I. FINANCING OF PRIVATE BIOTECHNOLOGY COMPANIES: $153.19M

Company

Location

Date

Amt. (M)

Details


Anacor Pharmaceuticals Inc.

Palo Alto, Calif.

10/29

$7

Anacor raised $3M in April in a first round and $4M in October in a second round for a total of $7M; investors in both rounds were Rho Ventures and Aberdare Ventures

Aptanomics SA

Lyon, France

10/28

€7
(US$6.9)

Aptanomics raised US$6.9M in a financing with investors CDC Innovation, Bioam, Ventech and AGF Private Equity

Codexis Inc.

Redwood City, Calif.

10/4

$25

Codexis raised $25M in its first private financing since its establishment as a subsidiary of Maxygen Inc.; CMEA Ventures and Pequot Ventures led the round, which included investments from ChevronTexaco Technology Ventures and Maxygen

CreAgri Inc.

Hayward, Calif.

10/11

$8.3

CreAgri raised $8.3M in its first round led by Burrill & Company; other investors were POSCO BioVentures, DSM Venturing BV, Foragen Technologies Management LP and Aurora Equity LLC

EcoBiotics Ltd.

Brisbane, Australia

10/30**

A$3
(US$1.62)

EcoBiotics raised US$1.62 from investors

Enact Pharma plc

Salisburg, UK

10/16**

£0.4
(US$0.62)

Enact raised US$620,000 in a financing with New Opportunities Investment Trust plc

Etiologics Ltd.

Oxford, UK

10/7

£3.5
(US$5.25)

Etiologics raised $5.25M in initial venture capital backing from MVM Ltd. and ABN AMRO Capital

Kemia Inc.

San Diego

10/30

$16.5

Kemia raised $16.5M in a Series A financing; investors were Forward Ventures, Alta Partners and Texas Pacific Group

MerLion Pharmaceuticals Pte. Ltd.

Singapore

10/30

$13

MerLion raised $13M in its first round led by Aravis; other investors were BioVeda, EDB BioMedical Sciences Investment Fund, JAFCO Asia Technology, Novartis BioVentures, Temasek Holdings and UOB Hermes Asia Technology

Neurogenetics Inc.

La Jolla, Calif.

10/30

$10

Neurogenetics raised $10M in a Series B financing; investors were Alta Partners, Advent International, GIMV Venture Capital, Novartis Venture Fund, S.R. One Ltd. and Eisai Co. Ltd.

Peninsula Pharmaceuticals Inc.

Fremont, Calif.

10/28

$22.1

Peninsula raised $22.1M in a financing led by Domain Associates; other investors were Canaan Partners, A.M. Pappas & Associates, Montreux Equity Partners, Mitsubishi International Corp. and Sears Capital Management Inc.

Pieris Proteolab AG

Freising, Germany

10/31

€12
(US$12)

Pieris raised US$12M in a Series A financing led by Global Life Science Ventures and Gilde Investment Management BV; other investors were Bay Tech Venture Capital, ABN AMRO Capital, BioM Venture Capital and TransConnect

Rubicon Genomics Inc.

Ann Arbor, Mich.

10/1

$3.5

Rubicon raised $3.5M in a Series B round led by ARCH Development Partners, with participation from Duchossois TECnology Partners, Sloan Ventures and individual investors

Sireen AG

Martinsried, Germany

10/30

€5
(US$4.9)

Sireen raised US$4.9M from a syndicate of investors led by DVC Deutsche Venture Capital and including ABN AMRO Capital

Sucampo Pharmaceuticals Inc.

Bethesda, Md.

10/11

$4.5

Sucampo raised another $4.5M in a Series A round with a $3M investment from Mizuho Capital Co. Ltd. and a $1.5M investment from Diamond Capital Co. Ltd.

Xerion Pharmaceuticals Inc.

Martinsried, Germany

10/8

€12.3
(US$12)

Xerion closed its third round of financing, raising US$12M; Heidelberg Innovation and Nextech Ventures led the round; other investors were 3i, IKB Venture Capital and BioM


II. MILESTONE PAYMENTS AND EQUITY INVESTMENTS FROM EXISTING CORPORATE PARTNERS: $12M

Company (Symbol)#*

Partner (Country)

Amt. (M)

Triggering Event

Details (Date)


Applied Molecular Evolution Inc. (AMEV)

Eli Lilly and Co.

ND

Milestone payment

Applied Molecular received the payment for successfully meeting criteria for improving the potency, affinity and stability of the molecule as specified in the collaboration agreement (10/16)

ArQule Inc. (ARQL)

Wyeth

ND

Milestone payment

ArQule received the payment after Wyeth nominated a compound targeted in women's health to its development pipeline (10/7)

Atrix Laboratories Inc. (ATRX)

Sanofi-Synthelabo Inc. (France)

$6

Milestone payment

Atrix received $6M for the introduction of Eligard 22.5 mg to treat advanced prostate cancer (10/15)

Direvo Biotech AG* (Germany)

Novozymes A/S (Denmark)

ND

Milestone payment

Direvo received the payment after an achievementin its collaboration to optimize an industrial enzyme for one of Novozymes' core industry segments (10/2)

ImmunoGen Inc. (IMGN)

Boehringer Ingelheim International GmbH (Germany)

ND

Milestone payment

ImmunoGen received an undisclosed payment for initiating clinical trials in its collaboration with Boehringer to develop an anticancer agent using DM1 Tumor-Activated Prodrug technology (10/15)

Maxygen Holdings Ltd. (subsidiary of Maxygen Inc.; MAXY)

InterMune Inc.

$1

Milestone payment

Maxygen received the payment for achieving drug performance criteria in its alliance with InterMune to develop a next-generation version of Actimmune that can be taken once weekly rather than three times a week (10/7)

Nastech Pharmaceutical Co. Inc. (NSTK)

Pharmacia Corp.

$1

Milestone payment

Nastech received the payment as part of its collaboration for intranasally administered apomorphine for male and female sexual dysfunction (10/2)

Targeted Genetics Corp. (TGEN)

Biogen Inc.

$4

Equity investment

Targeted Genetics received $4M after issuing 5.8M shares at 69 cents each to Biogen as part of a September 2000 equity purchase commitment in the companies' collaboration to develop up to four gene therapy products (10/8)


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Denotes privately held company.

** Denotes the date the item ran in BioWorld International.

ND = Not disclosed.