Company

Stock Price 12/31/00

Stock Price 12/31/01

Stock Price Change(%)

Shares Out (M)*

Mkt. Cap. (M)**

3-Dimensional Pharmaceuticals Inc. (Nasdaq:DDDP)

14.8125

8.4900

-42.7

22.0

186.7

Aclara BioSciences Inc. (Nasdaq:ACLA)

10.8750

5.0700

-53.4

35.8

181.4

Affymetrix Inc. (Nasdaq:AFFX)

74.4375

37.7500

-49.3

57.9

2,187.2

Agilent Technologies Inc. (NYSE:A)

54.7500

28.5100

-47.9

460.6

13,132.8

Applied Molecular Evolution Inc. (Nasdaq:AMEV)

17.0625

12.3100

-27.9

23.6

290.5

Ariad Pharmaceuticals Inc.1 (Nasdaq:ARIA)

4.7500

5.3300

12.2

30.2

160.9

Array BioPharma Inc. (Nasdaq:ARRY)

8.9375

14.8600

66.3

23.5

349.1

Bruker Daltonics Inc. (Nasdaq:BDAL)

23.5625

16.3500

-30.6

54.9

897.2

Celera Genomics Group (NYSE:CRA)

36.1250

26.6900

-26.1

62.2

1,659.4

Ciphergen Biosystems Inc. (Nasdaq:CIPH)

13.2500

8.0000

-39.6

27.0

215.6

Commonweatlh Biotechnologies Inc. (Nasdaq:CBTE)

3.7500

2.7200

-27.5

2.1

5.6

Compugen Ltd. (Nasdaq:CGEN)

6.2500

4.7000

-24.8

26.0

122.2

CuraGen Corp. (Nasdaq:CRGN)

27.3125

22.3700

-18.1

48.7

1,089.3

CytoGenix Inc. (OTC BB:CYGX)

0.1250

0.1950

56.0

41.7

8.1

DeCode genetics Inc. (Nasdaq:DCGN)

10.5000

9.8000

-6.7

45.2

442.7

Deltagen Inc. (Nasdaq:DGEN)

10.4375

9.2000

-11.9

32.1

295.1

Discovery Partners International Inc. (Nasdaq:DPII)

12.1250

7.4000

-39.0

24.2

179.2

Diversa Corp. (Nasdaq:DVSA)

17.9375

14.1500

-21.1

35.5

501.7

DNAPrint genomics Inc. (Nasdaq:DNAP)

0.1094

0.0500

-54.3

413.3

20.7

Exact Sciences Corp.2 (Nasdaq:EXAS)

14.0000

10.2600

-26.7

18.8

192.7

Exelixis Pharmaceuticals Inc. (Nasdaq:EXEL)

14.6250

16.6200

13.6

49.5

822.9

Genaera Corp. (Nasdaq:GENR)

2.2188

3.9000

75.8

32.9

128.2

Genaissance Pharmaceuticals Inc. (Nasdaq:GNSC)

18.0000

4.6500

-74.2

22.8

105.9

Gene Logic Inc. (Nasdaq:GLGC)

18.3750

18.8400

2.5

26.7

503.7

Genencor International Inc. (Nasdaq:GCOR)

18.0000

15.9600

-11.3

59.9

956.4

Genome Therapeutics Corp. (Nasdaq:GENE)

6.9688

6.8100

-2.3

22.8

155.0

Genomic Solutions Inc. (Nasdaq:GNSL)

7.6250

2.4000

-68.5

24.3

58.4

Genomica Corp. (Nasdaq:GNOM)

5.2810

4.5600

-13.7

23.0

104.9

Genset SA3 (Nasdaq:GENXY; Nouveau Marche: GENSET)

12.6250

2.6700

-78.9

8.1

21.6

Genzyme Molecular Oncology (Nasdaq:GZMO)

9.1875

8.0000

-12.9

16.7

133.8

Human Genome Sciences Inc. (Nasdaq:HGSI)

69.3125

33.7200

-51.4

127.8

4,309.5

Hyseq Inc. (Nasdaq:HYSQ)

14.3750

7.7200

-46.3

19.1

147.5

ID Biomedical Corp. (Nasdaq:IDBE; TSE:IDB)

4.8750

4.3000

-11.8

30.0

129.1

Incyte Genomics Inc. (Nasdaq:INCY)

24.8750

19.4400

-21.8

66.4

1,290.9

InforMax Inc. (Nasdaq:INMX)

10.3750

2.9500

-71.6

24.3

71.8

Invitrogen Corp. (Nasdaq:IVGN)

86.3750

61.9300

-28.3

53.0

3,279.9

Large Scale Biology Corp. (Nasdaq:LSBC)

9.5000

4.5000

-52.6

24.6

110.6

Lexicon Genetics Inc. (Nasdaq:LEXG)

16.6250

11.5400

-30.6

51.9

599.1

LION Bioscience AG (Nasdaq:LEON; Neur Markt:LIO)

75.3750

16.2500

-78.4

18.8

304.8

Lynx Therapeutics Inc. (Nasdaq:LYNX)

