Published Jan. 3 & 10 (EPO); Dec. 28 & Jan. 4 (WO); Jan. 10 (GB)
Alexion Pharma Pig xenograft WO 95/35120
New Haven, Conn. protection
Monoclonal antibodies against pig antigen presenting cells; forreducing rejection responses to xenografts.
Amgen Megakaryocyte EPO 690 127
Thousand Oaks, Calif. growth factors
Genes for megakaryocyte growth and development factors, encodedproteins, soluble forms.
Astra Penicillin binding GB 2 290 792
Sodertlje, Sweden protein
Soluble derivatives of penicillin binding protein fused to affinitymatrix binding protein; for purification.
Bio-Technology General Superoxide EPO 691 401 &
New York dismutase analogs 691 406
Genes for human manganese superoxide dismutase and analogs,encoded proteins, preparation; for treating inflammation.
California, Univ. of Lyme disease WO 95/35114
Oakland, Calif. vaccine
Gene for a Lyme disease antigen, encoded protein, expression vector;for use as a vaccine.
Cancer Res. Inst. Anti-proteolytic EPO 691 350
Copenhagen, Denmark antibodies
Monoclonal antibodies that inhibit binding between u-PA and u-PAR; for counteracting localized proteolytic activity.
Celltech Therapeutics Recombinant WO 95/35375
Slough, U.K. IL-5 antibodies
Recombinant antibodies to interleukin (IL)-5 that have heavy and/orlight chain residues from the donor antibody.
Chemoserotherap. Res. Inst. HIV antigen EPO 690 132
Kumamoto, Japan antibody
Monoclonal antibody to conserved region of a glycoprotein coatantigen of HIV; for treating multiple variants.
Children's Hosp. Bacterial adhesin WO 96/00233
E. coli chromosomal DNA encoding an adhesin that mediatesbacterial colonization of intestines.
Chiron IL-8 receptor WO 95/35376
Emeryville, Calif. binding domains
Recombinant polypeptides with interleukin (IL)-8 receptor bindingdomains; for identifying agonists/antagonists.
Chugai Caldecrin WO 96/00287
Gene for caldecrin, encoded protein, transformed host, productionprocess.
Ciba-Geigy Japan Heat-stable WO 96/00293
Hyogo, Japan prolylendopeptidase
Gene for heat-stable prolylendopeptidase, encoded protein,transformed host, production process.
Cornell Univ. Thermostable WO 96/00281
Ithaca, N.Y. cellulase
Gene for a thermostable cellulase, encoded protein, gene fragments,recombinant cellulases.
Dade Intl. Guanidine-free WO 96/00228
Deerfield, Ill. DNA isolation
Rapid isolation of nucleic acid using guanidine-free solutions; forobtaining suitable material for cloning.
Dan, M.D. Glioma therapy WO 95/35374
Don Mills, Ont.
Genes for monoclonal antibodies to cell cycle independent gliomasurface antigen; for treating gliomas.
Doheny Eye Inst. Protocadherins WO 96/00289
Genes for protocadherins and variants, encoded proteins, antibodies,recombinant production methods.
Du Pont Modified starch WO 95/35027
Wilmington, Del. genotype
Grain with a genotype that causes the resulting plant to producestarch with modified functional properties.
Duke Univ. Autoimmune EPO 690 307
Durham, N.C. antigen retrieval
Autoimmune antigens identified by inserting DNA library into cells,binding secreted antigens, and cloning genes.
Florida, Univ. of Oxalate assay WO 95/35377
Genes for formyl-CoA transferase and oxalyl CoA decarboxylase; fordetection of oxalate in biological samples.
Fred Hutchinson CTCF genes WO 95/35319
Cancer Res. Ctr.
Genes for CTCF, encoded proteins, antibodies to them; foridentifying mutants.
Gene Shears Optimized WO 96/00232
Neutral Bay, Australia ribozymes
Optimized ribozymes, including those embedded in tRNAs; fordiagnostic and therapeutic uses.
Genetics Inst. IL-3-like factors EPO 691 403
Genes for primate interleukin (IL)-3-like hematopoietic growthfactors, encoded proteins.
Georgetown Univ. Herpes tumor WO 96/00007
Replication competent herpes simplex virus vectors with defectivegenes; for killing malignant brain tumor cells.
Gist-Brocades More active WO 95/35382
Delft, Netherlands a-amylases
Amylolytic enzymes with improved properties and greater activitythat are derived from a-amylases.
Hoechst Schering Agrevo Antiviral EPO 691 402
Modified satellite RNAs and satellite viruses for adapted ribozymes;for use as antivirals (in German).
