Company (Symbol)

Offer Date

Number Shares/Units (M)*

Price Per Share/Unit ($)

Gross ($M)*

Net ($M)

Shares Out (M)

Post-Offering Market Cap ($M)@

Lead UnderWriter**

Other UnderWriters

Powderject Pharmaceuticals plc1 (LSE:PJP; UK)***

2/1

8.0S

$11.06

$88.8

$85.8

72.4

$800

RF

Abgenix Inc. (ABGX)

3/4

3.2S

$15

$48.5

$48.1

14.8

$222

BRS

LB, PGE

ChiRex Inc.2 (CHRX)

3/19

2.9S

$19

$54.6

$51.1

12.3

$234

CSFBC

DRW, HQ, LM

QLT Phototherapeutics Inc. (QLTI)

3/30

3.16S

$43.63

$138

$131.1

27.3

$1,191

CIBC

BTAB, INGB, NB,

Cerus Corp. (CERS)

3/31

2.2S

$21

$46.2

$43.9

11.4

$239

MSC

BTAB, SGC

AltaRex Corp. (TSE:AXO)***

5/7

39.1S

$0.34

$13.3

$112.1

55.1

$19

FMSL

HSBC

Synsorb Biotech Inc. (SYBB; TSE: SYB)***

5/13

10.1S

$1.17

$11.9

$11.3

30

$35.1

TDS

HSBC, LOM, CCC

Trimeris Inc. (TRMS)

5/27

2.9S

$11.75

$33.8

$31.4

13.6

$160

INGB

BRS, SGC

Alliance Pharmaceutical Corp. (ALLP)

6/11

9.5

$2.45

$23.3

$22.1

33.2

$81

CR (placement agent)

Ribozyme Pharmaceuticals Inc. (RZYM)

7/7

1.8S

$3.50

$6.3

$5.8

11

$39

HQ (placement agent)

Angiotech Pharmaceuticals Inc. (TSE:ANP)***

7/9

1.5S

$7.8

$11.52

$10.4

LBG

LOM

Alizyme plc3 (LSE:AZM)***

7/21

7.0U

$1.19

$8.4

$7.9

49

$58.3

N/A

NeoTherapeutics Inc. (NEOT)

8/3

1.2S

$9.38

$11.3

$7.6

7.7

$72.23

JC

Shaman Pharmaceuticals Inc. (OTC BB:SHMN)

8/24

0.7S

$15

$10.7

$10.2

3.1

$46.5

AC

Pharmacyclics Inc. (PCYC)

9/24

2.3S

$38.75

$89.1

$83.6

12.5

$484.4

MSDW

HQ, PGE

Connetics Corp. (CNCT)

10/1

4.8S

$6

$28.8

$21

25.6

$153.6

WDR

HQ, RJA

CV Therapeutics Inc. (CVTX)

10/6

5.75

$12

$69

$65.5

16.3

$195.6

DLJ

BRS, JPM, SGC

Emisphere Technologies Inc. (EMIS)

10/28

2S

$11

$22

$20.4

14.2

$156.2

HQ

Genentech Inc. (NYSE:DNA)

10/20

20S

$143.5

$2,870

$2,726.5

128.4

$18,425.4

JPM

GSC, ML, WDR, RS

Invitrogen Corp. (Pull Note from issue)

10/27

5.9S

$25

$60

$41.5

18

$450

DLJ

HQ, USBPJ, DRW

Magainin Pharmaceuticals Inc. (MAGN)

10/15

4S $1.125

$1.00

$11

$9.6

27.9

$27.9

Shares directly offered by the company

Vion Pharmaceuticals Inc. (VION)

10/26

2.5S

$5

$12.5

$11.9E

17.9

$89.5

BMC

ViroPharma Inc. (VPHM)

10/22

3S

$19

$57

$53.3

14.6

$277.4

MSDW

USBPJ

Advanced Tissue Sciences Inc. (ATIS)

11/10

3.7U

$4

$15

$14.25

ND

Shares directly offered by the company

Alexion Pharmaceuticals Inc. (ALXN)

11/30

3S

$14

$47.8

$45.41

11.2

$156.8

USBPJ

HQ

BioCryst Pharmaceuticals Inc. (BCRX)

11/3

2S

$25.25

$50.5

$47.97

17.2

$434.3

SSB

HQ, RJA

Ilex Oncology Inc. (ILXO)

11/23

4.6S

$14

$64.4

$55.3

21.4

$299.6

CIBC

PVHG, USBPJ

ImClone Systems Inc. (IMCL)

11/19

3.1S

$32

$101.2

$94.3

28.4

$908.8

MSDW

ML, PVHG, WDR

Inex Pharmaceuticals Corp. (TSE:IEX)

11/23

4.9S

$2.55

$12.6

$11.9E

ND

NB

RBC, YS

Progenics Pharmaceuticals Inc. (PGNX)

11/19

2.3S

$19

$43.7

$41.1

11.6

$220.4

CIBC

RS, PVH, GKMC,

January - December 1999 FOLLOW-ON TOTAL: $4,061.22M

NOTES:

* Number of shares (or units) sold in the offering includes those sold to satisfy overallotment options, in full or in part, when disclosed. Likewise, gross proceeds include revenues for the sale of shares (or units) to satisfy overallotment options, in full or in part, where applicable.

** See Underwriters' Key on Page 6

***Converted to U.S. dollars based on exchange rate at the time of the offering.

@ Market capitalization calculated is based on offering price.

LSE=London Stock Exchange; TSE=Toronto Stock Exchange

1 PowderJect Pharmaceuticals plc sold 8.03M common shares on the London Stock Exchange (LSE) in a placing and open offer on a 1-for-8 basis. Prices have been converted at an exchange rate of £0.606/US$1.

2 ChiRex Inc. filed a shelf registration in 1998, which became effective on 12/28/98, covering the future sale of up to $100M in debt securities, preferred stock, depositary shares, warrants and common stock. The shares were offered as part of that shelf registration.

3 Alizyme plc's offered units, each consisting of two ordinary shares and one warrant, exercisable at 40p