Published Aug. 30 & Sept. 6 (EPO); Aug. 17, 24, & 31(WO)
Abbott Labs Hepatitis GB virus WO 95/21922
Abbott Park, Ill.
Hepatitis GB virus (HGBV) DNA and amino acidsequences, HGBV antibodies; for diagnosis andtreatment.
Affymax Fragmented DNA WO 95/22625
De Ruydekade, reassemblyNetherlands Antilles
Methods for DNA reassembly after randomfragmentation; for molecular evolution.
Agritech Labs Inhibin puberty WO 95/22980
Grand Prairie, Tex. acceleration
Coding sequence of inhibin, encoded protein; foraccelerating puberty in birds.
Ajinomoto Bacterial glutamic EPO 670 370
Tokyo acid production
Escherichia coli strains whose metabolic pathways aremodified to increase L-glutamic acid production.
Ajinomoto Corynebacterial WO 95/23224
Tokyo L-lysine production
Corynebacteria strains whose metabolic pathways aremodified to increase L-lysine productivity.
Akzo Nobel Tumor associated WO 95/22613
Arnhem, Netherlands antibodies
Transformed B-cells from cancer patients immunizedagainst autologous tumor antigen, produced monoclonalantibodies.
Akzo Nobel T cell receptor WO 95/23164
Arnhem, Netherlands fragment
Coding sequence of variable region of a T-cell receptorassociated with an immune disease, encoded protein.
American Cyanamid G-protein coupled WO95/21925
Wayne, N.J. receptors
Coding sequence of G-protein coupled receptors; forexpression in yeast.
American Red Cross Transgenic WO 95/22249
Washington fibrinogen
Transgenic animals that produce fibrinogen, fragments,fusions, and other variants in their milk.
Amgen Cell cycle protein WO 95/21917
Thousand Oaks, Calif.
Coding sequence of a mammalian cell cycle protein,encoded protein; for controlling cell division.
Amicon Mobile site WO 95/23236
Beverly, Mass. sequencing
Gene sequencing that uses mobile DNA sites for DNApolymerases.
Angeletti Inst. Molec. Optimized HCV WO95/22985
Biol. Res. protease activity
Pomezia, Italy
Coding sequences of hepatitis C virus (HCV) proteinsthat give a protein with an optimal serine proteaseactivity.
BASF CD45-associated WO 95/21916
Ludwigshafen, Germany protein
Coding sequence of a CD45-associated protein, encodedprotein; for treating immune system disease.
Becton Dickinson Mycobacteria EPO 669 402
Franklin Lakes, N.J. oligo probes
Oligonucleotide probes that are specific forMycobacterium kansasii; for detection.
Boehringer Ingelheim Interferon-regulatory EPO 669400
Ingelheim, Germany factor-1
Coding sequence of interferon-regulatory factor-1; formeasuring gene inactivation and diagnosing cancer.
Boehringer Mannheim 3'-RNA labeling EPO669 395
Mannheim, Germany
Use of terminal transferase and deoxynucleotides to label3'-RNA (in German).
Brazil, Republic of Anchored WO 95/22614
Rio de Janeiro, Brazil recombinant proteins
Production of recombinant proteins anchored byglycosylphosphatidylinositol in yeast production strains.
Brigham & Women's Hosp. TIL stimulating WO95/21862
Boston fragment
Antigenic oncogene protein fragment; for stimulating thegrowth of tumor infiltrating lymphocytes (TIL).
Brigham & Women's Hosp. Integrin WO95/22610
Boston subunit
Coding sequence of integrin subunit, encoded protein,expression vectors, and host cells.
California, Univ. of Lung cancer WO 95/22624
Oakland, Calif. chromosomal abnormalities
Detection of chromosomal abnormalities that arecorrelated with lung cancer; for diagnosis.
Case Western Res. Univ. Homeobox growth WO95/23161
Cleveland inhibitor
Coding sequence of a homeobox-related gene encodingan inhibitor of vascular smooth muscle cell growth.
Cleveland Clinic Fdn. 2-5A-dependent WO95/22245
Cleveland RNases
Coding sequences of 2-5A-dependent RNases, encodedprotein; for inhibiting viral replication.
