Published Sept. 11 & 18 (EPO); Sept. 6 & 12 (WO); Sept. 18 (GB)
Abbott Labs Phosphorylated WO 96/27017 &
Abbott Park, Ill. protein expression 27018
Vector containing a recombinant protein and its kinase; forphosphorylating before secretion in bacteria.
Akzo Nobel HIV-2 infected EPO 731 165
Arnhem, the Netherlands cell line
Human T-cell line chronically infected with HIV-2; for purificationof gp120 and assay of infection.
Akzo Nobel HIV-1 group WO 96/27012
Arnhem, the Netherlands O antigens
Antigens from HIV-1 group O variant strains, encoding genes; fordiagnosis.
Amrad Vascular endothelial WO 96/27007
Kew, Australia growth factor
Gene for a vascular endothelial growth factor-like protein, encodedprotein; for vascular therapy.
Arkansas, Univ. of Natural killer WO 96/26744
Little Rock, Ark. protein
Gene for a natural killer lytic associated protein, encoded protein; forenhancing the activity of natural killer cells.
Asahi Cytoplasmic EPO 732 398
Osaka, Japan tyrosine kinase
Gene for a cytoplasmic tyrosine kinase whose expression isinfluenced by blood cell differentiation, encoded protein.
Asahi Variable EPO 732 404
Osaka, Japan region library
Vector designed to prepare an antibody variable region library.
Astra Mycobacterial GB 2 298 862
Sodertlje, Sweden polymerase sigma subunits
Genes for the sigma subunits of Mycobacterium tuberculosis RNApolymerase; for identifying inhibitors.
Bio Merieux Rheumatoid EPO 731 168
Marcy l'Etoile, France arthritis retrovirus
Isolation of a retrovirus that is associated with rheumatoid arthritis(in French).
Biomay Cladosporium WO 96/27005
Linz, Austria herbarum
Genes for Cladosporium herbarum allergens, encoded allergens; forallergy treatment.
California, Univ. of Vascular disease WO 96/26742
Oakland, Calif. gene therapy
Replication-deficient adenovirus with inserted transgenes; forperipheral vascular disease gene therapy.
California Inst. Technol. Neuron-restrictive WO 96/27665
Pasadena, Calif. silencer factor proteins
Gene for neuron-restrictive silencer factor proteins, encoded proteins,antibodies.
Canji Viral vector WO 96/27677
San Diego purification
Purification of recombinant viral vectors with anion exchange andimmobilized metal ion chromatography resins.
Cell Genesys Chimeric signal EPO 732 402
Foster City, Calif. transduction receptors
Chimeric receptors that are involved in signal transduction pathways,encoding genes; for therapeutics.
Cephalon Alzheimer's EPO 732 399
W. Chester, Penn. proteases
Chymotrypsin-like proteases that cleave a-amyloid precursor proteinof Alzheimer's disease; for identifying inhibitors.
Cephalon Transgenic WO 96/27395
W. Chester, Penn. SOD deficiency
Gene-targeted transgenic animal that is deficient in the superoxidedismutase (SOD) gene, vectors, cells.
Chiron Yeast hepatitis EPO 732 403
Emeryville, Calif. antigen expression
Yeast expression systems with vectors having GAPDH promoters;for producing hepatitis B surface antigen.
Cornell Univ. Interdependent WO 96/27021
Ithaca, N.Y. adenoviral gene therapy
Expression modulation during gene therapy by transfection withinterdependent adenoviral vectors.
Edinburgh, Univ. of Secretory gene EPO 731 169
Edinburgh, U.K. trap vectors
Secretory gene trap vectors; for isolating extracellular proteins andmaking cells with mutant secretory genes.
Fox Chase Cancer Ctr. Metastasis- WO 96/27609
Philadelphia associated gene
Chromosome 17 gene whose disruption is associated with cell growthand tumor development; for diagnosing metastases.
Genentech Heteromultimeric WO 96/27011
S. San Francisco proteins
Three-dimensional protein structure modification: for constructingmultimeric proteins with heterologous subunits.
Genentech Mutant signal WO 96/27016
S. San Francisco sequence vectors
Vectors with mutant signal sequences having reduced translationalstrength; for optimizing expression.
Genentech Fusion protein WO 96/27671
S. San Francisco cleavage
Bacterial subtilisin variants that cleave substrates at basic residues;for cleaving fusion proteins.
Genetics Inst. Megakaryocyte EPO 732 401
Cambridge, Mass. stimulating factor
Gene for a human megakaryocyte stimulating factor, encodedprotein, purification; for use as a therapeutic.
Glorioso et al. Herpes infected WO 96/27672
Cheswick, Penn. tissue treatment
Vector with a herpes virus promoter and a structural gene of interest;for treating herpes infected neurological tissues.