Human Genome Sciences 5-lipoxygenase- WO 95/35372
Rockville, Md. activating protein II
Gene for 5-lipoxygenase-activating protein II, encoded protein; foridentifying antagonists and mutations.
Human Genome Sciences Retinoic acid WO 96/00242
Rockville, Md. receptor epsilon
Gene for retinoic acid receptor epsilon, encoded protein; foridentifying binding ligands.
Human Genome Sciences ICE-like WO 96/00297
Rockville, Md. apoptosis protease-1/2
Genes for interleukin-1a converting enzyme (ICE)-like apoptosisprotease-1 and 2, encoded proteins.
Immuno Factor VIII EPO 690 126
Vienna, Austria fragments
Derivatives and fragments of Factor VIII, preparation methods; forhemophilia A treatment.
Immuno TBE virus vaccines EPO 691 404
Improved vaccines for immunization against TBE virus infection,methods of preparation (in German).
Imp. Coll. Sci. Tech. Med. Schistosoma WO 95/35370
Schistosoma protein antigen; for use as an anti-coagulant or vaccine.
Innogenetics Specific eubacterial WO 96/00298
Ghent, Belgium probes
Simultaneous detection and identification of eubacterial strains withspecific nucleic acid probes.
Inst. Hlth. Welfare Swine fever WO 95/35380
Leiystad, Netherlands virus
Swine fever virus genome, expression vector with partial sequences;for diagnosis and prevention.
Inst. Phys. Chem. Res. Cytotoxic EPO 690 125
Saltama, Japan lymphocyte immunotherapy
Culture of tumor cells and lymphocytes; for isolating tumor cytotoxiclymphocytes for adoptive immunotherapy.
Johns Hopkins Univ. Gene delivery WO 96/00295
Baltimore, Md. particles
Enzymatically degradable gelatin with bound nucleic acid and a cellsurface ligand; for targeted gene delivery.
Johnson & Johnson Horseradish EPO 690 071
Clin. Diag. peroxidase antibodies
Inhibitor and anti-inhibitor monoclonal antibodies to horseradishperoxidase; for conjugation to ligands.
Kirin Beer Glucan elicitor WO 95/35371
Gene for glucan elicitor receptor, encoded protein, expression vector,plant cells containing the gene.
Krebs Res. Inst. Aromatase WO 96/00231
Heidelberg, Germany oligonucleotide
Antisense oligonucleotide that is suitable for use in inhibiting theexpression of aromatase.
La Jolla Cancer Res. Fdn. Contactin WO 95/35373
La Jolla, Calif.
Gene for human contactin, encoded protein, its production; fortreating neuron damage.
Ludwig Inst. Cancer Res. Cytolytic WO 95/35500
New York T cell production
Production of cytolytic T cells that are specific for a peptide/MHCcomplex.
Ludwig Inst. Cancer Res. Immortal WO 96/00285
New York cells
Cells with immortalizing gene together with a gene of interest,animals containing these cells.
Mass. Gen. Hosp. Melatonin WO 95/35320
Genes for melatonin receptors, encoded proteins, antibodies; forfinding antagonists and controlling circadian rhythms.
Mass. Inst. Technol. Lipoprotein WO 96/00288
Cambridge, Mass. scavengers
Gene for scavenger receptor type proteins with an affinity formodified lipoproteins, encoded proteins.
MRC (Med. Res. Counc.) Non-infectious WO 96/00294
London viral particles
Viral particle designed to deliver its nucleic acid to a cell but notinfect the cell.
Merck Contraceptive WO 95/35118
Rahway, N.J. vaccine
Sperm surface protein; for disrupting sperm-egg interactions andpreventing fertilization.
Merck Streptomyces WO 96/00282
Rahway, N.J. expression vectors
Streptomyces expression cassettes useful for gene expression.
Miller, J.E. cDNA synthesis WO 95/35369
Methods for synthesizing cDNAs using a synthetic polynucleotidetemplate primer molecule.
Mt. Sinai Sch. Med. Ligation-depen- WO 95/35390
New York dent amplification
Identification of target sequences by ligating complementarysequences and ligand-mediated isolation followed by PCR.
Netherlands Org. Biol. Res. Protease EPO 691 409
The Hague, Netherlands assay
Modified proenzymes used as substrates to detect protease activity inbiological samples.
Netherlands Org. Biol. Res. Transforming WO 95/35389
The Hague, Netherlands difficult bacteria
Introducing genetic material into difficult to transformmicroorganisms by using osmotic shock and low pH.
Nitta Gelatin Culturing EPO 691 400
Osaka, Japan embedded cells
Embedding animal cells by mixing cells with collagen, gelling thenattaching droplets, and adding medium.
