Published May 3 (EPO); April 27 (WO); May 3 (GB)

Affibody Technol. WO 00/23580

Affinity separation methods

Stockholm, Sweden

Methods of affinity separation using immobilized proteinaceous ligands having modified asparagine.

Alabama, Univ. of WO 00/23623

Fas promoter polymorphisms

Birmingham, Ala.

Fas/Fas ligand promoter polymorphisms; for determining the risk of autoimmune disease and non-lymphatic cancer.

Albani, S. WO 00/23053

T cell isolation

Encinitas, Calif.

Liposomes containing MHC peptide complexes bound to solid supports; for retrieving antigen-specific T cells.

Arch Develop. WO 00/23603

Type 2 diabetes genes


Identification of genes associated with type 2 diabetes, encoded proteins; for diagnostics and therapeutics.

Ariad Gene Therapeutics WO 00/23600

Self-aggregation domains

Cambridge, Mass.

Domains for conditional self-aggregation in endoplasmic reticulum, fusion proteins, encoding gene sequences.

Ariad Gene Therapeutics WO 00/23602

Retention domains

Cambridge, Mass.

Domains for conditional retention in endoplasmic reticulum, fusion proteins containing them, encoding gene sequences.

Aventis WO 00/23604

Protein production system

Frankfurt, Germany

Expression vectors having Stylonychia lemnae regulatory sequences; for heterologous protein production.

Avigen WO 00/23116

Factor VIII expression

Alameda, Calif.

Adeno-associated vectors for the expression of Factor VIII in transfected target cells.

Biogen WO 00/23472

Interferon-_ fusions

Cambridge, Mass.

Interferon-_ fusion proteins, mutants; for affecting the immune system.

Bioimage WO 00/23091

Reduced cAMP cleavage

Soborg, Denmark

Dislocation of cyclic nucleotide phophodiesterases from their anchoring sites; for reduced cleavage of cAMP.

Bioimage WO 00/23615

Cellular response measure

Soborg, Denmark

Detection of intracellular translocation/redistribution of biologically active proteins to measure cellular response.

Bios Group WO 00/23933

Genetic regulatory networks

Santa Fe, N.M.

Experimental and algorithmic methods for analyzing genetic regulatory networks and grouping genes into them.

Boehringer Ingelheim WO 00/23584

Cancer immunotherapy antigen

Ingelheim, Germany

Alternate translation product of a tumor-associated antigen, antigenic peptides, encoding gene; for cancer immunotherapy.

Brownlee, M. WO 00/23568

Reducing reactive oxygen species

Bronx, N.Y.

Identifying agents that reduce mitochondrial overproduction of reactive oxygen species in cells.

California, Univ. of WO 00/23579

Antibodies from yeasts

Oakland, Calif.

Large-scale production of functionally assembled antigen-specific intact recombinant antibodies in yeasts.

Carlsson, B., et al. WO 00/23475

Hyperlipidemia treatment

Goteborg, Sweden

Intracellular C-terminal HDL receptor domain peptides, analogs, fragments, encoding genes; for hyperlipidemia.

Children's Hosp. WO 00/23569

Transgenic emphysema model


Transgenics lacking surfactant protein D and its encoding gene; for modeling emphysema and finding therapeutics.

Chugai EPO 997 152

Lymphatic tumor antibodies


Specific antibodies that have cytotoxic activity and can be used as therapeutics against lymphatic tumors.

Chugai WO 00/23610

Reduced cytokine inflammation


Inhibition of TAK1 signal transduction; for reduced production of inflammatory cytokines.

City of Hope WO 00/23573

Cancer T-cell therapy

Duarte, Calif.

CD20-specific redirected T cells; for cellular immunotherapy of CD20+ malignancies.

Cognetix WO 00/23092

Anti-inflammatory therapeutics

Salt Lake City

Contulakin-G, analogs, encoding gene sequences; for anti-inflammatory therapeutics.

CSIRO (Comm. Sci. Ind. Res. Org.) WO 00/23601

Less antigenic drug delivery

Campbell, Australia

Encapsulation of growth hormones within semipermeable membranes; for drug delivery with lesser immune response.

Cornell Univ. WO 00/23571

Oligodendrocyte separation

Ithaca, N.Y.

Transfection of cell preparations with an oligodendrocyte-specific promoter linked to a reporter; for cell separation.

Curagen WO 00/23100

Hypertension genes

New Haven, Conn.

16 genes differentially expressed in hypertensive rats; for developing therapeutics for hypertension and renal failure.

Delta Biotech GB 2 343 184

Protein production system

Nottingham, UK

Modification of Ubc4p/5p activity in fungal cells; for increasing recombinant protein production.

Duke Univ. WO 00/23624

Proliferative disease screen

Durham, N.C.

Measuring upregulation of the CLN3 gene; for screening for the risk of proliferative diseases.

Fordham Univ. WO 00/23093

Tissue repair promotion

Bronx, N.Y.

Heat shock proteins complexed with antigenic molecules; for promoting tissue repair.

