Published March 8 (EPO); March 2 (WO); March 8 (GB)

Abbott Labs WO 00/12720

Polyunsaturated acids

Abbott Park, Ill.

Elongase genes involved in the elongation of polyunsaturated acids; for production.

Antex Biologics WO 00/12133

Neisseria vaccines

Gaithersburg, Md.

Neisseria proteins, encoding gene sequences, antibodies; for inducing an immune response.

Antex Biologics WO 00/12535

Meninigitis vaccines

Gaithersburg, Md.

Neisseria meningitidis NMASP polypeptides, encoding gene sequences, antibodies; for meningitis vaccines.

Aventis Pharma WO 00/12738

Targeting adenoviral vectors

Antony, France

Adenovirus vectors having modified fiber and hexon proteins; for targeting heterologous genes to specific tissues.

BASF WO 00/12739

Liver gene therapy

Worcester, Mass.

Methods and compositions for expressing heterologous genes in liver cells using hepadnaviral vectors; for gene therapy.

BASF WO 00/12748

Riboflavin production

Ludwigshafen, Germany

Microorganisms having inserted genes for riboflavin synthesis; for riboflavin production.

Bavarian Nordic Res. Ctr. WO 00/12737

Cell differentiation marker

Copenhagen, Denmark

Guanylate binding protein as an inhibitor of cell proliferation and marker of cell differentiation.

Bayer WO 00/12702

Colorectal cancer diagnostics

East Walpole, Mass.

Human genes differentially expressed in colorectal cancer, variants, encoded proteins, antisense, antibodies.

Becton Dickinson EPO 985 931

Syphilis immunoassay

Franklin Lakes, N.J.

Detection of antibodies to Troponema pallidum, fusion protein antigens; for diagnosing syphilis.

Biotech & Genetic Engineer. Ctr. EPO 985 729

Streptokinase mutants


Streptokinase mutants that retain plasminogen activator complex formation activity but have less antigenicity.

Boehringer Ingelheim WO 00/12696

Uncoupling protein 3 promoters

Ingelheim, Germany

Cell-specific promoters of uncoupling protein 3 expression; for high-throughput modulator screens.

Boston Univ. WO 00/12544

IRAP binding proteins


IRAP binding proteins, fusions, antigenic peptides, antibodies, transgenics; for diagnostics and therapeutics.

British Columbia, Univ. of WO 00/12528

Antimicrobial peptides

Vancouver, B.C.

Anti-endotoxic antimicrobial cationic peptides; for treating respiratory infections and accelerating wound healing.

Canag Diagnostics WO 00/12559

S100 antibodies

Goteborg, Sweden

Monoclonal antibodies against the calcium binding protein S100; for isoform immunoassays.

Cedars-Sinai Med. Ctr. WO 00/12710

Ataxin-2 binding protein

Los Angeles

Ataxin-2 binding protein gene, encoded ptotein, antisense, antibodies, transgenics; for diagnostics and therapeutics.

Chugai WO 00/12749

Sterol regulation inhibitors


Methods for screening sterol regulatory element binding protein pathway inhibitors; for therapeutics.

Chugai Inst. Molec. Med. WO 00/12712

Nerve differentiation factor

Ibaraki, Japan

Nerve differentiation factor, encoding gene sequences; for diagnostics and therapeutics.

Danisco GB 2 341 391

UDP-galactose epimerase

Copenhagen, Denmark

UDP-galactose epimerase, encoding gene sequences; for diagnostics and therapeutics.

Dendreon WO 00/12560

Tumor cell apoptosis


Human MHC class II, HLA-DR-specific antibodies; for inducing apoptosis in HLA-DR antigen positive tumor cells.

Desmos WO 00/12690

Laminin for bone growth

San Diego

Administration of laminin 5 in combination with other osteogenic and angiogenic factors; for bone growth.

Diacrin WO 00/12138

Immune rejection reduction

Charlestown, Mass.

Cells expressing immunoregulatory molecules that inhibit T cell activation; for reducing immune rejection.

