Company (Symbol)

Offer Date

Number Shares/Units (M)*

Price Per Share/Unit ($)

Gross ($M)*

Net ($M)

Shares Out (M)

Post-Offering Market Cap ($M)@

Lead UnderWriter**

Other UnderWriters

Albany Molecular Research Inc.1 (AMRI)

2/3

2.82S

$20

$56.3

$52.9

12.8

$256

INGB

HQ

AnorMED Inc.2 (TSE:AOM)***

2/25

5.2S

$4.04

$20.8

$19.8

20.5

$82.8

NB

Invitrogen Corp.3 (IVGN)

2/26

3.0S

$15

$45

$41.1

12.6

$189

DLJ

WDR, PJI

MorphoSys AG2 (Neuer Mkt:MORG)***

3/9

1.03S

$27.25

$28

$26

3.6

$98

DBAG

Immtech International (IIMMT)

4/27

1.15S

$10

$11.5

$9.2

5.15

$51.5

WRI

NCHK, CES

VaxGen Inc. (VXGN)

6/30

3.56S

$13

$46.3

$42.1

11.3

$146.4

PS

PZC

Genentech Inc. (NYSE:DNA)

7/20

22S

$97

$2,134

129.3

$12,542

JPM

GS, ML, WDR, BRS

BioMarin Pharmaceutical Inc. (BMRN)

7/22

5.2S

$13

$67.6

$XX.X

34.8

$452.4

USBPJ

VS, SSL, LSC

Biopure Corp. (BPUR)

7/30

3.5S

$12

$42

$37.9

22.1

$265

JPM

AHH, RWB

Genomics One Corp. (MSE:GNX)

11/24

3U

$0.85

$2.56

$2.18

ND

PGS

Oncolytics Biotech Inc. (ASE:ONC)

11/8

4S

$0.58

$2.3

$2.04

ND

CCC

Symyx Technologies Inc. (SMMX)

11/17

5.5S

$14

$77

$54.8

27.7

$387.8

CSFBC

DLJ, IA, SC

Maxygen Inc. (MAXY)

12/22

6.9S

$16

$110.4

$102

29.9

$478.4

GS

RS, IA

January - December 1999 IPO TOTAL: $2,643.76M

NOTES:

* Number of shares (or units) sold in the offering includes those sold to satisfy overallotment options, in full or in part, when disclosed. Likewise, gross proceeds include revenues for the sale of shares (or units) to satisfy overallotment options, in full or in part, where applicable.

** See Underwriters' Key on Page 6

***Converted to U.S. dollars based on exchange rate at the time of the offering.

@ Market capitalization calculated is based on offering price.

LSE = London Stock Exchange; ND = Not disclosed, reported and/or available

1 Albany Molecular Research Inc. had originally filed a prospectus for an initial public offering (IPO) of 2.2M shares priced between $15 and $17 each on 7/9/98. The company postponed the offering in early September due to market conditions, but reactivated it in January 1999, offering the same number of shares at a higher price range. However, it ended up selling 0.3M more shares than planned at $1 above the high end of the offering range.

2 AnorMED Inc.'s IPO occurred in Canada; MorphoSys' was in Germany.

3 On 1/28/99, Invitrogen Corp. raised the number of shares to be offered in its IPO to 3.5M from 3M. The company sold 3M shares, while existing stockholders sold 0.5M.

# Roche Holdings Inc., Genentech's major stockholder, offered all the shares of common stock in this transaction and

received the proceeds of the offering.