9.0000

4.0300

-55.2

13.8

55.5

Maxygen Inc. (Nasdaq:MAXY)

24.5000

17.5700

-28.3

33.9

596.4

MediChem LifeSciences Inc. (Nasdaq:MCLS)

4.6250

1.4500

-68.6

26.6

38.6

Millennium Pharmaceuticals Inc. (Nasdaq:MLNM)

61.8750

24.5100

-60.4

221.4

5,425.5

Myriad Genetics Inc. (Nasdaq:MYGN)

82.7500

52.6400

-36.4

23.5

1,239.4

Nanogen Inc. (Nasdaq:NGEN)

9.0000

5.7700

-35.9

21.6

124.4

NaPro Biotherapeutics Inc. (Nasdaq:NPRO)

8.4844

11.4000

34.4

28.2

321.9

Onyx Pharmaceuticals Inc. (Nasdaq:ONXX)

14.8750

5.1200

-65.6

18.5

94.8

Orchid Biosciences Inc. (Nasdaq:ORCH)

14.0000

5.5000

-60.7

39.5

217.5

Oxford Glycosciences plc (Nasdaq:OGSI; LSE:OGS)

21.2500

9.7000

-54.4

N/A

N/A

Paradigm Genetics Inc.4 (Nasdaq:PDGM)

10.0000

5.7000

-43.0

31.4

179.2

Regeneron Pharmaceuticals Inc. (Nasdaq:REGN)

35.2656

28.1600

-20.1

41.2

1,159.2

Rigel Pharmaceuticals Inc. (Nasdaq:RIGL)

10.0000

4.6500

-53.5

37.6

174.8

Sangamo BioSciences Inc. (Nasdaq:SGMO)

19.5000

9.3400

-52.1

24.4

228.3

Sequenom Inc. (Nasdaq:SQNM)

14.0000

10.6700

-23.8

37.4

398.6

SignalGene Inc.5 (TSE:SGI)

C$0.8

C$0.39

-51.3

121.9

C$47.6

SYN X Pharma Inc.6 (TSE:SYY)

N/A

C$7.75

N/A

10.1

C$78.2

Synaptic Pharmaceutical Corp. (Nasdaq:SNAP)

5.1250

6.0200

17.5

10.9

65.9

Tm Bioscience Corp. (CDNX:TMC)

C$0.46

C$0.39

-15.2

99.9

C$39.0

Transgenomic Inc. (Nasdaq:TBIO)

10.5000

11.0000

4.8

23.2

255.7

Variagenics Inc. (Nasdaq:VGNX)

11.8594

3.0800

-74.0

23.4

72.0

ZymoGenetics Inc.7 (Nasdaq:ZGEN)

-

45

540

Notes:

There are 68 public genomics companies profiled. The 61 companies listed in this table include only those trading on American and Canadian stock exchanges.

Autogen Ltd. (ASX:AGT), Genesis Research and Development Corp. Ltd. (NZSE:GEN; ASX:GEN), GPC Biotech AG (Neuer Markt:GPC), MediGene AG (Neuer Markt:MDG), Pharmagene plc (LSE:PGN), Proteome Sciences plc (LSE:PRM) and Proteome Systems Inc. (an unlisted public company) are not included in this table.

All numbers are in U.S. dollars unless otherwise noted; US$1 = C$1.59.

* Shares outstanding data were compiled from corporate quarterly statements for the period ending Sept. 30, 2001, company websites and other sources. Numbers were rounded for data presentation.

** Market capitalization values, calculated by multiplying the Dec. 31, 2001, stock prices by shares outstanding, are approximate. Numbers were rounded for data presentation.

N/A = Not available; ASX = Australian Stock Exchange; CDNX = Canadian Venture Exchange; LSE = London Stock Exchange; NYSE = New York Stock Exchange; NZSE = New Zealand Stock Exchange; OTC BB = Over the Counter Bulletin Board; TSE = Toronto Stock Exchange

1. The number of shares outstanding for Ariad Pharmaceuticals Inc. does not include the private placement in November 2001 of 1,927,712 shares of common stock.

2. Exact Sciences Corp.'s shares began trading on Jan. 31, 2001, following an IPO at $14 per share. The percentage change of -26.71 reflects the loss from the IPO price through Dec. 31, 2001.

3. The number of shares outstanding for Genset SA are ordinary shares as of Sept. 30, 2001, or 24,315,550 equivalent American depositary shares.

4. The number of shares outstanding for Paradigm Genetics Inc. includes the private placement in October 2001 of approximately 5.1 million shares of common stock.

5. The number of shares outstanding for SignalGene Inc. is as of Jan. 25, 2002.

6. The Dec. 31, 2000, stock price for SYN X Pharma Inc. was not available; SYN X traded on the Canadian Venture Exchange on that date. It began trading on the Toronto Stock Exchange on Aug. 1, 2001.

7. ZymoGenetics Inc. went public on Feb. 1, 2002, selling 10 million shares at $12 per share. Shares outstanding are as of the IPO date.