I. FINANCING OF PRIVATE BIOTECHNOLOGY COMPANIES: $198.914M

Company

Location

Date

Amt. (M)

Details

Alnylam Pharmaceuticals Inc.

Cambridge, Mass.

8/2

$17

Alnylam raised $17M in Series A and B financings with Polaris Venture Partners, ARCH Venture Partners and Atlas Venture

Amoebics Ltd.

Edinburgh, UK

8/21**

£0.5 (US$0.763)

Amoebics raised US$763,000 in a second-round funding from a group of Scottish investors led by the Archangel Syndicate

Archemix Corp.

Cambridge, Mass.

8/13

$51.75

Archemix raised a total of $51.75M in its Series A financing led by Schroder Ventures Life Sciences, Atlas Venture and Prospect Venture Partners; other investors were Rho Ventures, Care Capital, MDS Capital, Posco BioVentures and U.S. Trust Private Equity

Cureon A/S

Copenhagen, Denmark

8/14**

DKK34 (US$4.5)

Cureon raised US$4.5M from a consortium of Scandinavian investors

Dharmacon Research Inc.

Lafayette, Colo.

8/23

$5.7

Dharmacon Research completed a $5.7M round of equity financing led by Boulder Ventures Ltd., with Telegraph Hill Partners also participating

Evolutec Ltd.

Oxford, UK

8/8

£1.82 (US$2.78)

Evolutec raised US$2.78M through the issuance of ordinary shares; Friends, Ivory & Sime plc led the round, with the remainder purchased by private investors

Medgenics Inc.

Misgav, Israel

8/28**

$10

Medgenics raised $10M in a Series B financing, mostly from Israeli-based funds and matching funds by earlier investors led by Alta Partners

Nobex Corp.

Research Triangle Park, N.C.

8/13

$35

Nobex raised $35M in a private placement of Series F preferred stock; the round was led by AEA Investors, and included EndPoint Late Stage Fund I LP, HealthCap, and a group of venture capital firms based in Taiwan

Noxxon Pharma AG

Berlin

8/22

9.3 (US$9.03)

Noxxon Pharma completed an internal mezzanine financing round led by Merlin Biosciences; other investors were WestLB, Hannover Finanz, DEWB, Berlin Capital Fund, Viscardi, Oppenheim and Peppermint

ParinGenix Inc.

Charlotte, N.C.

8/12

$4

ParinGenix raised $4M in a private financing; lead investors were Academy Venture Fund, Research Corp. Technologies and A.P. Kennedy Family Securities

Phico Therapeutics Ltd.

Cambridge, UK

8/14**

£0.45 (US$0.691)

Phico raised US$691,000 from Cambridge Research and Innovation Ltd., Providence Investment Company Ltd., Emblem Technology Partners Ltd. and business angels

Quorex Pharmaceuticals Inc.

Carlsbad, Calif.

8/6

$10.6

Quorex raised $10.6M in an extension to its Series B round that originally raised about $20M in early 2001; investors were Prism Venture Partners, Johnson & Johnson Development Corp., Tullis-Dickerson & Co. Inc., IngleWood Ventures, China Development Industrial Bank and Pacific Growth Equities

Serenex Inc.

Durham, N.C.

8/20

$15

Serenex raised $15M in a Series B financing led by Intersouth Partners; other investors were Lilly BioVentures and Seaflower Ventures, as well as Mediphase Venture Partners

Spherics Inc.

Lincoln, R.I.

8/14

$10

Spherics completed a second round of financing raising $10M; investors were Zero Stage Capital, CB Health Ventures, PODHolding Inc. and Eastman Ventures

Sucampo Pharmaceuticals Inc.

Bethesda, Md.

8/8

$16

Sucampo raised $16M when Fujisawa Pharmaceuticals Co. Ltd., Orix Corp. and UFJ Capital Co. Ltd. purchased $8M, $5M and $3M in stock, respectively

Xention Discovery Ltd.

Cambridge, UK

8/21**

£4

(US$6.1)

Xention was formed with US$6.1M in venture capital backing; the financing was led by MVM Ltd.

II. MILESTONE PAYMENTS AND EQUITY INVESTMENTS FROM EXISTING CORPORATE PARTNERS: $3.875M

Company (Symbol)#*

Partner (Country)

Amt. (M)

Triggering Event

Details (Date)

AltaRex Corp. (OTC BB:ALXFF; TSE:AXO)

United Therapeutics Corp. (UTHR)

$2.475

Investment

Pursuant to terms of a collaboration, United exercised a warrant to purchase 3.25M AltaRex common shares for $1.6M; it also purchased a debenture for $875,000 (8/16)

Biodiem Ltd.* (Australia)

Merck & Co. Inc.

ND

Milestone payment

Biodiem received the payment associated with its licensing agreement to develop, manufacture and market a live attenuated influenza vaccine, delivered by nasal spray (8/29)

Cytokinetics Inc.*

GlaxoSmithKline plc (UK)

ND

Milestone payment

Cytokinetics received a payment for beginning a Phase I trial of a small-molecule inhibitor of kinesin spindle protein (8/12)

Exelixis Inc. (EXEL)

Bristol-Myers Squibb Co.

ND

Milestone payment

Exelixis received an undisclosed milestone payment after the companies completed selection of a set of cancer targets (8/6)

Isis Pharmaceuticals Inc. (ISIS)

Amgen Inc. (AMGN)

ND

Milestone payment

Isis received the payment from Amgen for research progress in the companies' three-year antisense drug discovery collaboration (8/14)

MorphoSys AG (Germany; Neuer Markt:MOR)

Centocor Corp. (unit of Johnson & Johnson)

ND

Milestone payment

MorphoSys received the payment for achieving a milestone in its collaboration to deliver several antibodies against a target molecule (8/21**)

Neurobiological Technologies Inc. (NTII)

Merz Pharmaceuticals GmbH (Germany)

$1.4

Milestone payment

Neurobiological received a $1.4M payment for achieving goals related to the marketing launch of Memantine in Europe (8/12)

Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Denotes privately held company.

** Denotes the date the item ran in BioWorld International.

ND = Not disclosed.

OTC BB = Over-the-Counter Bulletin Board; TSE = Toronto Stock Exchange