Harvard Univ. ELF-2 ligand WO 96/26958
Cambridge, Mass. of Eph
Gene for the ELF-2 ligand of the Eph receptor tyrosine kinases,encoded proteins; for neurological growth.
Hisamitsu Pharma Glutamate WO 96/26957
Saga, Japan transporters
Gene sequences for glutamate transporters and muteins, encodedproteins.
Human Genome Sciences Amine WO 96/27009
Rockville, Md. transporter
Gene for a human amine transporter protein, encoded protein; foridentifying agonists and antagonists.
Hybridon VEGF antisense WO 96/27006
Worcester, Mass. therapy
Oligonucleotides that are complementary to vascular endothelialgrowth factor (VEGF); for antisense therapy.
Imp. Cancer Res. Technol. Transgenic WO 96/27019
Transgenic animals expressing integrins in the suprabasal layer of theepidermis; for use as a psoriasis model.
INSERM (Natl. Inst. HIV-1 group WO 96/27013
Hlth. Med. Res.) O strains
HIV-1 group O retrovirus strains, fragments of these retroviruses; foruse as immunogens and diagnostic reagents.
INSERM (Natl. Inst. E2 protein WO 96/27613
Hlth. Med. Res.) antibodies
Monoclonal and polyclonal antibodies against a specific region of theE2 protein; for detecting/controlling tumors.
Italian Ministry Univ. Res. Chimeric EGF WO 96/27010
Rome receptor antibody
Chimeric mouse-human monoclonal antibody against the EGFreceptor, nucleic acid and amino acid sequences.
Italian Natl. Counc. Res. t(14;18) WO 96/27663
Rome translocation antisense
Antisense that hybridizes to the pre-mRNA of the disrupted gene int(14;18) translocated cells; for therapy.
Italian Natl. Counc. Res. B lymphocyte WO 96/27664
Rome IgH antisense
Antisense that hybridizes to the pre-mRNA of an immunoglobulin H(IgH) gene expressed in B lymphocytes; for therapy.
Loyola Univ. Immortalized WO 96/27004
Chicago fusion partners
Oncogenes expressed in lymphoid tissue injected into nuclei offertilized ova; for making hybridoma fusion partners.
NeXstar Pharma Exponential WO 96/27605
Boulder, Colo. ligand enrichment
Nucleic acid ligands produced by exponential enrichment; foridentifying therapeutically useful ligands.
Nippon Zoki Pharma Ambiguous EPO 731 176
Osaka, Japan sequence amplification
Duplication and amplification of a gene with an ambiguous DNAsequence; for isolating pathogenic organism genes.
Pharmacia Doxorubicin WO 96/27014
Milan, Italy production
Host cell with recombinant vector containing daunorubicin 14-hydroxylase; for making doxorubicin from daunorubicin.
Pharmacia & Upjohn Multidrug WO 96/27015
Kalamazoo, Mich. resistance protein kinase
Gene for a protein kinase associated with multidrug resistance,encoded protein.
Q.B.I. Enterprises Expression WO 96/27676
New Ziona, Israel vector kit
Vector with a weak promoter, transcription initiation factor gene, anda cloning cassette; for producing proteins
Rhone-Poulenc Rorer Atherosclerosis WO 96/27020
Antony, France gene therapy
Monocytes modified to express high density lipoprotein (LDL); foratherosclerosis gene therapy.
Shionogi Phospholipase C-a EPO 731 164
Gene for human phospholipase C-a, encoded protein, vectors; for useas an anti-inflammatory therapeutic.
Sumitomo Pharma Recombinant EPO 732 405
Osaka, Japan DNA virus vector
Recombinant DNA virus bearing a foreign gene; for transfection andgene therapy.
Tonen Calcium EPO 731 166
Tokyo binding proteins
Genes for calcium binding proteins, encoded proteins, antibodies tothem, for production.
Tularik Activated T WO 96/26959
S. San Francisco cell nuclear factor
Genes for the human nuclear factor of activated T cells, encodedproteins; for identifying diagnostic agents.
Washington Univ. Herpesvirus WO 96/26951
St. Louis detection
Genetically engineered cell lines with an expression vector having aherpesvirus-sensitive promoter; for detection.
Whitehead Inst. Genetically EPO 732 397
Cambridge, Mass. transduced hepatocytes
Hepatocytes transfected with heterologous genes and methods ofproducing and transplanting them.
Xoma Chimeric EPO 731 167
Berkeley, Calif. antibodies
Gene sequences that produce chimeric immunoglobulin moleculesand functional fragments; for humanization.
Yale University Vertebrate WO 96/27610
New Haven, Conn. Serrate genes
Genes for vertebrate Serrate genes, encoded proteins, antibodies; fordiagnosis and therapy.
Zeneca Diagnostic EPO 731 177
London base detection
Method of characterizing and detecting diagnostic base sequences innucleic acids in a sample.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.