cell treatment

Galveston, Texas

Ex vivo treatment of diseased cells with interferon-a; for treating infectious disease and cancer.

Gamida Cell WO 00/18885

Growing undifferentiated cells

Savyon, Israel

Expansion of cells in culture while preventing cell differentiation that can be used in vivo and ex vivo.

Glycox WO 00/18891

Diabetes complications diagnosis

Auckland, New Zealand

Assay for fructosamine oxidase in blood plasma; for diagnosing diabetes-associated vascular complications.

HSP Res. Inst. EPO 992 588

Therapeutic production

Osaka, Japan

Vectors encoding Dsb proteins and a therapeutic protein; for production of recombinant therapeutics.

Incyte Genomics WO 00/18915

Membrane organizational proteins

Palo Alto, Calif.

Membrane-associated organizational proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/18919

Kinesin-like motor protein

Palo Alto, Calif.

Human kinesin-like motor protein, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/18922

Carbohydrate-associated proteins

Palo Alto, Calif.

Human carbohydrate-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/18924

Small proline-rich proteins

Palo Alto, Calif.

Human small proline-rich proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Innogenetics EPO 992 580 & 581

T-cell HCV epitopes

Ghent, Belgium

Immunodominant human T-cell stimulating epitopes of the hepatitis C virus (HCV); for therapeutics.

Inst. Phys. & Chem. Res. WO 00/18426

HIV-derived apoptosis inducer

Saitama, Japan

Apoptosis inducers derived from the protein encoded by the HIV-1 vpr gene; for treating cancer and AIDS.

Isis Pharma WO 00/18784

RhoG antisense

Carlsbad, Calif.

Antisense oligonucleotide compositions for modulating RhoG expression; for treating RhoG-associated diseases.

Isis Pharma WO 00/18785

CD71 antisense

Carlsbad, Calif.

Antisense oligonucleotide compositions for modulating CD71 expression; for treating CD71-associated diseases.

Isis Pharma WO 00/18786

RIP-1 antisense

Carlsbad, Calif.

Antisense oligonucleotide compositions for modulating RIP-1 expression; for treating RIP-1-associated diseases.

Johns Hopkins Univ. WO 00/18903

Epilepsy gene therapy

Baltimore

Electrical silencing gene transfer using adenoviral vectors; for treating epilepsy and intractable pain.

Kansas, Univ. Med. Ctr. WO 00/18430

HIV vaccines

Kansas City, Kan.

Live, pathogenic, modified simian HIV; for HIV infection prevention and vaccination.

Krebs Res. Inst. WO 00/18907

Anti-inflammatory antisense

Heidelberg, Germany

Antisense oligos for inhibiting expression of the adhesion molecule ICAM-1; for treating inflammation.

Kyowa Hakko Kogyo WO 00/18805

Immunotherapy antibodies

Tokyo

Antibodies to a transmembrane matrix metalloprotease; for treating immune system diseases.

Leuven Res. & Develop. WO 00/18436

Stroke treatment

Leuven, Belgium

Compounds that reduce a2-antiplasmin in vivo; for treating focal ischemic strokes.

Lindhofer, H. WO 00/18435

Tumor immunotherapy

Grobenzell, Germany

Time-staggered use of tumor cells in combination with intact, heterologous antibodies for immunization.

Lindhofer, H. WO 00/18806

Immunotherapy antibodies

Grobenzell, Germany

Bispecific and trispecific antibodies specifically reacting with inducible surface antigens on T cells.

Ludwig Inst. Cancer Res. WO 00/18212

PDGF C

New York

Platelet-derived growth factor (PDGF) C, encoding gene sequences; for diagnostics and therapeutics.

Mass. Inst. Technol. WO 00/18960

SNP genome scans

Cambridge, Mass.

Genotyping using single nucleotide polymorphisms (SNPs) to perform high-throughput genome scans.

Max Planck Res. Inst. WO 00/18955

Shotgun clone preselection

Berlin

Preselection of shotgun clones from genomic DNA using specific probes; for more efficient sequence analysis.

Maxygen WO 00/18906

Codon-altered gene libraries

Redwood City, Calif.

Shuffling and recombining codon-altered libraries of nucleic acids; for making new proteins and altered vectors.