Diadexus WO 00/12761

Baldder cancer antibodies

Santa Clara, Calif.

Antibodies to bladder cancer antigens; for diagnosing, imaging, staging, monitoring, and treating bladder cancer.

Duke Univ. WO 00/12740

Adenoviral vectors

Durham, N.C.

Adenoviral vectors with deletions in IVa2, 100K, polymerase, or preterminal protein regions; for gene therapy.

Eli Lilly WO 00/12117

Wnt homologs


Wnt homolog proteins, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.

Eli Lilly WO 00/12532

Factor VIII homologs


Factor VIII homologs, encoding gene sequences, antibodies, transgenics, production methods; for therapeutics.

Eli Lilly WO 00/12551

TGF-b binding protein


Human latent transforming growth factor (TGF)-b binding protein 3, encoding gene; for finding TGF-b inhibitors.

Fuso Pharma WO 00/12691

Hepatitis C diagnostics

Osaka, Japan

Enhancer sequences; for potentiating the expression of genes and diagnosing hepatitis C.

Gene Logic WO 00/11942

Ischemic heart gene

Gaithersburg, Md.

Human gene differentially expressed in ischemic heart tissue; for cardiac disease diagnostics and therapeutics.

Genentech WO 00/12562

Factor IX/IXa antibodies

S. San Francisco

Human anti-Factor IX/IXa antibodies, encoding gene sequences, fragments; for therapeutics.

Genentech WO 00/12708

Membrane-bound proteins

S. San Francisco

Pro-polypeptides from receptor and membrane-bound proteins, encoding genes, fusions, antibodies; for therapeutics.

Genoclipp Biotech WO 00/12725

Artemisinin synthesis

Groningen, Netherlands

Gene encoding amorpha-4,11-diene sythase; for transfection into cells and production of artemisinin.

Genoplex WO 00/12764

AIDS-related genes


Comparison of human and primate gene sequences using statistical methods; for finding AIDS-related genes.

Genvec WO 00/12765

Gene therapy vector purity

Gaithersburg, Md.

Determination of viral gene transfer vector stock purity using mass-to-charge ratio methods on fragmented samples.

Hawaii Biotech Group WO 00/12128

Flavivirus vaccines

Aiea, Hawaii

Recombinant flavivirus nonstructural protein fused to a truncated envelope protein; for vaccines and diagnostics.

Hayashibara Seibutsu WO/12555

IL-18 binding protein

Okayama, Japan

Interleukin (IL)-18 binding protein, encoding gene sequences, regulators; for immunotherapeutics.

Hong Kong, Univ. of WO 00/12677

Bursal disease virus vaccine

Hong Kong

Site-directed mutagenesis of recombinant infectious bursal disease virus; for attenuated vaccines.

Human Genome Sciences WO 00/12678

Staphylococcus vaccines

Rockville, Md.

Staphylococcus aureus genes, encoded proteins, production methods; for diagnostics and therapeutics.

Incyte Genomics WO 00/12685

Neurotransmitter processing genes

Palo Alto, Calif.

Genes associated with neurotransmitter processing, encoded proteins, antibodies, modulators; for therapeutics.

Incyte Genomics WO 00/12703

Protein transport molecules

Palo Alto, Calif.

Protein transport-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/12711

Membrane channel proteins

Palo Alto, Calif.

Human membrane channel proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/12742

Genome remodeling


Transfer of male germ cell promoter controlled Cre-mediated recombinase into oocytes; for genome remodeling.

Inst. Hormones & Plant Res. WO 00/12697

Estrogen receptor-b

Hamburg, Germany

Bovine estrogen receptor-b, fragments, encoding gene sequences; for identifying modulators.

Invitrogen WO 00/126787

Subcloning system

Carlsbad, Calif.

Cell-free cloning system having site-specific recombination sequences; for rapid recombinase-mediated subcloning.

Isis Pharma WO 00/12527

TRADD antisense

Carlsbad, Calif.

Antisense oligonucleotides for modulating TRADD expression; for diagnostics and therapeutics.