N. Carolina, Univ. of CDK6 inhibiting WO 95/35115
Chapel Hill, N.C. protein
Gene for a CDK6 inhibiting protein, encoded protein, antibodies toit, antisense oligonucleotides.
Novo Nordisk Yeast WO 95/35384 &
Bagsvaerd, Denmark expression host 95/35385
Yeast expression system lacking proteases and having vector withyeast signal sequence; for production in yeast.
Novo Nordisk Biotech Laccase WO 96/00290
Gene for Polyporus laccase, encoded protein, methods ofpurification.
Nutrasweet Amino acid EPO 691 405
Deerfield, Ill. hypersecretion
Insertion of a DNA inversion gene into bacteria; for hypersecretionof amino acids.
Pasteur Inst. Mycobacterium WO 96/00299
Paris xenopi probe
Nucleic acid probe that is specific to Mycobacterium xenopi; fordetection and identification.
Pennsylvania, Univ. of Ethylene WO 95/35318
Philadelphia sensitivity genes
Plant genes for ethylene sensitivity and pathogen resistance, encodedproteins.
Pennsylvania, Univ. of Alzheimer's WO 95/35366
Transgenic animals exhibiting Aa deposits characteristic ofAlzheimer's disease; for identifying therapeutics.
Perkin-Elmer Nucleic acid EPO 691 148
Norwalk, Conn. separation
Separation of double-stranded from single-stranded nucleic acidsusing solid support materials with aralkylamines.
Pioneer Hi-Bred Intl. Plant genes WO 95/35383
Des Moines, Iowa affecting growth
Genes for gibberellic acid biosynthesis; for making transgenic plantswith altered growth characteristics.
Pittsburgh, Univ. of Nitric oxide WO 96/00006
Gene for inducible nitric oxide synthase, encoded protein; fortreatment of vascular disorders and diseases.
Schering Insoluble protein WO 95/35368
Kenilworth, N.J. extraction
Insoluble mammalian protein extraction from bacteria while avoidingirreversible insolubilization of host proteins.
Scottish Crop Res. Inst. Spliceosomal WO 95/35386
Dundee, U.K. protein gene promoters
Promoters from potato and maize spliceosomal protein genes; forexpression of heterologous proteins.
Snow Milk Osteoblast WO 96/00240
Sapporo, Japan growth factor
Protein with osteoblast proliferating activity, its amino acid sequence;for treating bone disease.
SCRAS (Soc. Res. Sci. Isoprenyl protein GB 2 290 791
Applic. Counc.) transferase
Oligonucleotides that hybridize to genes or transcription products ofisoprenyl protein transferase.
Stanford Univ. Cyclophilin WO 95/35501
Stanford, Calif. ligand
Gene for the cyclophilin ligand, a calcium signal modulating protein,encoded protein; for screening drugs.
Stanford Univ. T cell anergy WO 96/00300
Stanford, Calif. genes
Methods for identification of T cell anergy genes; for monitoringinduction of tolerance.
Symbicom Lyme disease WO 95/35379
Umea, Sweden vaccine
Genes for Lyme disease antigen, encoded antigen, antibodies to it;for diagnosis and vaccination.
Taisho Pharma Liver growth EPO 691 347
Gene for hepatic parenchymal growth substance obtained fromhemihepatectomized tissue, encoded protein.
Texas, Univ. of Lyme disease WO 95/35119
Austin, Tex. mutants vaccine
Surface protein from mutant bacteria that cause Lyme disease; forvaccine.
Toagosei Endothelial cell WO 96/00286
Tokyo growth factor oligo
Antisense nucleic acid that binds endothelial cell growth factor gene;for expression inhibition.
Torchilin et al. Autoantibody WO 96/00084
Charlestown, Mass. cancer therapy
Antinuclear autoantibody from an aged mammal that binds cellsurface tumor antigens; for cancer therapy.
Unilever Hydrophobic WO 95/35381 &
Rotterdam, Netherlands lipase variants 96/00292
Variants of Pseudomonas lipase in which the surface hydrophobicityhad been increased.
USDA (U.S. Dept. Agricult.) Virus resistant WO 95/35024
Beltsville, Md. plants
Genes for proteins inducing resistance to tobacco mosaic virus,encoded proteins; for making transgenic plants.
Vertex Pharma IL-1a converting WO 95/35367
Cambridge, Mass. enzyme
Crystal structure and mutants of interleukin (IL)-1a convertingenzyme; for designing inhibitors.
Wellcome Fdn. Suicide vectors EPO 690 129
Vectors with thymidine kinase gene and tissue-specific controlelements; for targeting cancer cells for suicide.
Zeneca Modified starch WO 95/35026
Transgenic/mutated plants with a genotype modification resulting inproduction of functionally modified starch.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.