Gardella, T.J., et al. WO 00/23594

Bioactive PTH peptides

Needham, Mass.

Bioactive peptides and derivatives of parathyroid hormone (PTH) and PTH-related peptide; for bone therapeutics.

Gemini Research WO 00/23618

Osteoporosis diagnostics

Cambridge, UK

Polymorphism in a TGF-SS gene correlated with osteoporosis; for diagnostics and therapeutics.

Genvec WO 00/23088

Inhibiting adenoviral immunoresponse

Gaithersburg, Md.

Using systemic neutralizing antibodies to inhibit immune responses during adenoviral-based gene therapy.

Georgetown Univ. WO 00/23590

Regulating NFkappaB activation


Modulators of TRAF3 degradation; for controlling TRAF3-mediated CD40 regulation of NFkappaB activation.

Georgia, Med. Coll. of WO 00/23606

Retiroviral vectors

Augusta, Ga.

Enhancer, insulator, and promoter sequences from human-like globin genes; for use in retroviral vectors.

Hook, V.Y.H. WO 00/23576

Alzheimer's secretases

La Jolla, Calif.

Selecting secretases that cleave amyloid precursor protein; for inhibiting Alzheimer's A_ protein peptide production.

Human Genome Sciences WO 00/23572

TNF receptor-related gene

Rockville, Md.

TNF receptor-related gene 12, encoded protein, protein production methods; for diagnostics and therapeutics.

Immunex WO 00/23094

Platelet activation inhibition


Soluble CD39 polypeptides; for inhibiting platelet activation and recruitment.

Incyte Genomics WO 00/23466

RNA binding proteins

Palo Alto, Calif.

Human RNA binding proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/23589

Apoptosis-related proteins

Palo Alto, Calif.

Proliferation- and apoptosis-related proteins, encoding gene sequences, antibodies, modulators; for therapeutics.

Introgene WO 00/23587

Alzheimer's gene therapy

Leiden, the Netherlands

Gene therapy for Alzheimer's disease by delivering the apolipoprotein E gene in humanized glial cells.

Japan Sci. & Technol. WO 00/23468

Signal transducers

Saitama, Japan

Human signal transducing proteins STAM2a and STAM2b, encoding gene sequences, antibodies.

Japan Sci. & Technol. WO 00/23586

Signal transducers

Saitama, Japan

Human signal transducing protein Gfr40, encoding gene sequences, antibodies.

Japan Tissue Engineering WO 00/23582

Transfected cell grafts

Aichi, Japan

Mucosal epithelial cell sheet that has had its cells transfected with a therapeutic gene; for making grafts.

Keygene WO 00/23620

DNA fingerprints

Wageningen, the Netherlands

Generation of DNA fingerprints using fragmentation and amplification of sample nucleic acids

Krebs Res. Ctr. WO 00/23583

Apoptosis modulator assay

Heidelberg, Germany

Identification of p53 binding areas on the CD95 DNA receptor; for finding apoptosis modulators.

Leukosite WO 00/23599

ER protein degradation

Cambridge, Mass.

Human proteins responsible for degradation of proteins in the endoplasmic reticulum (ER).

Ludwig Inst. Cancer Res. WO 00/23565

Neuropilin binding antagonist

New York

Neuropilin receptor extracellular domain, ligand-binding fragment, analogs, antibodies; for antagonists.

Ludwig Inst. Cancer Res. WO 00/23625

Nuclear body-associated proteins

New York

SCP proteins, encoding gene sequences; for analysis of SCP proteins associated with nuclear bodies.

Marine Biotech Inst. EPO 997 536

Topoisomerase gene footprint


Methods of identifying eukaryotes using a gene sequence in the intron-containing region of type II topoisomerase gene.

Methylgene WO 00/23112

Modifying methylation

St. Laurent, Que.

Modulation of mammalian gene expression regulated by methylation by using antisense oligos.

Millennium Pharma WO 00/23470

NIP2 protein homologs

Cambridge, Mass.

NIP2 protein homologs, encoding gene sequences, fusions, antigenic peptides, antibodies, transgenics.

Millennium Pharma WO 00/23588

G-protein coupled receptors

Cambridge, Mass.

G-protein coupled receptors, encoding genes; for modulator screens, diagnostics, and therapeutics.

Millennium Pharma WO 00/23784

Type II diabetes risk

Cambridge, Mass.

Measurement of mutations in carboxypeptidase E and its encoding gene; for determining type II diabetes risk.

Montana, Univ. of WO 00/23595

Neisseria anti-infectives

Missoula, Mont.

Neisseria gonorrhoeae and N. meningitidis Omp85 proteins, encoding genes; for treating gonorrhea and meningitis.

NIH (Natl. Inst. Hlth.) WO 00/23955

Antibodies for chronic disease

Bethesda, Md.

Chimeric virus-like particles for inducing autoantibodies to treat chronic infection, inflammation, and cancer.

Novartis WO 00/23567

Hematopoietic stem cell renewal

Basel, Switzerland

Promotion of hematopoietic stem cell self-renewal by treating with histone deacetylase and its inhibitors.