Med. Res. Counc. (MRC) WO 00/18941

Artificial chromosomes

London

Autonomously replicating mammalian artificial chromosomes; for inserting useful genes into cells.

Millennium Biotherapeutics WO 00/18800

Immunomodulatory proteins

Cambridge, Mass.

TANGO 191 and 195 immunmodulatory proteins, encoding gene sequences; for diagnostics and therapeutics.

Millennium Biotherapeutics WO 00/18904

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Millennium Pharma WO 00/18782

HRPCA 9/10 genes

Cambridge, Mass.

HRPCA 9 and 10 gene sequences, encoded proteins, production methods; for diagnostics and therapeutics.

Millennium Pharma WO 00/18890

Protein phosphatases

Cambridge, Mass.

Protein phosphatases, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 00/18899

ACE homolog

Cambridge, Mass.

Angiotensin converting enzyme (ACE) homolog, encoding gene sequences; for treating blood pressure-related disorders.

Millennium Pharma WO 00/18923

G protein-coupled receptor

Cambridge, Mass.

G protein-coupled receptor family protein, encoding gene, fusions, antigenic fragments, antibodies, transgenics.

Millennium Pharma WO 00/18952

Antibacterial screens

Cambridge, Mass.

Essential genes from Bacillus subtilis and Streptococcus pneumoniae, homologs, orthologs; for antibacterial screens.

Millennium Pharma WO 00/18961

Prostate cancer expression analysis

Cambridge, Mass.

Expression analysis of nucleic acids and polypeptides useful in prostate cancer diagnosis and treatment.

Nebraska, Univ. of WO 00/18239

Liver cells for transplant

Lincoln, Neb.

Reversibly immortalized liver cells, methods of production; for transplantation.

New England Biolabs WO 00/18881

Peptide ligation methods

Beverly, Mass.

Target proteins fused to a protein splicing element; for peptide ligation.

New England Med. Ctr. EPO 992 578

Intracytoplasmic labeling

Boston

Labeling intracytoplasmic molecules using permeabilizing agents to allow labels to traverse the cell membrane.

New York, State Univ. of WO 00/18894

Immunosuppression

Albany, N.Y.

IkappaB kinase that regulates NFkappaB gene transcription, encoding gene, antibodies; for immunosuppression.

N. Shore-Long Island Jewish Res. Ctr. WO 00/18238

Methylation pattern detection

Manhasset, N.Y.

Nucleic acid probes for detecting mutations and methylation patterns in genes; for diagnostics and therapeutics.

Progenics Pharma WO 00/18432

Viral disease vaccines

Tarrytown, N.Y.

Cellular carbohydrates that are overexpressed in viral diseases, molecular mimics; for viral disease vaccines.

Qiagen EPO 992 583

Vector purification

Hilden, Germany

Purifying covalently closed circular DNA using anion exchange chromatography.

Regeneron Pharma WO 00/18932

Cytokine inactivation

Tarrytown, N.Y.

Fusion peptides that bind and inactivate cytokines, encoding gene sequences; for receptor-based antagonists.

RIKEN EPO 992 587

IP3 binding polypeptide

Wako, Japan

High affinity inositol 1,4,5-triphosphate (IP3) binding polypeptide, encoding gene; for affecting cell signalling.

Rockefeller Univ. WO 00/18896

Venom enzymes

New York

Polistinae venom enzymes, such as phospholipase and hyaluronidase; for recombinant production.

Schering-Plough EPO 992 584

Langerhans cell antigen

Kenilworth, N.J.

Purified mammalian Langerhans cell antigen, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Schering-Plough WO 00/18803

Flt3 ligands

Kenilworth, N.J.

Purified mammalian Flt3 ligands, variants, antibodies, modulators; for diagnostics and therapeutics.

Searle WO 00/18905

Circularly-permuted proteins

Chicago

Inserting circularly-permuted genes into a display vector; for producing circularly-permuted proteins.

Seeger, S. WO 00/18956

Sequencing method

Donau, Germany

Nucleic acid sequencing on immobilized supports using laser-related methods.

Seiki, M. WO 00/18900

Metalloprotease inhibitors

Tokyo

Transmembrane matrix metalloprotease, encoding gene sequences; for inhibitor screens.

