Findings from the phase III NOVA trial of niraparib in women with recurrent ovarian cancer blasted shares of developer Tesaro Inc. to an historic high after the company reported the trial achieved its primary endpoint of statistically significant progression-free survival (PFS) compared to control across germline BRCA mutation (gBRCAmut) carriers and non-gBRCAmut carriers, including those with homologous recombination deficient (HRD) tumors.