Noxxon Pharma WO 00/23616

Amplifying molecular matrices


Iterative exponential amplification of molecular matrices in solid phase systems using reversible linkers.

Opperbas Holding WO 00/23115

Trauma antibody therapeutics

Amsterdam, the Netherlands

Treatment of trauma and graft rejection using liposomes with DNA encoding CTLA4 immunoglobulin or CD40 ligand antibodies.

Otsuka Pharma WO 00/23476

Neovascular peptides


Neovascular-specific peptides, dendrimer preparations; for selectively delivering drugs to cancer tissues.

Pfizer EPO 997 528

Increased avermectin production

Groton, Conn.

Streptomyces avermitilis genes that regulate avermectin polyketide synthase; for increased production.

Powderject Vaccines WO 00/23592

Minimal promoters

Madison, Wis.

Minimal promoters; for linkage to transfected genes and use in expression of foreign proteins for vaccines.

Queensland, Univ. of WO 00/23474

Protein engineering

Brisbane, Australia

Searchable computer database with three-dimensional protein structure framework entries; for protein engineering.

Schering-Plough EPO 997 476

Langerhans cell antibodies

Levallois-Perret, France

Antibodies to a mammalian Langerhans cell antigen, purified proteins, encoding gene sequences; for diagnostics.

Scripps Res. Inst. WO 00/23456

Modified pyrimidines

La Jolla, Calif.

Modified pyrimidines that contain functional groups that mimic naturally occurring amino acid residues.

Signal Pharma WO 00/23581

Transcription and replication modulators

San Diego

Plasmid dual reporter systems for the independent evaluation of modulators of transcription and replication.

Singer, R.H., et al. WO 00/23621

Intracellular RNA visualization

New York

Visualizating the location and movement of RNAs in living cells in real time using a fluorescent binding protein.

Smith, S.J. WO 00/23799

Quantifying cellular protein

Bronx, N.Y.

Quantifying cellular proteins in tissue by using a cell imaging densitometer.

SmithKline Beecham WO 00/23467

Antibacterial screens


Bacterial birA polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/23574

Hepatitis A vaccines

Rixensart, Belgium

Inactivated hepatitis A virus free of host cell contamination; for vaccines.

SmithKline Beecham WO 00/23575

Antibacterial screens


Bacterial ugc polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/23611

Antibacterial screens


Bacterial fabG polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

South Carolina, Med. Univ. of WO 00/23469

IGF diabetes treatment

Charleston, S.C.

Fragments of insulin-like growth factor (IGF) and IGF binding protein; for preventing diabetes complications.

Spectral Diagnostics WO 00/23585

Diagnosing heart attacks


Stable, circulating degradation polypeptides of cardiac troponin I; for heart attack diagnostics.

Sunol Molecular EPO 997 477

MHC fusion complexes

Miramar, Fla.

MHC molecule fusion complexes; for identifying peptides that modulate T cell activity and induce immune responses.

Sunol Molecular WO 00/23087

Polyspecific binding molecules

Miramar, Fla.

Single-chain polyspecific binding molecules having a single-chain T-cell receptor and a single-chain antibody.

Takara Shuzo EPO 997 530

DNA polymerase-related factors

Kyoto, Japan

Thermostable DNA polymerase-associated factors that can enhance the DNA synthesizing activity of DNA polymerase.

Tepnel Medical WO 00/23619

Detecting single-stranded DNA

Altrincham, UK

Template chain reactions used for the detection of single-stranded target nucleic acid sequences.

Texas, Univ. of WO 00/23596

Modulating cholesterol

Austin, Texas

Cholesterol 25-hydroxylase, gene probes and primers; for screening modulators of serum cholesterol.

Texas Heart Inst. WO 00/22929

Atherosclerosis therapy


Gene transfer of human E2F-1 gene to vascular smooth muscle cells; for regressing atherosclerotic plaques.

U-Bisys WO 00/23570

Altering cell membranes

Utrecht, the Netherlands

Altering properties of cells or particles with cellular membranes using lipid-modified proteinaceous molecules.

Valigene WO 00/23622

Sorting cDNA libraries

New York

Labeling, sorting, and screening cDNA libraries using specific peptide-labeled oligonucleotides as tags.

Washington Univ. WO 00/23083

Anti-apoptotic BAX proteins

St. Louis

Truncated BAX polypeptides that are anti-apoptotic in neurons; for inhibiting neurodegeneration.

Xencor WO 00/23564

Protein design automation

Pasadena, Calif.

Protein design automation for generating computationally prescreened secondary libraries of proteins.

Yeda Res. & Develop WO 00/23082

Lupus erythematosus therapy

Rehovot, Israel

Down-regulating the autoimmune response to the C-terminal DNA-binding domain of p53; for treating lupus erythematosus.

Zymogenetics WO 00/23591

Secreted pancreatic protein


Highly expressed secreted pancreatic protein, encoding chromosome 1 gene, polymorphisms; for diagnostics.