Sibia Neurosciences EPO 992 585

Calcium channel subunits

La Jolla, Calif.

Human calcium channel subunits, encoding genes, variants; for identifying modulators.

Singapore Republic WO 00/18958 & 18968

Hepatitis B inhibitors

Singapore

In vitro PCR-based amplification assay for human hepatitis B virus DNA polymerase; for screening inhibitors.

SmithKline Beecham WO 00/18437 & 18804

Angiogenesis modulation

Philadelphia

Tie2 receptor agonist and antagonist antibodies; for use in modulating angiogenesis.

SmithKline Beecham WO 00/18797

Antibacterial screens

Philadelphia

Bacterial map proteins, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/18929

Respiratory infection vaccines

Rixensart, Belgium

Chimeric proteins having immunogenic fragments of RSV and other viral proteins; for respiratory infection vaccines.

Southern California, Univ. of WO 00/18240

Gene therapy vector

Los Angeles

Recombinant replication competent retroviral vector encoding a cell-specific ligand; for gene therapy.

Southern California, Univ. of WO 00/18421

Metastasis prevention

Los Angeles

Contortrostatin, variants, fragments, encoding gene sequences, production methods; for preventing metastasis.

Synaptic Pharma WO 00/18438

Neuropeptide FF receptor

Paramus, N.J.

Mammalian neuropeptide FF receptor gene, encoded protein, antibodies, transgenics; for identifying modulators.

Takeda Chemical EPO 992 189

Vitamin D transgenics

Osaka, Japan

Transgenics having the 25-hydroxylated vitamin D3-24-hydroxylase gene; for modeling various diseases.

Temple Univ. WO 00/18802

Polymeric hemoglobin mutants

Philadelphia

Human _-globin mutant polypeptides, encoding gene sequences; for making polymeric hemoglobin mutants.

Ulster, Univ. of WO 00/19208

Bladder cancer diagnosis

Newtownabbey, UK

Assay for 37kDa epidermal growth factor receptor fragment in urine; for diagnosing bladder and prostate cancer.

U.S. Surgical EPO 992 586

Modified matrix proteins

Norwalk, Conn.

Extracellular matrix proteins with modified amino acid residues; for altering their physiological activity.

Urogenesys WO 00/18925

Prostate cancer gene

Santa Monica, Calif.

Gene expressed in prostate cancer, encoding gene sequences; for diagnostics and therapeutics.

Utah, Univ. of WO 00/18965

Multiplex genotyping

Salt Lake City, Utah

Multiplex genotyping using fluorescent hybridization probes and PCR-based amplification methods.

Utrecht Univ. WO 00/18913

Tumor suppressor gene

Utrecht, Netherlands

Chromosome 19 gene, homologs, fragments, derivatives; for tumor suppression.

Variagenics WO 00/18967

Nucleotide variance detection

Cambridge, Mass.

Methods for analyzing nucleotide sequences, including variance detection, without full sequence determination.

Wales, Univ. of EPO 992 582

Schistosomiasis vaccine

Bangor, UK

Recombinant fusion protein with schistosome carcarial elastase and bacterial protein fragments; for vaccines.

Washington Univ. WO 00/18783

Breast cancer therapeutic

St. Louis, Mo.

Mammaglobin, a secreted mammary-specific breast cancer protein, encoding gene; for diagnostics and therapeutics.

Washington Univ. WO 00/18787

Wolfram Syndrome gene

St. Louis, Mo.

Chromosome 4 gene associated with Wolfram Syndrome, mutations, encoded protein, antibodies; for therapy.

Washington Univ. WO 00/18799

Neurotrophic factor artemin

St. Louis, Mo.

Neurotrophic factor artemin, encoding gene sequences; for diagnostics and therapeutics.

World Fdn. AIDS Res. & Prevention WO 00/18433

HIV vaccines

Paris

Use of antigenic complexes of HIV envelope proteins and HLA class I antigens as HIV vaccines.

Zheng, S. WO 00/18911

Intestinal cancer suppression

Zhejiang, China

Gene located on chromosome 14 that is down-regulated in large intestine cancer; for cancer suppression.

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