Columbia Univ. Vertebrate WO 95/23223
New York hedgehog homolog
Coding sequence of vertebrate homolog of hedgehog(vhh-1) which is expressed by the notochord.
CSIRO (Comm. Sci. Pathogen-resistant WO95/21924Indus. Res. Org.) plants
Campbell, Australia
Coding sequence of glucose oxidase; for creating disease-resistant transgenic plants.
Curie, Pierre & Marie, Univ. Gene therapy WO95/22617
Paris system
Host cell-vector system for use in gene therapy that isviral-based and produces defective infectious viruses.
Daiichi AT/AT-III complex EPO 669 344
Tokyo antibodies
Monoclonal antibodies to antithrombin (AT)-antithrombin III (AT-III) complexes; for diagnostic use.
Dana-Farber Cancer Inst. Nucleic acid WO95/22618
Boston delivery system
Fusion protein with target cell and nucleic acid bindingmoieties; for stable transgene expression.
Freiburg Univ. Cloned fibroblasts WO 95/23216
Freiburg, Germany transfected
Preparation of fibroblast clones from donors, genetransfection method, transfected fibroblast clones.
Fujirebio Treponema EPO 670 494
Tokyo antibody
Treponema pallidum antibody; for use in a sensitive assayfor the antibody.
Fujisawa Recombinant WO 95/23220
Osaka, Japan 2KLGA
Transformed bacterial strains used to make 2-keto-L-gulonic acid (2KLGA); for producing ascorbic acid.
Fuso Pharma Yeast probes EPO 670 373
Osaka, Japan
Nucleotide probe specific to the yeast, Candida albicans;for infection diagnosis.
Grunenthal Improved bifunctional EPO 669394
Aachen, Germany urokinase
Bifunctional derivatives of urokinase with improvedfibrinolytic and antithrombin inhibiting activities [inGerman].
Hoffmann-La Roche Long DNA EPO 669 401
Basel, Switzerland amplification
PCR amplification of DNA sequences of greater than 10kilobases using thermostable enzymes.
Illinois, Univ. of Affecting cisplatin WO95/22612
Urbana, Ill. sensitivity
Genetic suppressor elements that confer resistance tocisplatin, genes associated with sensitivity to cisplatin.
Imclone Systems VEGF receptor WO95/21868
New York antibodies
Monoclonal antibodies to the extracellular domain ofvascular endothelial growth factor (VEGF) receptor.
Immusol Hepatitis B WO 95/22600
San Diego ribozymes
Coding sequences for ribozymes that treat hepatitis Binfection, encoded ribozymes.
Isis Innovation Hypoxic gene WO 95/21927
Oxford, U.K. therapy
Vectors with a coding sequence of a therapeutic proteinlinked to a promoter induced by hypoxia.
Kirin Brewery Thrombopoietin WO 95/21919
Tokyo
Coding sequence of thrombopoietin polypeptides,encoded proteins, antibodies; for treating plateletdisorders.
Landegren, U. Circularizable probe WO 95/22623
Uppsala, Sweden detection
arget nucleic acid detection by probe binding andcyclization, followed by digestion and isolation.
Leeds, Univ. of Anti-parasitic WO 95/23229
Leeds, U.K. transgenic plants
Transgenic plants with a gene for an inhibitor of adigestive enzyme of a parasite.
Li-Cor Fluorescent EPO 670 374
Lincoln, Neb. labeled DNA
Marking DNA strands with fluorescent labels; foridentifying specific strands.
Ludwig Inst. Cancer Res. MAGE-1 on WO95/21630
New York abnormal cells
Methods for identification of MAGE-1 derived peptideson abnormal cells; for diagnosis and therapy.
Ludwig Inst. Immunointeractive WO 95/21865,Cancer Res. molecules WO 95/21866
New York
Molecules that are immunointeractive with animalgrowth factor receptors; for diagnosis and treatment.
Macfarlane Burnet Non-pathogenic WO95/21912Ctr. Med. Res. HIV strains
Fairfield, Australia
Non-pathogenic strains of HIV-1 and their geneticsequences; for AIDS diagnosis and treatment.