Itoh, K., et al. WO 00/12701

SART-3 tumor antigen

Saga, Japan

Tumor antigen SART-3, peptides, derivatives, encoding gene sequences; for diagnostics and therapeutics.

Japanese Ind. Sci. & Tech. Agency WO 00/12686

Ribozyme expression


Systems for expressing functional nucleic acids such as ribozymes.

Kao EPO 985 731

Mutated a-amylases


Mutated a-amylases having alkaline pH optima and tolerance to oxidizing agents.

KS Biomedix WO 00/12556

High affinity antibodies

Esher, UK

High affinity monoclonal antibodies, methods for immunoassays using these antibodies.

Kyowa Hakko Kogyo WO 00/12550

Transporter polypeptide


Transporter polypeptide, encoding gene sequences, antibodies; for identifying ligands.

L-Huillier, P.J., et al. WO 00/12552

Mammary-specific transcription factor

Hamilton, New Zealand

Mammary-specific transcription factor BrEts, encoding gene; for breast cancer diagnostics and therapeutics.

Mass. Inst. Technol. WO 00/12726

Rational heparinases

Cambridge, Mass.

Rationally designed heparinases derived fron heparinase I and II, encoding gene sequences; for therapeutics.

Microbiol. Res. Authority WO 00/12718

Meningococcal infection vaccine

Salisbury, UK

Superoxide dismutase, encoding gene sequences, antibodies; for eliciting immunity to meningococcal infections.

Millennium Biotherapeutics WO 00/12707

G-protein coupled receptor

Cambridge, Mass.

14926 G-protein coupled receptor, encoding gene; for modulator identification, diagnostics, and therapeutics.

Millennium Pharma WO 00/12762

Melanoma inhibition

Cambridge, Mass.

TANGO 130 genes, encoded protein related to melanoma-inhibiting protein, antigens, antibodies, transgenics.

Monash Univ. WO 00/12695

Tumor transcription modulators

Clayton, Australia

ELF5, a member of the ETS protein family, encoding gene, antibodies; for modulating transcription in tumors.

Myriad Genetics WO 00/12694

Prostate cancer gene

Salt Lake City

Chromosome 1-linked prostate cancer susceptibility gene, splice variants; for multisite tumor suppression.

NIH (Natl. Inst. Hlth.) WO 00/12706

Reproductive tissue protein

Bethesda, Md.

PAGE-3 gene which is preferentially expressed in normal reproductive tissues; for inhibiting cancer growth.

New England Biolabs EPO 985 730

SnaB1 restriction enzyme

Beverly, Mass.

SnaB1 methylase gene from Sphaerotilus natans, production and purification methods; for DNA digestion.

New York, State Univ. of WO 00/12546

Mammalian elk potassium channel

Albany, N.Y.

Mammalian elk potassium channel, encoding gene sequences; for identifying modulators.

New York Univ. WO 00/12679

Ubiquitin ligases

New York

Ubiquitin ligases, encoding gene sequences, transgenics; for cancer diagnostics and therapeutics.

New York Univ. WO 00/12683

Pluripotent stem cells

New York

Pluripotent stem cells with a fibroblast growth factor receptor on cell surfaces.

Nexstar Pharma WO 00/12530

Deoxyuridine conjugates

Boulder, Colo.

Site-directed covalent conjugation of deoxyuridine to selected moieties.

North Carolina, Univ. of WO 00/12693

Shuttling large DNA inserts

Chapel Hill, N.C.

Recombinant herpes virus-based plasmid for producing large-insert episomes; for shuttling large genomic DNA inserts.

Ontario Cancer Inst. WO 00/12719

Acute leukemia gene


CDC2-related kinase associated with acute leukemia, encoding gene sequences; for diagnostics and therapeutics.

Pan Pacific Pharma GB 2 341 389

Bee venom protein

Menlo Park, Calif.

Bee venom protein, encoding gene sequences, antibodies; for treating inflammatory diseases.

Pausch, M.H., et al. WO 00/12704 & 12705

G protein-coupled receptors

Princeton, N.J.