Mass. Gen. Hosp. Chimeric CD4 cells WO95/21528
Boston
Coding sequence of a chimeric CD4 receptor, receptorbearing cells; for immune response against HIV-infectedcells.
Max-Planck Inst. Insulin mediator WO95/23231
Munich, Germany cells
Cell lines with insulin receptor and receptorphosphotyrosine phosphatase; for identifying insulinmediators.
Merck FK-506 binding WO 95/21861
Rahway, N.J. protein
Cytosolic protein that binds FK-506 and othermacrolides; for immunosuppressant assays.
Michigan, Univ. of Bone cell WO 95/22611
Ann Arbor, Mich. transfection
Methods for transferring nucleic acids into bone cells insitu; for treating bone diseases.
Mitsubishi Glutamate receptor EPO 669 397
Tokyo mutein
Coding sequence of mutated glutamate receptor gene,encoded protein; for study of the central nervous system.
Mogen Intl. Fungal-resistant WO 95/21929
Leiden, Netherlands plants
Coding sequence of antifungal proteins, encodedproteins; for making resistant transgenic plants.
NIH (Natl. Inst. Hlth.) Hepatitis E WO 95/21858
Bethesda, Md. peptides
Coding sequences of a mosaic hepatitis E viruspolypeptide and epitopes, encoded proteins.
Nexstar Pharma Thrombin/bFGF WO95/21853
Boulder, Colo. ligands
Nucleic acid ligands to thrombin and basic fibroblastgrowth factor (bFGF).
Novo Nordisk Factor VIII:C EPO 670 332
Bagsvaerd, Denmark activity protein
Coding sequence of a human Factor VIII:C-like proteinwith A and C subunit sequences, but not those of the Bsubunit.
Novo Nordisk Lipolytic enzyme WO 95/22615
Bagsvaerd, Denmark mutein
Mutagenized lipolytic enzyme with decreaseddependence on calcium and/or improved tolerance todetergents.
Olsen et al. Seedling tissue WO 95/23230
As, Norway vector
Expression system for germinating seedling tissue with avector driven by the lipid transfer protein gene promoter.
Ono Pharma Programmed cell EPO 670 369
Osaka, Japan death protein
Coding sequence for a membrane protein involved inprogrammed cell death, encoded protein.
Ono Pharma PGI2 receptor WO 95/21863
Osaka, Japan
Coding sequence of prostaglandin I2 (PGI2) receptor,encoded protein, antibodies to the protein.
Oregon Hlth. Sci. Univ. ATP-sensitive WO95/21943
Portland, Ore. potassium channels
Coding sequences of ATP-sensitive potassium channelproteins, encoded proteins; for diabetes treatment.
Oregon Reg. Primate Ctr. Bombesin- WO95/23159
Beaverton, Ore. related peptide
Coding sequence of bombesin-related peptide, encodedpeptide, expression vector, host cells.
Pasteur Merieux Combinatorial WO95/21914
Lyon, France antibody vectors
Vector populations with mixtures of antibody lightchain/heavy chain variable region coding sequences.
Penn. St. Univ. Self-incompatibility WO95/21913
University Park, Penn. gene
Antisense DNA to the self-incompatibility gene in plants;for eliminating self-incompatibility in transgenic plants.
Pfizer Canine/feline WO 95/23218,
New York cell lines WO 95/23219
Immortalized canine and feline cell lines; for makingdiagnostic reagents and vaccines.
Procter & Gamble Osteosarcoma WO 95/21918
Cincinnati, Ohio cell lines
Rat osteosarcoma cell lines, growth factor produced, andprotein purification methods.
Qiagen Single/double-strand WO 95/21849
Hilden, Germany chromatography
Chromatographic process for separating single-strandedand double-stranded nucleic acids.
Queensland, Univ. of Insect cell WO 95/23215
St. Lucia, Australia expression
Production of large quantities of virus, viral orrecombinant proteins from low infection multiplicityinsect cells.
Rhone-Poulenc Rorer Cationic peptide WO95/21931
Antony, France transfection
Complexes of nucleic acids and cationic oligopeptides;for use in transforming cells during gene therapy.
Rhone-Poulenc Rorer Galanin receptor WO95/22608
Antony, France activity
Coding sequence of proteins with galanin receptoractivity, encoded proteins, expression host cells.
Rhone-Poulenc Rorer Alzheimer's WO 95/22616
Antony, France model
Transgenic animal model of Alzheimer's disease withinserted plaque gene.
Ribozyme Pharma Ribozymes WO 95/23225
Boulder, Colo.
Enzymatic RNA molecules that can be used to inhibit theexpression of disease-related genes
Rochester, Univ. of Tolerogenic WO 95/21916
Rochester, N.Y. peptides
Coding sequence of tolerogenic peptides presented asepitopes on fusion immunoglobulins; for cell expression.
Royal Cancer Hosp. Inst. MAP kinase WO95/21923
London phosphatases
Coding sequences of MAP kinase phosphatases, encodedproteins, antibodies; for control of cell growth.
Schering Thymokine WO 95/21921
Kenilworth, N.J.
Coding sequence of thymokine, encoded protein,antibodies; for diagnostic assay kits.
Seikagaku Glucan affinity EPO 669 396
Tokyo factor
Coding sequence for horseshoe crab amebocyte factorhaving high affinity for fungal cell wall glucan.
Shimadzu PCR bacterial EPO 669 399
Kyoto, Japan identification
Oligonucleotides complementary to genes specific to avariety of bacterial strains; for diagnosis by PCR.
SmithKline Beecham Methanolic yeast WO95/21928
Rixensart, Belgium production strains
Vectors encoding heterologous proteins under the controlof yeast sequences; for methanolic yeast fermentation.
SmithKline Beecham ESTs in disease WO95/21944
King of Prussia, Penn.
Identification of genes differentially expressed indiseased animals using expressed sequence tags (EST).
Stanford Univ. CD4 T-cell ligands WO 95/21915
Palo Alto, Calif.
Coding sequences for ligands binding to activated CD4 Tcells, encoded proteins, antibodies.
Stichting Pathol. Res. Genital HPV probes WO95/22626
Amsterdam, Netherlands
Oligonucleotide probes specific to human genitalpapilloma virus (HPV) genotypes; for PCR-based assay.
Syntro Recombinant WO 95/22607
Lenexa, Kan. equine herpesvirus
Equine herpesviruses with inserted foreign genes; forproducing fetal-safe, live recombinant viruses.
Unilever Galactanase activity WO 95/23228
London protein
Coding sequence of an enzyme with exo-(1 to 4)-a-D-galactanase activity, encoded protein.
Vanderbilt Univ. Vacuolating toxin WO95/22988
Nashville, Tenn.
Coding sequence of Helicobacter pylori vacuolatingtoxin, encoded protein, deficient strains; forimmunization.
Vermont, Univ. of Diabetes T cells WO95/21623
Burlington, Vt.
Receptor from T cells mediating diabetes; for treatmentor gene therapy.
Washington, Univ. of HIV reverse WO 95/22622
Seattle transcriptase inhibitors
Methods for detection of compounds that inhibit HIVreverse transcriptase; for AIDS therapy.
Wellcome Fdn. Glutamate WO 95/22609
London receptors
Coding sequences of human glutamate receptors, encodedproteins; for ligand screening.
Wistar Inst. RNA editing WO 95/22604
Philadelphia enzymes
Coding sequence of RNA editing enzymes, encodedproteins, methods of use.
Yeshiva Univ. Mycobacteria- WO 95/23226
Bronx, N.Y. inhibiting gene
Mycobacterial diaminopimelic acid gene; for use inpreventing infection.
Yissum Res. Develop. Acetylcholine- WO 95/23158
Jerusalem sterase transgenes
Transgenic animals with alternative forms of humanacetylcholinesterase genes; for ligand assay.
Zeneca Pectin esterase WO 95/23227
London isoenzyme
Coding sequence of pectin esterase isoenzyme, transgenicplants; for modifying fruit-ripening characteristics.
Zymogenetics Hematopoietic WO 95/21920
Seattle proteins
Coding sequences for hematopoietic proteins andfragments, encoded proteins, antibodies; for cell growthstudy.
Zymogenetics Orphan receptor WO 95/21930
Seattle cells
Methods for obtaining cells producing ligands for orphanreceptors, identification of ligand coding sequences.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.