Constitutively active mutant heterologous G protein-coupled receptors; for enhanced functional expression.

Pittsburgh, Univ. of WO 00/12545

Bladder nuclear matrix proteins


Bladder nuclear matrix proteins, encoding gene sequences; for cancer diagnostics and therapeutics.

Princeton Univ. WO 00/12526

Modulating cell growth

Princeton, N.J.

Identification of p53-induced and -repressed target genes; for modulation of cell proliferation.

Promega WO 00/12728

Clostridial toxins

Madison, Wis.

Expression and production of clostridial toxins and proteins in bacteria; for vaccines and neurological therapeutics.

Quark Biotech WO 00/12139 & 12525

Hypoxia-regulated genes

Pleasanton, Calif.

Hypoxia-regulated genes, encoded proteins; for identifying neuroprotective agents.

Roche Diagnostics WO 00/12558

Islet cell antibodies

Mannheim, Germany

Human monoclonal antibodies against islet cell antigen IA-2, production methods; for detecting islet cell antigens.

Rochester, Univ. of WO 00/12763

PSA regulatory sequences

Rochester, N.Y.

Regulatory sequences of prostate specific antigen (PSA); for transgenics and controlling heterologous gene expression.

Schering WO 00/12543

Farnesyl protein transferase

Kenilworth, N.J.

Crystalline farnesyl protein transferase, substrate and inhibitor complexes; for structural determinations.

Shionogi WO 00/1277700

CDw108 protein

Osaka, Japan

CDw108 protein, encoding gene sequences, antisense, antibodies; for diagnostics and therapeutics.

SmithKline Beecham WO 00/12105

RAMP2a protein


RAMP2a protein, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/12106

GABA B1AA receptor


GABA B1AA receptor, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/12531

Antibacterial screens


RatC polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

Synaptic Pharma WO 00/12692

GABABR2 receptor

Paramus, N.J.

GABABR2 receptor, encoding gene, antisense, antibodies, transgenics; for modulator screens.

Taiho Pharma WO 00/12561

Thymidylate synthase antibodies


Anti-human thymidylate synthase monoclonal antibodies, production hybridoma cells; for immunoassays.

Terumo EPO 985 732

Chimeric collagen


Trimeric chimera protein containing collagen fused to a biologically active peptide; for fibril formation.

Transgene WO 00/12741

Adenoviral vectors

Strasbourg, France

Adenoviral vectors with heterologous genes inducible by inserted transcriptional activator genes; for therapeutics.

Trinity Coll. WO 00/12689

Staphylococcal vaccines

Dublin, Ireland

Cell wall-associated coagulase-negative staphylococcal proteins, encoding genes; for vaccines.

Urogenesys WO 00/12709

Prostate cancer protein

Santa Monica, Calif.

Helix-loop-helix protein highly expressed in prostate cancer, encoding gene; for diagnostics and therapeutics.

Vertex Pharma WO 00/12727

Protease inhibitor assay

Cambridge, Mass.

Fusion proteins for measuring protease activity, encoding gene sequences; for finding protease modulators.

Wisconsin, Univ. of WO 00/12682

Primate transplantation cells

Madison, Wis.

Primate embryonic stem cells that are MHC-matched to specific recipients; for transplantation.

Worldwide Medical WO 00/12529

Anti-sperm antibodies

Irvine, Calif.

Assay for anti-sperm antibodies to infertility-associated sperm antigens; for modulating fertility.

Yeda Res. & Develop. WO 00/127699

Apoptosis modulator

Rehovot, Israel

Transcription factor TAFIID subunit, modified fragment, encoding gene sequences; for modulating apoptosis.

Yu, L., et al. WO 00/12717 & 12721-12723

Lysozyme family gene

Shanghai, China

Human lysozyme family genes, encoded proteins, recombinant production methods; for diagnostics and therapeutics.

Zeneca WO 00/12698

Deltex Notch signal protein


Human Deltex-like gene, encoded Deltex Notch signaling protein; for regulating tissue physiology.